TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 409.861 | Formula: C20H24ClNO6
H donors: 1 H acceptors: 4 LogP: 6.07 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O[Cl](=O)(=O)=O.COc1cc2c(cc1OC)CCCN1C2c2ccccc2CC1
InChi: 1S/C20H23NO2.ClHO4/c1-22-18-12-15-7-5-10-21-11-9-14-6-3-4-8-16(14)20(21)17(15)13-19(18)23-2;2-1(3,4)5/h3-4,6,8,12-13,20H,5,7,9-11H2,1-2H3;(H,2,3,4,5)
InChiKey: KKQZJPLWOUOAPG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.5326	0.5326
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0495	0.0495
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0102	0.1325	0.1325
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0045	0.0495	0.0495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0554	0.7921	0.7921
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0361	0.0361
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0234	0.3247	0.3143
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1761	0.1761
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0045	0.0495	0.0349
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0045	0.0495	0.0495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.5326	0.5326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0518	0.7396	0.7396
Plasmodium vivax	hypothetical protein, conserved	0.0045	0.0495	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0697	1	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0045	0.0495	0.0495
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0045	0.0495	0.0161
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.0495	0.0495
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0132	0.1761	0.1761
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0045	0.0495	0.0349
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0132	0.1761	0.1761
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0045	0.0495	0.0495
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0045	0.0495	0.0349
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0045	0.0495	0.0495
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0045	0.0495	0.0263
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0329	0.4644	0.4456
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0554	0.7921	0.7921
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.0495	0.0495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0595	0.8514	0.8514
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0045	0.0495	0.0495
Schistosoma mansoni	serine/threonine-protein kinase	0.0024	0.0182	0.0182
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0045	0.0495	0.0495
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0045	0.0495	0.0495
Loa Loa (eye worm)	phosphatidylinositol 3	0.0697	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0045	0.0495	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0234	0.3247	0.3247
Plasmodium vivax	hypothetical protein	0.0045	0.0495	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0697	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.0495	0.0495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0697	1	1
Entamoeba histolytica	hypothetical protein	0.0132	0.1761	0.1761
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0234	0.3247	0.3247
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.0495	0.0495
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.0031	0.0031
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0339	0.0339
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0234	0.3247	0.2895
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.0495	0.0495
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0045	0.0495	0.0495
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0045	0.0495	0.0349
Echinococcus granulosus	nervana 2	0.0021	0.0148	0.0148
Brugia malayi	Protein kinase domain containing protein	0.0034	0.0339	0.0339
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0045	0.0495	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0142	0.191	0.191
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0452	0.6435	0.6435
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0087	0.1105	0.1105
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0032	0.0308	0.0308
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0187	0.2565	0.2565
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0045	0.0495	0.0495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0412	0.585	0.585
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0045	0.0495	0.0495
Brugia malayi	FAT domain containing protein	0.0102	0.1325	0.1325
Loa Loa (eye worm)	phosphatidylinositol 3	0.0234	0.3247	0.3247
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0045	0.0495	0.0263
Echinococcus granulosus	nervana 2	0.0021	0.0148	0.0148
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0234	0.3247	0.3247
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0045	0.0495	0.0349
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0045	0.0495	0.0495
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0045	0.0495	0.0495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0234	0.3247	0.3247
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0132	0.1761	0.1761
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0697	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0234	0.3247	0.3143
Echinococcus granulosus	serine threonine protein kinase nrc	0.0021	0.0151	0.0151
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.0495	0.0495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0132	0.1761	0.1761
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0554	0.7921	0.7921
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0045	0.0495	0.0495
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0132	0.1761	0.1761
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0697	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0045	0.0495	0.0495
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0024	0.0182	0.0182
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0339	0.0339
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0234	0.3247	0.3247
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0234	0.3247	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0416	0.5911	0.5911
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0234	0.3247	0.3247
Loa Loa (eye worm)	hypothetical protein	0.0147	0.198	0.198
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0021	0.0151	0.0151
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0697	1	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.0361	0.0361
Echinococcus multilocularis	nervana 2	0.0021	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0495	0.0495
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0045	0.0495	0.0495
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0339	0.0339
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0045	0.0495	0.0161
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0045	0.0495	0.0495
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0555	0.7929	0.7857
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0045	0.0495	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0416	0.5911	0.5911
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0102	0.1325	0.1325
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0045	0.0495	0.0495
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0087	0.1105	0.0969
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.5317	0.5317
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0339	0.0339
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0045	0.0495	0.0495
Echinococcus multilocularis	Zinc finger, PHD finger	0.0045	0.0495	0.0495
Echinococcus granulosus	serine/threonine protein kinase	0.0024	0.0182	0.0182
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0045	0.0495	0.0495
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0339	0.0339
Echinococcus multilocularis	rac serine:threonine kinase	0.0024	0.0182	0.0182
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0045	0.0495	0.0349
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0045	0.0495	0.0349
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0412	0.585	0.585
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0045	0.0495	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0518	0.7396	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.0361	0.0361
Echinococcus multilocularis	nervana 2	0.0021	0.0148	0.0148
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0045	0.0495	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0292	0.0292
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0697	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0132	0.1761	0.1635
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.5317	0.5317
