Detailed information for compound 1642193

Basic information

Technical information
  • TDR Targets ID: 1642193
  • Name: (2Z)-N-(3,4-dichlorophenyl)-4-[2-[3,5-di(phen yl)pyrazol-1-yl]-4-methyl-1,3-thiazol-5-yl]-2 -(methylhydrazinylidene)-4-oxobutanamide
  • MW: 603.522 | Formula: C30H24Cl2N6O2S
  • H donors: 2 H acceptors: 4 LogP: 8.29 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN/N=C(\C(=O)Nc1ccc(c(c1)Cl)Cl)/CC(=O)c1sc(nc1C)n1nc(cc1c1ccccc1)c1ccccc1
  • InChi: 1S/C30H24Cl2N6O2S/c1-18-28(27(39)17-25(36-33-2)29(40)35-21-13-14-22(31)23(32)15-21)41-30(34-18)38-26(20-11-7-4-8-12-20)16-24(37-38)19-9-5-3-6-10-19/h3-16,33H,17H2,1-2H3,(H,35,40)/b36-25-
  • InChiKey: HZALSSOMBXGOSR-LAKKEJQSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2Z)-N-(3,4-dichlorophenyl)-4-[2-[3,5-di(phenyl)pyrazol-1-yl]-4-methyl-thiazol-5-yl]-2-(methylhydrazono)-4-oxo-butanamide
  • (2Z)-N-(3,4-dichlorophenyl)-4-[2-[3,5-di(phenyl)-1-pyrazolyl]-4-methyl-5-thiazolyl]-2-(methylhydrazono)-4-oxobutanamide
  • (2Z)-N-(3,4-dichlorophenyl)-4-[2-[3,5-di(phenyl)pyrazol-1-yl]-4-methyl-thiazol-5-yl]-4-keto-2-(methylhydrazono)butyramide
  • (2Z)-N-(3,4-dichlorophenyl)-4-[2-[3,5-di(phenyl)pyrazol-1-yl]-4-methyl-1,3-thiazol-5-yl]-2-(methylhydrazinylidene)-4-oxo-butanamide
  • AIDS-137379
  • AIDS137379
  • N-(3,4-Dichlorophenyl)-4-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-2-(methylhydrazono)-4-oxobutanamide
  • NSC641431

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/RYK protein kinase 0.0073 0.1726 0.3965
Schistosoma mansoni cpg binding protein 0.0028 0.0592 0.0592
Echinococcus granulosus tyrosine protein kinase HCK 0.0073 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0073 0.1726 0.3965
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0132 0.0303
Loa Loa (eye worm) hypothetical protein 0.0073 0.1726 0.3965
Echinococcus granulosus protein tyrosine kinase 0.0073 0.1726 0.1726
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.1726 0.3965
Schistosoma mansoni nuclear hormone receptor 0.001 0.0132 0.0132
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0132 0.0132
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Brugia malayi Receptor family ligand binding region containing protein 0.0073 0.1726 0.3965
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0103 0.2509 0.2509
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.1726 0.1726
Schistosoma mansoni hypothetical protein 0.0073 0.1726 0.1726
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0103 0.2509 0.5764
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Brugia malayi SH2 domain containing protein 0.0103 0.2509 0.5764
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0176 0.4352 0.4352
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0073 0.1726 0.3965
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.1726 0.1726
Echinococcus granulosus tyrosine protein kinase Src42A 0.0103 0.2509 0.2509
Echinococcus multilocularis insulin receptor 0.0073 0.1726 0.1726
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.1726 0.1726
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0773 0.0773
Echinococcus granulosus ephrin type A receptor 4 A 0.0073 0.1726 0.1726
Brugia malayi Protein kinase domain containing protein 0.0176 0.4352 1
Brugia malayi SH2 domain containing protein 0.0176 0.4352 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0103 0.2509 0.5764
Loa Loa (eye worm) TK protein kinase 0.0073 0.1726 0.3965
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0132 0.0132
Schistosoma mansoni ephrin receptor 0.0073 0.1726 0.1726
Schistosoma mansoni tyrosine kinase 0.0176 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0303
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Echinococcus multilocularis SH2 motif 0.0103 0.2509 0.2509
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.1726 0.3965
Echinococcus multilocularis SH2 motif 0.0103 0.2509 0.2509
Brugia malayi nuclear receptor NHR-88 0.001 0.0132 0.0303
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0073 0.1726 0.3965
Schistosoma mansoni protein kinase 0.0073 0.1726 0.1726
Trypanosoma brucei Pseudokinase, putative 0.0073 0.1726 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0176 0.4352 0.4352
Brugia malayi protein-tyrosine kinase 0.0176 0.4352 1
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.1726 0.1726
Loa Loa (eye worm) TK/FER protein kinase 0.0176 0.4352 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0132 0.0303
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) TK/FER protein kinase 0.0176 0.4352 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0103 0.2509 0.5764
Toxoplasma gondii protein kinase domain-containing protein 0.0073 0.1726 1
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0073 0.1726 0.1726
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Brugia malayi Protein kinase domain containing protein 0.0176 0.4352 1
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0099 0.0228
