TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 436.453 | Formula: C23H30FO5P
H donors: 3 H acceptors: 5 LogP: 3.31 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C[C@@H](CP(=O)(CCc1c(cc(cc1c1ccc(c(c1)C)F)C)C(C)C)O)O
InChi: 1S/C23H30FO5P/c1-14(2)20-9-15(3)10-21(17-5-6-22(24)16(4)11-17)19(20)7-8-30(28,29)13-18(25)12-23(26)27/h5-6,9-11,14,18,25H,7-8,12-13H2,1-4H3,(H,26,27)(H,28,29)/t18-/m0/s1
InChiKey: IZGDXVLRMHXOJV-SFHVURJKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	HMG-CoA reductase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Leishmania mexicana	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	Get druggable targets OG5_127955	All targets in OG5_127955
Trypanosoma brucei gambiense	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	Get druggable targets OG5_127955	All targets in OG5_127955
Leishmania donovani	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	Get druggable targets OG5_127955	All targets in OG5_127955
Trypanosoma congolense	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Candida albicans	hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis)	Get druggable targets OG5_127955	All targets in OG5_127955
Leishmania infantum	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127955	All targets in OG5_127955
Candida albicans	hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis)	Get druggable targets OG5_127955	All targets in OG5_127955
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	Get druggable targets OG5_127955	All targets in OG5_127955
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	Get druggable targets OG5_127955	All targets in OG5_127955
Schistosoma japonicum	ko:K00021 3-hydroxy-3-methylglutaryl-CoA reductase [EC1.1.1.34], putative	Get druggable targets OG5_127955	All targets in OG5_127955
Leishmania braziliensis	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	Get druggable targets OG5_127955	All targets in OG5_127955
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	Get druggable targets OG5_127955	All targets in OG5_127955

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	importin beta, putative	0.003	0.0149	0.0091
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0106	0.0286
Onchocerca volvulus		0.005	0.0378	1
Schistosoma mansoni	survival motor neuron protein	0.005	0.0378	0.0942
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Giardia lamblia	Prolyl-tRNA synthetase	0.0063	0.0528	0.7336
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0064	0.0543	0.0742
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0591	0.2267
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0165	0.1707	0.336
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2209	0.4385
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0041	0.0277	0.1018
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1707	0.486
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0543	0.0987
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.0953	0.3658
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.0953	0.2638
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0145	0.0177
Echinococcus granulosus	lysyl tRNA synthetase	0.0047	0.0344	0.0581
Schistosoma mansoni	sugar transporter	0.0029	0.0145	0.0255
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Plasmodium vivax	importin-beta 2, putative	0.003	0.0149	0.0091
Toxoplasma gondii	sugar transporter ST3	0.0029	0.0145	0.0133
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0029	0.0145	0.0506
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0543	0.0987
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0145	0.0557
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0047	0.0344	0.1729
Loa Loa (eye worm)	hypothetical protein	0.01	0.0953	0.2638
Schistosoma mansoni	glucose transporter	0.0029	0.0145	0.0255
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0064	0.0543	0.0488
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Trichomonas vaginalis	myo-inositol transporter, putative	0.0029	0.0145	0.0403
Leishmania major	hypothetical protein, conserved	0.0026	0.0106	0.0286
Entamoeba histolytica	protein kinase, putative	0.0064	0.0543	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Schistosoma mansoni	glucose transport protein	0.0209	0.2209	0.6342
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0106	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Schistosoma mansoni	protein kinase	0.0064	0.0543	0.1428
Schistosoma mansoni	hypothetical protein	0.0174	0.1812	0.5172
Schistosoma mansoni	hypothetical protein	0.0032	0.017	0.0329
Schistosoma mansoni	hypothetical protein	0.0032	0.017	0.0329
Schistosoma mansoni	sugar transporter	0.0029	0.0145	0.0255
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0145	0.0177
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0543	0.0987
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0078	0.0698	0.2975
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.017	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0589	0.1565
Trichomonas vaginalis	glucose transporter, putative	0.0065	0.0552	0.2296
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.004	0.0263	1
Brugia malayi	hypothetical protein	0.0029	0.0145	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.1384
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0528	0.1384
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.017	0.0329
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0145	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0393	0.0986
Leishmania major	glucose transporter, lmgt1	0.0065	0.0552	0.2996
Loa Loa (eye worm)	hypothetical protein	0.0243	0.2605	0.751
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0068	0.0589	0.1565
