Detailed information for compound 165613

Basic information

Technical information
  • TDR Targets ID: 165613
  • Name: methyl N-methoxy-N-methylsulfonylcarbamate
  • MW: 183.183 | Formula: C4H9NO5S
  • H donors: 0 H acceptors: 3 LogP: -0.26 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)N(S(=O)(=O)C)OC
  • InChi: 1S/C4H9NO5S/c1-9-4(6)5(10-2)11(3,7)8/h1-3H3
  • InChiKey: ZBWGCLSVORXWIV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl N-methoxy-N-methylsulfonyl-carbamate
  • N-methoxy-N-methylsulfonylcarbamic acid methyl ester
  • N-mesyl-N-methoxy-carbamic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major glucose transporter, lmgt2 0.007 0.0606 0.8651
Leishmania major GTP-binding protein, putative 0.0023 0.0115 0.164
Schistosoma mansoni sugar transporter 0.0032 0.0201 0.0579
Schistosoma mansoni hypothetical protein 0.005 0.0391 0.1124
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0031 0.0442
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.014 0.2002
Toxoplasma gondii protein kinase, putative 0.0636 0.6612 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0031 0.0442
Trichomonas vaginalis glucose transporter, putative 0.007 0.0606 0.269
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0031 0.0062
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0425 0.6071
Plasmodium falciparum importin beta, putative 0.0032 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Echinococcus granulosus geminin 0.0188 0.1856 0.3711
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0044 0.0333 0.1477
Plasmodium falciparum mitogen-activated protein kinase 2 0.0364 0.3724 0.3724
Entamoeba histolytica hypothetical protein 0.005 0.0399 0.6679
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0024 0.0119 0.2978
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0391 0.0782
Toxoplasma gondii facilitative glucose transporter GT1 0.0225 0.2253 0.3408
Trypanosoma cruzi hexose transporter, putative 0.0038 0.027 0.386
Schistosoma mansoni sugar transporter 0.0032 0.0201 0.0579
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Trypanosoma cruzi hexose transporter 0.007 0.0606 0.8651
Echinococcus multilocularis neuropeptide receptor A26 0.0484 0.5 1
Schistosoma mansoni glucose transport protein 0.0225 0.2253 0.6474
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0069 0.0597 0.0903
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Echinococcus multilocularis solute carrier family 22 0.0032 0.0201 0.0403
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0432 0.1635
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0225 0.2253 0.4507
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Trichomonas vaginalis myo-inositol transporter, putative 0.0032 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0068 0.0582 0.9752
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0068 0.0582 1
Echinococcus multilocularis lysyl tRNA synthetase 0.005 0.0399 0.0797
Echinococcus granulosus solute carrier family 22 0.0032 0.0201 0.0403
Schistosoma mansoni glucose transport protein 0.0225 0.2253 0.6474
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0031 0.0089
Plasmodium vivax calcium-dependent protein kinase, putative 0.0069 0.0597 0.0597
Brugia malayi lysyl-tRNA synthetase 0.005 0.0399 0.1508
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Brugia malayi Latrophilin receptor protein 2 0.005 0.0391 0.148
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0201 0.0894
Echinococcus multilocularis calcium dependent protein kinase 0.0065 0.0552 0.1103
Echinococcus multilocularis General substrate transporter 0.0193 0.1918 0.3835
Schistosoma mansoni hypothetical protein 0.0225 0.2253 0.6474
Trypanosoma brucei glucose transporter, putative 0.007 0.0606 0.8651
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0115 0.023
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0068 0.0582 0.2202
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0068 0.0582 0.1672
Echinococcus multilocularis solute carrier family 22 0.0032 0.0201 0.0403
Trypanosoma cruzi hexose transporter, putative 0.007 0.0606 0.8651
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0204 0.0309
Toxoplasma gondii sugar transporter ST1 0.0032 0.0201 0.0305
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0115 0.164
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0031 0.0031
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0425 0.6071
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0031 0.0047
Toxoplasma gondii sugar transporter ST3 0.0032 0.0201 0.0305
Echinococcus granulosus survival motor neuron protein 1 0.0262 0.2643 0.5285
Echinococcus multilocularis geminin 0.0188 0.1856 0.3711
Brugia malayi RNA, U transporter 1 0.0091 0.0829 0.3136
Trichomonas vaginalis glucose transporter, putative 0.007 0.0606 0.269
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Entamoeba histolytica Ran family GTPase 0.0023 0.0115 0.1925
Echinococcus granulosus neuropeptide receptor A26 0.0484 0.5 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.007 0.0606 0.8651
Plasmodium falciparum lysine--tRNA ligase 0.005 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0053 0.0425 0.1222
Brugia malayi Sugar transporter family protein 0.0032 0.0201 0.0762
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.0399 0.1145
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0117 0.0233
Echinococcus multilocularis survival motor neuron protein 1 0.0262 0.2643 0.5285
Entamoeba histolytica hypothetical protein 0.0026 0.014 0.235
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0391 0.1124