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0073 0.1726 0.1726
Brugia malayi Variant SH3 domain containing protein 0.0103 0.2509 0.5764
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.1726 0.1726
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0073 0.1726 0.1726
Echinococcus granulosus tyrosine protein kinase Fyn 0.0176 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.0073 0.1726 0.3965
Schistosoma mansoni hypothetical protein 0.0398 1 1
Onchocerca volvulus 0.0103 0.2509 0.5764
Trypanosoma cruzi protein kinase, putative 0.0073 0.1726 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0176 0.4352 0.4352
Schistosoma mansoni tensin 0.0103 0.2509 0.2509
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0103 0.2509 0.5764
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0032
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0073 0.1726 0.1726
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0073 0.1726 0.1726
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0073 0.1726 0.1726
Schistosoma mansoni serine/threonine RGC 0.0073 0.1726 0.1726
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0176 0.4352 0.4352
Echinococcus multilocularis cpg binding protein 0.003 0.0633 0.0633
Plasmodium falciparum protein kinase, putative 0.0073 0.1726 0.5
Brugia malayi SH2 domain containing protein 0.0103 0.2509 0.5764
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1726 1
Trichomonas vaginalis STE family protein kinase 0.0073 0.1726 1
Leishmania major protein kinase, putative 0.0073 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0773 0.1775
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0132 0.0303
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0073 0.1726 0.1726
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0103 0.2509 0.5764
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0073 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1726 0.3965
Echinococcus granulosus protein kinase 0.0073 0.1726 0.1726
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Brugia malayi beta-lactamase family protein 0.0035 0.0773 0.1775
Echinococcus multilocularis activated cdc42 kinase 1 0.0073 0.1726 0.1726
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0073 0.1726 0.3965
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.1726 0.1726
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0132 0.0132
Brugia malayi Tyrosine-protein kinase PR2 0.0073 0.1726 0.3965
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0132 0.0132
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0073 0.1726 0.3965
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0176 0.4352 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.1726 0.1726
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0032
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.1726 0.1726
Schistosoma mansoni SH2A 0.0103 0.2509 0.2509
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0103 0.2509 0.2509
Trichomonas vaginalis protein kinase atn1, putative 0.0073 0.1726 1
Loa Loa (eye worm) TK protein kinase 0.0073 0.1726 0.3965
Echinococcus granulosus N chimaerin 0.0103 0.2509 0.2509
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0073 0.1726 0.1726
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Schistosoma mansoni tyrosine kinase 0.0176 0.4352 0.4352
Brugia malayi CXXC zinc finger family protein 0.0028 0.0592 0.1361
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0103 0.2509 0.5764
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Echinococcus granulosus signal transduction protein lnk realted 0.0103 0.2509 0.2509
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0073 0.1726 0.1726
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0103 0.2509 0.2509
Toxoplasma gondii protein kinase 0.0073 0.1726 1
Brugia malayi SH2 domain containing protein 0.0103 0.2509 0.5764
Brugia malayi hypothetical protein 0.0073 0.1726 0.3965
Echinococcus granulosus tyrosine protein kinase Fyn 0.0176 0.4352 0.4352
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.1726 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Onchocerca volvulus 0.0176 0.4352 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0014 0.0014
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.1726 0.3965
Echinococcus multilocularis tyrosine protein kinase Abl 0.0176 0.4352 0.4352
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0073 0.1726 0.3965
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0073 0.1726 0.3965
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0773 0.4337
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0073 0.1726 0.1726
Brugia malayi ecdysteroid receptor 0.001 0.0132 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1726 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0073 0.1726 0.1726
Echinococcus multilocularis protein KINase family member (kin 25) 0.0073 0.1726 0.1726
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0073 0.1726 0.3965
Loa Loa (eye worm) hypothetical protein 0.0035 0.0773 0.1775
