Detailed information for compound 1649930

Basic information

Technical information
  • TDR Targets ID: 1649930
  • Name: N-[(6-methylchromen-4-ylidene)amino]aniline
  • MW: 250.295 | Formula: C16H14N2O
  • H donors: 1 H acceptors: 0 LogP: 4.06 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)/c(=N/Nc1ccccc1)/cco2
  • InChi: 1S/C16H14N2O/c1-12-7-8-16-14(11-12)15(9-10-19-16)18-17-13-5-3-2-4-6-13/h2-11,17H,1H3/b18-15+
  • InChiKey: LGEVMCFFTMWWBP-OBGWFSINSA-N  


Substructure search Similarity search

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Synonyms

  • N-[(6-methyl-4-chromenylidene)amino]aniline
  • [(6-methylchromen-4-ylidene)amino]-phenyl-amine
  • NCI60_004545
  • NSC601994

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sugar transporter 0.0014 0.0216 0.0894
Leishmania major hypothetical protein, conserved 0.0014 0.0216 0.303
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0216 0.0374
Toxoplasma gondii sugar transporter ST3 0.0014 0.0216 0.0327
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0233 0.5387 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0216 0.0374
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Trypanosoma brucei glucose transporter, putative 0.0031 0.062 0.868
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Trypanosoma brucei glucose transporter, putative 0.0031 0.062 0.868
Trypanosoma cruzi hexose transporter, putative 0.0031 0.062 0.868
Leishmania major hypothetical protein, conserved 0.001 0.0115 0.1606
Entamoeba histolytica protein kinase, putative 0.0032 0.0625 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Onchocerca volvulus 0.0014 0.0216 1
Schistosoma mansoni glucose transport protein 0.0101 0.2262 1
Schistosoma mansoni sugar transporter 0.0014 0.0216 0.0894
Echinococcus multilocularis rab protein 3 0.001 0.0115 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.2262 1
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0216 0.0894
Giardia lamblia Hexose transporter 0.0014 0.0216 0.346
Echinococcus granulosus General substrate transporter 0.0087 0.1928 0.3535
Brugia malayi major facilitator superfamily protein 0.0014 0.0216 0.0374
Plasmodium vivax CDK-related protein kinase 6, putative 0.0429 1 1
Onchocerca volvulus Putative transporter 0.0014 0.0216 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0625 0.1135
Plasmodium falciparum hexose transporter 0.0101 0.2262 0.225
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0216 0.6499
Brugia malayi Sugar transporter family protein 0.0101 0.2262 0.4183
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0216 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0012 0.0175 0.0296
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0413 0.074
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0596 0.2583
Brugia malayi hypothetical protein 0.001 0.0115 0.0185
Onchocerca volvulus 0.0014 0.0216 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0625 0.0611
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0625 0.1135
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Loa Loa (eye worm) hypothetical protein 0.0032 0.0625 0.1135
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0115 0.1606
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0216 0.5239
Brugia malayi Sugar transporter family protein 0.0014 0.0216 0.0374
Loa Loa (eye worm) hypothetical protein 0.0025 0.0462 0.0831
Mycobacterium ulcerans sugar transporter 0.0014 0.0216 0.5239
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0115 0.0507
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0566 0.1017
Trypanosoma cruzi hexose transporter 0.0031 0.062 0.868
Entamoeba histolytica hypothetical protein 0.0023 0.0413 0.6521
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0625 0.0611
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0216 0.5239
Onchocerca volvulus 0.0014 0.0216 1
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0216 0.0327
Trypanosoma brucei glucose transporter, putative 0.0031 0.062 0.868
Echinococcus granulosus solute carrier family 22 0.0014 0.0216 0.0371
Loa Loa (eye worm) hypothetical protein 0.003 0.0596 0.108
Trichomonas vaginalis glucose transporter, putative 0.0031 0.062 0.274
Trypanosoma brucei glucose transporter 2A 0.0031 0.062 0.868
Echinococcus granulosus rab protein 3 0.001 0.0115 0.0183
Onchocerca volvulus 0.0014 0.0216 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0216 0.303
Trypanosoma brucei glucose transporter 1E 0.0031 0.062 0.868
Onchocerca volvulus 0.0014 0.0216 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Trichomonas vaginalis GTP binding protein rare7l, putative 0.001 0.0115 0.0507
Plasmodium falciparum ras-related protein Rab-5A 0.001 0.0115 0.0099
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0216 0.303
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2262 0.4183
Leishmania major glucose transporter, lmgt2 0.0031 0.062 0.868
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0216 0.5239
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2262 0.4183
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0333 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Loa Loa (eye worm) sugar transporter 0.0014 0.0216 0.0374
Schistosoma mansoni protein kinase 0.0032 0.0625 0.2713
Toxoplasma gondii protein kinase, putative 0.0286 0.6622 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.062 0.868
Trichomonas vaginalis sugar transporter, putative 0.0031 0.062 0.274
Entamoeba histolytica hypothetical protein 0.001 0.0115 0.1626
Onchocerca volvulus 0.0014 0.0216 1
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0069
Brugia malayi hypothetical protein 0.0014 0.0216 0.0374
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0413 0.6932
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0413 0.0624
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0216 0.0374
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0016 0.0024
Giardia lamblia Sugar-proton symporter 0.0014 0.0216 0.346
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Toxoplasma gondii sugar transporter ST1 0.0014 0.0216 0.0327
