Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Rattus norvegicus | Cannabinoid CB1 receptor | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Rattus norvegicus | Cannabinoid CB2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Cannabinoid CB2 receptor | 360 aa | 297 aa | 21.9 % | |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Cannabinoid CB2 receptor | 360 aa | 311 aa | 20.6 % |
Onchocerca volvulus | Cannabinoid CB2 receptor | 360 aa | 330 aa | 20.9 % | |
Echinococcus granulosus | neuropeptide receptor | Cannabinoid CB2 receptor | 360 aa | 337 aa | 24.0 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Cannabinoid CB2 receptor | 360 aa | 370 aa | 23.8 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Cannabinoid CB2 receptor | 360 aa | 323 aa | 22.6 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Cannabinoid CB2 receptor | 360 aa | 360 aa | 23.1 % |
Echinococcus multilocularis | neuropeptide receptor | Cannabinoid CB2 receptor | 360 aa | 299 aa | 24.7 % |
Onchocerca volvulus | Phospholipase d-related homolog | Cannabinoid CB2 receptor | 360 aa | 309 aa | 23.3 % |
Echinococcus granulosus | allatostatin A receptor | Cannabinoid CB2 receptor | 360 aa | 363 aa | 22.9 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Cannabinoid CB2 receptor | 360 aa | 370 aa | 23.5 % |
Onchocerca volvulus | Cannabinoid CB2 receptor | 360 aa | 389 aa | 21.1 % | |
Schistosoma mansoni | opsin-like receptor | Cannabinoid CB2 receptor | 360 aa | 314 aa | 22.0 % |
Echinococcus multilocularis | allatostatin A receptor | Cannabinoid CB2 receptor | 360 aa | 342 aa | 22.8 % |
Onchocerca volvulus | Cannabinoid CB2 receptor | 360 aa | 327 aa | 19.6 % | |
Loa Loa (eye worm) | neuropeptide F receptor | Cannabinoid CB2 receptor | 360 aa | 348 aa | 24.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aldehyde dehydrogenase | 0.0044 | 0.0285 | 0.0285 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0029 | 0.0108 | 0.0108 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0131 | 0.1289 | 0.1289 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0037 | 0.0193 | 0.0193 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0131 | 0.1289 | 0.1289 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0029 | 0.0108 | 0.0108 |
Echinococcus granulosus | muscleblind protein | 0.022 | 0.2313 | 0.2313 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0044 | 0.0285 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0037 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.2313 | 0.2313 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0044 | 0.0285 | 0.0285 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.0108 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0044 | 0.0285 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0131 | 0.1289 | 0.1289 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.0108 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0044 | 0.0285 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0345 | 0.3759 | 0.3759 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0029 | 0.0108 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0037 | 0.0198 | 0.0198 |
Trypanosoma brucei | glucosidase, putative | 0.0029 | 0.0108 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0044 | 0.0285 | 0.0285 |
Echinococcus multilocularis | muscleblind protein | 0.022 | 0.2313 | 0.2313 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0345 | 0.3759 | 0.3759 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0029 | 0.0108 | 0.5 |
Onchocerca volvulus | 0.0886 | 1 | 1 | |
Echinococcus multilocularis | protein will die slowly | 0.0886 | 1 | 1 |
Echinococcus granulosus | protein will die slowly | 0.0886 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0131 | 0.1289 | 0.1289 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0025 | 0.006 | 0.006 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0044 | 0.0285 | 0.0285 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0037 | 0.0198 | 0.0198 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0029 | 0.0108 | 0.0108 |
Echinococcus multilocularis | muscleblind protein 1 | 0.022 | 0.2313 | 0.2313 |
Brugia malayi | Protein kinase domain containing protein | 0.0345 | 0.3759 | 0.3759 |
Brugia malayi | Muscleblind-like protein | 0.022 | 0.2313 | 0.2313 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0029 | 0.0108 | 0.0108 |
Onchocerca volvulus | 0.0076 | 0.0649 | 0.0649 | |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.2313 | 0.2313 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0037 | 0.0198 | 0.0198 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0131 | 0.1289 | 0.1289 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0037 | 0.0198 | 0.0198 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0037 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | WD40 repeat protein | 0.0886 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0037 | 0.0193 | 0.0193 |
Schistosoma mansoni | hypothetical protein | 0.0886 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0037 | 0.0198 | 0.0198 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0044 | 0.0285 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0029 | 0.0108 | 0.0108 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0037 | 0.0193 | 0.0193 |
Schistosoma mansoni | alpha-glucosidase | 0.0113 | 0.1077 | 0.1077 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0193 | 0.0193 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0044 | 0.0285 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0037 | 0.0198 | 0.0198 |
Schistosoma mansoni | alpha-glucosidase | 0.0113 | 0.1077 | 0.1077 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.006 | 0.006 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0044 | 0.0285 | 0.5 |
Trichomonas vaginalis | WD repeat domain, putative | 0.0886 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0037 | 0.0198 | 0.0198 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 15.3 nM | Agonist activity at human recombinant CB2 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation | ChEMBL. | 22738271 |
Ki (binding) | = 2.34 nM | Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting | ChEMBL. | 22738271 |
Ki (binding) | = 2.73 nM | Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting | ChEMBL. | 22738271 |
Ki (binding) | = 215 nM | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in CHO cell membranes incubated for 90 mins by scintillation counting | ChEMBL. | 22738271 |
Ki (binding) | = 240 nM | Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat brain by scintillation counting | ChEMBL. | 22738271 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.