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1726 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0059 0.0059
Brugia malayi Tensin 0.0103 0.2509 0.5764
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0103 0.2509 0.2509
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0103 0.2509 0.2509
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0014 0.0014
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0176 0.4352 0.4352
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0073 0.1726 0.3965
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1726 0.3965
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0103 0.2509 0.2509
Echinococcus granulosus tyrosine protein kinase pr2 0.0073 0.1726 0.1726
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0073 0.1726 1
Brugia malayi bone morphogenetic protein type 1 receptor 0.0073 0.1726 0.3965
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0303
Loa Loa (eye worm) SH2 domain-containing protein 0.0103 0.2509 0.5764
Echinococcus multilocularis c src tyrosine kinase 0.0176 0.4352 0.4352
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0014 0.0032
Entamoeba histolytica SH2 domain containing protein 0.0103 0.2509 0.2981
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0059 0.0059
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.1726 0.1726
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Brugia malayi hypothetical protein 0.0103 0.2509 0.5764
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0103 0.2509 0.2509
Trichomonas vaginalis esterase, putative 0.0035 0.0773 0.4337
Schistosoma mansoni tyrosine kinase 0.0176 0.4352 0.4352
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Echinococcus granulosus insulin receptor 0.0073 0.1726 0.1726
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0176 0.4352 0.4352
Loa Loa (eye worm) TK/EGFR protein kinase 0.0073 0.1726 0.3965
Echinococcus granulosus activin receptor type 0.0073 0.1726 0.1726
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0073 0.1726 0.1726
Echinococcus multilocularis growth factor receptor bound protein 2 0.0103 0.2509 0.2509
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0073 0.1726 0.1726
Loa Loa (eye worm) TK/FER protein kinase 0.0176 0.4352 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0132 0.0303
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0773 0.5
Echinococcus granulosus SH2 motif 0.0103 0.2509 0.2509
Brugia malayi hypothetical protein 0.0005 0.0014 0.0032
Echinococcus multilocularis ephrin type A receptor 4 A 0.0073 0.1726 0.1726
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0103 0.2509 0.2981
Echinococcus granulosus suppressor of cytokine signaling 7 0.0103 0.2509 0.2509
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Loa Loa (eye worm) TK/ROR protein kinase 0.0073 0.1726 0.3965
Schistosoma mansoni ephrin receptor 0.0073 0.1726 0.1726
Giardia lamblia Kinase, NEK 0.0073 0.1726 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0073 0.1726 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0073 0.1726 0.1726
Schistosoma mansoni protein kinase 0.0073 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0073 0.1726 0.1726
Brugia malayi hypothetical protein 0.0005 0.0014 0.0032
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0132 0.0132
Echinococcus granulosus raf serine:threonine protein kinase 0.0073 0.1726 0.1726
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0132 0.0132
Schistosoma mansoni protein kinase 0.0073 0.1726 0.1726
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Loa Loa (eye worm) TK protein kinase 0.0073 0.1726 0.3965
Plasmodium vivax tyrosine kinase-like protein, putative 0.0073 0.1726 1
Entamoeba histolytica protein kinase, putative 0.0103 0.2509 0.2981
Schistosoma mansoni growth factor receptor-bound protein 0.0103 0.2509 0.2509
Echinococcus granulosus tyrosine kinase 0.0176 0.4352 0.4352
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0132 0.0303
Loa Loa (eye worm) TK protein kinase 0.0073 0.1726 0.3965
Echinococcus multilocularis activin receptor type 0.0073 0.1726 0.1726
Onchocerca volvulus 0.0103 0.2509 0.5764
Schistosoma mansoni nck2/grb4 0.0103 0.2509 0.2509
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.1726 1
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Schistosoma mansoni signal transduction protein lnk-related 0.0103 0.2509 0.2509
Schistosoma mansoni hypothetical protein 0.0103 0.2509 0.2509
Echinococcus granulosus tyrosine protein kinase Src64B 0.0176 0.4352 0.4352
Brugia malayi tRNA modification GTPase TrmE family protein 0.0103 0.2509 0.5764
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Echinococcus granulosus tyrosine kinase 0.0176 0.4352 0.4352
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0073 0.1726 0.3965
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.1726 0.1726
Brugia malayi hypothetical protein 0.0073 0.1726 0.3965
Echinococcus multilocularis tyrosine protein kinase Blk 0.0176 0.4352 0.4352
