TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 278.262 | Formula: C16H10N2O3
H donors: 0 H acceptors: 2 LogP: 2.76 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: Cn1c(=O)nc2c(c1=O)cc1c(o2)ccc2c1cccc2
InChi: 1S/C16H10N2O3/c1-18-15(19)12-8-11-10-5-3-2-4-9(10)6-7-13(11)21-14(12)17-16(18)20/h2-8H,1H3
InChiKey: JOBGEKFFHGDIPU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sirtuin 2	Starlite/ChEMBL	References
Homo sapiens	sirtuin 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	transcriptional regulator, Sir2 family protein	Get druggable targets OG5_127826	All targets in OG5_127826
Echinococcus multilocularis	chromatin regulatory protein sir2	Get druggable targets OG5_127826	All targets in OG5_127826
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	Get druggable targets OG5_129944	All targets in OG5_129944
Brugia malayi	NAD-dependent deacetylase SIRT1	Get druggable targets OG5_129944	All targets in OG5_129944
Leishmania mexicana	silent information regulator 2, putative,NAD-dependent SIR2, putative	Get druggable targets OG5_127826	All targets in OG5_127826
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	Get druggable targets OG5_127826	All targets in OG5_127826
Loa Loa (eye worm)	transcriptional regulator	Get druggable targets OG5_127826	All targets in OG5_127826
Giardia lamblia	NAD-dependent histone deacetylase Sir2	Get druggable targets OG5_129944	All targets in OG5_129944
Schistosoma mansoni	chromatin regulatory protein sir2	Get druggable targets OG5_127826	All targets in OG5_127826
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	Get druggable targets OG5_129944	All targets in OG5_129944
Schistosoma japonicum	expressed protein	Get druggable targets OG5_129944	All targets in OG5_129944
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129944	All targets in OG5_129944
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	Get druggable targets OG5_127826	All targets in OG5_127826
Trypanosoma brucei gambiense	silent information regulator 2,NAD-dependent SIR2	Get druggable targets OG5_127826	All targets in OG5_127826
Trypanosoma brucei	Silent information regulator 2 related protein 1	Get druggable targets OG5_127826	All targets in OG5_127826
Schistosoma japonicum	ko:K01463 sirtuin (silent mating type information regulation 2 homolog) 2 [EC:3.5.1.-], putative	Get druggable targets OG5_127826	All targets in OG5_127826
Trypanosoma congolense	silent information regulator 2	Get druggable targets OG5_127826	All targets in OG5_127826
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	Get druggable targets OG5_127826	All targets in OG5_127826
Leishmania major	silent information regulator 2, putative	Get druggable targets OG5_127826	All targets in OG5_127826
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	Get druggable targets OG5_129944	All targets in OG5_129944
Candida albicans	one of two genes similar to S. cerevisiae SIR2 (YDL042C) NAD+-dependent histone deacetylase	Get druggable targets OG5_129944	All targets in OG5_129944
Candida albicans	likely SIR2 family histone deacetylase similar to S. cerevisiae HST2 (YPL015C) involved in telomeric chromatin silencing	Get druggable targets OG5_127826	All targets in OG5_127826
Candida albicans	one of two genes similar to S. cerevisiae SIR2 (YDL042C) NAD+-dependent histone deacetylase	Get druggable targets OG5_129944	All targets in OG5_129944
Giardia lamblia	Hypothetical protein	Get druggable targets OG5_127826	All targets in OG5_127826
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129944	All targets in OG5_129944
Leishmania infantum	silent information regulator 2, putative	Get druggable targets OG5_127826	All targets in OG5_127826
Schistosoma japonicum	ko:K01463 sirtuin 1 (silent mating type information regulation 2, homolog) 1 [EC:3.5.1.-], putative	Get druggable targets OG5_129944	All targets in OG5_129944
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	Get druggable targets OG5_129944	All targets in OG5_129944
Leishmania donovani	Silent information regulator 2 related protein 1	Get druggable targets OG5_127826	All targets in OG5_127826
Trypanosoma cruzi	Silent information regulator 2 related protein 1	Get druggable targets OG5_127826	All targets in OG5_127826
Leishmania braziliensis	NAD-dependent SIR2, putative	Get druggable targets OG5_127826	All targets in OG5_127826
Trypanosoma cruzi	Silent information regulator 2 related protein 1	Get druggable targets OG5_127826	All targets in OG5_127826
Schistosoma mansoni	chromatin regulatory protein sir2	Get druggable targets OG5_127826	All targets in OG5_127826
