Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Homo sapiens | UDP-glucose ceramide glucosyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0075 | 0.2124 | 0.1906 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0181 | 0.0111 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0181 | 0.0111 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.104 | 0.0976 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5437 | 0.5405 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.104 | 0.0976 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0181 | 0.0111 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.169 | 0.163 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0925 | 0.0925 |
Echinococcus granulosus | geminin | 0.0165 | 0.5437 | 0.5405 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0764 | 0.051 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.104 | 0.0793 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.104 | 0.0976 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0677 | 0.061 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0677 | 0.061 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0288 | 1 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.104 | 0.104 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.104 | 0.0976 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0855 | 0.0855 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0288 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.104 | 0.0976 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.011 | 0.011 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.011 | 0.0039 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.104 | 0.0976 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.104 | 0.0976 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0131 | 0.4176 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1965 | 0.1965 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.1557 | 0.1497 |
Echinococcus multilocularis | geminin | 0.0165 | 0.5437 | 0.5405 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0767 | 0.0767 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.1557 | 0.1497 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0288 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5437 | 0.5405 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0288 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 nM | Inhibition of GCS assessed as amount of UDP glucose after 3 hrs by Fluorometry analysis | ChEMBL. | 22497444 |
IC50 (binding) | = 120 nM | Inhibition of GCS in human A549 cells assessed as decrease in GM1 synthesis after 72 hrs by Fluorescence assay | ChEMBL. | 22497444 |
IC50 (ADMET) | = 1530 nM | Inhibition of human CYP3A4 using testosterone as substrate after 45 mins | ChEMBL. | 22497444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.