Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | plasmepsin VI | 0.0075 | 0.1033 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0057 | 0.0747 | 0.0647 |
Onchocerca volvulus | 0.0072 | 0.0983 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0057 | 0.0747 | 0.0647 |
Schistosoma mansoni | notch | 0.0018 | 0.012 | 0.0035 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0091 | 0.1301 | 0.3292 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0056 | 0.0727 | 0.1692 |
Onchocerca volvulus | 0.0018 | 0.012 | 0.0145 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0018 | 0.012 | 0.0013 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.1024 | 0.2546 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0056 | 0.0727 | 0.3549 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0138 | 0.2048 | 0.5377 |
Loa Loa (eye worm) | Poly(ADP-ribose) glycohydrolase | 0.024 | 0.3706 | 0.3638 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0727 | 0.6816 |
Onchocerca volvulus | 0.0057 | 0.0747 | 0.7309 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 0.0727 | 0.1962 |
Schistosoma mansoni | notch | 0.0018 | 0.012 | 0.0035 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0018 | 0.012 | 0.0013 |
Brugia malayi | Animal haem peroxidase family protein | 0.0057 | 0.0747 | 0.0647 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Brugia malayi | EGF-like domain containing protein | 0.0018 | 0.012 | 0.0013 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0075 | 0.1033 | 0.2573 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.012 | 0.0035 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0056 | 0.0727 | 0.1692 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Echinococcus granulosus | peroxidasin | 0.0057 | 0.0747 | 0.1749 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0018 | 0.012 | 0.0145 |
Onchocerca volvulus | 0.0018 | 0.012 | 0.0145 | |
Brugia malayi | notch-like transmembrane receptor | 0.0018 | 0.012 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0075 | 0.1033 | 0.2573 |
Echinococcus multilocularis | peroxidasin | 0.0057 | 0.0747 | 0.1749 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0727 | 0.6816 |
Wolbachia endosymbiont of Brugia malayi | signal transduction histidine kinase and receiver | 0.0015 | 0.0071 | 1 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0107 | 0.1552 | 0.3373 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0138 | 0.2048 | 0.5377 |
Plasmodium falciparum | plasmepsin I | 0.0075 | 0.1033 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0056 | 0.0727 | 0.1962 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0057 | 0.0747 | 0.0647 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0018 | 0.012 | 0.0013 |
Mycobacterium leprae | TWO COMPONENT SENSOR HISTIDINE KINASE PRRB | 0.0065 | 0.0874 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0057 | 0.0747 | 0.0647 |
Loa Loa (eye worm) | Notch2 | 0.0018 | 0.012 | 0.0013 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.024 | 0.3706 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0057 | 0.0747 | 0.0647 |
Onchocerca volvulus | 0.0057 | 0.0747 | 0.7309 | |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0138 | 0.2048 | 0.1962 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0221 | 0.3396 | 0.9139 |
Onchocerca volvulus | 0.0057 | 0.0747 | 0.7309 | |
Onchocerca volvulus | 0.0018 | 0.012 | 0.0145 | |
Echinococcus multilocularis | jun protein | 0.0091 | 0.1301 | 0.3292 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0056 | 0.0727 | 0.1692 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.012 | 0.0035 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0018 | 0.012 | 0.0035 |
Loa Loa (eye worm) | notch protein | 0.0018 | 0.012 | 0.0013 |
Mycobacterium tuberculosis | Two component sensor histidine kinase PrrB | 0.0065 | 0.0874 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0057 | 0.0747 | 0.0647 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Brugia malayi | EGF-like domain containing protein | 0.0018 | 0.012 | 0.0013 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0056 | 0.0727 | 0.1692 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.012 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Brugia malayi | hypothetical protein | 0.0072 | 0.0983 | 0.0885 |
Entamoeba histolytica | hypothetical protein | 0.0107 | 0.1552 | 0.3373 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0018 | 0.012 | 0.0035 |
Brugia malayi | EGF-like domain containing protein | 0.0018 | 0.012 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Schistosoma mansoni | septate junction protein | 0.0018 | 0.012 | 0.0035 |
Brugia malayi | Muscle positioning protein 4 | 0.0018 | 0.012 | 0.0013 |
Plasmodium vivax | plasmepsin IV, putative | 0.0075 | 0.1033 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.0727 | 0.1721 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0727 | 0.6816 |
Echinococcus multilocularis | poly(ADP ribose) glycohydrolase | 0.024 | 0.3706 | 1 |
Onchocerca volvulus | 0.0018 | 0.012 | 0.0145 | |
Brugia malayi | EGF-like domain containing protein | 0.0018 | 0.012 | 0.0013 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0455 | 0.0933 |
Brugia malayi | MAP kinase sur-1 | 0.0056 | 0.0727 | 0.0626 |
Schistosoma mansoni | slit | 0.0018 | 0.012 | 0.0035 |
Schistosoma mansoni | cell polarity protein | 0.0018 | 0.012 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1033 | 0.0936 |
Brugia malayi | Peroxidasin | 0.0057 | 0.0747 | 0.0647 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.012 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0221 | 0.3396 | 0.9139 |
Onchocerca volvulus | 0.0018 | 0.012 | 0.0145 | |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0056 | 0.0727 | 0.0626 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0455 | 0.0965 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Schistosoma mansoni | notch | 0.0018 | 0.012 | 0.0035 |