Candida albicans	likely SIR2 family histone deacetylase similar to S. cerevisiae HST2 (YPL015C) involved in telomeric chromatin silencing	Get druggable targets OG5_127826	All targets in OG5_127826
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	Get druggable targets OG5_129944	All targets in OG5_129944
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	Get druggable targets OG5_127826	All targets in OG5_127826
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	Get druggable targets OG5_129944	All targets in OG5_129944
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	Get druggable targets OG5_127826	All targets in OG5_127826
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	Get druggable targets OG5_127826	All targets in OG5_127826
Schistosoma mansoni	chromatin regulatory protein sir2	Get druggable targets OG5_129944	All targets in OG5_129944
Echinococcus granulosus	chromatin regulatory protein sir2	Get druggable targets OG5_127826	All targets in OG5_127826
Schistosoma mansoni	chromatin regulatory protein sir2	Get druggable targets OG5_127826	All targets in OG5_127826

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	transcriptional regulatory protein sir2a	sirtuin 2	234 aa	207 aa	26.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.004	0.0084	0.0282
Echinococcus multilocularis	prolyl endopeptidase	0.2073	1	1
Trypanosoma brucei	SIR2-like protein 4, putative	0.004	0.0084	0.0025
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0217	0.0951	0.0874
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0217	0.0951	0.0951
Toxoplasma gondii	aspartyl protease ASP3	0.0091	0.0335	0.0253
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0217	0.0951	0.0897
Schistosoma mansoni	chromatin regulatory protein sir2	0.0154	0.0644	0.0644
Brugia malayi	Peptidase family M1 containing protein	0.0035	0.0059	0.0006
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0217	0.0951	0.0897
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0217	0.0951	1
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0154	0.0644	0.6552
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0154	0.0644	0.0588
Schistosoma mansoni	inhibitor of apoptosis protein	0.0053	0.0149	0.0149
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0217	0.0951	1
Leishmania major	sir2-family protein-like protein	0.004	0.0084	0.0025
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0217	0.0951	0.0951
Brugia malayi	follicle stimulating hormone receptor	0.0227	0.0999	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0149	0.0149
Trypanosoma cruzi	hypothetical protein, conserved	0.0046	0.0117	0.0117
Giardia lamblia	Hypothetical protein	0.0154	0.0644	0.6452
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.1856	0.894	1
Loa Loa (eye worm)	transcriptional regulator	0.004	0.0084	0.0084
Brugia malayi	prolyl oligopeptidase family protein	0.0217	0.0951	0.0903
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0046	0.0117	0.0376
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0824	0.3911	0.3911
Mycobacterium tuberculosis	Probable peptidase	0.0824	0.3911	0.4321
Brugia malayi	transcriptional regulator, Sir2 family protein	0.004	0.0084	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0053	0.0053
Onchocerca volvulus	Deterin homolog	0.0053	0.0149	0.009
Brugia malayi	prolyl oligopeptidase family protein	0.0217	0.0951	0.0903
Mycobacterium ulcerans	Sir2-like regulatory protein	0.004	0.0084	0.0065
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0171	0.0724	0.745
Schistosoma mansoni	chromatin regulatory protein sir2	0.0171	0.0724	0.0724
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0053	0.0149	0.0149
Brugia malayi	transcriptional regulator, Sir2 family protein	0.004	0.0084	0.0031
Trypanosoma cruzi	oligopeptidase b	0.0824	0.3911	0.3911
Onchocerca volvulus		0.0053	0.0149	0.009
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.004	0.0084	0.0025
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0035	0.0059	0.0059
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0053	0.0149	0.0149
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0217	0.0951	1
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0035	0.0059	0.0059
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.004	0.0084	0.0084
Schistosoma mansoni	hypothetical protein	0.0033	0.0053	0.0053
Trypanosoma brucei	oligopeptidase b	0.0824	0.3911	0.3875
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0154	0.0644	0.0644
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0824	0.3911	0.5
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0154	0.0644	0.6552
Loa Loa (eye worm)	aminopeptidase N	0.0035	0.0059	0.0059
Schistosoma mansoni	chromatin regulatory protein sir2	0.0154	0.0644	0.0644
