Detailed information for compound 1645013

Basic information

Technical information
  • TDR Targets ID: 1645013
  • Name: [(1E,3E)-2,3-dinitro-4-phenylbuta-1,3-dienyl] benzene
  • MW: 296.277 | Formula: C16H12N2O4
  • H donors: 0 H acceptors: 4 LogP: 4.08 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)/C(=C/c1ccccc1)/C(=C\c1ccccc1)/[N+](=O)[O-]
  • InChi: 1S/C16H12N2O4/c19-17(20)15(11-13-7-3-1-4-8-13)16(18(21)22)12-14-9-5-2-6-10-14/h1-12H/b15-11+,16-12+
  • InChiKey: CDIAVOLAJKVLGQ-JOBJLJCHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(1E,3E)-2,3-dinitro-4-phenyl-buta-1,3-dienyl]benzene

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0045 0.0206 0.0206
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.007 0.044 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.5827 0.5827
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.007 0.044 0.044
Echinococcus granulosus serine/threonine protein kinase 0.005 0.0248 0.0248
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.007 0.044 0.044
Echinococcus granulosus serine threonine protein kinase nrc 0.0045 0.0206 0.0206
Trypanosoma brucei rac serine-threonine kinase, putative 0.0073 0.0462 0.0023
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.007 0.044 0.044
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0589 0.529 0.529
Schistosoma mansoni phosphatidylinositol 4-kinase 0.007 0.044 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.1054 0.1054
Schistosoma mansoni hypothetical protein 0.016 0.1275 0.1275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0653 0.5887 0.5887
Plasmodium falciparum phosphatidylinositol 4-kinase 0.007 0.044 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.087 0.7917 0.7822
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0462 0.0462
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.044 0.044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.044 0.044
Entamoeba histolytica hypothetical protein 0.0207 0.1714 0.1714
Entamoeba histolytica hypothetical protein 0.007 0.044 0.044
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.007 0.044 0.044
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0122 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0869 0.7909 0.7909
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0462 0.0462
Schistosoma mansoni fkbp-rapamycin associated protein 0.0207 0.1714 0.1714
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.059 0.5299 0.5299
Entamoeba histolytica hypothetical protein 0.007 0.044 0.044
Entamoeba histolytica protein kinase, putative 0.0073 0.0462 0.0462
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0207 0.1714 0.1539
Loa Loa (eye worm) phosphatidylinositol 3 0.1092 1 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0045 0.0201 0.0201
Plasmodium vivax hypothetical protein, conserved 0.007 0.044 1
Mycobacterium leprae conserved hypothetical protein 0.007 0.044 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0812 0.7381 0.7381
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.01 0.01
Loa Loa (eye worm) phosphatidylinositol 3 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0869 0.7909 0.7909
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0207 0.1714 0.1714
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0153 0.0153
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.007 0.044 0.0028
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0366 0.3208 0.3208
Giardia lamblia GTOR 0.1092 1 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0207 0.1714 0.1714
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0366 0.3208 0.3208
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.007 0.044 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.044 0.044
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0122 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0366 0.3208 0.3208
Loa Loa (eye worm) phosphatidylinositol 3 0.007 0.044 0.044
Loa Loa (eye worm) phosphatidylinositol 3 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0366 0.3208 0.3208
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.016 0.1275 0.1275
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.007 0.044 0.044
Schistosoma mansoni serine/threonine-protein kinase 0.005 0.0248 0.0248
Onchocerca volvulus 0.007 0.044 0.5
Echinococcus multilocularis 0.007 0.044 0.044
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.01 0.01
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1092 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.007 0.044 0.044
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0122 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.023 0.1934 0.1934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0366 0.3208 0.3208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0653 0.5887 0.5887
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0366 0.3208 0.3208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0366 0.3208 0.3208
Brugia malayi p70 ribosomal S6 kinase beta 0.0068 0.042 0.042
Echinococcus multilocularis Glutaredoxin protein 5 0.0045 0.0201 0.0201
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1092 1 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.007 0.044 0.044
Echinococcus granulosus serine protein kinase ATM 0.0207 0.1714 0.1714
Echinococcus multilocularis Zinc finger, PHD finger 0.007 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0366 0.3208 0.3208
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0207 0.1714 0.1714
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1092 1 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.007 0.044 0.044
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1092 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.5827 0.5827
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.007 0.044 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.2523 0.2523
Echinococcus granulosus Glutaredoxin protein 5 0.0045 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0136 0.1054 0.1054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0709 0.6415 0.6415
Loa Loa (eye worm) hypothetical protein 0.0223 0.1863 0.1863
Entamoeba histolytica protein kinase, putative 0.0073 0.0462 0.0462
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.007 0.044 0.0028
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0077
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.007 0.044 0.0239
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0068 0.042 0.042
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.007 0.044 0.044
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0366 0.3208 0.3065
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.007 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0207 0.1714 0.1714
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.007 0.044 0.044
Entamoeba histolytica protein kinase rad3, putative 0.0207 0.1714 0.1714
Plasmodium falciparum phosphatidylinositol 3-kinase 0.007 0.044 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.007 0.044 0.044
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.007 0.044 0.0028
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1092 1 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.007 0.044 0.044
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0462 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0812 0.7381 0.7381
Trichomonas vaginalis PIKK family atypical protein kinase 0.059 0.5299 0.5299
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0207 0.1714 0.1714
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0366 0.3208 0.2895
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.007 0.044 0.044
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.007 0.044 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0869 0.7909 0.7909
Loa Loa (eye worm) hypothetical protein 0.016 0.1275 0.1275
Trichomonas vaginalis PIKK family atypical protein kinase 0.059 0.5299 0.5299
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.044 0.044
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0366 0.3208 0.3208
Trichomonas vaginalis PIKK family atypical protein kinase 0.1092 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.007 0.044 0.044
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.007 0.044 0.044
Schistosoma mansoni hypothetical protein 0.007 0.044 0.044
Giardia lamblia Hypothetical protein 0.007 0.044 0.0239