Leishmania major glucose transporter, lmgt1 0.007 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Echinococcus granulosus solute carrier family 22 0.0032 0.0201 0.0403
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0069 0.0597 0.8517
Trichomonas vaginalis sugar transporter, putative 0.007 0.0606 0.269
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0031 0.0062
Leishmania major myo-inositol/proton symporter (MIT) 0.0032 0.0201 0.2874
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0079 0.0701 1
Echinococcus granulosus neuropeptide s receptor 0.0484 0.5 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0204 0.2916
Leishmania major hypothetical protein, conserved 0.0053 0.0425 0.6071
Echinococcus multilocularis solute carrier family 22 0.0032 0.0201 0.0403
Mycobacterium ulcerans sugar transporter 0.0032 0.0201 0.5052
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0031 0.0089
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0115 0.164
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.014 0.0622
Echinococcus granulosus GPCR family 2 0.005 0.0391 0.0782
Loa Loa (eye worm) hypothetical protein 0.005 0.0391 0.1124
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0201 0.0894
Plasmodium falciparum calcium-dependent protein kinase 5 0.0069 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0068 0.0582 0.1672
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0031 0.0442
Echinococcus multilocularis snurportin 1 0.0341 0.3481 0.6961
Mycobacterium ulcerans integral membrane transport protein 0.0032 0.0201 0.5052
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0031 0.0973
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Schistosoma mansoni glucose transporter 0.0032 0.0201 0.0579
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0225 0.2253 0.4507
Plasmodium vivax proline--tRNA ligase, putative 0.0079 0.0701 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Loa Loa (eye worm) hypothetical protein 0.0032 0.0204 0.0587
Schistosoma mansoni hypothetical protein 0.0341 0.3481 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0225 0.2253 0.4507
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0032 0.0201 0.0403
Schistosoma mansoni hypothetical protein 0.005 0.0391 0.1124
Plasmodium vivax CDK-related protein kinase 6, putative 0.0955 1 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0068 0.0582 0.2202
Trichomonas vaginalis sugar transporter, putative 0.007 0.0606 0.269
Echinococcus multilocularis synaptic vesicle 2 protein 0.0032 0.0201 0.0403
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.0399 0.1145
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0069 0.0597 0.0597
Schistosoma mansoni protein kinase 0.0069 0.0597 0.1715
Schistosoma mansoni hypothetical protein 0.0024 0.0117 0.0335
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0069 0.0597 0.1194
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0031 0.0442
Schistosoma mansoni hypothetical protein 0.0053 0.0432 0.1241
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0031 0.0062
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.1001 0.3787
Toxoplasma gondii lysine-tRNA ligase 0.005 0.0399 0.0603
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0079 0.0701 1
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0425 0.0643
Trypanosoma brucei glucose transporter 2A 0.007 0.0606 0.8651
Trypanosoma brucei sugar transporter, putative 0.0032 0.0201 0.2874
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0225 0.2253 0.4507
Onchocerca volvulus 0.0053 0.0432 1
Leishmania major lysyl-tRNA synthetase, putative 0.005 0.0399 0.5689
Trypanosoma brucei THT1 - hexose transporter, putative 0.007 0.0606 0.8651
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0043 0.0318 0.5469
Plasmodium vivax sugar transporter, putative 0.0032 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0032 0.0201 0.5052
Brugia malayi Sugar transporter family protein 0.0225 0.2253 0.8527
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Trypanosoma cruzi sugar transporter, putative 0.0032 0.0201 0.2874
Brugia malayi Cam kinase protein 1 0.0069 0.0597 0.2258
Plasmodium falciparum calcium-dependent protein kinase 1 0.0069 0.0597 0.0597
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0069 0.0597 0.1194
Schistosoma mansoni protein kinase 0.0069 0.0597 0.1715
Schistosoma mansoni hypothetical protein 0.005 0.0391 0.1124
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0201 0.2874
Leishmania major protein kinase, putative 0.0069 0.0597 0.8517
Loa Loa (eye worm) hypothetical protein 0.0068 0.0582 0.1672
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Trichomonas vaginalis sugar transporter, putative 0.007 0.0606 0.269
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Loa Loa (eye worm) hypothetical protein 0.0262 0.2643 0.7593
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0425 0.0425
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0201 0.0762
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0391 0.148
Trypanosoma brucei glucose transporter, putative 0.007 0.0606 0.8651
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0069 0.0597 0.0597
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0115 0.164
Trypanosoma brucei glucose transporter, putative 0.007 0.0606 0.8651
Trypanosoma cruzi hexose transporter, putative 0.007 0.0606 0.8651
Echinococcus granulosus snurportin 1 0.0341 0.3481 0.6961
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0391 0.0782
Echinococcus granulosus importin subunit beta 1 0.0032 0.0204 0.0409