Entamoeba histolytica	hypothetical protein, conserved	0.004	0.0084	0.0282
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0217	0.0951	0.0874
Plasmodium falciparum	plasmepsin IX	0.0091	0.0335	0.2889
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0171	0.0724	0.745
Loa Loa (eye worm)	hypothetical protein	0.2073	1	1
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0217	0.0951	1
Loa Loa (eye worm)	prolyl oligopeptidase	0.0217	0.0951	0.0951
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.004	0.0084	0.0025
Leishmania major	oligopeptidase b	0.0824	0.3911	0.3875
Brugia malayi	prolyl oligopeptidase family protein	0.0217	0.0951	0.0903
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0053	0.0149	0.0096
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0171	0.0724	0.0668
Schistosoma mansoni	hypothetical protein	0.0053	0.0149	0.0149
Schistosoma mansoni	chromatin regulatory protein sir2	0.004	0.0084	0.0084
Brugia malayi	Peptidase family M1 containing protein	0.0035	0.0059	0.0006
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0217	0.0951	1
Trichomonas vaginalis	conserved hypothetical protein	0.0217	0.0951	1
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0171	0.0724	0.7376
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0154	0.0644	0.0588
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0035	0.0059	0.0059
Trypanosoma brucei	prolyl endopeptidase	0.2073	1	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.004	0.0084	0.0282
Schistosoma mansoni	cathepsin D (A01 family)	0.0104	0.04	0.04
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.2073	1	1
Plasmodium vivax	aspartyl protease, putative	0.0091	0.0335	0.2889
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0035	0.0059	0.0059
Toxoplasma gondii	prolyl endopeptidase	0.2073	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0217	0.0951	0.0951
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.004	0.0084	0.0084
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0217	0.0951	0.0897
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0824	0.3911	0.3875
Schistosoma mansoni	chromatin regulatory protein sir2	0.004	0.0084	0.0084
Trypanosoma cruzi	hypothetical protein, conserved	0.0217	0.0951	0.0951
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0053	0.0149	0.0096
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.2073	1	1
Trypanosoma cruzi	aminopeptidase, putative	0.0035	0.0059	0.0059
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.004	0.0084	0.0025
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0217	0.0951	0.0951
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.004	0.0084	0.0025
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0171	0.0724	0.745
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0149	0.0149
Brugia malayi	prolyl oligopeptidase family protein	0.0217	0.0951	0.0903
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0217	0.0951	1
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0824	0.3911	0.3911
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0154	0.0644	0.6552
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0217	0.0951	0.0951
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0217	0.0951	1
Leishmania major	hypothetical protein, conserved	0.0046	0.0117	0.0058
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.004	0.0084	0.0084
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0053	0.0149	0.009
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0217	0.0951	0.0951
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0217	0.0951	0.0951
Echinococcus multilocularis	aminopeptidase N	0.0035	0.0059	0.0059
Trypanosoma cruzi	oligopeptidase b	0.0824	0.3911	0.3911
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0217	0.0951	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0129	0.0076
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0035	0.0059	0.0059
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0035	0.0059	0.0059
Schistosoma mansoni	chromatin regulatory protein sir2	0.0154	0.0644	0.0644
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0035	0.0059	0.0059
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0154	0.0644	0.0644
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0171	0.0724	0.0674
Loa Loa (eye worm)	prolyl oligopeptidase	0.0217	0.0951	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0131	0.053	0.053
Schistosoma mansoni	chromatin regulatory protein sir2	0.004	0.0084	0.0084
Plasmodium vivax	aspartyl protease, putative	0.0091	0.0335	0.2889
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0171	0.0724	0.0724
Leishmania major	hypothetical protein, conserved	0.0046	0.0117	0.0058