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2262 0.4154
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0216 0.0201
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0134 0.2978
Echinococcus multilocularis General substrate transporter 0.0087 0.1928 0.3559
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0233 0.5387 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0625 0.1135
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0016 0.0024
Leishmania major glucose transporter, lmgt3 0.0031 0.062 0.868
Onchocerca volvulus 0.0014 0.0216 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.3743 0.3733
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.2262 0.3416
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0413 0.5783
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0413 0.0398
Leishmania major hypothetical protein, conserved 0.001 0.0115 0.1606
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0714 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0413 0.1826
Entamoeba histolytica protein kinase, putative 0.0032 0.0625 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0714 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Echinococcus granulosus solute carrier family 22 0.0014 0.0216 0.0371
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0956
Schistosoma mansoni hypothetical protein 0.001 0.0115 0.0441
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0714 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.062 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.062 0.274
Onchocerca volvulus 0.0014 0.0216 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0333 0.5587
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0956
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0216 0.0371
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0625 0.0611
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0625 0.0944
Trypanosoma cruzi hexose transporter, putative 0.0031 0.062 0.868
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0235 0.5424 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Schistosoma mansoni hypothetical protein 0.0101 0.2262 1
Brugia malayi Ras-related protein ypt4 0.001 0.0115 0.0185
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Trypanosoma brucei glucose transporter, putative 0.0031 0.062 0.868
Trichomonas vaginalis hypothetical protein 0.001 0.0115 0.0507
Plasmodium vivax ras-related protein Rab-5A, putative 0.001 0.0115 0.0099
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0625 0.1127
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0216 0.0956
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0413 0.1769
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Onchocerca volvulus 0.0014 0.0216 1
Echinococcus multilocularis ras-related protein rab-5 0.001 0.0115 0.0185
Echinococcus multilocularis GTP binding protein Parf 0.001 0.0115 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0115 0.1606
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0016 0.0377
Echinococcus granulosus solute carrier family 22 0.0014 0.0216 0.0371
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0625 0.1127
Toxoplasma gondii sugar transporter ST2 0.0014 0.0216 0.0327
Onchocerca volvulus 0.0014 0.0216 1
Schistosoma mansoni protein kinase 0.0032 0.0625 0.2713
Echinococcus multilocularis solute carrier family 22 0.0014 0.0216 0.0374
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0625 0.0611
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0566 0.1024
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0016 0.0468
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0625 0.0944
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2262 0.4183
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0956
Trypanosoma brucei glucose transporter, putative 0.0031 0.062 0.868
Schistosoma mansoni sugar transporter 0.0014 0.0216 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0348 0.1536
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0216 0.303
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0625 0.0611
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0625 0.1135
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0413 0.0735
Schistosoma mansoni sugar transporter 0.0014 0.0216 0.0894
Trypanosoma brucei Rab-like 5, small G protein 0.001 0.0115 0.1606
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Echinococcus multilocularis solute carrier family 22 0.0014 0.0216 0.0374
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0413 0.6849
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0625 0.0611
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Brugia malayi major facilitator superfamily protein 0.0014 0.0216 0.0374
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0714 0.07
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0134 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0115 0.0185
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0413 1
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0413 0.0398
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0596 0.1073
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0216 0.303
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0216 0.0374
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0216 0.303
Echinococcus multilocularis solute carrier family 22 0.0014 0.0216 0.0374
Schistosoma mansoni protein kinase 0.0032 0.0625 0.2713
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0625 0.0611
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Trypanosoma brucei sugar transporter, putative 0.0014 0.0216 0.303
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Schistosoma mansoni glucose transporter 0.0014 0.0216 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2262 0.4154
Trichomonas vaginalis sugar transporter, putative 0.0031 0.062 0.274
Trypanosoma brucei glucose transporter, putative 0.0031 0.062 0.868
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Echinococcus multilocularis solute carrier family 22 0.0014 0.0216 0.0374
