TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 355.775 | Formula: C18H14ClN3O3
H donors: 1 H acceptors: 3 LogP: 3.93 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)n1nc(c2c1n(O)c1c(c2=O)cc(cc1)Cl)C
InChi: 1S/C18H14ClN3O3/c1-10-16-17(23)14-8-11(19)6-7-15(14)22(24)18(16)21(20-10)12-4-3-5-13(9-12)25-2/h3-9,24H,1-2H3
InChiKey: ITSBKPPNNBPRHM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SRSF protein kinase 1	Starlite/ChEMBL	No references
Homo sapiens	aurora kinase B	Starlite/ChEMBL	No references
Homo sapiens	mitogen-activated protein kinase kinase kinase kinase 4	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Candida albicans	one of two genes similar to S. cerevisiae SKY1 (YMR216C) which phosphorylaties mRNA shuttle protein Npl3p	Get druggable targets OG5_127107	All targets in OG5_127107
Loa Loa (eye worm)	CMGC/SRPK protein kinase	Get druggable targets OG5_127107	All targets in OG5_127107
Echinococcus granulosus	expressed protein	Get druggable targets OG5_127107	All targets in OG5_127107
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_127107	All targets in OG5_127107
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Serine/threonine-protein kinase mig-15, putative	Get druggable targets OG5_128641	All targets in OG5_128641
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	serine/threonine protein kinase, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	serine/arginine-rich protein specific kinase SRPK, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	serine/threonine-protein kinase, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Candida albicans	one of two genes similar to S. cerevisiae SKY1 (YMR216C) which phosphorylaties mRNA shuttle protein Npl3p	Get druggable targets OG5_127107	All targets in OG5_127107
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine:threonine protein kinase mig 15	Get druggable targets OG5_128641	All targets in OG5_128641
Trypanosoma cruzi	serine/arginine-rich protein specific kinase SRPK, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128641	All targets in OG5_128641
Toxoplasma gondii	cell-cycle-associated protein kinase SRPK, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Kinase, CMGC SRPK	Get druggable targets OG5_127107	All targets in OG5_127107
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127107	All targets in OG5_127107
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	GM10776, related	Get druggable targets OG5_127107	All targets in OG5_127107
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	protein kinase CMGC group, Sky1p like S/T protein kinase probably involved in RNA metabolism	Get druggable targets OG5_127107	All targets in OG5_127107
Schistosoma japonicum	Mitogen-activated protein kinase kinase kinase kinase 4, putative	Get druggable targets OG5_128641	All targets in OG5_128641
Schistosoma japonicum	IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing	Get druggable targets OG5_128641	All targets in OG5_128641
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	probable protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_127107	All targets in OG5_127107
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	serine/arginine-rich protein specific kinase SRPK, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Leishmania infantum	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	expressed protein	Get druggable targets OG5_127107	All targets in OG5_127107
Theileria parva	serine/threonine protein kinase, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Schistosoma japonicum	Serine/threonine-protein kinase mig-15, putative	Get druggable targets OG5_128641	All targets in OG5_128641
Loa Loa (eye worm)	STE/STE20/MSN protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Echinococcus multilocularis		Get druggable targets OG5_128641	All targets in OG5_128641
Cryptosporidium hominis	protein kinase domain	Get druggable targets OG5_127107	All targets in OG5_127107
Schistosoma japonicum	ko:K08831 SFRS protein kinase, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_128641	All targets in OG5_128641
Leishmania mexicana	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase	Get druggable targets OG5_127107	All targets in OG5_127107
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	serine/arginine-rich protein specific kinase SRPK, putative,protein kinase, putative	Get druggable targets OG5_127107	All targets in OG5_127107
