Detailed information for compound 1653155

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 421.406 | Formula: C21H19N5O5
  • H donors: 2 H acceptors: 4 LogP: 3.09 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(ncnc2cc1OC)Oc1cccc(c1)NC(=O)Nc1noc(c1)C
  • InChi: 1S/C21H19N5O5/c1-12-7-19(26-31-12)25-21(27)24-13-5-4-6-14(8-13)30-20-15-9-17(28-2)18(29-3)10-16(15)22-11-23-20/h4-11H,1-3H3,(H2,24,25,26,27)
  • InChiKey: SFVQKUIJLYJJCY-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0097
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0112 0.0119
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0117 0.0189
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.085 0.0962
Echinococcus granulosus RUN 0.002 0.0122 0.0299
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0457 0.4726
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Trichomonas vaginalis glutaminase, putative 0.0284 0.5723 0.5719
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0374 0.0415
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.1454 0.3794
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0194 0.3819 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0776 0.0878
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0112 0.0273
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.087 0.226
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0186 0.0307
Brugia malayi PHD-finger family protein 0.0019 0.0117 0.0125
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.4714 0.5382
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0065
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0112 0.0273
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0373 0.0958
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0733 0.1269
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0117 0.1228
Loa Loa (eye worm) hypothetical protein 0.0102 0.186 0.2117
Echinococcus granulosus phd:f box containing protein 0.0019 0.0112 0.0273
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0111 0.027
Plasmodium vivax CDK-related protein kinase 6, putative 0.043 0.8814 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.1378
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.0259 0.0286
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0111 0.0118
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0111 0.027
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0111 0.0118
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0374 0.0415
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.085 0.8868
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0062 0.1015 0.1151
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.1851 0.1844
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0186 0.031
Giardia lamblia PHD finger protein 15 0.0059 0.0963 0.1599
Plasmodium falciparum protein kinase 7 0.0286 0.5773 0.6546
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0374 0.0415
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0457 0.0778
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0112 0.018
Schistosoma mansoni nAChR subunit 0.0019 0.0111 0.018
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0186 0.031
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0186 0.031
Schistosoma mansoni polycystin 1-related 0.002 0.0122 0.0199
Plasmodium falciparum phd finger protein, putative 0.0059 0.0963 0.1084
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0372 0.0364
Schistosoma mansoni nAChR subunit 0.0019 0.0111 0.018
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.2769 1
Schistosoma mansoni nAChR subunit 0.0019 0.0111 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0105 0.0097
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0481 0.1241
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Trypanosoma brucei glucose transporter, putative 0.0031 0.0372 0.3886
Plasmodium vivax SET domain protein, putative 0.0061 0.1004 0.1131
Brugia malayi Doublecortin family protein 0.002 0.0122 0.013
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0111 0.0118
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0372 0.3831
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0457 0.0509
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.052 0.0512
Brugia malayi jmjC domain containing protein 0.0194 0.3819 0.4359
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0111 0.018
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.1851 0.4834
Echinococcus granulosus dna polymerase eta 0.002 0.0132 0.0324
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.1378
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.5975 0.5972
Schistosoma mansoni inositol monophosphatase 0.0038 0.052 0.0895
Loa Loa (eye worm) hypothetical protein 0.0031 0.0373 0.0417
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0097
Schistosoma mansoni hypothetical protein 0.0019 0.0117 0.0191
Loa Loa (eye worm) doublecortin family protein 0.002 0.0122 0.013
Schistosoma mansoni nAChR subunit 0.0019 0.0111 0.018
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0963 0.1655
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0111 0.027
Leishmania major DNA polymerase kappa, putative 0.002 0.0132 0.13
Entamoeba histolytica hypothetical protein 0.0023 0.0186 0.0092
Schistosoma mansoni DNA polymerase eta 0.002 0.0132 0.0216
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.085 0.8868
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.052 0.0887
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0132 0.0216
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0105 0.0169
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0438 0.0491
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.5975 0.5972
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0111 0.027
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.085 0.8868
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.035 0.0598
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0323 0.0825
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.1084 0.2822
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.1004 0.1727
Schistosoma mansoni transient receptor potential channel 0.0098 0.1789 0.3115
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0042
Giardia lamblia DINP protein human, muc B family 0.002 0.0132 0.0207
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0373 0.0417
Schistosoma mansoni hypothetical protein 0.002 0.0122 0.0199
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0253
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0105 0.011
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0059 0.0957 0.166
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.1004 0.2613
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0065
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0122 0.0299
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0112 0.0273
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.1084 0.2822
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0372 0.0364
Trypanosoma brucei glucose transporter, putative 0.0031 0.0372 0.3886
Brugia malayi follicle stimulating hormone receptor 0.0236 0.4714 0.5382