Brugia malayi SH2 domain containing protein 0.0103 0.2509 0.5764
Loa Loa (eye worm) TK/Met protein kinase 0.0073 0.1726 0.3965
Mycobacterium ulcerans beta-lactamase 0.0035 0.0773 0.5
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1726 0.3965
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0073 0.1726 0.1726
Trichomonas vaginalis protein tyrosine kinase, putative 0.0073 0.1726 1
Brugia malayi Protein kinase domain containing protein 0.0176 0.4352 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0176 0.4352 0.4352
Echinococcus multilocularis integrin linked protein kinase 0.0073 0.1726 0.1726
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0132 0.0303
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1389 0.1389
Onchocerca volvulus 0.0103 0.2509 0.5764
Echinococcus granulosus tyrosine protein kinase Fyn 0.0176 0.4352 0.4352
Giardia lamblia Kinase 0.0073 0.1726 0.5
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0103 0.2509 0.5764
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0132 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0132 0.0303
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0132 0.0132
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0103 0.2509 0.5764
Echinococcus multilocularis kinase suppressor of Ras 1 0.0073 0.1726 0.1726
Echinococcus multilocularis N chimaerin 0.0103 0.2509 0.2509
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Brugia malayi nuclear receptor RXR 0.0005 0.0014 0.0032
Leishmania major protein kinase, putative 0.0073 0.1726 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.1726 0.1726
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0103 0.2509 0.2509
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0176 0.4352 0.4352
Loa Loa (eye worm) SH2 domain-containing protein 0.0103 0.2509 0.5764
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0073 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0032
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0176 0.4352 0.4352
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.1726 0.1726
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0132 0.0132
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0073 0.1726 0.3965
Loa Loa (eye worm) TK/FER protein kinase 0.0176 0.4352 1
Brugia malayi Variant SH3 domain containing protein 0.0103 0.2509 0.5764
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0132 0.0132
Echinococcus multilocularis tyrosine protein kinase shark 0.0176 0.4352 0.4352
Schistosoma mansoni cpg binding protein 0.003 0.0633 0.0633
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0014 0.0032
Echinococcus granulosus tensin 0.0103 0.2509 0.2509
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0132 0.0303
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0303
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0103 0.2509 0.2509
Loa Loa (eye worm) TK protein kinase 0.0073 0.1726 0.3965
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0176 0.4352 0.4352
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Brugia malayi Guanylyl cyclase protein 23 0.0073 0.1726 0.3965
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.1726 0.3965
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Schistosoma mansoni protein kinase 0.0073 0.1726 0.1726
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Echinococcus granulosus cpg binding protein 0.003 0.0633 0.0633
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) TK/FER protein kinase 0.0176 0.4352 1
Onchocerca volvulus 0.0073 0.1726 0.3965
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1228 0.4778
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0032
Echinococcus multilocularis tyrosine protein kinase HCK 0.0073 0.1726 0.1726
Brugia malayi Sex muscle abnormal protein 5 0.0103 0.2509 0.5764
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0073 0.1726 0.1726
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0773 0.0773
Loa Loa (eye worm) TK/INSR protein kinase 0.0073 0.1726 0.3965
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0132 0.0303
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Echinococcus granulosus tyrosine protein kinase Src42A 0.0176 0.4352 0.4352
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1726 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0132 0.0303
Echinococcus granulosus integrin linked protein kinase 0.0073 0.1726 0.1726
Loa Loa (eye worm) TK/EPH protein kinase 0.0073 0.1726 0.3965
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0059 0.0059
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0103 0.2509 0.2509
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Echinococcus multilocularis tyrosine protein kinase 0.0073 0.1726 0.1726
Brugia malayi C-terminal src kinase protein 1 0.0073 0.1726 0.3965
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0303
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0176 0.4352 0.4352
Onchocerca volvulus 0.0073 0.1726 0.3965
Schistosoma mansoni coup transcription factor 0.001 0.0132 0.0132