Echinococcus granulosus nervana 2 0.0045 0.0201 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0932 0.8506 0.8506
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0869 0.7909 0.7909
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.007 0.044 0.044
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0517 0.4614 0.4366
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.007 0.044 0.044
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.007 0.044 0.0239
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.044 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0366 0.3208 0.2895
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.007 0.044 0.044
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0366 0.3208 0.3065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0207 0.1714 0.1714
Giardia lamblia Phosphatidylinositol 4-kinase 0.007 0.044 0.0239
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0207 0.1714 0.1714
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.007 0.044 0.0239
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0589 0.529 0.529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1092 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0869 0.7909 0.7909
Trichomonas vaginalis PIKK family atypical protein kinase 0.059 0.5299 0.5299
Echinococcus multilocularis rac serine:threonine kinase 0.005 0.0248 0.0248
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.007 0.044 0.044
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0462 0.0462
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0207 0.1714 0.1539
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0462 0.0462
Entamoeba histolytica protein kinase, putative 0.0068 0.042 0.042
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.007 0.044 0.0239
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.007 0.044 0.044
Trypanosoma cruzi rac serine-threonine kinase, putative 0.005 0.0248 0.0043
Entamoeba histolytica PH domain containing protein kinase, putative 0.005 0.0248 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.044 0.044
Echinococcus multilocularis serine protein kinase ATM 0.0207 0.1714 0.1714
Trichomonas vaginalis PIKK family atypical protein kinase 0.0812 0.7381 0.7381
Trypanosoma cruzi Protein kinase B 0.005 0.0248 0.0043
Plasmodium vivax hypothetical protein 0.007 0.044 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.007 0.044 0.044
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0462 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.1054 0.1054
Loa Loa (eye worm) hypothetical protein 0.007 0.044 0.044
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.007 0.044 0.0028
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1092 1 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0366 0.3208 0.2895
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0042 0.0042
Echinococcus granulosus nervana 2 0.0045 0.0201 0.0201
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.007 0.044 0.0239
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0153 0.0153
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.007 0.044 0.044
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.007 0.044 0.0239
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0454 0.4025 0.375
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0045 0.0206 0.0206
Brugia malayi FAT domain containing protein 0.016 0.1275 0.1275
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.007 0.044 0.044
Leishmania major phosphatidylinositol 3-kinase, putative 0.0366 0.3208 0.2895
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0207 0.1714 0.1714
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.007 0.044 0.044
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.007 0.044 0.044
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.007 0.044 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1092 1 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0462 0.0462
Entamoeba histolytica hypothetical protein 0.007 0.044 0.044
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0207 0.1714 0.1332
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0136 0.1054 0.0866
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.007 0.044 0.0028
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0122 0.0122
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.007 0.044 0.044
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0462 0.0462
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0045 0.0201 0.0201
Echinococcus multilocularis nervana 2 0.0045 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.023 0.1934 0.1934
Trypanosoma cruzi target of rapamycin kinase 3 0.087 0.7917 0.7874
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1092 1 1
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0589 0.529 0.529
Toxoplasma gondii target of rapamycin (TOR), putative 0.0812 0.7381 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0653 0.5887 0.5887
Schistosoma mansoni phosphatidylinositol 4-kinase 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0812 0.7381 0.7381
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.044 0.044
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.007 0.044 0.044
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.007 0.044 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.007 0.044 0.044
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.007 0.044 0.044
Loa Loa (eye worm) phosphatidylinositol 3 0.0366 0.3208 0.3208
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0207 0.1714 0.1714
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.007 0.044 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0812 0.7381 0.7381
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1092 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.007 0.044 0.044
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.007 0.044 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0812 0.7381 0.7381
Entamoeba histolytica hypothetical protein 0.007 0.044 0.044
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.007 0.044 0.044
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.007 0.044 0.0239
Trypanosoma brucei target of rapamycin kinase 3, putative 0.087 0.7917 0.7822
Trichomonas vaginalis conserved hypothetical protein 0.016 0.1275 0.1275
Entamoeba histolytica protein kinase 2, putative 0.0045 0.0206 0.0206
Schistosoma mansoni serine/threonine-protein kinase 0.005 0.0248 0.0248
Toxoplasma gondii FATC domain-containing protein 0.0207 0.1714 0.1858
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.007 0.044 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0812 0.7381 0.7381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0733 0.6636 0.6636
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.016 0.1275 0.1275
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.007 0.044 0.044
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1092 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.023 0.1934 0.2175
Entamoeba histolytica PH domain containing protein kinase, putative 0.005 0.0248 0.0248
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0207 0.1714 0.1714
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.044 0.044
Loa Loa (eye worm) AGC/AKT protein kinase 0.0073 0.0462 0.0462
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.007 0.044 0.0239
Loa Loa (eye worm) phosphatidylinositol 3 0.007 0.044 0.044
Onchocerca volvulus 0.007 0.044 0.5
Echinococcus multilocularis nervana 2 0.0045 0.0201 0.0201
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.007 0.044 0.044
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.007 0.044 0.0239
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1092 1 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1092 1 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.797 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.818 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.799 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.792 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.772 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.768 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.756 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.672 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.63 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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