Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0068 | 0.0631 | 0.0628 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0273 | 0.0157 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0273 | 0.2503 |
Entamoeba histolytica | Rad52/22 family double-strand break repair protein, putative | 0.011 | 0.1095 | 0.1981 |
Onchocerca volvulus | 0.0036 | 0.0273 | 0.0059 | |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0068 | 0.0631 | 0.1496 |
Onchocerca volvulus | 0.0036 | 0.0273 | 0.0059 | |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0063 | 0.0574 | 0.8813 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0273 | 0.0157 |
Schistosoma mansoni | hypothetical protein | 0.0473 | 0.513 | 0.6624 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0242 | 0.2561 | 0.957 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0273 | 0.5 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0912 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0273 | 0.0284 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0244 | 0.0315 |
Giardia lamblia | DNA repair protein RAD52 | 0.0386 | 0.4162 | 0.5 |
Echinococcus granulosus | dnaJ subfamily B | 0.0473 | 0.513 | 0.513 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0265 | 0.0342 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0552 | 0.5997 | 0.7727 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0709 | 0.7745 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0068 | 0.0631 | 0.1496 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0473 | 0.513 | 0.513 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Schistosoma mansoni | alpha-glucosidase | 0.0709 | 0.7745 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0337 | 0.0337 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0242 | 0.2561 | 0.957 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0068 | 0.0631 | 0.0631 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0165 | 0.1705 | 0.2969 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.0244 | 0.0119 |
Entamoeba histolytica | DNA repair and recombination protein RAD52, putative | 0.0386 | 0.4162 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0251 | 0.2663 | 0.3392 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.2418 | 1 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0552 | 0.5997 | 0.7743 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0154 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0068 | 0.0631 | 0.0749 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0337 | 0.0435 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0068 | 0.0631 | 0.0767 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0552 | 0.5997 | 0.7697 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0265 | 0.0342 |
Schistosoma mansoni | alpha-glucosidase | 0.0709 | 0.7745 | 1 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0068 | 0.0631 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0068 | 0.0631 | 0.1496 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0337 | 0.0337 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0251 | 0.2663 | 0.3306 |
Onchocerca volvulus | 0.0476 | 0.5163 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0154 | 0.0128 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0273 | 0.0353 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0068 | 0.0631 | 0.0767 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0273 | 0.2503 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Schistosoma mansoni | alpha glucosidase | 0.0068 | 0.0631 | 0.0814 |
Onchocerca volvulus | 0.0036 | 0.0273 | 0.0059 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0273 | 0.0273 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0709 | 0.7745 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0068 | 0.0631 | 0.1496 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0709 | 0.7745 | 0.7745 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0154 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0068 | 0.0631 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0068 | 0.0631 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0273 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.0244 | 0.0246 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0273 | 0.5 |
Leishmania major | glycosyl hydrolase-like protein | 0.0068 | 0.0631 | 1 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0068 | 0.0631 | 0.0786 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0068 | 0.0631 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0631 | 0.0628 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0273 | 0.0284 |
Trypanosoma brucei | glucosidase, putative | 0.0068 | 0.0631 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0709 | 0.7745 | 0.7745 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0273 | 0.2503 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0273 | 0.0353 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0068 | 0.0631 | 0.0749 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.1803 | 0.6401 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0273 | 0.2503 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0273 | 0.0273 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.0265 | 0.0265 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0273 | 0.0284 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0068 | 0.0631 | 0.0767 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.1803 | 0.6401 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0273 | 0.0284 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0068 | 0.0631 | 0.0631 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0273 | 0.2503 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0068 | 0.0631 | 1 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0068 | 0.0631 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.0265 | 0.0265 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0709 | 0.7745 | 0.7745 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0912 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0337 | 0.0435 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0068 | 0.0631 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0337 | 0.0367 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.1095 | 0.1981 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0068 | 0.0631 | 0.1496 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0071 | 0.0658 | 0.0849 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
TC50 (ADMET) | > 1000 nM | Cytotoxicity against human PBMC | ChEMBL. | 22858097 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.