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.1726 0.1726
Echinococcus granulosus c src tyrosine kinase 0.0176 0.4352 0.4352
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0073 0.1726 0.1726
Echinococcus multilocularis raf serine:threonine protein kinase 0.0073 0.1726 0.1726
Echinococcus granulosus hypothetical protein 0.0103 0.2509 0.2509
Onchocerca volvulus 0.0073 0.1726 0.3965
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Onchocerca volvulus 0.0073 0.1726 0.3965
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Loa Loa (eye worm) hypothetical protein 0.0035 0.0773 0.1775
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0773 0.0773
Echinococcus multilocularis protein kinase 0.0073 0.1726 0.1726
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0073 0.1726 0.1726
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.1726 0.3965
Echinococcus granulosus SHC transforming protein 3 0.0103 0.2509 0.2509
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0073 0.1726 0.3965
Brugia malayi Variant SH3 domain containing protein 0.0103 0.2509 0.5764
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Echinococcus granulosus SH2 domain containing adapter protein F 0.0103 0.2509 0.2509
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0132 0.0132
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0073 0.1726 0.3965
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0773 0.0773
Schistosoma mansoni protein tyrosine kinase 0.0073 0.1726 0.1726
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Brugia malayi RhoGAP domain containing protein 0.0103 0.2509 0.5764
Echinococcus granulosus tyrosine protein kinase shark 0.0176 0.4352 0.4352
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0132 0.0132
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.1726 0.3965
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0073 0.1726 0.1726
Echinococcus granulosus suppressor of cytokine signaling 6 0.0103 0.2509 0.2509
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Brugia malayi Variant SH3 domain containing protein 0.0103 0.2509 0.5764
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0073 0.1726 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0132 0.0303
Echinococcus multilocularis transfer RNA-Thr 0.0073 0.1726 0.1726
Brugia malayi Protein kinase domain containing protein 0.0176 0.4352 1
Schistosoma mansoni tyrosine protein kinase 0.0073 0.1726 0.1726
Plasmodium falciparum tyrosine kinase-like protein 0.0073 0.1726 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0176 0.4352 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0073 0.1726 0.3965
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0014 0.0032
Loa Loa (eye worm) TK protein kinase 0.0176 0.4352 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Schistosoma mansoni hypothetical protein 0.0103 0.2509 0.2509
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.1726 0.1726
Onchocerca volvulus 0.0035 0.0773 0.1775
Schistosoma mansoni tensin-related 0.0103 0.2509 0.2509
Loa Loa (eye worm) TK/ALK protein kinase 0.0073 0.1726 0.3965
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0059 0.0059
Echinococcus multilocularis NCK adaptor protein 0.0103 0.2509 0.2509
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0073 0.1726 0.3965
Echinococcus multilocularis 0.0103 0.2509 0.2509
Brugia malayi nuclear hormone receptor 0.001 0.0132 0.0303
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1726 0.3965
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.1726 0.1726
Loa Loa (eye worm) TK/FER protein kinase 0.0176 0.4352 1
Onchocerca volvulus 0.0073 0.1726 0.3965
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0773 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.0073 0.1726 0.1726
Echinococcus multilocularis heat shock protein 70 0.0073 0.1726 0.1726
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.1726 0.3965
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.1726 0.3965
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.1726 0.3965
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0176 0.4352 0.4352
Brugia malayi beta-lactamase 0.0035 0.0773 0.1775
Loa Loa (eye worm) protein kinase domain-containing protein 0.0073 0.1726 0.3965
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Echinococcus multilocularis tyrosine kinase 0.0073 0.1726 0.1726
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0132 0.0303
Loa Loa (eye worm) TK/FAK protein kinase 0.0073 0.1726 0.3965
Loa Loa (eye worm) SH2 domain-containing protein 0.0103 0.2509 0.5764
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0132 0.0132
Brugia malayi integrin-linked kinase 0.0073 0.1726 0.3965
Loa Loa (eye worm) hypothetical protein 0.0035 0.0773 0.1775
Loa Loa (eye worm) TK/FER protein kinase 0.0176 0.4352 1
Echinococcus multilocularis tensin 0.0103 0.2509 0.2509
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0073 0.1726 0.3965
Schistosoma mansoni thyroid hormone receptor 0.001 0.0132 0.0132
