TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 268.274 | Formula: C13H12N6O
H donors: 2 H acceptors: 5 LogP: 0.43 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O[C@@H]1Cc2c([C@H]1n1nnc3c1ncnc3N)cccc2
InChi: 1S/C13H12N6O/c14-12-10-13(16-6-15-12)19(18-17-10)11-8-4-2-1-3-7(8)5-9(11)20/h1-4,6,9,11,20H,5H2,(H2,14,15,16)/t9-,11-/m1/s1
InChiKey: UUTJDBSNKBWMBE-MWLCHTKSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine protease, putative	0.004	0.1733	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0507	0.0507
Schistosoma mansoni	cathepsin B (C01 family)	0.0017	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0027	0.0027
Echinococcus multilocularis	cathepsin b	0.0157	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0085
Leishmania major	cathepsin L-like protease	0.0074	0.415	1
Echinococcus multilocularis	cysteine protease	0.0074	0.415	0.415
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0157	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.004	0.1733	0.1733
Echinococcus multilocularis	ecdysone induced protein 78C	0.0016	0.0027	0.0027
Echinococcus multilocularis	FTZ F1 alpha	0.0016	0.0027	0.0027
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0017	0.0085	0.0206
Entamoeba histolytica	cysteine proteinase 2	0.004	0.1733	0.4054
Plasmodium vivax	vivapain-1	0.004	0.1733	0.4176
Plasmodium vivax	unspecified product	0.004	0.1733	0.4176
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.2163	0.2163
Schistosoma mansoni	coup transcription factor	0.0016	0.0027	0.0027
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0051	0.2502	0.2502
Toxoplasma gondii	cathepsin CPL	0.0074	0.415	1
Entamoeba histolytica	cysteine proteinase, putative	0.004	0.1733	0.4054
Entamoeba histolytica	cysteine protease, putative	0.004	0.1733	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0085
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0085	0.0085
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.415	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.415	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0017	0.0085	0.0085
Brugia malayi	nuclear receptor NHR-88	0.0016	0.0027	0.0027
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0074	0.415	0.415
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0074	0.415	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0085	0.0085
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0016	0.0027	0.0027
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0016	0.0027	0.0027
Plasmodium falciparum	serine repeat antigen 6	0.0017	0.0085	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0027	0.0027
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0016	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0507	0.0507
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.415	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0027	0.0027
Onchocerca volvulus		0.0051	0.2502	0.6003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0051	0.2502	0.5946
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0017	0.0085	0.0206
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0074	0.415	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0085	0.0085
Plasmodium falciparum	serine repeat antigen 8	0.0017	0.0085	0.0206
Leishmania major	cathepsin L-like protease	0.0074	0.415	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.415	1
Leishmania major	cathepsin L-like protease	0.0074	0.415	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0074	0.415	0.415
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.415	1
Brugia malayi	ecdysteroid receptor	0.0016	0.0027	0.0027
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0017	0.0085	0.0206
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.415	0.415
Leishmania major	cathepsin L-like protease	0.0074	0.415	1
Onchocerca volvulus	Cathepsin L homolog	0.0074	0.415	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0017	0.0085	0.0085
Schistosoma mansoni	cathepsin F (C01 family)	0.0074	0.415	0.415
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.415	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0016	0.0027	0.0027
Entamoeba histolytica	cysteine proteinase, putative	0.0074	0.415	1
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0085	0.0085
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0016	0.0027	0.0027
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0085	0.0085
Brugia malayi	cathepsin F-like cysteine proteinase	0.0017	0.0085	0.0085
Onchocerca volvulus		0.0074	0.415	1
Entamoeba histolytica	cysteine protease, putative	0.004	0.1733	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.004	0.1733	0.4176
Onchocerca volvulus		0.0074	0.415	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.3152	0.7594
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.415	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.415	1
Echinococcus multilocularis	cysteine protease	0.0074	0.415	0.415
Trypanosoma cruzi	cruzipain precursor, putative	0.0023	0.0507	0.0507
Onchocerca volvulus		0.0017	0.0085	0.0142
Loa Loa (eye worm)	steroid hormone receptor	0.0016	0.0027	0.0027
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0051	0.2502	0.2502