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative	Get druggable targets OG5_128641	All targets in OG5_128641
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127107	All targets in OG5_127107
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	aurora kinase B	303 aa	299 aa	22.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.012	0.0201
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.0533	0.0533
Giardia lamblia	Aurora kinase	0.0071	0.0533	1
Loa Loa (eye worm)	TAR-binding protein	0.0073	0.056	0.0943
Brugia malayi	serine/threonine-protein kinase 6	0.0071	0.0533	0.0897
Echinococcus granulosus	intermediate filament protein	0.0031	0.0012	0.0012
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase 7. -TRUNCATED-	0.0133	0.133	0.2237
Loa Loa (eye worm)	CMGC/SRPK protein kinase	0.0064	0.0437	0.0736
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0049	0.0049
Echinococcus granulosus	lamin dm0	0.0031	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0938	0.1578
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0071	0.0533	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0034	0.0049	0.0049
Entamoeba histolytica	protein kinase , putative	0.0071	0.0533	1
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0357	0.0601
Echinococcus granulosus	lamin	0.0031	0.0012	0.0012
Brugia malayi	Protein kinase domain containing protein	0.0402	0.4826	0.8119
Loa Loa (eye worm)	hypothetical protein	0.0398	0.4777	0.8037
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0351	0.0591
Loa Loa (eye worm)	STE/STE7/MEK7 protein kinase	0.0133	0.133	0.2237
Schistosoma mansoni	lamin	0.0031	0.0012	0.0012
Schistosoma mansoni	hypothetical protein	0.004	0.012	0.012
Onchocerca volvulus		0.0031	0.0012	0.0073
Trypanosoma brucei	aurora B kinase	0.0071	0.0533	1
Loa Loa (eye worm)	AUR protein kinase	0.0071	0.0533	0.0897
Schistosoma mansoni	protein kinase	0.0106	0.0986	0.0986
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0012	0.0021
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0533	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0533	0.5
Entamoeba histolytica	protein kinase, putative	0.0071	0.0533	1
Brugia malayi	RNA recognition motif domain containing protein	0.0073	0.056	0.0943
Schistosoma mansoni	cellular tumor antigen P53	0.0057	0.0351	0.0351
Schistosoma mansoni	lamin	0.0031	0.0012	0.0012
Leishmania major	protein kinase, putative	0.0071	0.0533	1
Loa Loa (eye worm)	hypothetical protein	0.0398	0.4777	0.8037
Onchocerca volvulus		0.0031	0.0012	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0012	0.0021
Trypanosoma cruzi	serine/arginine-rich protein specific kinase SRPK, putative	0.0064	0.0437	0.8208
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0488	0.5943	1
Loa Loa (eye worm)	STE/STE20/MSN protein kinase	0.0076	0.0593	0.0997
Loa Loa (eye worm)	AUR protein kinase	0.0071	0.0533	0.0897
Brugia malayi	serine/threonine protein kinase 6	0.0071	0.0533	0.0897
Trypanosoma brucei	serine/arginine-rich protein specific kinase SRPK, putative	0.0064	0.0437	0.8208
Schistosoma mansoni	kinase	0.0161	0.1697	0.1697
Echinococcus granulosus	tar DNA binding protein	0.0073	0.056	0.056
Loa Loa (eye worm)	STE/STE7/MEK4 protein kinase	0.0161	0.1697	0.2855
Loa Loa (eye worm)	STE/STE7/MEK7 protein kinase	0.0133	0.133	0.2237
Brugia malayi	serine/threonine kinase 12	0.0071	0.0533	0.0897
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0071	0.0533	1
Echinococcus multilocularis	lamin dm0	0.0031	0.0012	0.0012
Schistosoma mansoni	microtubule-associated protein tau	0.08	1	1
Schistosoma mansoni	protein kinase	0.0034	0.0049	0.0049
Schistosoma mansoni	protein kinase	0.0076	0.0593	0.0593
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0161	0.1697	0.1697
Echinococcus multilocularis	tar DNA binding protein	0.0073	0.056	0.056
Loa Loa (eye worm)	AUR protein kinase	0.0071	0.0533	0.0897
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.0402	0.4826	0.8119
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0034	0.0049	0.0049
Brugia malayi	RNA binding protein	0.0073	0.056	0.0943
Schistosoma mansoni	serine/threonine protein kinase	0.0292	0.3399	0.3399
Brugia malayi	intermediate filament protein	0.0031	0.0012	0.0021
Echinococcus multilocularis	musashi	0.0031	0.0012	0.0012
Trypanosoma cruzi	aurora B kinase, putative	0.0071	0.0533	1
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0049	0.0049
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.03	0.3508	0.3508