Plasmodium vivax tyrosine kinase-like protein, putative 0.0073 0.1726 1
Echinococcus multilocularis protein tyrosine kinase 0.0073 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0303
Onchocerca volvulus 0.0103 0.2509 0.5764
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0073 0.1726 0.1726
Echinococcus multilocularis SH2 domain containing protein 7 0.0103 0.2509 0.2509
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0132 0.0132
Giardia lamblia Protein 21.1 0.0073 0.1726 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0176 0.4352 0.4352
Schistosoma mansoni tensin-related 0.0103 0.2509 0.2509
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0773 0.4337
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.1726 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Onchocerca volvulus 0.0073 0.1726 0.3965
Schistosoma mansoni suppressor of cytokine signaling 0.0103 0.2509 0.2509
Schistosoma mansoni protein kinase 0.0073 0.1726 0.1726
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0073 0.1726 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0132 0.0303
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0103 0.2509 0.2509
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.5572 1
Echinococcus multilocularis tensin 0.0103 0.2509 0.2509
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Echinococcus granulosus natriuretic peptide receptor 1 0.0073 0.1726 0.1726
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0132 0.0132
Echinococcus granulosus receptor type guanylyl cyclase 0.0073 0.1726 0.1726
Echinococcus granulosus expressed conserved protein 0.0103 0.2509 0.2509
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0014 0.0014
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0073 0.1726 0.3965
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0073 0.1726 0.1726
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0176 0.4352 0.4352
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0103 0.2509 0.5764
Schistosoma mansoni tyrosine kinase 0.0176 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0073 0.1726 0.5
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Echinococcus granulosus tyrosine protein kinase 0.0073 0.1726 0.1726
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0132 0.0303
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0103 0.2509 0.2509
Loa Loa (eye worm) SRC-1 0.0176 0.4352 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0132 0.0303
Onchocerca volvulus 0.0176 0.4352 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) TK/FER protein kinase 0.0176 0.4352 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0176 0.4352 0.4352
Brugia malayi SH2 domain containing protein 0.0176 0.4352 1
Brugia malayi SH2 domain containing protein 0.0103 0.2509 0.5764
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0132 0.0132
Loa Loa (eye worm) TK protein kinase 0.0073 0.1726 0.3965
Loa Loa (eye worm) TK protein kinase 0.0073 0.1726 0.3965
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0132 0.0132
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Brugia malayi SH2 domain containing protein 0.0103 0.2509 0.5764
Schistosoma mansoni protein kinase 0.0073 0.1726 0.1726
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0073 0.1726 0.3965
Schistosoma mansoni protein kinase 0.0073 0.1726 0.1726
Onchocerca volvulus 0.0176 0.4352 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0132 0.0303
Schistosoma mansoni thyroid hormone receptor 0.001 0.0132 0.0132
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0132 0.0132
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Onchocerca volvulus 0.0035 0.0773 0.1775
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0303
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Plasmodium falciparum protein kinase, putative 0.0073 0.1726 0.5
Loa Loa (eye worm) hypothetical protein 0.0073 0.1726 0.3965
Schistosoma mansoni protein kinase 0.0073 0.1726 0.1726
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0132 0.0303
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.1726 1
Onchocerca volvulus 0.0176 0.4352 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0103 0.2509 0.2509
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0132 0.0303
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Echinococcus multilocularis SHC transforming protein 3 0.0103 0.2509 0.2509
Schistosoma mansoni cpg binding protein 0.003 0.0633 0.0633
Leishmania major hypothetical protein, conserved 0.0073 0.1726 1
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0103 0.2509 0.2509
Echinococcus granulosus SH2 domain containing protein 7 0.0103 0.2509 0.2509
Brugia malayi SRC-1 0.0176 0.4352 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0103 0.2509 0.2509
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Brugia malayi Furin-like cysteine rich region family protein 0.0073 0.1726 0.3965
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0103 0.2509 0.2509
