Detailed information for compound 1647109

Basic information

Technical information
  • TDR Targets ID: 1647109
  • Name: (2Z)-N-(2-methylphenyl)-3-oxo-2-[(pyridine-3- carbothioylamino)methylidene]butanamide
  • MW: 339.411 | Formula: C18H17N3O2S
  • H donors: 2 H acceptors: 3 LogP: 3.06 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)/C(=C/NC(=S)c1cccnc1)/C(=O)Nc1ccccc1C
  • InChi: 1S/C18H17N3O2S/c1-12-6-3-4-8-16(12)21-17(23)15(13(2)22)11-20-18(24)14-7-5-9-19-10-14/h3-11H,1-2H3,(H,20,24)(H,21,23)/b15-11-
  • InChiKey: MVONRUAZLXPXGR-PTNGSMBKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2Z)-N-(2-methylphenyl)-3-oxo-2-[(pyridine-3-carbothioylamino)methylene]butanamide
  • (2Z)-N-(2-methylphenyl)-3-oxo-2-[[(3-pyridyl-thioxomethyl)amino]methylene]butanamide
  • (Z)-2-acetyl-N-(2-methylphenyl)-3-(pyridine-3-carbothioylamino)acrylamide
  • (2Z)-N-(2-methylphenyl)-3-oxo-2-[(pyridin-3-ylcarbothioylamino)methylidene]butanamide
  • AIDS-141883
  • AIDS141883
  • NSC658316
  • 2-Acetyl-N-(2-methylphenyl)-3-((3-pyridinylcarbothioyl)amino)acrylamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0098 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0901 0.5888 0.5888
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0098 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0409 0.2632 0.2632
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.0133 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.1185 0.1185
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0098 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0989 0.6467 0.6467
Loa Loa (eye worm) hypothetical protein 0.0311 0.1983 0.1983
Echinococcus granulosus nervana 2 0.002 0.0064 0.0064
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0147 0.0147
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0098 0.058 0.058
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0098 0.058 0.0518
Loa Loa (eye worm) phosphatidylinositol 3 0.0098 0.058 0.058
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0511 0.3307 0.2895
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0153 0.0153
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0013 0.0013
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0511 0.3307 0.3307
Loa Loa (eye worm) phosphatidylinositol 3 0.0098 0.058 0.058
Entamoeba histolytica hypothetical protein 0.0288 0.1835 0.1835
Trichomonas vaginalis PIKK family atypical protein kinase 0.1524 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0098 0.058 0.058
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1524 1 1
Plasmodium vivax hypothetical protein 0.0098 0.058 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0511 0.3307 0.3307
Loa Loa (eye worm) phosphatidylinositol 3 0.1524 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0098 0.058 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0098 0.058 0.058
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0098 0.058 0.058
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0079 0.0079
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0098 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.1301 0.8528 0.8528
Trichomonas vaginalis PIKK family atypical protein kinase 0.1212 0.794 0.794
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0098 0.058 0.058
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0721 0.4693 0.4613
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0098 0.058 0.0613
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0098 0.058 0.058
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0098 0.058 0.0518
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0098 0.058 0.058
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0288 0.1835 0.1835
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0288 0.1835 0.1835
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0098 0.058 0.0518
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0098 0.058 0.058
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0098 0.058 0.058
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0098 0.058 0.044
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1524 1 1
Plasmodium vivax hypothetical protein, conserved 0.0098 0.058 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1133 0.742 0.742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0823 0.5368 0.5368
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0098 0.058 0.058
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0098 0.058 0.0518
Loa Loa (eye worm) hypothetical protein 0.0288 0.1835 0.1835
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0511 0.3307 0.3263
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0098 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0823 0.5368 0.5368
Trichomonas vaginalis PIKK family atypical protein kinase 0.1212 0.794 0.794
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0098 0.058 0.058
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0223 0.1403 0.1403
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0098 0.058 0.058
Giardia lamblia Hypothetical protein 0.0098 0.058 0.0518
Toxoplasma gondii FATC domain-containing protein 0.0288 0.1835 0.2335
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0064 0.0064
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0098 0.058 0.058
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0098 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.1212 0.794 0.794
Mycobacterium leprae conserved hypothetical protein 0.0098 0.058 0.5
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0098 0.058 0.058
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0288 0.1835 0.1781
Trichomonas vaginalis PIKK family atypical protein kinase 0.0823 0.5368 0.5368
Onchocerca volvulus 0.0098 0.058 0.5
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0098 0.058 0.0613
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0288 0.1835 0.1781
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1524 1 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.1133 0.742 1
Echinococcus multilocularis nervana 2 0.002 0.0064 0.0064
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.0133 0.0133
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0098 0.058 0.058
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0169 0.0169
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0098 0.058 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0901 0.5888 0.5888
Giardia lamblia Phosphatidylinositol 4-kinase 0.0098 0.058 0.0518
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0079 0.0079
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0098 0.058 0.0518
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0147 0.0147
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0098 0.058 0.058
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0079 0.0079
Echinococcus multilocularis Zinc finger, PHD finger 0.0098 0.058 0.058
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0098 0.058 0.058
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0153 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0822 0.5359 0.5359
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0098 0.058 0.058
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.019 0.1185 0.1127
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.5947 0.5947
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0223 0.1403 0.1403
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0098 0.058 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1213 0.7948 0.7917
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0098 0.058 0.058
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0098 0.058 0.044
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0147 0.0147
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0098 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0098 0.058 0.058
Echinococcus multilocularis nervana 2 0.002 0.0064 0.0064
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0169 0.0169
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1524 1 1
Loa Loa (eye worm) hypothetical protein 0.0321 0.2053 0.2053
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.002 0.0065 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0511 0.3307 0.3307
Leishmania major phosphatidylinositol 3-kinase, putative 0.0511 0.3307 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.5947 0.5947
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0511 0.3307 0.3307
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0079 0.0079
Entamoeba histolytica protein kinase, putative 0.0033 0.0147 0.0147
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0098 0.058 0.058
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1524 1 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0288 0.1835 0.1835
