Detailed information for compound 1694457

Basic information

Technical information
  • TDR Targets ID: 1694457
  • Name: 2-[(4-methoxyphenoxy)carbonyl-[(1S)-1-[4-[2-( 5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phen yl]ethyl]amino]acetic acid
  • MW: 530.568 | Formula: C30H30N2O7
  • H donors: 1 H acceptors: 4 LogP: 5.59 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)OC(=O)N([C@H](c1ccc(cc1)OCCc1nc(oc1C)c1ccccc1)C)CC(=O)O
  • InChi: 1S/C30H30N2O7/c1-20(32(19-28(33)34)30(35)39-26-15-13-24(36-3)14-16-26)22-9-11-25(12-10-22)37-18-17-27-21(2)38-29(31-27)23-7-5-4-6-8-23/h4-16,20H,17-19H2,1-3H3,(H,33,34)/t20-/m0/s1
  • InChiKey: CUADMYMMZWFUCY-FQEVSTJZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-methoxyphenoxy)carbonyl-[(1S)-1-[4-[2-(5-methyl-2-phenyl-oxazol-4-yl)ethoxy]phenyl]ethyl]amino]acetic acid
  • 2-[[(4-methoxyphenoxy)-oxomethyl]-[(1S)-1-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]ethyl]amino]acetic acid
  • 2-[(4-methoxyphenoxy)carbonyl-[(1S)-1-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]ethyl]amino]ethanoic acid
  • 331744-64-0
  • D05397
  • Peliglitazar (USAN)
  • BMS 426707-01
  • Glycine, N-((4-methoxyphenoxy)carbonyl)-N-((1S)-1-(4-(2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy)phenyl)ethyl)-
  • Peliglitazar
  • Peliglitazar [USAN:INN]