Echinococcus granulosus activated cdc42 kinase 1 0.0073 0.1726 0.1726
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0103 0.2509 0.2509
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0773 0.1775
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0303
Schistosoma mansoni tyrosine kinase 0.0176 0.4352 0.4352
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0073 0.1726 0.1726
Onchocerca volvulus 0.0176 0.4352 1
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.1726 0.3965
Echinococcus granulosus tyrosine kinase 0.0073 0.1726 0.1726
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0102 0.0102
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0103 0.2509 0.2509
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0132 0.0132
Schistosoma mansoni protein kinase 0.0073 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0035 0.0773 0.1775
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.1726 0.1726
Schistosoma mansoni tyrosine kinase 0.0176 0.4352 0.4352
Loa Loa (eye worm) TK/DDR protein kinase 0.0073 0.1726 0.3965
Brugia malayi STAT protein, DNA binding domain containing protein 0.0103 0.2509 0.5764
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0132 0.0303
Brugia malayi ephrin receptor 1 precursor 0.0073 0.1726 0.3965
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0073 0.1726 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0132 0.0303
Schistosoma mansoni protein kinase 0.0073 0.1726 0.1726
Schistosoma mansoni shc transforming protein 0.0103 0.2509 0.2509
Loa Loa (eye worm) hypothetical protein 0.0035 0.0773 0.1775
Loa Loa (eye worm) TK protein kinase 0.0073 0.1726 0.3965
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.1726 0.3965
Mycobacterium ulcerans lipase LipD 0.0035 0.0773 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.1726 0.3965
Loa Loa (eye worm) TK/FER protein kinase 0.0176 0.4352 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0773 0.1775
Mycobacterium ulcerans hypothetical protein 0.0035 0.0773 0.5
Onchocerca volvulus 0.001 0.0132 0.0303
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0103 0.2509 0.2509
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0132 0.0132
Onchocerca volvulus 0.0103 0.2509 0.5764
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0176 0.4352 1
Echinococcus multilocularis SH2 motif 0.0103 0.2509 0.2509
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0773 0.4337
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0176 0.4352 0.4352
Schistosoma mansoni growth factor receptor-bound protein 0.0103 0.2509 0.2509
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Echinococcus multilocularis protein kinase 0.0073 0.1726 0.1726
Trichomonas vaginalis TK family protein kinase 0.0073 0.1726 1
Schistosoma mansoni tensin 0.0103 0.2509 0.2509
Brugia malayi steroid hormone receptor 0.001 0.0132 0.0303
Onchocerca volvulus 0.0028 0.0592 0.1361
Mycobacterium leprae Probable lipase LipE 0.0035 0.0773 0.5
Loa Loa (eye worm) beta-lactamase 0.0035 0.0773 0.1775
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0176 0.4352 0.4352
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0132 0.0132
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0773 0.4337
Echinococcus multilocularis FL cytokine receptor 0.0073 0.1726 0.1726
Echinococcus granulosus FTZ F1 alpha 0.001 0.0132 0.0132
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) TK protein kinase 0.0073 0.1726 0.3965
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0132 0.0303
Onchocerca volvulus 0.0073 0.1726 0.3965
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0073 0.1726 0.1726
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.1726 0.3965
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0773 0.4337
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.1726 0.1726
Plasmodium falciparum protein kinase, putative 0.0073 0.1726 0.5
Loa Loa (eye worm) hypothetical protein 0.0073 0.1726 0.3965
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Loa Loa (eye worm) TK/ABL protein kinase 0.0176 0.4352 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0176 0.4352 1
Brugia malayi SH2 domain containing protein 0.0103 0.2509 0.5764
Schistosoma mansoni GTPase activating protein 0.0103 0.2509 0.2509
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0073 0.1726 0.3965
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Onchocerca volvulus 0.0035 0.0773 0.1775
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0073 0.1726 0.1726
Echinococcus granulosus tyrosine protein kinase Blk 0.0176 0.4352 0.4352
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0132 0.0303
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0073 0.1726 1
Loa Loa (eye worm) STAT protein 0.0103 0.2509 0.5764
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Brugia malayi beta-lactamase family protein 0.0035 0.0773 0.1775
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Toxoplasma gondii STE kinase 0.0073 0.1726 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0132 0.0303
