Detailed information for compound 165825

Basic information

Technical information
  • TDR Targets ID: 165825
  • Name: 2-(2-phenylethynyl)-1,3-benzothiazole
  • MW: 235.304 | Formula: C15H9NS
  • H donors: 0 H acceptors: 1 LogP: 4.43 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)C#Cc1nc2c(s1)cccc2
  • InChi: 1S/C15H9NS/c1-2-6-12(7-3-1)10-11-15-16-13-8-4-5-9-14(13)17-15/h1-9H
  • InChiKey: QYJZAKHWVZBDEI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi PHD-finger family protein 0.0029 0.0328 0.0634
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.294 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0152 0.0223
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.8107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.059
Echinococcus multilocularis importin subunit beta 1 0.0029 0.033 0.0482
Loa Loa (eye worm) hypothetical protein 0.0234 0.5171 0.7566
Echinococcus granulosus jumonji domain containing protein 0.004 0.059 0.0864
Mycobacterium tuberculosis Conserved protein 0.0035 0.0485 0.0981
Onchocerca volvulus 0.0035 0.0485 0.6205
Mycobacterium ulcerans hypothetical protein 0.0035 0.0485 0.165
Loa Loa (eye worm) hypothetical protein 0.0035 0.0485 0.071
Loa Loa (eye worm) hypothetical protein 0.0035 0.0485 0.071
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.051 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0485 0.071
Mycobacterium tuberculosis Conserved protein 0.0035 0.0485 0.0981
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0167 0.3595 0.5495
Loa Loa (eye worm) hypothetical protein 0.0049 0.0807 0.118
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0404 0.0617
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0245 0.0375
Trichomonas vaginalis ran, putative 0.0021 0.0152 0.0239
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2094 0.3064
Plasmodium falciparum protein kinase 7 0.0293 0.6542 0.6542
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0485 0.071
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0201 0.0294
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0152 0.0233
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.5171 0.7566
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0025 0.0049
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0485 0.9522
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2094 0.3064
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0485 0.071
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0485 0.1297
Trypanosoma brucei glucose transporter 2A 0.0032 0.0413 0.8107
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0294
Leishmania major hypothetical protein, conserved 0.0025 0.0245 0.481
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.6378 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0404 0.7919
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.059
Echinococcus granulosus importin subunit beta 1 0.0029 0.033 0.0482
Schistosoma mansoni hypothetical protein 0.0048 0.0782 0.1144
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0452 0.0874
Loa Loa (eye worm) hypothetical protein 0.0049 0.082 0.1199
Loa Loa (eye worm) beta-lactamase 0.0035 0.0485 0.071
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0201 0.0389
Trypanosoma cruzi hexose transporter 0.0032 0.0413 0.8107
Schistosoma mansoni survival motor neuron protein 0.0048 0.0782 0.1144
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.6378 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0119 0.0241
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.051 0.051
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.8107
Echinococcus granulosus peregrin 0.0029 0.0328 0.0479
Plasmodium falciparum phd finger protein, putative 0.0029 0.0328 0.0328
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0245 0.0245
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.0648
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0485 0.9522
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0201 0.395
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.5171 0.7566
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0782 0.1512
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2094 0.3064
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.2094 0.3284
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0404 0.0404
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0203 0.0318
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0388 0.0379
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0388 0.0609
Schistosoma mansoni glucose transport protein 0.0104 0.2094 0.3064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Echinococcus multilocularis snurportin 1 0.0305 0.6835 1
Schistosoma mansoni glucose transport protein 0.0104 0.2094 0.3064
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1853 0.2711
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0201 0.0308
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.082 0.1199
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0485 0.165
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Schistosoma mansoni protein kinase 0.0032 0.0404 0.059
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0201 0.5
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.294 0.5944
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0404 0.059
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0152 0.0223
Echinococcus multilocularis peregrin 0.0029 0.0328 0.0479
Mycobacterium ulcerans lipase LipD 0.0035 0.0485 0.165
Echinococcus granulosus GPCR family 2 0.0016 0.0025 0.0037
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0404 0.0404
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0388 0.0609
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0404 0.078
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0404 0.059
Giardia lamblia PHD finger protein 15 0.0029 0.0328 0.0514
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0413 0.0648
Schistosoma mansoni importin beta-1 0.0029 0.033 0.0482
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0485 0.0981
Loa Loa (eye worm) hypothetical protein 0.0035 0.0485 0.071
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0025 0.0037
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.082 0.1585
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0201 0.0294
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.059
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 0.0685
Plasmodium falciparum hexose transporter 0.0104 0.2094 0.2094
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.0648