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0216 0.0374
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0216 0.0956
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0596 0.9521
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0016 0.0377
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0596 0.108
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0115 0.1606
Onchocerca volvulus 0.0014 0.0216 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.062 0.868
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0596 0.2634
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Brugia malayi Sugar transporter family protein 0.0014 0.0216 0.0374
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0596 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0333 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0413 1
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0413 0.5783
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0216 0.0374
Brugia malayi hypothetical protein 0.0014 0.0216 0.0374
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Loa Loa (eye worm) hypothetical protein 0.0023 0.0413 0.074
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.062 0.274
Brugia malayi RAB, member of RAS oncogene family-like 5 0.001 0.0115 0.0185
Echinococcus granulosus solute carrier family 22 0.0014 0.0216 0.0371
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0625 0.0611
Schistosoma mansoni glucose transport protein 0.0101 0.2262 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.062 0.274
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Leishmania major protein kinase, putative 0.0032 0.0625 0.8751
Trypanosoma cruzi hexose transporter, putative 0.0031 0.062 0.868
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0625 0.1135
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Brugia malayi hypothetical protein 0.0014 0.0216 0.0374
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0413 0.1769
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2262 0.4154
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0714 0.1079
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0285 0.3994
Entamoeba histolytica hypothetical protein 0.001 0.0115 0.1626
Plasmodium vivax sugar transporter, putative 0.0014 0.0216 0.0201
Onchocerca volvulus 0.0014 0.0216 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0625 0.1127
Plasmodium vivax hexose transporter 0.0101 0.2262 0.225
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0596 0.108
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0956
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0625 0.1135
Plasmodium falciparum protein kinase 7 0.0286 0.6622 0.6617
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.3743 0.5652
Brugia malayi Cam kinase protein 1 0.0032 0.0625 0.1135
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0625 0.1127
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0216 0.6499
Onchocerca volvulus 0.0014 0.0216 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.3743 0.3733
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2262 0.4154
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0625 0.1135
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0625 0.0944
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0714 1
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0216 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0374
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0596 0.2583
Trypanosoma brucei glucose transporter, putative 0.0031 0.062 0.868
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0413 0.5783
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0714 0.07
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0625 0.2763
Leishmania major glucose transporter, lmgt1 0.0031 0.062 0.868
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0596 0.108
Trypanosoma brucei glucose transporter, putative 0.0031 0.062 0.868
Trichomonas vaginalis glucose transporter, putative 0.0031 0.062 0.274
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.062 0.868
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.2262 0.4183
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0625 0.8751
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Onchocerca volvulus 0.0014 0.0216 1
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0216 0.0374
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0714 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0216 0.0371
Trypanosoma cruzi Rab-like 5, small G protein 0.001 0.0115 0.1606
Onchocerca volvulus 0.0014 0.0216 1
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0134 0.3243
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0596 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0413 0.074
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0413 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0625 0.0611
Schistosoma mansoni glucose transport protein 0.0101 0.2262 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0115 0.0185
Loa Loa (eye worm) sugar transporter 0.0101 0.2262 0.4183
Echinococcus granulosus GTP binding protein Parf 0.001 0.0115 0.0183
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0016 0.0262
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0625 0.2713
Brugia malayi Protein kinase domain containing protein 0.0233 0.5387 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0596 0.108
Loa Loa (eye worm) hypothetical protein 0.001 0.0115 0.0185
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0956
Onchocerca volvulus 0.0014 0.0216 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.71 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.551 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.53 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.422 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.382 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.181 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.15 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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