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0069 0.0597 0.2258
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0032 0.0201 1
Leishmania major glucose transporter, lmgt3 0.007 0.0606 0.8651
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.0399 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Schistosoma mansoni hypothetical protein 0.0188 0.1856 0.5331
Trypanosoma brucei glucose transporter, putative 0.007 0.0606 0.8651
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0225 0.2253 0.4507
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0364 0.3724 0.3724
Leishmania major importin beta-1 subunit, putative 0.0026 0.014 0.2002
Giardia lamblia Sugar-proton symporter 0.0032 0.0201 0.346
Echinococcus granulosus General substrate transporter 0.0193 0.1918 0.3835
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Brugia malayi hypothetical protein 0.0032 0.0201 0.0762
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0031 0.0062
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0031 0.0442
Plasmodium falciparum protein kinase 7 0.0636 0.6612 0.6612
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0364 0.3724 0.5632
Loa Loa (eye worm) hypothetical protein 0.0107 0.1001 0.2875
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0079 0.0701 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.1526 0.5775
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0115 0.0174
Trichomonas vaginalis sugar transport protein, putative 0.0032 0.0201 0.0894
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0032 0.0201 0.0201
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0115 0.1974
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0031 0.0047
Trypanosoma brucei glucose transporter, putative 0.007 0.0606 0.8651
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0341 0.3481 1
Trichomonas vaginalis CAMK family protein kinase 0.0069 0.0597 0.2648
Brugia malayi Sugar transporter family protein 0.0032 0.0201 0.0762
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0425 0.0425
Plasmodium falciparum hexose transporter 0.0225 0.2253 0.2253
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0032 0.0201 0.6328
Toxoplasma gondii sugar transporter ST2 0.0032 0.0201 0.0305
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0117 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0201 0.0894
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0043 0.0318 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0031 0.0117
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0425 0.6071
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.005 0.0399 0.5689
Brugia malayi major facilitator superfamily protein 0.0032 0.0201 0.0762
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0225 0.2253 0.4507
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0031 0.0062
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0069 0.0597 0.1715
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0069 0.0597 0.0903
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0031 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0606 0.269
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0115 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0225 0.2253 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0069 0.0597 0.0597
Entamoeba histolytica protein kinase, putative 0.0069 0.0597 1
Entamoeba histolytica protein kinase, putative 0.0069 0.0597 1
Trichomonas vaginalis importin beta-1, putative 0.0026 0.014 0.0622
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0597 0.1715
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0069 0.0597 0.1715
Trypanosoma brucei THT1 - hexose transporter, putative 0.007 0.0606 0.8651
Trypanosoma brucei glucose transporter, putative 0.007 0.0606 0.8651
Schistosoma mansoni glucose transport protein 0.0225 0.2253 0.6474
Echinococcus granulosus synaptic vesicle 2 protein 0.0032 0.0201 0.0403
Echinococcus multilocularis GPCR, family 2 0.005 0.0391 0.0782
Loa Loa (eye worm) sugar transporter 0.0032 0.0201 0.0579
Giardia lamblia Hexose transporter 0.0032 0.0201 0.346
Echinococcus multilocularis neuropeptide s receptor 0.0484 0.5 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.1526 0.5775
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0031 0.0031
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0069 0.0597 0.1194
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0031 0.0117
Chlamydia trachomatis proline--tRNA ligase 0.0024 0.0119 0.2978
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0391 0.0782
Schistosoma mansoni hypothetical protein 0.0107 0.1001 0.2875
Plasmodium falciparum calcium-dependent protein kinase 3 0.0069 0.0597 0.0597
Schistosoma mansoni ran 0.0023 0.0115 0.033
Loa Loa (eye worm) sugar transporter 0.0225 0.2253 0.6474
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Plasmodium vivax hexose transporter 0.0225 0.2253 0.2253
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Schistosoma mansoni sugar transporter 0.0032 0.0201 0.0579
Plasmodium vivax lysine--tRNA ligase, putative 0.005 0.0399 0.0399
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0115 0.0435
Leishmania major hypothetical protein, conserved 0.0032 0.0201 0.2874
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0069 0.0597 0.1194
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0068 0.0582 0.1672
Loa Loa (eye worm) hypothetical protein 0.005 0.0399 0.1145
Chlamydia trachomatis lysine--tRNA ligase 0.005 0.0399 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0115 0.023
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0201 0.0762