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Brugia malayi	hypothetical protein	0.0029	0.0145	0.0557
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0073	0.0647	0.3573
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0106	0.0286
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0063	0.0528	0.2027
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0029	0.0145	0.0087
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0165	0.1707	0.6551
Giardia lamblia	Lysyl-tRNA synthetase	0.0047	0.0344	0.4454
Trypanosoma brucei	sugar transporter, putative	0.0029	0.0145	0.0525
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.017	0.0227
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0552	0.2296
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0145	0.0403
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0106	0.0047
Leishmania major	protein kinase, putative	0.0064	0.0543	0.2939
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0543	0.0987
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0064	0.0543	0.0488
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Mycobacterium ulcerans	integral membrane transport protein	0.0029	0.0145	0.0506
Trichomonas vaginalis	glucose transporter, putative	0.0065	0.0552	0.2296
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0552	0.2996
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0064	0.0543	0.0488
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0552	0.2996
Plasmodium vivax	lysine--tRNA ligase, putative	0.0047	0.0344	0.0287
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0552	0.2296
Echinococcus multilocularis	survival motor neuron protein 1	0.0243	0.2605	0.5193
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0064	0.0543	0.0488
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0064	0.0543	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0032	0.017	0.0329
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0647	0.3573
Trypanosoma cruzi	hexose transporter, putative	0.0029	0.0145	0.0525
Plasmodium falciparum	proline--tRNA ligase	0.0073	0.0647	0.0592
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0552	0.2996
Trypanosoma cruzi	sugar transporter, putative	0.0029	0.0145	0.0525
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0063	0.0528	0.0957
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0073	0.0647	0.0901
Schistosoma mansoni	patched 1	0.0068	0.0589	0.1565
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0317	0.3449	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0106	0.0047
Echinococcus granulosus	Protein patched homolog 1	0.0068	0.0589	0.1082
Echinococcus granulosus	solute carrier family 22	0.0029	0.0145	0.0177
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0145	0.0255
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0063	0.0528	0.9693
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0063	0.0528	0.2027
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0029	0.0145	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0064	0.0543	0.1428
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0059	0.0225
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Schistosoma mansoni	hypothetical protein	0.0174	0.1812	0.5172
Plasmodium vivax	proline--tRNA ligase, putative	0.0073	0.0647	0.0592
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0145	0.0403
Loa Loa (eye worm)	sugar transporter	0.0209	0.2209	0.6342
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0338	0.3688	0.3651
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.017	0.0652
Echinococcus granulosus	General substrate transporter	0.018	0.1871	0.3696
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Echinococcus multilocularis	GPCR, family 2	0.0032	0.017	0.0227
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0106	0.0286
Echinococcus granulosus	importin subunit beta 1	0.003	0.0149	0.0184
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0338	0.3688	0.3651
Plasmodium falciparum	protein kinase 7	0.059	0.6593	0.6572
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.0165	0.1707	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.0953	0.3658
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0026	0.0103	0.0132
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0165	0.1707	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0647	0.3573
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0552	0.2996
Schistosoma mansoni	hypothetical protein	0.0317	0.3449	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0047	0.0344	0.3046
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0064	0.0543	0.0742
Schistosoma mansoni	glucose transport protein	0.0209	0.2209	0.6342
Brugia malayi	major facilitator superfamily protein	0.0029	0.0145	0.0557
Schistosoma mansoni	sugar transporter	0.0029	0.0145	0.0255
Toxoplasma gondii	transporter, major facilitator family protein	0.0029	0.0145	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Schistosoma mansoni	glucose transport protein	0.0209	0.2209	0.6342
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0064	0.0543	0.0742
Leishmania major	myo-inositol/proton symporter (MIT)	0.0029	0.0145	0.0525
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0047	0.0344	0.1729
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0068	0.0589	0.1565
Brugia malayi	hypothetical protein	0.0026	0.0106	0.0406
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2209	0.4385
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0552	0.2996
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0552	0.2996
Treponema pallidum	prolyl-tRNA synthetase	0.0022	0.0062	0.5
Trypanosoma cruzi	hexose transporter	0.0065	0.0552	0.2996
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0552	0.2996
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0552	0.2996