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1004 0.1743
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.004 0.0559 0.0551
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0194 0.3819 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0957 0.0949
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.035 0.0342
Schistosoma mansoni glucose transport protein 0.0101 0.1851 0.3224
Echinococcus multilocularis transient receptor potential gamma protein 0.0098 0.1789 0.4672
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0374 0.0415
Brugia malayi hypothetical protein 0.002 0.0122 0.013
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.052 0.5393
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.1378
Schistosoma mansoni rab6-interacting 0.002 0.0122 0.0199
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0113 0.038
Loa Loa (eye worm) hypothetical protein 0.002 0.0132 0.0141
Loa Loa (eye worm) hypothetical protein 0.003 0.035 0.0391
Loa Loa (eye worm) hypothetical protein 0.0059 0.0963 0.1091
Brugia malayi Pre-SET motif family protein 0.0061 0.1004 0.1139
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0111 0.027
Echinococcus multilocularis nAChR subunit 0.0019 0.0111 0.027
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.052 0.5393
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Brugia malayi Cation transporter family protein 0.0019 0.0111 0.0118
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0111 0.027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0186 0.0203
Echinococcus multilocularis transient receptor potential ion channel A 0.0095 0.1719 0.449
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0963 0.1084
Schistosoma mansoni nAChR subunit 0.0019 0.0111 0.018
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.1851 0.4834
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.5975 0.5972
Plasmodium falciparum protein kinase 6 0.043 0.8814 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.1851 0.3195
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0112 0.018
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.1851 0.4834
Schistosoma mansoni inositol monophosphatase 0.0038 0.052 0.0895
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0186 0.0465
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.004 0.0559 0.5802
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.2769 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0371 0.0414
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0132 0.0141
Trypanosoma brucei glucose transporter, putative 0.0031 0.0372 0.3886
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0374 0.0415
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.085 0.0842
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0111 0.0118
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.1227 0.3197
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0481 0.0541
Onchocerca volvulus 0.0019 0.0111 0.0103
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0111 0.0118
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0112 0.0273
Brugia malayi jmjC domain containing protein 0.0072 0.1227 0.1394
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.085 0.0842
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0111 0.027
Echinococcus granulosus General substrate transporter 0.0087 0.1549 0.4043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0733 0.1902
Trypanosoma cruzi hexose transporter 0.0031 0.0372 0.3831
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Leishmania major hypothetical protein, conserved 0.0019 0.0112 0.1095
Toxoplasma gondii hypothetical protein 0.0019 0.0105 0.0168
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0111 0.018
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0111 0.0118
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0111 0.027
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0776 0.0878
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0373 0.0417
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0372 0.0364
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0026 0.0259 0.0286
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.085 0.2207
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.1851 0.4834
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0186 0.0177
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0065
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.035 0.0573
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0026 0.0259 0.0657
Brugia malayi Cation transporter family protein 0.0019 0.0111 0.0118
Loa Loa (eye worm) sugar transporter 0.0101 0.1851 0.2107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.5975 0.5972
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0132 0.0216
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0117 0.1228
Schistosoma mansoni rab6-interacting 0.002 0.0122 0.0199
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0373 0.0958
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0026 0.0259 0.0657
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Onchocerca volvulus 0.0019 0.0111 0.0103
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.3181 0.5503
Echinococcus granulosus transient receptor potential ion channel A 0.0095 0.1719 0.449
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0059 0.0957 0.2489
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0045 0.0042
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0132 0.0324
Echinococcus granulosus peregrin 0.0059 0.0963 0.2504
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1004 0.1743
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0097
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0132 0.0123
Loa Loa (eye worm) glutaminase 0.0284 0.5723 0.6537
Echinococcus multilocularis General substrate transporter 0.0087 0.1549 0.4043
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0186 0.0203
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0132 0.0324
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0372 0.3831
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.3181 0.3602
Echinococcus granulosus jumonji domain containing protein 0.0082 0.1454 0.3794
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0373 0.0958
Brugia malayi Cytochrome P450 family protein 0.0031 0.0371 0.0414
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0186 0.031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0733 0.1902
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.1851 0.4834
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.2769 0.4831
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0059 0.0957 0.0949
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0186 0.1867
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0112 0.0182
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.0259 0.0251
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0111 0.0118
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Schistosoma mansoni glucose transport protein 0.0101 0.1851 0.3224
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0374 0.0634
