TDR Targets

Basic information

Technical information

TDR Targets ID: 169271
Name: 1-[4-[3-[4-[bis(4-fluorophenyl)methyl]piperid in-1-yl]propoxy]-2-methoxyphenyl]ethanone
MW: 493.585 | Formula: C30H33F2NO3
H donors: 0 H acceptors: 1 LogP: 6.3 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(OCCCN2CCC(CC2)C(c2ccc(cc2)F)c2ccc(cc2)F)ccc1C(=O)C
InChi: 1S/C30H33F2NO3/c1-21(34)28-13-12-27(20-29(28)35-2)36-19-3-16-33-17-14-24(15-18-33)30(22-4-8-25(31)9-5-22)23-6-10-26(32)11-7-23/h4-13,20,24,30H,3,14-19H2,1-2H3
InChiKey: FKRCUXNEGDSKAA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[4-[3-[4-[bis(4-fluorophenyl)methyl]-1-piperidyl]propoxy]-2-methoxy-phenyl]ethanone
1-[4-[3-[4-[bis(4-fluorophenyl)methyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone
1-[4-[3-[4-[bis(4-fluorophenyl)methyl]piperidin-1-yl]propoxy]-2-methoxy-phenyl]ethanone
1-[4-[3-[4-[bis(4-fluorophenyl)methyl]piperidino]propoxy]-2-methoxy-phenyl]ethanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine proteinase, putative	0.0037	0.0345	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.006	0.085	0.085
Echinococcus multilocularis	tumor protein p63	0.0315	0.6626	0.6626
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0037	0.0345	0.0345
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0159	0.3093	0.3093
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0053	0.0053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.085	0.2749
Echinococcus granulosus	calpain 5	0.0025	0.0053	0.0053
Brugia malayi	Papain family cysteine protease containing protein	0.0037	0.0345	0.0345
Onchocerca volvulus		0.004	0.0414	0.4865
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0345	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0345	0.4054
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.006	0.085	0.085
Trypanosoma cruzi	cysteine protease, putative	0.0037	0.0345	0.0345
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.085	0.2623
Brugia malayi	Cathepsin L-like precursor	0.006	0.085	0.085
Brugia malayi	cathepsin L-like precursor	0.0045	0.0506	0.0506
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0159	0.3093	0.3093
Onchocerca volvulus		0.0046	0.0542	0.637
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.085	0.2623
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.085	0.2749
Onchocerca volvulus		0.006	0.085	1
Loa Loa (eye worm)	calpain family protein 1	0.0048	0.058	0.058
Brugia malayi	calpain 7	0.0025	0.0053	0.0053
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.085	0.2749
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0345	0.4054
Brugia malayi	Cathepsin L-like precursor	0.006	0.085	0.085
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0345	0.4054
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0159	0.3093	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0037	0.0345	0.0345
Brugia malayi	MH2 domain containing protein	0.0111	0.2017	0.2017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.085	0.2623
Echinococcus granulosus	cathepsin L cysteine proteinase	0.006	0.085	0.085
Loa Loa (eye worm)	hypothetical protein	0.004	0.0414	0.0414
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0025	0.0053	0.0053
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0053	0.0053
Echinococcus granulosus	tumor protein p63	0.0315	0.6626	0.6626
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.006	0.085	0.2749
Leishmania major	cathepsin L-like protease	0.006	0.085	0.2623
Loa Loa (eye worm)	transcription factor SMAD2	0.0111	0.2017	0.2017
Trypanosoma cruzi	cruzipain precursor, putative	0.006	0.085	0.085
Echinococcus multilocularis	cysteine protease	0.006	0.085	0.085
Onchocerca volvulus	Cathepsin F homolog	0.006	0.085	1
Brugia malayi	Cathepsin L-like precursor	0.006	0.085	0.085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0345	0.1114
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.085	0.2749
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.085	0.2749
Leishmania major	cathepsin L-like protease	0.006	0.085	0.2623
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0345	0.4054
Onchocerca volvulus		0.006	0.085	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.085	0.2749
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0053	0.0053
Toxoplasma gondii	cathepsin CPL	0.006	0.085	0.2749
Loa Loa (eye worm)	cysteine protease	0.006	0.085	0.085
Echinococcus multilocularis	calpain	0.0025	0.0053	0.0053
Loa Loa (eye worm)	calpain family protein 1	0.0065	0.0968	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0968	0.0968
Echinococcus granulosus	cathepsin b	0.0464	1	1
Brugia malayi	Cathepsin L-like precursor	0.0045	0.0506	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0506	0.0506
Onchocerca volvulus		0.006	0.085	1
Echinococcus multilocularis	calpain family protein 1, d	0.0048	0.058	0.058
Brugia malayi	Cathepsin L-like precursor	0.0045	0.0506	0.0506
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0464	1	1
Echinococcus granulosus	cathepsin L	0.0037	0.0345	0.0345
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.085	0.2623
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0506	0.0506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.085	0.2749