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.2163	0.2163
Toxoplasma gondii	cathepsin CPC2	0.0017	0.0085	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0027	0.0027
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0074	0.415	0.415
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.3152	0.7594
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.415	1
Entamoeba histolytica	cysteine protease, putative	0.004	0.1733	0.4054
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0017	0.0085	0.0206
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.415	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0017	0.0085	0.0085
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0016	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2502	0.2502
Plasmodium vivax	serine-repeat antigen (SERA)	0.0017	0.0085	0.0206
Entamoeba histolytica	cysteine proteinase, putative	0.004	0.1733	0.4054
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0157	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.2163	0.2163
Brugia malayi	Cathepsin L-like precursor	0.0074	0.415	0.415
Plasmodium falciparum	cysteine proteinase falcipain 1	0.004	0.1733	0.4176
Trypanosoma cruzi	cysteine peptidase, putative	0.004	0.1733	0.1733
Schistosoma mansoni	thyroid hormone receptor	0.0016	0.0027	0.0027
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0016	0.0027	0.0027
Brugia malayi	nuclear hormone receptor	0.0016	0.0027	0.0027
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.415	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.2163	0.2163
Echinococcus granulosus	cathepsin b	0.0157	1	1
Brugia malayi	fibroinase precursor	0.0017	0.0085	0.0085
Echinococcus granulosus	cathepsin b	0.0157	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0507	0.0507
Plasmodium vivax	unspecified product	0.0023	0.0507	0.1221
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0017	0.0085	0.0206
Entamoeba histolytica	cysteine proteinase 1, putative	0.004	0.1733	0.4054
Echinococcus granulosus	cathepsin l1	0.0074	0.415	0.415
Schistosoma mansoni	cathepsin C	0.0017	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0085
Brugia malayi	Cathepsin L-like precursor	0.0074	0.415	0.415
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0507	0.0507
Plasmodium falciparum	serine repeat antigen 7	0.0017	0.0085	0.0206
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0017	0.0085	0.0085
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0016	0.0027	0.0027
Entamoeba histolytica	cysteine protease, putative	0.004	0.1733	0.4054
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0016	0.0027	0.0027
Onchocerca volvulus		0.0074	0.415	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.415	1
Plasmodium vivax	vivapain-3	0.004	0.1733	0.4176
Brugia malayi	Cathepsin L-like precursor	0.0074	0.415	0.415
Leishmania major	cathepsin L-like protease	0.0074	0.415	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0085	0.0085
Plasmodium falciparum	serine repeat antigen 3	0.0017	0.0085	0.0206
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.415	0.415
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0074	0.415	0.415
Entamoeba histolytica	cysteine protease, putative	0.004	0.1733	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0157	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0027	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0016	0.0027	0.0027
Leishmania major	cathepsin L-like protease	0.0074	0.415	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.3152	0.7543
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.415	1
Entamoeba histolytica	cysteine protease, putative	0.004	0.1733	0.4054
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0016	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.415	1
Onchocerca volvulus		0.0074	0.415	1
Plasmodium falciparum	serine repeat antigen 2	0.0017	0.0085	0.0206
Brugia malayi	Papain family cysteine protease containing protein	0.0074	0.415	0.415
Schistosoma mansoni	retinoic acid receptor RXR	0.0016	0.0027	0.0027
Echinococcus multilocularis	cathepsin L	0.004	0.1733	0.1733
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.415	1
Brugia malayi	Cathepsin L-like precursor	0.0074	0.415	0.415
Brugia malayi	steroid hormone receptor	0.0016	0.0027	0.0027
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0085	0.0142
Echinococcus multilocularis	cathepsin L	0.0017	0.0085	0.0085
Plasmodium vivax	unspecified product	0.0017	0.0085	0.0206
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0074	0.415	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.3152	0.3152
Brugia malayi	Steroid receptor seven-up type 2	0.0016	0.0027	0.0027
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.004	0.1733	0.1733
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0016	0.0027	0.0027
Leishmania major	cysteine peptidase A (CPA)	0.0074	0.415	1
Plasmodium falciparum	serine repeat antigen 1	0.0017	0.0085	0.0206
Loa Loa (eye worm)	cathepsin B	0.006	0.3152	0.3152
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0016	0.0027	0.0027
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.2163	0.2163
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0016	0.0027	0.0027
