Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-glucosidase | 0.0709 | 0.7745 | 1 |
Echinococcus granulosus | dnaJ subfamily B | 0.0473 | 0.513 | 0.513 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0068 | 0.0631 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0068 | 0.0631 | 0.0767 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0068 | 0.0631 | 0.1496 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0063 | 0.0574 | 0.8813 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0273 | 0.0284 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.0265 | 0.0265 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0068 | 0.0631 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0071 | 0.0658 | 0.0849 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0251 | 0.2663 | 0.3392 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0273 | 0.2503 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0337 | 0.0435 |
Onchocerca volvulus | 0.0476 | 0.5163 | 1 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.2418 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0068 | 0.0631 | 0.0767 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0068 | 0.0631 | 0.0786 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0273 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Trypanosoma brucei | glucosidase, putative | 0.0068 | 0.0631 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0068 | 0.0631 | 0.0767 |
Schistosoma mansoni | alpha glucosidase | 0.0068 | 0.0631 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0154 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0473 | 0.513 | 0.513 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0068 | 0.0631 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0154 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0473 | 0.513 | 0.6624 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0068 | 0.0631 | 0.0631 |
Entamoeba histolytica | Rad52/22 family double-strand break repair protein, putative | 0.011 | 0.1095 | 0.1981 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0265 | 0.0342 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0273 | 0.0157 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0273 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0631 | 0.0628 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0068 | 0.0631 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0154 | 0.0128 |
Schistosoma mansoni | alpha-glucosidase | 0.0709 | 0.7745 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0273 | 0.0273 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0273 | 0.0353 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0068 | 0.0631 | 0.0631 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0709 | 0.7745 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0068 | 0.0631 | 0.0749 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0244 | 0.0315 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.1803 | 0.6401 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0273 | 0.2503 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0337 | 0.0337 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0709 | 0.7745 | 0.7745 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0165 | 0.1705 | 0.2969 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0068 | 0.0631 | 0.1496 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0912 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0265 | 0.0342 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0068 | 0.0631 | 1 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0273 | 0.0284 |
Onchocerca volvulus | 0.0036 | 0.0273 | 0.0059 | |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0273 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.0244 | 0.0246 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.1095 | 0.1981 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0273 | 0.2503 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0068 | 0.0631 | 0.1496 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0273 | 0.0284 |
Giardia lamblia | DNA repair protein RAD52 | 0.0386 | 0.4162 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0709 | 0.7745 | 0.7745 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0552 | 0.5997 | 0.7697 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0273 | 0.2503 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0709 | 0.7745 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0068 | 0.0631 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0273 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0273 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0273 | 0.0157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.1803 | 0.6401 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0068 | 0.0631 | 0.1496 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0068 | 0.0631 | 0.0628 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0242 | 0.2561 | 0.957 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0337 | 0.0367 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0068 | 0.0631 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0068 | 0.0631 | 0.0749 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0337 | 0.0435 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0251 | 0.2663 | 0.3306 |
Entamoeba histolytica | DNA repair and recombination protein RAD52, putative | 0.0386 | 0.4162 | 1 |
Onchocerca volvulus | 0.0036 | 0.0273 | 0.0059 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0273 | 0.0284 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0273 | 0.0273 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0552 | 0.5997 | 0.7727 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.0244 | 0.0119 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0273 | 0.2503 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2663 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0709 | 0.7745 | 0.7745 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0242 | 0.2561 | 0.957 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.0265 | 0.0265 |
Onchocerca volvulus | 0.0036 | 0.0273 | 0.0059 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0552 | 0.5997 | 0.7743 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0337 | 0.0337 |
Leishmania major | glycosyl hydrolase-like protein | 0.0068 | 0.0631 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0068 | 0.0631 | 0.1496 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1705 | 0.5989 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0068 | 0.0631 | 0.1496 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0912 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
TC50 (ADMET) | > 1000 nM | Cytotoxicity against human PBMC | ChEMBL. | 22858097 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.