Plasmodium falciparum importin beta, putative 0.0029 0.033 0.033
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Trichomonas vaginalis esterase, putative 0.0035 0.0485 0.0761
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0201 0.395
Loa Loa (eye worm) hypothetical protein 0.0034 0.0452 0.0661
Mycobacterium tuberculosis Conserved protein 0.0035 0.0485 0.0981
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0469 0.0686
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0025 0.0037
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 0.0685
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0328 0.0501
Onchocerca volvulus 0.0035 0.0485 0.6205
Brugia malayi beta-lactamase family protein 0.0035 0.0485 0.0938
Loa Loa (eye worm) hypothetical protein 0.0032 0.0404 0.059
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.8107
Loa Loa (eye worm) hypothetical protein 0.0035 0.0485 0.071
Mycobacterium ulcerans beta-lactamase 0.0035 0.0485 0.165
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0134 0.021
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0388 0.0751
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0201 0.0316
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0413 0.0648
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0328 0.0479
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0485 0.0761
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0469 0.0686
Entamoeba histolytica protein kinase, putative 0.0032 0.0404 0.0404
Toxoplasma gondii facilitative glucose transporter GT1 0.0104 0.2094 0.3201
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.4947 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0104 0.2094 0.3064
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.059
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1853 0.2711
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0485 0.0981
Brugia malayi hypothetical protein 0.0016 0.0037 0.0071
Echinococcus multilocularis General substrate transporter 0.0089 0.1752 0.2563
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0328 0.0501
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0152 0.0223
Leishmania major GTP-binding protein, putative 0.0021 0.0152 0.2987
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0357 0.0523
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0025 0.0037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0469 0.0686
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0201 0.0201
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.059
Entamoeba histolytica hypothetical protein 0.0023 0.0203 0.0081
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0201 0.0291
Brugia malayi jmjC domain containing protein 0.0093 0.1853 0.3583
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0201 0.395
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0485 0.0981
Leishmania major importin beta-1 subunit, putative 0.0023 0.0203 0.3975
Trypanosoma cruzi hexose transporter, putative 0.0018 0.007 0.1383
Brugia malayi beta-lactamase family protein 0.0035 0.0485 0.0938
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0201 0.0201
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0328 0.0328
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2094 0.3064
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0245 0.481
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.059
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0388 0.0568
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0485 0.0981
Schistosoma mansoni hypothetical protein 0.0104 0.2094 0.3064
Schistosoma mansoni ran 0.0021 0.0152 0.0223
Loa Loa (eye worm) hypothetical protein 0.0025 0.0245 0.0359
Brugia malayi beta-lactamase 0.0035 0.0485 0.0938
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.082 0.1585
Loa Loa (eye worm) hypothetical protein 0.0031 0.0388 0.0568
Echinococcus multilocularis jumonji domain containing protein 0.004 0.059 0.0864
Onchocerca volvulus 0.0035 0.0485 0.6205
Entamoeba histolytica hypothetical protein 0.0023 0.0201 0.0079
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0152 0.0294
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.294 1
Brugia malayi Importin beta-1 subunit 0.0029 0.033 0.0638
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0404 0.0633
Leishmania major glucose transporter, lmgt3 0.0032 0.0413 0.8107
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1042 0.1524
Loa Loa (eye worm) sugar transporter 0.0104 0.2094 0.3064
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0119 0.0241
Brugia malayi Sugar transporter family protein 0.0104 0.2094 0.405
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0469 0.0686
Mycobacterium leprae Probable lipase LipE 0.0035 0.0485 0.1297
Brugia malayi jmjC domain containing protein 0.0034 0.0469 0.0907
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0152 0.2987
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0152 0.0152
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0328 0.0479
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.051 0.0779
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Schistosoma mansoni ran 0.0021 0.0152 0.0223
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.8107
Schistosoma mansoni hypothetical protein 0.0305 0.6835 1
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0357 0.0523
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2094 0.3064
Schistosoma mansoni glucose transport protein 0.0104 0.2094 0.3064
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0485 0.071
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.059
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0294
Plasmodium falciparum proline--tRNA ligase 0.0036 0.051 0.051
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0413 0.8107
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0203 0.0318
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 1
Echinococcus granulosus snurportin 1 0.0305 0.6835 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0485 0.0761
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2094 0.3064
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.8107
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0245 0.481
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Leishmania major glucose transporter, lmgt1 0.0032 0.0413 0.8107
Leishmania major glucose transporter, lmgt2 0.0032 0.0413 0.8107
Schistosoma mansoni hypothetical protein 0.0168 0.3609 0.5279
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Schistosoma mansoni protein kinase 0.0032 0.0404 0.059