Loa Loa (eye worm) hypothetical protein 0.0019 0.0105 0.0111
Plasmodium vivax JmjC domain containing protein 0.0019 0.0112 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0803 0.0795
Schistosoma mansoni protein kinase 0.0031 0.0373 0.0639
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0111 0.018
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0374 0.0415
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0117 0.0124
Plasmodium vivax hexose transporter 0.0101 0.1851 0.2092
Toxoplasma gondii hypothetical protein 0.0052 0.0803 0.1379
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0372 0.0364
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0111 0.027
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.1851 0.4834
Brugia malayi glutaminase DH11.1 0.0284 0.5723 0.6537
Echinococcus multilocularis dna polymerase eta 0.002 0.0132 0.0324
Schistosoma mansoni protein kinase 0.0031 0.0373 0.0639
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.085 0.2207
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.085 0.1472
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0186 0.0297
Schistosoma mansoni transient receptor potential channel 0.0065 0.1084 0.1882
Loa Loa (eye worm) hypothetical protein 0.0034 0.0438 0.0491
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0117 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Brugia malayi Bromodomain containing protein 0.0059 0.0963 0.1091
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0372 0.3831
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0111 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0803 0.0795
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0019 0.0105 0.035
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.013
Leishmania major glucose transporter, lmgt3 0.0031 0.0372 0.3831
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0457 0.4726
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0259 0.0251
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0111 0.0118
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.035 0.0598
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0132 0.1378
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0111 0.0118
Brugia malayi PHD-finger family protein 0.0059 0.0963 0.1091
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0372 0.3886
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0457 0.4773
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Brugia malayi Cation transporter family protein 0.0019 0.0111 0.0118
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.052 0.0512
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0374 0.0415
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.085 0.1459
Schistosoma mansoni eyes absent homolog 0.0089 0.1597 0.278
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0373 0.0958
Schistosoma mansoni lipoxygenase 0.0055 0.087 0.1507
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0186 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0132 0.13
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.035 0.0919
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.085 0.0842
Trypanosoma brucei sugar transporter, putative 0.0014 0.0009 0.0089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.5975 0.5972
Schistosoma mansoni transient receptor potential channel 0.0065 0.1084 0.1882
Brugia malayi jmjC domain containing protein 0.0019 0.0112 0.0119
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.052 0.0895
Schistosoma mansoni nAChR subunit 0.0019 0.0111 0.018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0111 0.0118
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.035 0.0391
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0122 0.0299
Brugia malayi Inositol-1 0.0038 0.052 0.0585
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0059 0.0957 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0111 0.0118
Loa Loa (eye worm) hypothetical protein 0.003 0.035 0.0391
Schistosoma mansoni lipoxygenase 0.002 0.0122 0.0199
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.1378
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0132 0.1378
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.052 0.1342
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0132 0.1378
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0733 0.1269
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.035 0.0391
Brugia malayi Pre-SET motif family protein 0.0427 0.8751 1
Onchocerca volvulus 0.0061 0.1004 0.0997
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.5975 0.5972
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.085 0.8878
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0957 0.0949
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0112 0.0182
Echinococcus granulosus nAChR subunit 0.0019 0.0111 0.027
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0112 0.0118
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0111 0.027
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0111 0.018
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0132 0.0447
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.1084 0.2822
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0165 0.0179
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0119
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0165 0.0274
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.1227 0.2132
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0105 0.0168
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0122 0.0129
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.1227 0.1394
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0132 0.0216
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.085 0.8868
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0111 0.0118
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0373 0.0365
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0111 0.027
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.052 0.1342
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0111 0.0118
Brugia malayi Sugar transporter family protein 0.0101 0.1851 0.2107
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0427 0.8751 1
Leishmania major DNA polymerase eta, putative 0.002 0.0132 0.13
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0105 0.011
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0132 0.1378
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.1227 0.3197
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0373 0.0417
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0105 0.0169
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0111 0.018
Trypanosoma brucei glucose transporter 1E 0.0031 0.0372 0.3886
Brugia malayi AF-10 protein 0.0019 0.0117 0.0125
Onchocerca volvulus 0.0019 0.0111 0.0103
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0957 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0122 0.23 0.2621
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.0098 0.1789 0.2036
Trypanosoma brucei protein kinase, putative 0.0054 0.085 0.8878
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0105 0.0169
