Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0068 | 0.0631 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0068 | 0.0631 | 1 |
Leishmania major | glycosyl hydrolase-like protein | 0.0068 | 0.0631 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0273 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.0244 | 0.0246 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0273 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0068 | 0.0631 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0068 | 0.0631 | 0.0786 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0273 | 0.0284 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0631 | 0.0628 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Onchocerca volvulus | 0.0036 | 0.0273 | 0.0059 | |
Schistosoma mansoni | alpha glucosidase | 0.0068 | 0.0631 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0068 | 0.0631 | 0.1496 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0709 | 0.7745 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0273 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0709 | 0.7745 | 0.7745 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0154 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0709 | 0.7745 | 0.7745 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.0265 | 0.0265 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0068 | 0.0631 | 1 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0068 | 0.0631 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0337 | 0.0435 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0912 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0068 | 0.0631 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0337 | 0.0367 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.1095 | 0.1981 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0068 | 0.0631 | 0.1496 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0071 | 0.0658 | 0.0849 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0709 | 0.7745 | 0.7745 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0273 | 0.2503 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0068 | 0.0631 | 0.0749 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0273 | 0.0353 |
Trypanosoma brucei | glucosidase, putative | 0.0068 | 0.0631 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0273 | 0.2503 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.1803 | 0.6401 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.0265 | 0.0265 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0273 | 0.0273 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0068 | 0.0631 | 0.0767 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0273 | 0.0284 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.1803 | 0.6401 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0273 | 0.0284 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0273 | 0.2503 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0068 | 0.0631 | 0.0631 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0273 | 0.0284 |
Giardia lamblia | DNA repair protein RAD52 | 0.0386 | 0.4162 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0244 | 0.0315 |
Echinococcus granulosus | dnaJ subfamily B | 0.0473 | 0.513 | 0.513 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0265 | 0.0342 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0552 | 0.5997 | 0.7727 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0709 | 0.7745 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0473 | 0.513 | 0.513 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0068 | 0.0631 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0068 | 0.0631 | 0.0628 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0273 | 0.2503 |
Entamoeba histolytica | Rad52/22 family double-strand break repair protein, putative | 0.011 | 0.1095 | 0.1981 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0273 | 0.0157 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0273 | 0.0157 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0063 | 0.0574 | 0.8813 |
Onchocerca volvulus | 0.0036 | 0.0273 | 0.0059 | |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0068 | 0.0631 | 0.1496 |
Onchocerca volvulus | 0.0036 | 0.0273 | 0.0059 | |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0912 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0473 | 0.513 | 0.6624 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0273 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0242 | 0.2561 | 0.957 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0251 | 0.2663 | 0.3306 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0337 | 0.0337 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0068 | 0.0631 | 0.1496 |
Onchocerca volvulus | 0.0476 | 0.5163 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0273 | 0.0353 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0154 | 0.0128 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0068 | 0.0631 | 0.0767 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0273 | 0.2503 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0337 | 0.0337 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0242 | 0.2561 | 0.957 |
Schistosoma mansoni | alpha-glucosidase | 0.0709 | 0.7745 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.0244 | 0.0119 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0165 | 0.1705 | 0.2969 |
Entamoeba histolytica | DNA repair and recombination protein RAD52, putative | 0.0386 | 0.4162 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0251 | 0.2663 | 0.3392 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0068 | 0.0631 | 0.0631 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0154 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0337 | 0.0435 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0068 | 0.0631 | 0.0749 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0552 | 0.5997 | 0.7743 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.2418 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0709 | 0.7745 | 1 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0068 | 0.0631 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0068 | 0.0631 | 0.0767 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0265 | 0.0342 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0552 | 0.5997 | 0.7697 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 6830 nM | Cytotoxicity against PHA-stimulated human PBMC incubated for 6 hrs followed by compound-wash out measured after 6 days | ChEMBL. | 22533850 |
EC50 (ADMET) | > 227.7 uM | Cytotoxicity against human HeLa P4/R5 cells incubated for 2 hrs followed by compound-wash out measured after 46 hrs by MTS assay | ChEMBL. | 22533850 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.