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0025 0.0049
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.6835 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0167 0.3595 0.3595
Loa Loa (eye worm) hypothetical protein 0.0035 0.0485 0.071
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0404 0.0404
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0203 0.3975
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0404 0.059
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0388 0.0954
Brugia malayi hypothetical protein 0.0234 0.5171 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0037
Loa Loa (eye worm) hypothetical protein 0.0029 0.033 0.0482
Schistosoma mansoni hypothetical protein 0.0034 0.0452 0.0661
Leishmania major protein kinase, putative 0.0032 0.0404 0.7919
Echinococcus multilocularis GPCR, family 2 0.0016 0.0025 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0485 0.9522
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0388 0.0568
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0404 0.0617
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Plasmodium vivax importin-beta 2, putative 0.0029 0.033 0.033
Toxoplasma gondii ABC1 family protein 0.0035 0.0485 0.0742
Onchocerca volvulus 0.0048 0.0782 1
Leishmania major hypothetical protein, conserved 0.0035 0.0485 0.9522
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0485 0.0485
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0037
Entamoeba histolytica protein kinase, putative 0.0032 0.0404 0.0404
Brugia malayi Bromodomain containing protein 0.0029 0.0328 0.0634
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0485 0.0981
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0404 0.0404
Brugia malayi Cam kinase protein 1 0.0032 0.0404 0.078
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0404 0.0404
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1402 0.2051
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0152 0.0239
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0404 0.059
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0025 0.0037
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2094 0.3064
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0404 0.0404
Plasmodium vivax hexose transporter 0.0104 0.2094 0.2094
Schistosoma mansoni hypothetical protein 0.0168 0.3609 0.5279
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0404 0.0404
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0152 0.2987
Echinococcus granulosus geminin 0.0168 0.3609 0.5279
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0328 0.0479
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0404 0.0404
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0485 0.0761
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0485 0.0981
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0413 0.0648
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0245 0.0245
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0201 0.0316
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0037
Trypanosoma brucei glucose transporter 1E 0.0032 0.0413 0.8107
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0485 0.0938
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0485 0.0981
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0485 0.0761
Loa Loa (eye worm) hypothetical protein 0.0035 0.0485 0.071
Loa Loa (eye worm) hypothetical protein 0.0029 0.0328 0.0479
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0328 0.0479
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0404 0.0617
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0485 0.0761
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0152 0.0152
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0485 0.071
Brugia malayi RNA, U transporter 1 0.0081 0.1569 0.3035
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0245 0.0245
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0413 0.0648
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.051 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0025 0.0037
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0037
Schistosoma mansoni protein kinase 0.0032 0.0404 0.059
Toxoplasma gondii protein kinase, putative 0.0293 0.6542 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.033 0.647
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.0648
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.8107
Loa Loa (eye worm) hypothetical protein 0.0031 0.0388 0.0568
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.033 0.0504
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.033 0.647
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0469 0.0686
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0485 0.165
Loa Loa (eye worm) hypothetical protein 0.0023 0.0201 0.0294
Loa Loa (eye worm) hypothetical protein 0.0025 0.0251 0.0368
Brugia malayi hypothetical protein 0.0025 0.0245 0.0474
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0203 0.0318
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0388 0.0568
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.6378 1
Echinococcus multilocularis geminin 0.0168 0.3609 0.5279
Echinococcus granulosus General substrate transporter 0.0089 0.1752 0.2563
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0388 0.0568
Onchocerca volvulus Alhambra homolog 0.0029 0.0328 0.4191
Plasmodium falciparum mitogen-activated protein kinase 2 0.0167 0.3595 0.3595
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0388 0.0751
Plasmodium vivax CDK-related protein kinase 6, putative 0.044 1 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0404 0.0404
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0152 0.2987
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.6378 0.5
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0245 0.481
Schistosoma mansoni hypothetical protein 0.0029 0.0328 0.0479

Activities

Activity type Activity value Assay description Source Reference
DNA cleavage (binding) = 0 % Normalized percent cleavage of DNA from cleavage reactions (20 h) containing 100 mM compound and 50 mM (bp) supercoiled DNA at pH 8.0 in 20 mM TRIS buffer ChEMBL. 11677138
DNA cleavage (binding) = 0 % Normalized percent cleavage of DNA from cleavage reactions (20 h) containing 100 mM compound and 50 mM (bp) supercoiled DNA at pH 9.0 in 20 mM TRIS buffer ChEMBL. 11677138

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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