Schistosoma mansoni suppressor of cytokine signaling 0.0103 0.2509 0.2509
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1726 1
Schistosoma mansoni adapter molecule crk 0.0103 0.2509 0.2509
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0773 0.5
Trypanosoma brucei Flagellum attachment zone protein 20 0.0073 0.1726 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0176 0.4352 0.4352
Echinococcus granulosus tyrosine protein kinase Lyn 0.0176 0.4352 0.4352
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.1726 0.1726
Echinococcus granulosus fibroblast growth factor receptor 4 0.0073 0.1726 0.1726
Brugia malayi cytokine inducible SH2-containing protein 5 0.0103 0.2509 0.5764
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0073 0.1726 0.1726
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0103 0.2509 0.2509
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0073 0.1726 0.1726
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0073 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0303
Schistosoma mansoni tensin 0.0103 0.2509 0.2509
Onchocerca volvulus Tyrosine kinase homolog 0.0073 0.1726 0.3965
Brugia malayi Protein kinase domain containing protein 0.0073 0.1726 0.3965
Loa Loa (eye worm) hypothetical protein 0.0073 0.1726 0.3965
Echinococcus granulosus NCK adaptor protein 0.0103 0.2509 0.2509
Brugia malayi Protein kinase domain containing protein 0.0176 0.4352 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0176 0.4352 0.4352
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Plasmodium falciparum tyrosine kinase-like protein 0.0073 0.1726 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0176 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0073 0.1726 0.1726
Echinococcus multilocularis natriuretic peptide receptor 1 0.0073 0.1726 0.1726
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0176 0.4352 0.4352
Plasmodium vivax protein kinase, putative 0.0073 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1726 0.3965
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Echinococcus multilocularis tyrosine kinase 0.0176 0.4352 0.4352
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.1726 0.1726
Onchocerca volvulus 0.0073 0.1726 0.3965
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Echinococcus granulosus kinase suppressor of Ras 1 0.0073 0.1726 0.1726
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0132 0.0303
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0103 0.2509 0.2509
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0132 0.0132
Loa Loa (eye worm) serine/threonine protein kinase 0.0073 0.1726 0.3965
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Onchocerca volvulus 0.0176 0.4352 1
Loa Loa (eye worm) TK/ACK protein kinase 0.0073 0.1726 0.3965
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0073 0.1726 0.1726
Trypanosoma brucei protein kinase, putative 0.0073 0.1726 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0102 0.0234
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0073 0.1726 1
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.1726 0.1726
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0132 0.0303
Echinococcus multilocularis tyrosine protein kinase pr2 0.0073 0.1726 0.1726
Schistosoma mansoni vav2 0.0103 0.2509 0.2509
Echinococcus granulosus SH2 motif 0.0103 0.2509 0.2509
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0032
Brugia malayi hypothetical protein 0.0176 0.4352 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.1726 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0176 0.4352 0.4352
Brugia malayi Raf kinase 0.0073 0.1726 0.3965
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0132 0.0303
Onchocerca volvulus 0.0073 0.1726 0.3965
Onchocerca volvulus 0.0103 0.2509 0.5764
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0014 0.0014
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.2509 0.5764
Schistosoma mansoni tyrosine kinase 0.0073 0.1726 0.1726
Trichomonas vaginalis AGC family protein kinase 0.0073 0.1726 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0102 0.0102
Trypanosoma cruzi protein kinase, putative 0.0073 0.1726 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.1726 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0132 0.0132
Echinococcus multilocularis dnaJ subfamily B 0.0398 1 1
Schistosoma mansoni protein kinase 0.0073 0.1726 0.1726
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0592 0.1361

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.852 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.744 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.674 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.626 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.396 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.177 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.106 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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