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0132 0.0123
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.085 0.8868
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0373 0.3903
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.3181 0.3602
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.1378
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0045 0.0042
Trypanosoma brucei glucose transporter, putative 0.0031 0.0372 0.3886
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.5975 0.5972
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0374 0.0415
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0111 0.027
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0122 0.0299
Trichomonas vaginalis set domain proteins, putative 0.0485 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0111 0.0118
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.085 0.8868
Loa Loa (eye worm) glutaminase 2 0.0284 0.5723 0.6537
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.052 0.0512
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.1378
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0019 0.0105 0.035
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0372 0.0364
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0373 0.0958
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0132 0.0216
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0373 0.0958
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0112 0.0273
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0963 0.1091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0412 0.0461
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.1378
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0457 0.4726
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.085 0.1409
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0259 0.0251
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0111 0.0118
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0957 0.0949
Onchocerca volvulus 0.0019 0.0111 0.0103
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.1227 0.2132
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.1378
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0372 0.3886
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0776 0.0878
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0026 0.0259 0.0438
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 0.5975 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0111 0.0118
Brugia malayi Cam kinase protein 1 0.0031 0.0373 0.0417
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0111 0.0118
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0481 0.0541
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.1004 0.1743
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1004 0.1743
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0372 0.0364
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0111 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0803 0.0795
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0733 0.0829
Brugia malayi MAP kinase sur-1 0.0054 0.085 0.0962
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0374 0.0415
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0457 0.4726
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.1378
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0111 0.027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0117 0.0125
Schistosoma mansoni glucose transport protein 0.0101 0.1851 0.3224
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.085 0.2207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0733 0.1269
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Brugia malayi hypothetical protein 0.002 0.0122 0.013
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.004 0.0559 0.0551
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0186 0.1939
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0372 0.3831
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0132 0.13
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0112 0.0119
Loa Loa (eye worm) hypothetical protein 0.0089 0.1597 0.1817
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.085 0.2207
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0111 0.0118
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0435 0.1544
Schistosoma mansoni jumonji domain containing protein 0.0154 0.2974 0.519
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0132 0.0141
Toxoplasma gondii hypothetical protein 0.0019 0.0105 0.0168
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0111 0.027
Trypanosoma brucei glucose transporter, putative 0.0031 0.0372 0.3886
Schistosoma mansoni hypothetical protein 0.0034 0.0438 0.0752
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0112 0.1095
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0733 0.0829
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0112 0.0273
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0372 0.0364
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0112 0.0273
Echinococcus multilocularis dna polymerase kappa 0.002 0.0132 0.0324
Treponema pallidum fructose-bisphosphate aldolase 0.0296 0.5975 0.5
Schistosoma mansoni loxhd1 0.002 0.0122 0.0199
Entamoeba histolytica protein kinase, putative 0.0031 0.0373 0.0413
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0112 0.0182
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0186 0.0201
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0113 0.0031
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.052 0.0664
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.5975 0.5972
Schistosoma mansoni glutaminase 0.0284 0.5723 1
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0323 0.0825
Schistosoma mansoni hypothetical protein 0.0101 0.1851 0.3224
Loa Loa (eye worm) hypothetical protein 0.0089 0.1597 0.1817
Loa Loa (eye worm) hypothetical protein 0.0026 0.0259 0.0286
Brugia malayi jmjC domain containing protein 0.0019 0.0112 0.0119
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0132 0.13
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0374 0.0634
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Leishmania major protein kinase, putative 0.0031 0.0373 0.3848
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0132 0.13
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.087 0.226
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0112 0.0273
Schistosoma mansoni nAChR subunit 0.0019 0.0111 0.018
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0186 0.1867
Brugia malayi hypothetical protein 0.0089 0.1597 0.1817
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.5975 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0374 0.0634
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0122 0.0299
Onchocerca volvulus 0.002 0.0122 0.0114
Echinococcus granulosus transient receptor potential gamma protein 0.0098 0.1789 0.4672
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0112 0.0119
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0132 0.0447
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0963 0.1655
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0122 0.0129