Brugia malayi	calpain family protein 1	0.0065	0.0968	0.0968
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0159	0.3093	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0037	0.0345	0.096
Echinococcus granulosus	cathepsin l1	0.006	0.085	0.085
Entamoeba histolytica	cysteine proteinase, putative	0.0037	0.0345	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0464	1	1
Plasmodium vivax	vivapain-2	0.006	0.085	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0037	0.0345	0.0345
Plasmodium vivax	vivapain-3	0.0037	0.0345	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0464	1	1
Schistosoma mansoni	cellular tumor antigen P53	0.0046	0.0542	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0464	1	1
Plasmodium vivax	vivapain-2	0.006	0.085	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0037	0.0345	0.0345
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.085	0.2749
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.085	0.2749
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.085	0.2749
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0345	0.4054
Echinococcus multilocularis	hypothetical protein	0.0025	0.0053	0.0053
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.006	0.085	1
Onchocerca volvulus		0.0045	0.0506	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.085	0.2749
Brugia malayi	Cathepsin L-like precursor	0.006	0.085	0.085
Echinococcus granulosus	calpain 7 C02 family	0.0025	0.0053	0.0053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.085	0.2749
Trypanosoma cruzi	cysteine peptidase, putative	0.006	0.085	0.085
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0159	0.3093	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0506	0.0506
Echinococcus granulosus	cysteine protease	0.0037	0.0345	0.0345
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.006	0.085	0.085
Onchocerca volvulus	Cathepsin L homolog	0.006	0.085	1
Schistosoma mansoni	calpain C (C02 family)	0.0025	0.0053	0.0053
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0464	1	1
Brugia malayi	Cathepsin L-like precursor	0.006	0.085	0.085
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.006	0.085	0.085
Schistosoma mansoni	cathepsin F (C01 family)	0.0045	0.0506	0.0506
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0068	0.1035	0.1035
Schistosoma mansoni	calpain-7 (C02 family)	0.0025	0.0053	0.0053
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0053	0.0053
Leishmania major	cathepsin L-like protease	0.006	0.085	0.2623
Leishmania major	cathepsin L-like protease	0.006	0.085	0.2623
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0065	0.0968	0.0968
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.085	0.2749
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.085	0.2623
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.006	0.085	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0053	0.0053
Plasmodium vivax	calpain, putative	0.0025	0.0053	0.062
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0068	0.1035	0.1035
Entamoeba histolytica	cysteine proteinase, putative	0.0037	0.0345	0.4054
Echinococcus granulosus	calpain A	0.0025	0.0053	0.0053
Echinococcus granulosus	calpain A	0.0068	0.1035	0.1035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.085	0.2749
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.085	0.2623
Entamoeba histolytica	cysteine protease, putative	0.006	0.085	1
Entamoeba histolytica	cysteine proteinase, putative	0.006	0.085	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0037	0.0345	0.0345
Onchocerca volvulus	Cathepsin L homolog	0.006	0.085	1
Schistosoma mansoni	calpain-7 (C02 family)	0.0025	0.0053	0.0053
Schistosoma mansoni	cathepsin F (C01 family)	0.006	0.085	0.085
Echinococcus granulosus	calpain	0.0025	0.0053	0.0053
Loa Loa (eye worm)	calpain	0.0025	0.0053	0.0053
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.085	0.2749
Leishmania major	cathepsin L-like protease	0.006	0.085	0.2623
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.085	0.2749
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.085	0.2623
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0037	0.0345	0.4054
Leishmania major	cysteine peptidase A (CPA)	0.006	0.085	0.2623
Echinococcus multilocularis	cathepsin L cysteine protease	0.006	0.085	0.085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.085	0.2749
Leishmania major	cathepsin L-like protease	0.006	0.085	0.2623
Echinococcus multilocularis	cathepsin L	0.0037	0.0345	0.0345
Leishmania major	cathepsin L-like protease	0.006	0.085	0.2623
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0345	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0037	0.0345	0.0345
Entamoeba histolytica	cysteine proteinase 1, putative	0.0037	0.0345	0.4054
Echinococcus multilocularis	calpain 7 (C02 family)	0.0025	0.0053	0.0053
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0053	0.0053
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.085	0.2623
Brugia malayi	Papain family cysteine protease containing protein	0.0037	0.0345	0.0345
Giardia lamblia	Cathepsin B precursor	0.0159	0.3093	1