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.004	0.1733	0.1733
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0017	0.0085	0.0206
Schistosoma mansoni	cathepsin F (C01 family)	0.0051	0.2502	0.2502
Plasmodium falciparum	serine repeat antigen 9	0.0017	0.0085	0.0206
Entamoeba histolytica	cysteine protease, putative	0.004	0.1733	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.415	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.415	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.2163	0.2163
Echinococcus multilocularis	cathepsin b	0.0157	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0016	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.415	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.415	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0016	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0085
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.415	0.415
Onchocerca volvulus		0.0074	0.415	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.415	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0017	0.0085	0.0206
Trypanosoma cruzi	cruzipain precursor, putative	0.0074	0.415	0.415
Leishmania major	cathepsin L-like protease	0.0074	0.415	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0016	0.0027	0.0027
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.004	0.1733	0.1733
Plasmodium falciparum	serine repeat antigen 4	0.0017	0.0085	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2502	0.2502
Loa Loa (eye worm)	ctsf protein	0.0074	0.415	0.415
Loa Loa (eye worm)	hypothetical protein	0.0074	0.415	0.415
Brugia malayi	cathepsin L precursor	0.0017	0.0085	0.0085
Trypanosoma cruzi	major cysteine proteinase, putative	0.0017	0.0085	0.0085
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0085	0.0085
Entamoeba histolytica	cysteine proteinase, putative	0.004	0.1733	0.4054
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0016	0.0027	0.0027
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0016	0.0027	0.0027
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0157	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0157	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.2163	0.2163
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0016	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.415	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.3152	0.3152
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.415	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0016	0.0027	0.0027
Echinococcus multilocularis	cathepsin L cysteine protease	0.0074	0.415	0.415
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.415	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0074	0.415	0.415
Schistosoma mansoni	cathepsin s	0.0023	0.0507	0.0507
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0051	0.2502	0.5946
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0016	0.0027	0.0027
Brugia malayi	cathepsin F-like cysteine proteinase	0.0023	0.0507	0.0507
Onchocerca volvulus	Cathepsin F homolog	0.0074	0.415	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0023	0.0507	0.0507
Brugia malayi	Cathepsin L-like precursor	0.0074	0.415	0.415
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0016	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.415	1
Brugia malayi	cathepsin L-like precursor	0.0051	0.2502	0.2502
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0016	0.0027	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0016	0.0027	0.0027
Onchocerca volvulus	Cathepsin L homolog	0.0074	0.415	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.1733	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0027	0.0027
Echinococcus granulosus	cathepsin L	0.0017	0.0085	0.0085
Onchocerca volvulus		0.0074	0.415	1
Giardia lamblia	Cathepsin B precursor	0.006	0.3152	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.415	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0016	0.0027	0.0027
Trypanosoma cruzi	cysteine proteinase, putative	0.004	0.1733	0.1733
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0016	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.1733	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.004	0.1733	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0051	0.2502	0.5946
Loa Loa (eye worm)	cysteine protease	0.0074	0.415	0.415
Brugia malayi	cathepsin L-like cysteine proteinase	0.0017	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0027	0.0027
Echinococcus granulosus	ecdysone induced protein 78C	0.0016	0.0027	0.0027
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0017	0.0085	0.0206
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.415	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0017	0.0085	0.0085
Brugia malayi	Papain family cysteine protease containing protein	0.004	0.1733	0.1733
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.415	0.415
Toxoplasma gondii	cathepsin CPC1	0.0017	0.0085	0.0206
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.2163	0.2163
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0016	0.0027	0.0027
Brugia malayi	Cathepsin L-like precursor	0.0051	0.2502	0.2502