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.5975 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0957 0.0949
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.1378
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0186 0.0301
Onchocerca volvulus 0.002 0.0122 0.0114
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0963 0.167
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0111 0.027
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0957 0.0949
Toxoplasma gondii protein kinase, putative 0.0286 0.5773 1
Mycobacterium ulcerans glutaminase 0.0284 0.5723 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0372 0.3886
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0373 0.0958
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0059 0.0957 0.2489
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0111 0.0118
Trypanosoma brucei glucose transporter, putative 0.0031 0.0372 0.3886
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.085 0.0842
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.1084 0.2822
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0957 0.2488
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0111 0.027
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0963 0.2504
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0111 0.027
Echinococcus granulosus dna polymerase kappa 0.002 0.0132 0.0324
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0111 0.0118
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0111 0.027
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.1004 0.2613
Trypanosoma brucei unspecified product 0.002 0.0132 0.1378
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0122 0.0299
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0111 0.0118
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0776 0.0878
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0122 0.0299
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0481 0.1241
Trypanosoma brucei glucose transporter, putative 0.0031 0.0372 0.3886
Schistosoma mansoni transient receptor potential channel 4 0.0098 0.1789 0.3115
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.052 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0372 0.3886
Brugia malayi jmjC domain containing protein 0.0019 0.0112 0.0119
Echinococcus multilocularis RUN 0.002 0.0122 0.0299
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0009 0.0089
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0113 0.038
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0112 0.1095
Loa Loa (eye worm) inositol-1 0.0038 0.052 0.0585
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0957 0.0949
Schistosoma mansoni protein kinase 0.0031 0.0373 0.0639
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0457 0.0509
Brugia malayi jmjC domain containing protein 0.0019 0.0112 0.0119
Trypanosoma cruzi hexose transporter, putative 0.0017 0.007 0.0654
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0373 0.0639
Leishmania major glucose transporter, lmgt2 0.0031 0.0372 0.3831
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0127 0.0118
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0373 0.0958
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0059 0.0957 1
Entamoeba histolytica protein kinase, putative 0.0031 0.0373 0.0413
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0112 0.0182
Onchocerca volvulus 0.0019 0.0111 0.0103
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0117 0.0189
Leishmania major glucose transporter, lmgt1 0.0031 0.0372 0.3831
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.052 0.5434
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.035 0.0897
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0733 0.1902
Plasmodium falciparum hexose transporter 0.0101 0.1851 0.2092
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.035 0.0897
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0957 0.0949
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.1851 0.4834
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0112 0.0182
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0111 0.0118
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0957 0.0949
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0957 0.0949
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.052 0.5393
Echinococcus multilocularis GPCR, family 2 0.0016 0.0045 0.0097
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0132 0.0141
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.1004 0.2613
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0132 0.13
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0111 0.0118
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0963 0.2504
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0957 1
Schistosoma mansoni hypothetical protein 0.0059 0.0963 0.167
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0059 0.0957 0.0949
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0111 0.027
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0957 1
Onchocerca volvulus Alhambra homolog 0.0059 0.0963 0.0955
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0132 0.13
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0112 0.0273
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0186 0.0201
Echinococcus granulosus GPCR family 2 0.0016 0.0045 0.0097
Onchocerca volvulus 0.0019 0.0111 0.0103
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0112 0.1174
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0111 0.027
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0111 0.027
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.013
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0111 0.0118
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.1851 0.4834
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0111 0.027
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0186 0.0465
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0111 0.027
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0111 0.027
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0111 0.018
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0111 0.0118
Trypanosoma brucei glucose transporter 2A 0.0031 0.0372 0.3886
Loa Loa (eye worm) hypothetical protein 0.0061 0.1004 0.1139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0733 0.1902
Onchocerca volvulus Putative nachr subunit 0.0019 0.0111 0.0103
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0118
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0059 0.0957 0.0949
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0957 0.0949
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0435 0.1237
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.035 0.0374
Echinococcus multilocularis peregrin 0.0059 0.0963 0.2504

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 15000 nM Cytotoxicity against human A375 cells expressing BRAF V600E mutant after 72 hrs by cell titer blue assay ChEMBL. 22168626

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 22168626

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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