Onchocerca volvulus		0.006	0.085	1
Schistosoma mansoni	calpain (C02 family)	0.0025	0.0053	0.0053
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0345	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.006	0.085	0.085
Entamoeba histolytica	cysteine proteinase, putative	0.006	0.085	1
Onchocerca volvulus		0.006	0.085	1
Echinococcus multilocularis	calpain 5	0.0025	0.0053	0.0053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0345	0.1114
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.085	0.2623
Loa Loa (eye worm)	hypothetical protein	0.0048	0.058	0.058
Onchocerca volvulus		0.006	0.085	1
Giardia lamblia	Cathepsin B precursor	0.0159	0.3093	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.085	0.2749
Brugia malayi	calpain family protein 1	0.0065	0.0968	0.0968
Trypanosoma cruzi	cysteine peptidase, putative	0.006	0.085	0.085
Echinococcus multilocularis	calpain A	0.0068	0.1035	0.1035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.006	0.085	0.2749
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.085	0.2749
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0464	1	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.085	0.085
Entamoeba histolytica	cysteine proteinase 2	0.0037	0.0345	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0045	0.0506	0.1635
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.085	0.2749
Loa Loa (eye worm)	MH2 domain-containing protein	0.0111	0.2017	0.2017
Echinococcus multilocularis	cathepsin b	0.0464	1	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0053	0.0053
Toxoplasma gondii	cathepsin B	0.0159	0.3093	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0053	0.0053
Schistosoma mansoni	cathepsin F (C01 family)	0.006	0.085	0.085
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0345	0.4054
Plasmodium vivax	vivapain-1	0.0037	0.0345	0.4054
Echinococcus multilocularis	cysteine protease	0.006	0.085	0.085
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0801	0.0801
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0045	0.0506	0.0506
Loa Loa (eye worm)	ctsf protein	0.006	0.085	0.085
Leishmania major	cathepsin L-like protease	0.006	0.085	0.2623
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0068	0.1035	0.1035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.085	0.2623
Plasmodium vivax	unspecified product	0.0037	0.0345	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.006	0.085	0.085
Loa Loa (eye worm)	cathepsin B	0.0159	0.3093	0.3093
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0345	0.4054
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0045	0.0506	0.0506
Echinococcus multilocularis	cathepsin b	0.0464	1	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0542	0.0542
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0045	0.0506	0.1635
Echinococcus granulosus	cathepsin b	0.0464	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0045	0.0506	0.5946
Echinococcus granulosus	cathepsin l1	0.0045	0.0506	0.0506
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.085	0.2749
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0037	0.0345	0.096
Entamoeba histolytica	cysteine proteinase, putative	0.0037	0.0345	0.4054
Giardia lamblia	Cathepsin B precursor	0.0159	0.3093	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.006	0.085	1
Trypanosoma cruzi	cysteine peptidase, putative	0.006	0.085	0.085
Loa Loa (eye worm)	fibroinase	0.006	0.085	0.085
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0345	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0345	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.006	0.085	0.085
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.006	0.085	0.2623
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0068	0.1035	0.1035
Trypanosoma cruzi	cysteine proteinase, putative	0.0037	0.0345	0.0345
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0345	0.4054
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0025	0.0053	0.0053
Echinococcus granulosus	cathepsin l cysteine peptidase	0.006	0.085	0.085
Echinococcus granulosus	cathepsin L cysteine protease	0.0037	0.0345	0.0345
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.085	0.2749
Onchocerca volvulus		0.006	0.085	1
Brugia malayi	Cathepsin L-like precursor	0.006	0.085	0.085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.085	0.2749

Activities

Activity type	Activity value	Assay description	Source	Reference
Change (functional)	= -11 %	Antihypertensive activity expressed as change in mean arterial blood pressure (MABP) in spontaneously hypertensive rats (SHR), at 3-6h after 30 mg/kg oral administration	ChEMBL.	1920352
Change (functional)	= -5 %	Antihypertensive activity expressed as change in mean arterial blood pressure (MABP) in spontaneously hypertensive rats (SHR),at 0.5-2h after 30 mg/kg oral administration	ChEMBL.	1920352
pA2 (functional)	= 8.5	Calcium channel-blocking activity by determined by ability to antagonize calcium-induced contractions of isolated rabbit aortic strips	ChEMBL.	1920352

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL103383
PubChem: 15093874

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 169271