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0071	0.0533	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0357	0.0601
Schistosoma mansoni	protein kinase	0.0133	0.133	0.133
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0402	0.4826	0.4826
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0071	0.0533	0.0533
Brugia malayi	TAR-binding protein	0.0073	0.056	0.0943
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0357	0.0601
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0071	0.0533	1
Onchocerca volvulus	Kinase homolog	0.0161	0.1697	1
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.056	0.056
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0071	0.0533	0.0533
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0012	0.0021
Entamoeba histolytica	protein kinase domain containing protein	0.0071	0.0533	1
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.056	0.056
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0012	0.0021
Brugia malayi	probable protein kinase	0.0106	0.0986	0.166
Toxoplasma gondii	aurora kinase	0.0071	0.0533	1
Loa Loa (eye worm)	STE/STE20/KHS protein kinase	0.0034	0.0049	0.0082
Onchocerca volvulus		0.0057	0.0351	0.207
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.056	0.056
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.03	0.3508	0.3508
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.056	0.056
Loa Loa (eye worm)	hypothetical protein	0.004	0.012	0.0201
Brugia malayi	Serine/threonine-protein kinase F42G10.2	0.0161	0.1697	0.2855
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0034	0.0049	0.0049
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0488	0.5943	0.5943
Echinococcus multilocularis	tumor protein p63	0.0392	0.4696	0.4696
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0034	0.0049	0.0049
Echinococcus granulosus	dual specificity mitogen activated protein	0.0133	0.133	0.133
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0005	0.0008
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.056	0.056
Echinococcus multilocularis	lamin	0.0031	0.0012	0.0012
Echinococcus granulosus	tumor protein p63	0.0392	0.4696	0.4696
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0034	0.0049	0.0049
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0402	0.4826	0.4826
Echinococcus granulosus	aurora kinase A	0.0071	0.0533	0.0533
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0012	0.0012
Schistosoma mansoni	serine/threonine protein kinase	0.0407	0.4899	0.4899
Echinococcus multilocularis	aurora kinase A	0.0071	0.0533	0.0533
Echinococcus multilocularis	microtubule associated protein 2	0.08	1	1
Brugia malayi	Stress-activated protein kinase jnk-1	0.0488	0.5943	1
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0533	0.5
Echinococcus granulosus	c-Jun N-terminal kinases	0.0488	0.5943	0.5943
Echinococcus multilocularis	expressed protein	0.0064	0.0437	0.0437
Echinococcus granulosus	dual specificity mitogen activated protein	0.0161	0.1697	0.1697
Echinococcus granulosus	serine:threonine protein kinase mig 15	0.0102	0.0938	0.0938
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0073	0.056	0.0943
Schistosoma mansoni	protein kinase	0.0071	0.0533	0.0533
Brugia malayi	Protein kinase domain containing protein	0.0034	0.0049	0.0082
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0071	0.0533	1
Entamoeba histolytica	protein kinase, putative	0.0071	0.0533	1
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0133	0.133	0.133
Brugia malayi	Protein kinase domain containing protein	0.0064	0.0437	0.0736
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0034	0.0049	0.0049
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0533	0.5
Echinococcus granulosus	protein kinase	0.0076	0.0593	0.0593
Loa Loa (eye worm)	RNA binding protein	0.0073	0.056	0.0943
Schistosoma mansoni	serine/threonine protein kinase	0.0488	0.5943	0.5943
Echinococcus multilocularis		0.0076	0.0593	0.0593
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0357	0.0601
Echinococcus granulosus	expressed protein	0.0064	0.0437	0.0437

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (functional)	= 5.1	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: SRPK1	ChEMBL.	No reference
Ki (functional)	= 5.2	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K4	ChEMBL.	No reference
Ki (functional)	= 5.9	PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK12	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2007009

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1651035