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0045	0.0495	0.0495
Onchocerca volvulus		0.0045	0.0495	0.5
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0132	0.1761	0.1635
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0045	0.0495	0.0495
Mycobacterium leprae	conserved hypothetical protein	0.0045	0.0495	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0554	0.7921	0.7921
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0021	0.0148	0.0148
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0045	0.0495	0.0495
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0045	0.0495	0.0495
Toxoplasma gondii	FATC domain-containing protein	0.0132	0.1761	0.2049
Giardia lamblia	Hypothetical protein	0.0045	0.0495	0.0349
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0045	0.0495	0.0495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0467	0.6655	0.6655
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0409	0.0409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0518	0.7396	0.7396
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0339	0.0339
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0132	0.1761	0.1761
Brugia malayi	p70 ribosomal S6 kinase beta	0.0032	0.0308	0.0308
Schistosoma mansoni	hypothetical protein	0.0102	0.1325	0.1325
Trypanosoma cruzi	target of rapamycin kinase 3	0.0555	0.7929	0.7898
Entamoeba histolytica	hypothetical protein	0.0045	0.0495	0.0495
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0045	0.0495	0.0495
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0409	0.0409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0518	0.7396	0.7396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0697	1	1
Giardia lamblia	GTOR	0.0697	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0045	0.0495	0.0349
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.0495	0.0495
Trypanosoma cruzi	Protein kinase B	0.0024	0.0182	0.0031
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0045	0.0495	0.0495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0495	0.0495
Echinococcus multilocularis		0.0045	0.0495	0.0495
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0045	0.0495	0.0495
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0045	0.0495	0.0495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0132	0.1761	0.1761
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.198	0.198
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0339	0.0339
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0697	1	1
Entamoeba histolytica	hypothetical protein	0.0045	0.0495	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1325	0.1325
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0697	1	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0555	0.7929	0.7822
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0147	0.198	0.2359
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0021	0.0148	0.0148
Entamoeba histolytica	protein kinase, putative	0.0032	0.0308	0.0308
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0024	0.0182	0.0031
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0045	0.0495	0.0495
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.0361	0.0361
Entamoeba histolytica	protein kinase 2, putative	0.0021	0.0151	0.0151
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0045	0.0495	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1105	0.1105
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0045	0.0495	0.0263
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0045	0.0495	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0132	0.1761	0.1761
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.0495	0.0495
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0697	1	1
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0045	0.0495	0.0495
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0045	0.0495	0.0349
Entamoeba histolytica	protein kinase rad3, putative	0.0132	0.1761	0.1761
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0518	0.7396	0.7396
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.0495	0.0495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0234	0.3247	0.3247
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0045	0.0495	0.0263
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0045	0.0495	0.0495
Entamoeba histolytica	hypothetical protein	0.0045	0.0495	0.0495
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0045	0.0495	0.0495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0518	0.7396	0.7396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0518	0.7396	0.7396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0416	0.5911	0.5911
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0045	0.0495	0.0161
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.5326	0.5326
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0045	0.0495	0.0495
Echinococcus granulosus	Glutaredoxin protein 5	0.0021	0.0148	0.0148
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0045	0.0495	0.0349
Schistosoma mansoni	serine/threonine-protein kinase	0.0024	0.0182	0.0182
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0234	0.3247	0.3009
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0021	0.0151	0.0151
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0697	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0045	0.0495	0.0161
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0495	0.0495
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.1105	0.1105
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0697	1	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0045	0.0495	0.0495
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0045	0.0495	0.0495
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0045	0.0495	0.0349
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0234	0.3247	0.3247
Echinococcus granulosus	serine protein kinase ATM	0.0132	0.1761	0.1761
Schistosoma mansoni	hypothetical protein	0.0045	0.0495	0.0495
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.1325	0.1325
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0024	0.0182	0.0182
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.0495	0.0495
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0289	0.4059	0.3851
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.0495	0.0495
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0045	0.0495	0.0495
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0045	0.0495	0.0495
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0034	0.0339	0.0339
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0045	0.0495	0.0495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0554	0.7921	0.7921
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.5317	0.5317
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0697	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.5326	0.5326
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0045	0.0495	1
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0045	0.0495	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0132	0.1761	0.1761
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0045	0.0495	0.0349
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0045	0.0495	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0132	0.1761	0.1472
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0234	0.3247	0.3247
Entamoeba histolytica	hypothetical protein	0.0045	0.0495	0.0495
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0234	0.3247	0.3009
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0045	0.0495	0.0495
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0045	0.0495	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0045	0.0495	0.0263
Entamoeba histolytica	protein kinase, putative	0.0034	0.0339	0.0339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0518	0.7396	0.7396
Echinococcus multilocularis	serine protein kinase ATM	0.0132	0.1761	0.1761
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0045	0.0495	0.0495
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0327	0.0327
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0327	0.0327
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0045	0.0495	0.0495
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0045	0.0495	0.0495
Echinococcus multilocularis	Glutaredoxin protein 5	0.0021	0.0148	0.0148
Entamoeba histolytica	protein kinase, putative	0.0034	0.0339	0.0339
Onchocerca volvulus		0.0045	0.0495	0.5
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0132	0.1761	0.1761

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4.315	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.164	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2003593

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1647116