TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 407.512 | Formula: C22H29N7O
H donors: 1 H acceptors: 5 LogP: 3.03 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Oc1nc2c(n1C1CCN(CC1)C(c1nnnn1C1CCCC1)C1CC1)cccc2
InChi: 1S/C22H29N7O/c30-22-23-18-7-3-4-8-19(18)28(22)16-11-13-27(14-12-16)20(15-9-10-15)21-24-25-26-29(21)17-5-1-2-6-17/h3-4,7-8,15-17,20H,1-2,5-6,9-14H2,(H,23,30)
InChiKey: ZCJNRXWXBGDUJB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Ras and Rab interactor 1		No references
Homo sapiens	ABL proto-oncogene 1, non-receptor tyrosine kinase		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Abl	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Loa Loa (eye worm)	TK/ABL protein kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Brugia malayi	Tyrosine-protein kinase abl-1	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase ABL1, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0172	0.281	0.281
Schistosoma mansoni	nuclear receptor	0.028	0.4653	0.4653
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0595	1	1
Schistosoma mansoni	apoferritin-2	0.001	0.0046	0.0046
Echinococcus granulosus	thyroid hormone receptor alpha	0.028	0.4653	0.4653
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0107	0.1701	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0107	0.1701	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.028	0.4653	0.4653
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0314	0.5225	0.5225
Schistosoma mansoni	tyrosine kinase	0.0008	0.0017	0.0017
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0008	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.028	0.4653	0.4653
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0595	1	1
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0015	0.0127	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0008	0.0017	0.0017
Brugia malayi	MH1 domain containing protein	0.0019	0.0194	0.0194
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0314	0.5225	0.5225
Schistosoma mansoni	thyroid hormone receptor	0.0595	1	1
Schistosoma mansoni	nuclear hormone receptor	0.028	0.4653	0.4653
Echinococcus granulosus	c src tyrosine kinase	0.0008	0.0017	0.0017
Loa Loa (eye worm)	transcription factor SMAD2	0.0273	0.4523	0.4523
Brugia malayi	hypothetical protein	0.028	0.4653	0.4653
Brugia malayi	tailless protein	0.028	0.4653	0.4653
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0096	0.1518	0.8894
Echinococcus granulosus	expressed protein	0.001	0.0046	0.0046
Echinococcus multilocularis	FTZ F1 alpha	0.0595	1	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0103	0.1639	0.1639
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0015	0.0127	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0154	0.2497	0.2497
Brugia malayi	nuclear hormone receptor family member nhr-6	0.028	0.4653	0.4653
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.028	0.4653	0.4653
Loa Loa (eye worm)	hypothetical protein	0.0314	0.5225	0.5225
Loa Loa (eye worm)	Smad1	0.0019	0.0194	0.0194
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0595	1	1
Brugia malayi	nuclear receptor NHR-88	0.0595	1	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0424	0.0424
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0042	0.0597	0.3326
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0008	0.0017	0.0017
Loa Loa (eye worm)	MH1 domain-containing protein	0.0019	0.0194	0.0194
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0015	0.0127	0.0487
Brugia malayi	orphan nuclear receptor NR2E1	0.028	0.4653	0.4653
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0019	0.0194	0.0194
Echinococcus granulosus	Smad4	0.0019	0.0194	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Brugia malayi	RNA recognition motif domain containing protein	0.0071	0.1082	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0314	0.5225	0.5225
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0008	0.0017	0.0017
Brugia malayi	SRC-1	0.0008	0.0017	0.0017
Brugia malayi	hypothetical protein	0.028	0.4653	0.4653
Plasmodium vivax	SET domain protein, putative	0.0033	0.0445	0.6773
Brugia malayi	Nuclear hormone receptor-like 1	0.0595	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1082	0.1082
Echinococcus multilocularis	nuclear receptor nhr 48	0.028	0.4653	0.4653
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0595	1	1
Schistosoma mansoni	apoferritin-2	0.001	0.0046	0.0046
Brugia malayi	nuclear receptor RXR	0.0314	0.5225	0.5225
Schistosoma mansoni	ferritin	0.001	0.0046	0.0046
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0595	1	1
Echinococcus granulosus	nuclear receptor nhr 48	0.028	0.4653	0.4653
Schistosoma mansoni	Smad4	0.0019	0.0194	0.0194
Trypanosoma cruzi	trypanothione reductase, putative	0.0042	0.0597	1
Loa Loa (eye worm)	hypothetical protein	0.0314	0.5225	0.5225
Plasmodium falciparum	thioredoxin reductase	0.0042	0.0597	1
Trypanosoma brucei	trypanothione reductase	0.0042	0.0597	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0314	0.5225	0.5225
Trichomonas vaginalis	mercuric reductase, putative	0.0015	0.0127	0.0186
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0595	1	1
Echinococcus multilocularis	smad	0.0019	0.0194	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0118	0.1882	0.1882