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0217	0.0951	0.0897
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0154	0.0644	0.0644
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0217	0.0951	0.0951
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0217	0.0951	1
Entamoeba histolytica	hypothetical protein, conserved	0.0217	0.0951	1
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0217	0.0951	0.0897
Plasmodium falciparum	peptidase, putative	0.0217	0.0951	1
Mycobacterium tuberculosis	Conserved protein	0.0046	0.0117	0.0037
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0217	0.0951	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0129	0.0129
Mycobacterium ulcerans	hypothetical protein	0.0046	0.0117	0.015
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0724	0.0724
Schistosoma mansoni	cathepsin D (A01 family)	0.0104	0.04	0.04
Toxoplasma gondii	hypothetical protein	0.0217	0.0951	0.0874
Loa Loa (eye worm)	transcriptional regulator	0.0154	0.0644	0.0644
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0053	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0951	0.0951
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0154	0.0644	0.0644
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0035	0.0059	0.0059
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0217	0.0951	0.0951
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0035	0.0059	0.0059
Echinococcus granulosus	acylamino acid releasing enzyme	0.0217	0.0951	0.0897
Loa Loa (eye worm)	transcriptional regulator	0.004	0.0084	0.0084
Treponema pallidum	mcbG protein	0.0046	0.0117	0.5
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0217	0.0951	0.0951
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0217	0.0951	0.0897
Echinococcus granulosus	chromatin regulatory protein sir2	0.0154	0.0644	0.0588
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0129	0.0076
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0824	0.3911	0.3875
Loa Loa (eye worm)	sirtuin 4	0.004	0.0084	0.0084
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.004	0.0084	0.0282
Leishmania major	silent information regulator 2, putative	0.0154	0.0644	0.0588
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.004	0.0084	0.0282
Echinococcus granulosus	prolyl endopeptidase	0.2073	1	1
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.004	0.0084	0.0084
Mycobacterium ulcerans	NAD-dependent deacetylase	0.004	0.0084	0.0065
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.2073	1	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.004	0.0084	0.0282
Brugia malayi	hypothetical protein	0.0035	0.0059	0.0006
Plasmodium falciparum	plasmepsin X	0.0091	0.0335	0.2889
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0824	0.3911	0.3875
Echinococcus granulosus	inhibitor of apoptosis protein	0.0053	0.0149	0.009
Plasmodium vivax	hypothetical protein, conserved	0.0217	0.0951	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0046	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0951	0.0951
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0154	0.0644	0.0593
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.004	0.0084	0.0282
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0227	0.0999	0.0999
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0035	0.0059	0.0059
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0129	0.0129
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0824	0.3911	0.4321
Trypanosoma cruzi	prolyl endopeptidase	0.2073	1	1
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0824	0.3911	1
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.004	0.0084	0.0282
Onchocerca volvulus	Prolyl endopeptidase homolog	0.2073	1	1
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0154	0.0644	0.6552
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0171	0.0724	0.745

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 18.8 %	Induction of apoptosis in human U937 cell at 50 uM after 30 hrs by annexin V-FITC/ propidium iodide staining based flow cytometry analysis	ChEMBL.	22931526
IC50 (binding)	= 7 uM	Inhibition of human recombinant SIRT1 expressed in Escherichia coli cells using acetylated Lys side chain amino acids 379-382 (Arg-His-Lys-Lys(Ac)) p53 conjugated with aminomethylcoumarin as substrate by fluorescence assay	ChEMBL.	22931526
IC50 (binding)	= 11.2 uM	Inhibition of human recombinant SIRT2 expressed in Escherichia coli cells using acetylated Lys side chain amino acids 379-382 (Arg-His-Lys-Lys(Ac)) p53 conjugated with aminomethylcoumarin as substrate by fluorescence assay	ChEMBL.	22931526

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2171191

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1680305