Brugia malayi | Animal haem peroxidase family protein | 0.0057 | 0.0747 | 0.0647 |
Brugia malayi | Cadherin domain containing protein | 0.0018 | 0.012 | 0.0013 |
Brugia malayi | EGF-like domain containing protein | 0.0018 | 0.012 | 0.0013 |
Schistosoma mansoni | jun-related protein | 0.0074 | 0.1024 | 0.2546 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0138 | 0.2048 | 0.5527 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.012 | 0.0035 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0138 | 0.2048 | 0.5377 |
Schistosoma mansoni | notch | 0.0018 | 0.012 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0107 | 0.1552 | 0.4013 |
Brugia malayi | Poly | 0.024 | 0.3706 | 0.3638 |
Onchocerca volvulus | Slit protein homolog | 0.0018 | 0.012 | 0.0145 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0057 | 0.0747 | 0.0647 |
Plasmodium falciparum | plasmepsin II | 0.0075 | 0.1033 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0138 | 0.2048 | 0.5377 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0018 | 0.012 | 0.0013 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0138 | 0.2048 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.126 | 0.1165 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0057 | 0.0747 | 0.7309 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.024 | 0.3706 | 1 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0075 | 0.1037 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0018 | 0.012 | 0.0013 |
Schistosoma mansoni | peroxidasin | 0.0057 | 0.0747 | 0.1778 |
Onchocerca volvulus | Peroxidase homolog | 0.0057 | 0.0747 | 0.7309 |
Echinococcus granulosus | jun protein | 0.0091 | 0.1301 | 0.3292 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.012 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 0.0727 | 0.1962 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.024 | 0.3706 | 1 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0075 | 0.1033 | 0.2573 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0075 | 0.1033 | 0.2547 |
Onchocerca volvulus | Dual oxidase homolog | 0.0057 | 0.0747 | 0.7309 |
Brugia malayi | EGF-like domain containing protein | 0.0018 | 0.012 | 0.0013 |
Brugia malayi | P38 map kinase family protein 2 | 0.0138 | 0.2048 | 0.1962 |
Onchocerca volvulus | Putative cubilin | 0.0018 | 0.012 | 0.0145 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0455 | 0.0351 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0056 | 0.0727 | 0.1962 |
Schistosoma mansoni | poly(ADP-ribose) glycohydrolase | 0.024 | 0.3706 | 1 |
Schistosoma mansoni | notch | 0.0018 | 0.012 | 0.0035 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0056 | 0.0727 | 1 |
Echinococcus granulosus | polyADP ribose glycohydrolase | 0.024 | 0.3706 | 1 |
Trypanosoma brucei | poly(ADP-ribose) glycohydrolase, putative | 0.024 | 0.3706 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Entamoeba histolytica | hypothetical protein | 0.024 | 0.3706 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.012 | 0.0035 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0091 | 0.1301 | 0.3292 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0056 | 0.0727 | 0.3549 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0455 | 0.0933 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0018 | 0.012 | 0.0145 |
Onchocerca volvulus | Peroxidasin homolog | 0.0057 | 0.0747 | 0.7309 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Brugia malayi | Delta serrate ligand family protein | 0.0018 | 0.012 | 0.0013 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0455 | 0.0965 |
Onchocerca volvulus | Peroxidase homolog | 0.0057 | 0.0747 | 0.7309 |
Schistosoma mansoni | notch | 0.0018 | 0.012 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0075 | 0.1033 | 0.0936 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Brugia malayi | bZIP transcription factor family protein | 0.0091 | 0.1301 | 0.1206 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0056 | 0.0727 | 0.1721 |
Onchocerca volvulus | Peroxidasin homolog | 0.0057 | 0.0747 | 0.7309 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0727 | 0.6816 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0075 | 0.1033 | 0.2547 |
Plasmodium falciparum | plasmepsin IV | 0.0075 | 0.1033 | 1 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0138 | 0.2048 | 0.4435 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0138 | 0.2048 | 0.5377 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Mycobacterium ulcerans | two component system membrane associated sensor kinase | 0.0065 | 0.0874 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0629 | 1 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0018 | 0.012 | 0.0013 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0075 | 0.1033 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0138 | 0.2048 | 0.5527 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0138 | 0.2048 | 0.5377 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0018 | 0.012 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0075 | 0.1033 | 1 |
Schistosoma mansoni | peroxidasin | 0.0057 | 0.0747 | 0.1778 |
Brugia malayi | Animal haem peroxidase family protein | 0.0057 | 0.0747 | 0.0647 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0747 | 0.0647 |
Mycobacterium ulcerans | two component sensor histidine kinase PrrB | 0.0065 | 0.0874 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Brugia malayi | Blistered cuticle protein 3 | 0.0057 | 0.0747 | 0.0647 |
Brugia malayi | Cadherin domain containing protein | 0.0018 | 0.012 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.012 | 0.0013 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.024 | 0.3706 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.