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.0399 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0448 0.1286
Echinococcus multilocularis solute carrier family 22 0.0032 0.0201 0.0403
Trypanosoma brucei glucose transporter, putative 0.007 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0043 0.0318 1
Plasmodium falciparum proline--tRNA ligase 0.0079 0.0701 0.0701
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0069 0.0597 0.1194
Trypanosoma cruzi glucose transporter, putative 0.0032 0.0201 0.2874
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0079 0.0701 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.1526 0.4385
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0225 0.2253 0.4507
Plasmodium vivax importin-beta 2, putative 0.0032 0.0204 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0201 0.0894
Loa Loa (eye worm) major facilitator superfamily transporter 0.0032 0.0201 0.0579
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.005 0.0399 0.1769
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0079 0.0701 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0079 0.0701 0.106
Brugia malayi hypothetical protein 0.0032 0.0201 0.0762
Brugia malayi major facilitator superfamily protein 0.0032 0.0201 0.0762
Echinococcus granulosus solute carrier family 22 0.0032 0.0201 0.0403
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0068 0.0582 0.1164
Schistosoma mansoni sugar transporter 0.0032 0.0201 0.0579
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.005 0.0399 0.5689
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0032 0.0201 0.0579
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0068 0.0582 0.2583
Trichomonas vaginalis ran, putative 0.0023 0.0115 0.051
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0028 0.016 0.0459
Giardia lamblia Prolyl-tRNA synthetase 0.0068 0.0582 1
Brugia malayi hypothetical protein 0.0032 0.0201 0.0762
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0032 0.0201 0.2874
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0225 0.2253 0.4507
Toxoplasma gondii transporter, major facilitator family protein 0.0032 0.0201 0.0305
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Schistosoma mansoni ran 0.0023 0.0115 0.033
Schistosoma mansoni importin beta-1 0.0032 0.0204 0.0587
Plasmodium falciparum calcium-dependent protein kinase 2 0.0069 0.0597 0.0597
Schistosoma mansoni hypothetical protein 0.0188 0.1856 0.5331
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Loa Loa (eye worm) major facilitator superfamily transporter 0.0032 0.0201 0.0579
Trypanosoma brucei glucose transporter 1E 0.007 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Trypanosoma cruzi hexose transporter, putative 0.007 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0069 0.0597 0.1715
Brugia malayi hypothetical protein 0.0034 0.0227 0.0859
Brugia malayi hypothetical protein 0.0053 0.0425 0.161
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0032 0.0201 0.6328
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.005 0.0399 0.6849
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0069 0.0597 0.1194
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.0579
Giardia lamblia Lysyl-tRNA synthetase 0.005 0.0399 0.6849
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0606 0.269
Trypanosoma brucei glucose transporter, putative 0.007 0.0606 0.8651
Brugia malayi hypothetical protein 0.0262 0.2643 1
Echinococcus granulosus solute carrier family 22 0.0032 0.0201 0.0403
Echinococcus granulosus lysyl tRNA synthetase 0.005 0.0399 0.0797
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.1526 0.4385
Brugia malayi Importin beta-1 subunit 0.0032 0.0204 0.0773
Trypanosoma brucei THT1 - hexose transporter, putative 0.007 0.0606 0.8651
Treponema pallidum prolyl-tRNA synthetase 0.0024 0.0119 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0115 0.0115
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0391 0.0782
Schistosoma mansoni protein kinase 0.0069 0.0597 0.1715
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0201 0.0762
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0032 0.0201 0.5052
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0204 0.2916
Echinococcus granulosus calcium dependent protein kinase 0.0065 0.0552 0.1103
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0068 0.0582 0.1164
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0115 0.033
Echinococcus granulosus Sugar transporter ERD6 protein 0.0032 0.0201 0.0403
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0069 0.0597 0.1194
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0204 0.0409
Schistosoma mansoni survival motor neuron protein 0.0053 0.0432 0.1241
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.014 0.0622
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0425 0.0425
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0069 0.0597 0.0903
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0201 0.0894
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0069 0.0597 0.1194
Schistosoma mansoni hypothetical protein 0.005 0.0391 0.1124
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0069 0.0597 0.0597

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 1000 uM Inhibitory activity of the compound against yeast aldehyde dehydrogenase(AIDH) ChEMBL. 9667978
IC50 (binding) > 1000 uM Inhibitory activity of the compound against yeast aldehyde dehydrogenase(AIDH) ChEMBL. 9667978

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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