Loa Loa (eye worm)	SRC-1	0.0008	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.028	0.4653	0.4653
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0008	0.0017	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0595	1	1
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0008	0.0019	0.0019
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0019	0.0019
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0107	0.1701	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0015	0.0127	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0096	0.1518	0.8894
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0445	0.0445
Brugia malayi	nuclear receptor NHR-67	0.028	0.4653	0.4653
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0595	1	1
Echinococcus granulosus	GPCR family 2	0.0054	0.0805	0.0805
Schistosoma mansoni	nuclear hormone receptor	0.0595	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0008	0.0017	0.0017
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0445	0.6773
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.028	0.4653	0.4642
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0595	1	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0595	1	1
Brugia malayi	nuclear hormone receptor	0.0595	1	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0445	0.0445
Loa Loa (eye worm)	hypothetical protein	0.001	0.0053	0.0053
Brugia malayi	photoreceptor-specific nuclear receptor	0.0595	1	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.028	0.4653	0.4653
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0445	0.0445
Schistosoma mansoni	hypothetical protein	0.0054	0.0805	0.0805
Brugia malayi	MH1 domain containing protein	0.0019	0.0194	0.0194
Loa Loa (eye worm)	TAR-binding protein	0.0071	0.1082	0.1082
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0011	0.0061	0.0061
Brugia malayi	steroid hormone receptor	0.0595	1	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0595	1	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0595	1	1
Brugia malayi	Pre-SET motif family protein	0.0033	0.0445	0.0445
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0008	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0054	0.0805	0.0805
Echinococcus multilocularis	tar DNA binding protein	0.0071	0.1082	0.1082
Schistosoma mansoni	smad	0.0008	0.0019	0.0019
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0015	0.0127	1
Schistosoma mansoni	nuclear receptor nhr-48	0.028	0.4653	0.4653
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0011	0.0061	0.0061
Schistosoma mansoni	smad	0.0019	0.0194	0.0194
Onchocerca volvulus	Protein ultraspiracle homolog	0.0595	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0314	0.5225	0.5225
Onchocerca volvulus		0.0265	0.4381	0.437
Loa Loa (eye worm)	thioredoxin reductase	0.0042	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.028	0.4653	0.4653
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0595	1	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0071	0.1082	0.1082
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0445	0.0445
Schistosoma mansoni	hypothetical protein	0.0054	0.0805	0.0805
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0015	0.0127	1
Loa Loa (eye worm)	steroid hormone receptor	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0314	0.5225	0.5225
Schistosoma mansoni	tyrosine kinase	0.0008	0.0017	0.0017
Echinococcus multilocularis	GPCR, family 2	0.0054	0.0805	0.0805
Loa Loa (eye worm)	MH2 domain-containing protein	0.0019	0.0194	0.0194
Brugia malayi	nuclear receptor RXR	0.028	0.4653	0.4653
Schistosoma mansoni	retinoic acid receptor RXR	0.0595	1	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0595	1	1
Brugia malayi	conserved hypotetical protein	0.028	0.4653	0.4653
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1516	0.1516
Echinococcus multilocularis	c src tyrosine kinase	0.0008	0.0017	0.0017
Echinococcus granulosus	Nuclear hormone receptor HR96	0.028	0.4653	0.4653
Echinococcus granulosus	mothers against decapentaplegic 5	0.0019	0.0194	0.0194
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0015	0.0127	0.0127
Schistosoma mansoni	RAR-like nuclear receptor	0.0595	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0008	0.0017	0.0017
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0054	0.0805	0.0805
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0595	1	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0232	0.3835	0.3835
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0595	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0273	0.4523	0.4523
Echinococcus multilocularis	ferritin	0.001	0.0046	0.0046
Plasmodium vivax	glutathione reductase, putative	0.0042	0.0597	1
Toxoplasma gondii	thioredoxin reductase	0.0042	0.0597	1
Schistosoma mansoni	tyrosine kinase	0.025	0.4136	0.4136
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1082	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0096	0.1518	0.8894
Schistosoma mansoni	hypothetical protein	0.0054	0.0805	0.0805
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0595	1	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0445	0.0445
Loa Loa (eye worm)	hypothetical protein	0.028	0.4653	0.4653
Leishmania major	trypanothione reductase	0.0042	0.0597	1