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0543	0.1428
Brugia malayi	CHE-14 protein	0.0068	0.0589	0.2262
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0065	0.0552	0.2996
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0073	0.0647	0.3573
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2209	0.4385
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Schistosoma mansoni	lysyl-tRNA synthetase	0.0047	0.0344	0.084
Echinococcus granulosus	synaptic vesicle 2 protein	0.0029	0.0145	0.0177
Echinococcus multilocularis	neuropeptide receptor A26	0.0449	0.4963	1
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0165	0.1707	1
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0552	0.2296
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0145	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0106	0.0139
Toxoplasma gondii	facilitative glucose transporter GT1	0.0209	0.2209	0.3291
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0145	0.0557
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.2209	1
Toxoplasma gondii	sugar transporter ST2	0.0029	0.0145	0.0133
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0165	0.1707	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0063	0.0528	0.1384
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0064	0.0543	0.1428
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0552	0.2296
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0543	0.2252
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0084	0.0119
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0047	0.0344	0.1325
Mycobacterium ulcerans	sugar transporter	0.0029	0.0145	0.0506
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0029	0.0145	0.0177
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Plasmodium falciparum	lysine--tRNA ligase	0.0047	0.0344	0.0287
Brugia malayi	hypothetical protein	0.0243	0.2605	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Plasmodium vivax	sugar transporter, putative	0.0029	0.0145	0.0087
Trypanosoma brucei	glucose transporter 2A	0.0065	0.0552	0.2996
Echinococcus multilocularis	protein patched	0.0068	0.0589	0.1082
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0078	0.0698	0.2975
Trypanosoma cruzi	glucose transporter, putative	0.0029	0.0145	0.0525
Schistosoma mansoni	hypothetical protein	0.005	0.0378	0.0942
Brugia malayi	Sugar transporter family protein	0.0029	0.0145	0.0557
Echinococcus granulosus	Niemann Pick C1 protein	0.0068	0.0589	0.1082
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Schistosoma mansoni	protein kinase	0.0064	0.0543	0.1428
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Echinococcus granulosus	neuropeptide receptor A26	0.0449	0.4963	1
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0145	0.0403
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0063	0.0528	0.1384
Echinococcus multilocularis	calcium dependent protein kinase	0.006	0.0497	0.0895
Schistosoma mansoni	hypothetical protein	0.0032	0.017	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0084	0.0119
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0552	0.2296
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0543	0.0987
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0145	0.0403
Brugia malayi	Sugar transporter family protein	0.0029	0.0145	0.0557
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Schistosoma mansoni	importin beta-1	0.003	0.0149	0.0266
Echinococcus granulosus	snurportin 1	0.0317	0.3449	0.6914
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0149	0.0547
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2209	0.4385
Brugia malayi	RNA, U transporter 1	0.0084	0.0778	0.2985
Plasmodium falciparum	hexose transporter	0.0209	0.2209	0.2163
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0149	0.0138
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0029	0.0145	0.5
Toxoplasma gondii	lysine-tRNA ligase	0.0047	0.0344	0.0436
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0887	1	1
Echinococcus granulosus	solute carrier family 22	0.0029	0.0145	0.0177
Leishmania major	hypothetical protein, conserved	0.0029	0.0145	0.0525
Echinococcus multilocularis	snurportin 1	0.0317	0.3449	0.6914
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0145	0.0177
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.017	0.0227
Chlamydia trachomatis	lysine--tRNA ligase	0.0047	0.0344	1
Entamoeba histolytica	protein kinase, putative	0.0064	0.0543	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0647	0.3573
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0552	0.2996
Leishmania major	glucose transporter, lmgt2	0.0065	0.0552	0.2996
Brugia malayi	major facilitator superfamily protein	0.0029	0.0145	0.0557
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0064	0.0543	0.0488
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Schistosoma mansoni	hypothetical protein	0.0032	0.017	0.0329
Schistosoma mansoni	protein kinase	0.0064	0.0543	0.1428
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0029	0.0145	0.0177
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0215	0.0947
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0064	0.0543	0.2084
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0078	0.0698	0.2975
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.017	0.0652
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0029	0.0145	0.0177
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0165	0.1707	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0047	0.0344	0.1729
Trichomonas vaginalis	sugar transport protein, putative	0.0029	0.0145	0.0403
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0165	0.1707	0.336
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2209	0.4385
