Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0921 | 1 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0162 | 0.022 | 0.022 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.044 | 0.3806 | 0.3806 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.05 | 0.4581 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0471 | 0.4204 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0338 | 0.2495 | 0.2495 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0379 | 0.3018 | 0.4155 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0471 | 0.4204 | 0.4204 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0471 | 0.4204 | 0.4204 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0921 | 1 | 1 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0148 | 0.004 | 0.004 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0704 | 0.7207 | 0.7207 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0471 | 0.4204 | 0.4204 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0471 | 0.4204 | 0.4204 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.05 | 0.4581 | 0.4581 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0471 | 0.4204 | 0.4204 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0311 | 0.2148 | 0.2148 |
Brugia malayi | AMP-binding enzyme family protein | 0.044 | 0.3806 | 0.3948 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0306 | 0.2072 | 0.2574 |
Mycobacterium ulcerans | polyketide synthase | 0.05 | 0.4581 | 0.4581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0379 | 0.3018 | 0.3018 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0921 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0392 | 0.3192 | 0.4398 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.05 | 0.4581 | 0.6337 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0311 | 0.2148 | 0.2148 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.05 | 0.4581 | 0.4581 |
Mycobacterium ulcerans | polyketide synthase | 0.0471 | 0.4204 | 0.4204 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0471 | 0.4204 | 0.581 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0704 | 0.7207 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0335 | 0.2455 | 0.3708 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0704 | 0.7207 | 0.7207 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.044 | 0.3806 | 0.3889 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.05 | 0.4581 | 0.4581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0385 | 0.3098 | 0.3098 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0148 | 0.004 | 0.004 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0268 | 0.1585 | 0.1585 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0849 | 0.9077 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0471 | 0.4204 | 0.4361 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0704 | 0.7207 | 0.7207 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0392 | 0.3192 | 0.3192 |
Loa Loa (eye worm) | hypothetical protein | 0.0791 | 0.8332 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0471 | 0.4204 | 0.4204 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0457 | 0.4018 | 0.4018 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.05 | 0.4581 | 0.4581 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.05 | 0.4581 | 1 |
Mycobacterium ulcerans | thioesterase | 0.0392 | 0.3192 | 0.3192 |
Onchocerca volvulus | 0.082 | 0.87 | 0.9285 | |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.1535 | 0.0823 |
Mycobacterium ulcerans | thioesterase TesA | 0.0392 | 0.3192 | 0.3192 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0379 | 0.3018 | 0.3018 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0457 | 0.4018 | 0.4018 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0893 | 0.964 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0921 | 1 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.05 | 0.4581 | 0.4581 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0921 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.019 | 0.0588 | 0.0588 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0921 | 1 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0471 | 0.4204 | 0.4204 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0311 | 0.2148 | 0.2941 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0921 | 1 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.05 | 0.4581 | 0.6337 |
Loa Loa (eye worm) | fatty acid synthase | 0.0465 | 0.4124 | 0.4318 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 32 % | Growth inhibition of human MCF7 cells at 20 uM after 48 hrs by MTT assay | ChEMBL. | 22277074 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.