Plasmodium falciparum	glutathione reductase	0.0042	0.0597	1
Brugia malayi	glutathione reductase	0.0042	0.0597	0.0597
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0254	0.4198	0.4198
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0015	0.0127	1
Brugia malayi	MH2 domain containing protein	0.0019	0.0194	0.0194
Echinococcus granulosus	mothers against decapentaplegic 2	0.0008	0.0019	0.0019
Schistosoma mansoni	ferritin	0.001	0.0046	0.0046
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0008	0.0017	0.0017
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0314	0.5225	0.5225
Brugia malayi	Nuclear hormone receptor E75	0.028	0.4653	0.4653
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.028	0.4653	0.4653
Brugia malayi	hypothetical protein	0.0314	0.5225	0.5225
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0019	0.0019
Brugia malayi	nuclear hormone receptor family member odr-7	0.028	0.4653	0.4653
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.028	0.4653	0.4653
Loa Loa (eye worm)	hypothetical protein	0.028	0.4653	0.4653
Echinococcus granulosus	ferritin	0.001	0.0046	0.0046
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0054	0.0805	0.0805
Trichomonas vaginalis	set domain proteins, putative	0.0265	0.4381	1
Brugia malayi	Smad1	0.0019	0.0194	0.0194
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0595	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0008	0.0017	0.0017
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0595	1	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0015	0.0127	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0254	0.4198	0.4198
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0019	0.0194	0.0194
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0595	1	1
Trichomonas vaginalis	glutathione reductase, putative	0.0015	0.0127	0.0186
Schistosoma mansoni	smad1 5 8 and	0.0019	0.0194	0.0194
Loa Loa (eye worm)	DR-78	0.028	0.4653	0.4653
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0015	0.0127	0.0127
Schistosoma mansoni	nuclear hormone receptor	0.028	0.4653	0.4653
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0008	0.0017	0.0017
Schistosoma mansoni	ferritin light chain	0.001	0.0046	0.0046
Loa Loa (eye worm)	nuclear receptor NHR-67	0.028	0.4653	0.4653
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.028	0.4653	0.4653
Brugia malayi	MH1 domain containing protein	0.001	0.0053	0.0053
Onchocerca volvulus		0.0595	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.028	0.4653	0.4653
Brugia malayi	TAR-binding protein	0.0071	0.1082	0.1082
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.028	0.4653	0.4653
Echinococcus granulosus	tar DNA binding protein	0.0071	0.1082	0.1082
Brugia malayi	Nuclear hormone receptor E75	0.028	0.4653	0.4653
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0595	1	1
Brugia malayi	MH2 domain containing protein	0.0019	0.0194	0.0194
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0314	0.5225	0.5225
Loa Loa (eye worm)	glutathione reductase	0.0042	0.0597	0.0597
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0008	0.0017	0.0017
Mycobacterium tuberculosis	Probable oxidoreductase	0.0107	0.1701	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0595	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0595	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0008	0.0017	0.0017
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0019	0.0194	0.0194
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0595	1	1
Schistosoma mansoni	tyrosine kinase	0.0008	0.0017	0.0017
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0019	0.0194	0.0194
Brugia malayi	MH2 domain containing protein	0.0273	0.4523	0.4523
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0019	0.0019
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0595	1	1
Schistosoma mansoni	smad1 5 8 and	0.0019	0.0194	0.0194
Brugia malayi	mothers against decapentaplegic homolog 3	0.0008	0.0019	0.0019
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0595	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0008	0.0017	0.0017
Schistosoma mansoni	Smad4	0.0008	0.0019	0.0019
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0445	0.0445
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0008	0.0017	0.0017
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0008	0.0017	0.0017
Echinococcus granulosus	mothers against decapentaplegic 6	0.0008	0.0019	0.0019
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0015	0.0127	0.0127
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0008	0.0017	0.0017
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.028	0.4653	0.4653
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0008	0.0017	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.028	0.4653	0.4653
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0595	1	1
Brugia malayi	nuclear hormone receptor	0.028	0.4653	0.4653
Echinococcus granulosus	smad	0.0019	0.0194	0.0194
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0172	0.281	0.281
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0015	0.0127	0.0127
Echinococcus multilocularis	expressed protein	0.001	0.0046	0.0046
Treponema pallidum	NADH oxidase	0.0015	0.0127	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.028	0.4653	0.4653