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0064	0.0543	0.2939
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2209	0.4385
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Toxoplasma gondii	sugar transporter ST1	0.0029	0.0145	0.0133
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0552	0.2996
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.017	0.0227
Echinococcus multilocularis	lysyl tRNA synthetase	0.0047	0.0344	0.0581
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0591	0.1569
Entamoeba histolytica	hypothetical protein	0.0047	0.0344	0.5884
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0029	0.0145	0.0506
Giardia lamblia	Hexose transporter	0.0029	0.0145	0.1353
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0344	0.084
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Leishmania major	glucose transporter, lmgt3	0.0065	0.0552	0.2996
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0552	0.2996
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0552	0.2996
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0552	0.2996
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0145	0.0255
Giardia lamblia	Sugar-proton symporter	0.0029	0.0145	0.1353
Schistosoma mansoni	lysyl-tRNA synthetase	0.0047	0.0344	0.084
Echinococcus granulosus	sterol regulatory element binding protein	0.0068	0.0589	0.1082
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0084	0.0155
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Toxoplasma gondii	protein kinase, putative	0.059	0.6593	1
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0589	0.2468
Entamoeba histolytica	hypothetical protein	0.0024	0.0084	0.0528
Echinococcus granulosus	geminin	0.0174	0.1812	0.3576
Loa Loa (eye worm)	sugar transporter	0.0029	0.0145	0.0255
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0064	0.0543	0.0488
Echinococcus granulosus	GPCR family 2	0.0032	0.017	0.0227
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0378	0.1451
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0063	0.0528	0.0957
Trichomonas vaginalis	glucose transporter, putative	0.0029	0.0145	0.0403
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2209	0.4385
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0338	0.3688	0.5555
Brugia malayi	lysyl-tRNA synthetase	0.0047	0.0344	0.1319
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Echinococcus multilocularis	sterol regulatory element binding protein	0.0068	0.0589	0.1082
Echinococcus multilocularis	neuropeptide s receptor	0.0449	0.4963	1
Schistosoma mansoni	hypothetical protein	0.0209	0.2209	0.6342
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0552	0.2996
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.004	0.0263	1
Brugia malayi	Cam kinase protein 1	0.0064	0.0543	0.2084
Brugia malayi	Importin beta-1 subunit	0.003	0.0149	0.057
Brugia malayi	Sugar transporter family protein	0.0209	0.2209	0.8479
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0543	0.0987
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0063	0.0528	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0543	0.0987
Loa Loa (eye worm)	hypothetical protein	0.003	0.0149	0.0266
Trypanosoma brucei	glucose transporter 1E	0.0065	0.0552	0.2996
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0145	0.0403
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0209	0.2209	0.4385
Echinococcus granulosus	solute carrier family 22	0.0029	0.0145	0.0177
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0149	0.0547
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0047	0.0344	0.1712
Echinococcus granulosus	calcium dependent protein kinase	0.006	0.0497	0.0895
Plasmodium vivax	hexose transporter	0.0209	0.2209	0.2163
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0078	0.0698	1
Brugia malayi	hypothetical protein	0.0029	0.0145	0.0557
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0543	0.1428
Echinococcus multilocularis	General substrate transporter	0.018	0.1871	0.3696
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0064	0.0543	0.0488
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0064	0.0543	0.0987
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0106	0.0047
Echinococcus granulosus	solute carrier family 22	0.0029	0.0145	0.0177
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0084	0.0119
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0029	0.0145	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0145	0.0255
Echinococcus multilocularis	protein dispatched 1	0.0068	0.0589	0.1082
Schistosoma mansoni	sugar transporter	0.0029	0.0145	0.0255
Echinococcus granulosus	survival motor neuron protein 1	0.0243	0.2605	0.5193
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0063	0.0528	0.2183
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0084	0.0155
Echinococcus granulosus	neuropeptide s receptor	0.0449	0.4963	1
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0165	0.1707	0.486
Echinococcus multilocularis	geminin	0.0174	0.1812	0.3576
Schistosoma mansoni	hypothetical protein	0.0068	0.0591	0.1569
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0149	0.0184
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0064	0.0543	0.0488
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0145	0.0557
Echinococcus multilocularis	Niemann Pick C1 protein	0.0068	0.0589	0.1082
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0047	0.0344	0.1712

Activities

Activity type	Activity value	Assay description	Source	Reference
I50 (binding)	= 0.0038 uM	Inhibition of rat microsomal HMG-CoA reductase activity by 50%	ChEMBL.	2231594
IC50 (binding)	= 0.0038 uM	Inhibition of rat microsomal HMG-CoA reductase activity by 50%	ChEMBL.	2231594

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 165883