Schistosoma mansoni	thyroid hormone receptor	0.0016	0.0027	0.0027
Trypanosoma cruzi	major cysteine proteinase, putative	0.0017	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.415	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0017	0.0085	0.0206
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0074	0.415	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0017	0.0085	0.0085
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0017	0.0085	0.0206
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0017	0.0085	0.0206
Trypanosoma cruzi	cysteine protease, putative	0.004	0.1733	0.1733
Brugia malayi	Cathepsin L-like precursor	0.0074	0.415	0.415
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.415	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0016	0.0027	0.0027
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.415	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0017	0.0085	0.0085
Entamoeba histolytica	cysteine protease, putative	0.004	0.1733	0.4054
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0016	0.0027	0.0027
Plasmodium vivax	vivapain-2	0.0074	0.415	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.415	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0016	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0157	1	1
Onchocerca volvulus		0.0074	0.415	1
Trypanosoma cruzi	cysteine proteinase, putative	0.004	0.1733	0.1733
Entamoeba histolytica	cysteine proteinase, putative	0.0074	0.415	1
Entamoeba histolytica	cysteine protease, putative	0.004	0.1733	0.4054
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0017	0.0085	0.0206
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0074	0.415	0.415
Giardia lamblia	Cathepsin B precursor	0.006	0.3152	1
Giardia lamblia	Cathepsin B precursor	0.006	0.3152	1
Schistosoma mansoni	nuclear hormone receptor	0.0016	0.0027	0.0027
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0016	0.0027	0.0027
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0085	0.0085
Plasmodium vivax	serine-repeat antigen (SERA)	0.0017	0.0085	0.0206
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0016	0.0027	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0016	0.0027	0.0027
Plasmodium vivax	vivapain-2	0.0074	0.415	1
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0016	0.0027	0.0027
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0016	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0085
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0016	0.0027	0.0027
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0017	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2502	0.2502
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.004	0.1733	0.4176
Entamoeba histolytica	cysteine protease, putative	0.004	0.1733	0.4054
Entamoeba histolytica	cysteine protease, putative	0.004	0.1733	0.4054
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0016	0.0027	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0016	0.0027	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0016	0.0027	0.0027
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0023	0.0507	0.0507
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0017	0.0085	0.0206
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0507	0.0507
Brugia malayi	Papain family cysteine protease containing protein	0.004	0.1733	0.1733
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0016	0.0027	0.0027
Echinococcus multilocularis	cathepsin L cysteine protease	0.0074	0.415	0.415
Echinococcus granulosus	cathepsin l1	0.0051	0.2502	0.2502
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.2163	0.2163
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0085	0.0085
Echinococcus granulosus	cathepsin L	0.004	0.1733	0.1733
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.415	1
Entamoeba histolytica	cysteine protease, putative	0.0074	0.415	1
Toxoplasma gondii	cathepsin B	0.006	0.3152	0.7594
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0074	0.415	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.415	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.415	1
Brugia malayi	Cathepsin L-like precursor	0.0051	0.2502	0.2502
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0016	0.0027	0.0027
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0074	0.415	0.415
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0017	0.0085	0.0206
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0016	0.0027	0.0027
Echinococcus granulosus	cysteine protease	0.004	0.1733	0.1733
Plasmodium falciparum	serine repeat antigen 5	0.0017	0.0085	0.0206
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0016	0.0027	0.0027
Loa Loa (eye worm)	fibroinase	0.0074	0.415	0.415
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0027	0.0027
Echinococcus granulosus	cathepsin L cysteine protease	0.004	0.1733	0.1733
Entamoeba histolytica	cysteine protease, putative	0.004	0.1733	0.4054
Leishmania major	cathepsin L-like protease	0.0074	0.415	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0017	0.0085	0.0085
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.415	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2147339

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1684678