Brugia malayi	ecdysone receptor	0.028	0.4653	0.4653
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0595	1	1
Schistosoma mansoni	ferritin	0.001	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0445	0.0445
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0054	0.0805	0.0805
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Loa Loa (eye worm)	nuclear factor I	0.001	0.0053	0.0053
Brugia malayi	MH2 domain containing protein	0.0008	0.0019	0.0019
Brugia malayi	latrophilin 2 splice variant baaae	0.0118	0.1882	0.1882
Schistosoma mansoni	Smad4	0.0008	0.0019	0.0019
Onchocerca volvulus		0.0033	0.0445	0.0427
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.028	0.4653	0.4653
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0595	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0595	1	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0103	0.1639	0.1639
Plasmodium vivax	thioredoxin reductase, putative	0.0042	0.0597	1
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1082	0.1082
Brugia malayi	RNA binding protein	0.0071	0.1082	0.1082
Echinococcus granulosus	FTZ F1 alpha	0.0595	1	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.028	0.4653	0.4653
Schistosoma mansoni	hypothetical protein	0.0118	0.1882	0.1882
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0172	0.281	0.281
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0595	1	1
Brugia malayi	Pre-SET motif family protein	0.0232	0.3835	0.3835
Loa Loa (eye worm)	hypothetical protein	0.0172	0.281	0.281
Brugia malayi	nuclear receptor NHR-88	0.028	0.4653	0.4653
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0595	1	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0043	0.0607	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0595	1	1
Brugia malayi	Thioredoxin reductase	0.0042	0.0597	0.0597
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.028	0.4653	0.4653
Brugia malayi	hypothetical protein	0.0314	0.5225	0.5225
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0595	1	1
Schistosoma mansoni	zinc finger protein	0.028	0.4653	0.4653
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1082	0.1082
Brugia malayi	Nuclear hormone receptor-like 1	0.0314	0.5225	0.5225
Schistosoma mansoni	ferritin	0.001	0.0046	0.0046
Loa Loa (eye worm)	nuclear hormone receptor	0.028	0.4653	0.4653
Brugia malayi	Latrophilin receptor protein 2	0.0054	0.0805	0.0805
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0595	1	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.028	0.4653	0.4642
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0054	0.0805	0.0805
Loa Loa (eye worm)	hypothetical protein	0.028	0.4653	0.4653
Schistosoma mansoni	tyrosine kinase	0.0008	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.028	0.4653	0.4653
Schistosoma mansoni	smad1 5 8 and	0.0019	0.0194	0.0194
Onchocerca volvulus		0.028	0.4653	0.4642
Schistosoma mansoni	nuclear receptor	0.028	0.4653	0.4653
Mycobacterium tuberculosis	Probable reductase	0.0096	0.1518	0.8894
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0595	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0595	1	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0254	0.4198	0.4198
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0008	0.0017	0.0017
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1082	0.1082
Loa Loa (eye worm)	hypothetical protein	0.028	0.4653	0.4653
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0008	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.028	0.4653	0.4653
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0054	0.0805	0.0805
Echinococcus granulosus	ecdysone induced protein 78C	0.0595	1	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0096	0.1518	0.8894
Schistosoma mansoni	coup transcription factor	0.0595	1	1
Onchocerca volvulus	Bile acid receptor homolog	0.0595	1	1
Loa Loa (eye worm)	RNA binding protein	0.0071	0.1082	0.1082
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0008	0.0019	0.0019
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0595	1	1
Onchocerca volvulus		0.028	0.4653	0.4642
Brugia malayi	MH1 domain containing protein	0.001	0.0053	0.0053
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0043	0.0607	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0805	0.0805
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0445	0.0445
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.028	0.4653	0.4653
Brugia malayi	Steroid receptor seven-up type 2	0.0595	1	1
Loa Loa (eye worm)	hypothetical protein	0.028	0.4653	0.4653
Mycobacterium tuberculosis	Probable dehydrogenase	0.0096	0.1518	0.8894
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0096	0.1518	0.8894
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0595	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0314	0.5225	0.5225
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0054	0.0805	0.0805
Echinococcus multilocularis	Smad4	0.0019	0.0194	0.0194
Schistosoma mansoni	ferritin light chain	0.001	0.0046	0.0046

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 17.263 uM	PUBCHEM_BIOASSAY: TRFRET-based biochemical high throughput dose response assay for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1984216

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1649148