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0098 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.1212 0.794 0.794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0288 0.1835 0.1835
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0098 0.058 0.058
Echinococcus granulosus serine threonine protein kinase nrc 0.002 0.0065 0.0065
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0511 0.3307 0.3263
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1524 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0288 0.1835 0.1835
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0098 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0511 0.3307 0.3307
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0511 0.3307 0.3307
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0098 0.058 0.058
Echinococcus granulosus nervana 2 0.002 0.0064 0.0064
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0098 0.058 0.0518
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0098 0.058 0.0613
Loa Loa (eye worm) phosphatidylinositol 3 0.0511 0.3307 0.3307
Brugia malayi FAT domain containing protein 0.0223 0.1403 0.1403
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0098 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0822 0.5359 0.5359
Trichomonas vaginalis PIKK family atypical protein kinase 0.1133 0.742 0.742
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.5947 0.5947
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0098 0.058 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.1133 0.742 0.742
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0098 0.058 0.058
Entamoeba histolytica hypothetical protein 0.0098 0.058 0.058
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0098 0.058 0.058
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0098 0.058 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0511 0.3307 0.3307
Loa Loa (eye worm) phosphatidylinositol 3 0.0098 0.058 0.058
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0098 0.058 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.1133 0.742 0.742
Entamoeba histolytica protein kinase rad3, putative 0.0288 0.1835 0.1835
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0098 0.058 0.058
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1524 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0098 0.058 0.058
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0098 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0288 0.1835 0.1835
Mycobacterium tuberculosis Conserved hypothetical protein 0.0098 0.058 0.5
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0098 0.058 0.0518
Loa Loa (eye worm) hypothetical protein 0.019 0.1185 0.1185
Entamoeba histolytica protein kinase 2, putative 0.002 0.0065 0.0065
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0169 0.0169
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0098 0.058 0.058
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0079 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0137
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0064 0.0064
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0321 0.2053 0.2634
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1213 0.7948 0.7822
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1524 1 1
Loa Loa (eye worm) hypothetical protein 0.0223 0.1403 0.1403
Entamoeba histolytica hypothetical protein 0.0098 0.058 0.058
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1524 1 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0147 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.2053 0.2053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0288 0.1835 0.1835
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0098 0.058 0.058
Echinococcus multilocularis 0.0098 0.058 0.058
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0098 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.058 0.058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0098 0.058 0.058
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0098 0.058 0.058
Trypanosoma cruzi Protein kinase B 0.0022 0.0079 0.0013
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0098 0.058 0.0518
Giardia lamblia GTOR 0.1524 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1524 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1133 0.742 0.742
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0191 0.0191
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0098 0.058 0.058
Entamoeba histolytica hypothetical protein 0.0098 0.058 0.058
Schistosoma mansoni hypothetical protein 0.0223 0.1403 0.1403
Trypanosoma cruzi target of rapamycin kinase 3 0.1213 0.7948 0.7934
Entamoeba histolytica protein kinase, putative 0.0031 0.0133 0.0133
Schistosoma mansoni fkbp-rapamycin associated protein 0.0288 0.1835 0.1835
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0147 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.1022 0.6685 0.6685
Trichomonas vaginalis PIKK family atypical protein kinase 0.1133 0.742 0.742
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0191 0.0191
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0288 0.1835 0.1835
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0064 0.0064
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0147 0.0147
Onchocerca volvulus 0.0098 0.058 0.5
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0098 0.058 0.058
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0098 0.058 0.058
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0147 0.0147
Brugia malayi Protein kinase domain containing protein 0.0033 0.0147 0.0147
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0098 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.1133 0.742 0.742
Echinococcus multilocularis serine protein kinase ATM 0.0288 0.1835 0.1835
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0147 0.0147
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0098 0.058 0.0613
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0098 0.058 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0098 0.058 0.058
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0511 0.3307 0.3208
Entamoeba histolytica hypothetical protein 0.0098 0.058 0.058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0511 0.3307 0.3307
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0288 0.1835 0.1713
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0098 0.058 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0098 0.058 0.0518
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0288 0.1835 0.1835
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0098 0.058 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0098 0.058 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0822 0.5359 0.5359
Trichomonas vaginalis PIKK family atypical protein kinase 0.1524 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1212 0.794 0.794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0823 0.5368 0.5368
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0098 0.058 0.058
Entamoeba histolytica protein kinase, putative 0.0033 0.0147 0.0147
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0098 0.058 0.058
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0098 0.058 0.058
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0633 0.4113 0.4025
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0098 0.058 0.058
Loa Loa (eye worm) phosphatidylinositol 3 0.0098 0.058 0.058
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0223 0.1403 0.1403
Schistosoma mansoni hypothetical protein 0.0098 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0511 0.3307 0.3307
Echinococcus granulosus serine protein kinase ATM 0.0288 0.1835 0.1835
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0098 0.058 0.0518
Loa Loa (eye worm) phosphatidylinositol kinase 0.0098 0.058 0.058
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0098 0.058 0.058
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1524 1 1
Trichomonas vaginalis conserved hypothetical protein 0.019 0.1185 0.1185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.058 0.058
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0098 0.058 0.044
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1524 1 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.002 0.0065 0.0065
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0511 0.3307 0.3208
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0079 0.0079
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0098 0.058 0.0518
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0064 0.0064

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.626 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.51 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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