Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0153 | 0.0224 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0357 | 0.6799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3117 | 0.4584 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0042 | 0.0153 | 0.026 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0042 | 0.0153 | 0.026 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0214 | 0.3769 | 0.5544 |
Schistosoma mansoni | sphingoid long chain base kinase | 0.0313 | 0.5861 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0153 | 0.0224 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0339 | 0.0499 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0313 | 0.5861 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0214 | 0.3769 | 0.3673 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0042 | 0.0153 | 0.026 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0509 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0042 | 0.0153 | 0.026 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0042 | 0.0153 | 0.026 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0247 | 0.4483 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0357 | 0.6799 | 0.5 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0042 | 0.0153 | 0.0224 |
Echinococcus multilocularis | serotonin transporter | 0.0247 | 0.4483 | 0.4398 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.5861 | 0.862 |
Brugia malayi | Pax transcription factor protein 2 | 0.0284 | 0.5263 | 0.7741 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.2911 | 0.4967 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0339 | 0.0499 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0042 | 0.0153 | 0.0224 |
Brugia malayi | MH2 domain containing protein | 0.0141 | 0.2242 | 0.3297 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0247 | 0.4483 | 0.6594 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0214 | 0.3769 | 0.7077 |
Echinococcus granulosus | serotonin transporter | 0.0247 | 0.4483 | 0.4398 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0042 | 0.0153 | 0.026 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0042 | 0.0153 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0153 | 0.0224 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0153 | 0.0224 |
Loa Loa (eye worm) | serotonin transporter b | 0.0247 | 0.4483 | 0.6594 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.6799 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0357 | 0.6799 | 0.5 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0042 | 0.0153 | 0.026 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0339 | 0.0499 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0141 | 0.2242 | 0.3297 |
Onchocerca volvulus | 0.0284 | 0.5263 | 1 | |
Mycobacterium tuberculosis | Conserved protein | 0.0313 | 0.5861 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0214 | 0.3769 | 0.3673 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0153 | 0.0224 |
Toxoplasma gondii | hypothetical protein | 0.0042 | 0.0153 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.4483 | 0.6594 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0042 | 0.0153 | 0.0224 |
Plasmodium falciparum | transporter, putative | 0.0042 | 0.0153 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0247 | 0.4483 | 0.7649 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0284 | 0.5263 | 0.7741 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.4483 | 0.6594 |
Echinococcus granulosus | sphingosine kinase 1 | 0.0313 | 0.5861 | 0.5797 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0042 | 0.0153 | 0.026 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0141 | 0.2242 | 0.3297 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0042 | 0.0153 | 0.026 |
Echinococcus multilocularis | geminin | 0.0173 | 0.2911 | 0.2801 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0042 | 0.0153 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0042 | 0.0153 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.4483 | 0.6594 |
Echinococcus granulosus | geminin | 0.0173 | 0.2911 | 0.2801 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0247 | 0.4483 | 0.7649 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.2911 | 0.4967 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0042 | 0.0153 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0339 | 0.0499 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0214 | 0.3769 | 0.6431 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0042 | 0.0153 | 0.026 |
Toxoplasma gondii | hypothetical protein | 0.0042 | 0.0153 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0153 | 0.0224 |
Plasmodium vivax | amine transporter, putative | 0.0042 | 0.0153 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0042 | 0.0153 | 0.5 |
Schistosoma mansoni | sphingosine kinase A B | 0.0313 | 0.5861 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0153 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0153 | 0.0224 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0214 | 0.3769 | 0.5544 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0042 | 0.0153 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0153 | 0.0224 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0357 | 0.6799 | 0.5 |
Onchocerca volvulus | 0.0247 | 0.4483 | 0.8474 | |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0042 | 0.0153 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0313 | 0.5861 | 0.5 |
Plasmodium falciparum | amino acid transporter, putative | 0.0042 | 0.0153 | 0.5 |
Echinococcus multilocularis | sphingosine kinase 1 | 0.0313 | 0.5861 | 0.5797 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0247 | 0.4483 | 0.6594 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0042 | 0.0153 | 0.026 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0247 | 0.4483 | 0.6594 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.