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0028 0.0026 0.0044
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0292 0.1824 1
Brugia malayi Proteasome A-type and B-type family protein 0.0292 0.1824 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0055 0.0209 0.1019
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0028 0.0026 0.0044
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0041 0.0116 0.05
Echinococcus granulosus proteasome subunit alpha type 6 0.0028 0.0026 0.0044
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0041 0.0116 0.05
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0718 0.4716 0.4716
Brugia malayi beta-lactamase family protein 0.0068 0.0298 0.1516
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0028 0.0026 0.0044
Mycobacterium ulcerans lipoprotein LpqF 0.0718 0.4716 0.4716
Mycobacterium ulcerans proteasome PrcB 0.0292 0.1824 0.1824
Echinococcus multilocularis beta LACTamase domain containing family member 0.0068 0.0298 0.1553
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0055 0.021 0.1023
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0292 0.1824 0.1824
Echinococcus granulosus beta LACTamase domain containing family member 0.0068 0.0298 0.1553
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0718 0.4716 1
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0055 0.0209 0.1019
Mycobacterium tuberculosis Probable esterase LipL 0.0068 0.0298 0.0298
Toxoplasma gondii ABC1 family protein 0.0068 0.0298 0.1516
Echinococcus granulosus Proteasome subunit alpha beta 0.0028 0.0026 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0298 0.1516
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.0055 0.021 0.0392
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.0055 0.021 0.1023
Trypanosoma brucei beta lactamase 0.0718 0.4716 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0298 0.1516
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0068 0.0298 0.1553
Echinococcus granulosus proteasome subunit beta type 7 0.0028 0.0026 0.0044
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0292 0.1824 1
Trichomonas vaginalis D-aminoacylase, putative 0.0068 0.0298 0.1516
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0292 0.1824 1
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0028 0.0026 0.0044
Echinococcus multilocularis proteasome subunit alpha type 6 0.0028 0.0026 0.0044
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0055 0.021 0.1023
Loa Loa (eye worm) hypothetical protein 0.0068 0.0298 0.1516
Leishmania major proteasome beta 5 subunit, putative 0.0292 0.1824 1
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0055 0.0209 0.1019
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0028 0.0026 0.0044
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0029 0.0037 0.0108
Giardia lamblia Proteasome subunit beta type 2 0.0041 0.0116 0.05
Plasmodium vivax proteasome subunit beta type-1, putative 0.0055 0.0209 0.1019
Trichomonas vaginalis penicillin-binding protein, putative 0.0068 0.0298 0.1516
Echinococcus granulosus proteasome subunit alpha type 2 0.0028 0.0026 0.0044
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0028 0.0026 0.0044
Loa Loa (eye worm) hypothetical protein 0.0068 0.0298 0.1516
Trypanosoma brucei hypothetical protein, conserved 0.0068 0.0298 0.0581
Brugia malayi beta-lactamase 0.0068 0.0298 0.1516
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0068 0.0298 0.1516
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0298 0.1516
Echinococcus granulosus nmda type glutamate receptor 0.0029 0.0037 0.0108
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0028 0.0026 0.0044
Mycobacterium ulcerans proteasome PrcA 0.0028 0.0026 0.0026
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0433 0.278 0.278
Echinococcus multilocularis proteasome subunit beta type 6 0.0028 0.0026 0.0044
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0028 0.0026 0.0044
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0028 0.0026 0.0044
Plasmodium falciparum proteasome subunit beta type-5 0.0292 0.1824 1
Mycobacterium ulcerans esterase/lipase LipP 0.0068 0.0298 0.0298
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0292 0.1824 0.3835
Mycobacterium tuberculosis Probable lipase LipE 0.0068 0.0298 0.0298
Trichomonas vaginalis esterase, putative 0.0068 0.0298 0.1516
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.1496 1 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0028 0.0026 0.5
Leishmania major hypothetical protein, conserved 0.0068 0.0298 0.1516
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0028 0.0026 0.0044
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0292 0.1824 0.3835
Loa Loa (eye worm) hypothetical protein 0.0068 0.0298 0.1516
Loa Loa (eye worm) hypothetical protein 0.0068 0.0298 0.1516
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0068 0.0298 0.0298
Echinococcus multilocularis proteasome (prosome, macropain) 0.0292 0.1824 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0068 0.0298 0.0298
Brugia malayi protein-S isoprenylcysteine O-methyltransferase, putative 0.0055 0.021 0.1023
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0055 0.0209 0.1019
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0068 0.0298 0.1516
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0055 0.021 0.1023
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0041 0.0116 0.0192
Mycobacterium tuberculosis Conserved protein 0.0068 0.0298 0.0298
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0041 0.0116 0.05
Onchocerca volvulus 0.0068 0.0298 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0041 0.0116 0.0542
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.0055 0.021 0.1062
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0028 0.0026 0.0044
Echinococcus granulosus Proteasome subunit alpha type 7 0.0028 0.0026 0.0044
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0041 0.0116 0.05
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0068 0.0298 0.0298
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0055 0.021 0.1023
Trichomonas vaginalis penicillin-binding protein, putative 0.0068 0.0298 0.1516
Trypanosoma cruzi 20S proteasome subunit 0.0041 0.0116 0.05
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0292 0.1824 1
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0028 0.0026 0.0044
Plasmodium vivax proteasome subunit beta type-2, putative 0.0041 0.0116 0.05
Mycobacterium ulcerans lipase LipD 0.0068 0.0298 0.0298
Mycobacterium leprae conserved hypothetical protein 0.0068 0.0298 0.0581
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0028 0.0026 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0068 0.0298 0.1516
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0028 0.0026 0.0044
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0041 0.0116 0.0542
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0055 0.0209 0.1019
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0028 0.0026 0.0026
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0028 0.0026 0.0044
Brugia malayi beta-lactamase family protein 0.0068 0.0298 0.1516
Trichomonas vaginalis D-aminoacylase, putative 0.0068 0.0298 0.1516
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0028 0.0026 0.0044
Trypanosoma brucei proteasome beta 6 subunit 0.0055 0.0209 0.0391
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0028 0.0026 0.0044
Echinococcus granulosus subfamily T1A non peptidase ue 0.0028 0.0026 0.0044
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0055 0.021 0.1023
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.0055 0.021 0.1023
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.0055 0.021 0.1062
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0028 0.0026 0.0044
Mycobacterium ulcerans beta-lactamase 0.0068 0.0298 0.0298
Giardia lamblia Proteasome subunit beta type 1 0.0055 0.0209 0.1019
Loa Loa (eye worm) hypothetical protein 0.0068 0.0298 0.1516
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0068 0.0298 0.1553
Mycobacterium tuberculosis Conserved protein 0.0068 0.0298 0.0298
Loa Loa (eye worm) proteasome subunit beta type 2 0.0041 0.0116 0.05
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0028 0.0026 0.0044
Brugia malayi proteasome subunit beta type 1 0.0055 0.0209 0.1019
Onchocerca volvulus 0.0068 0.0298 1
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0028 0.0026 0.0044
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0028 0.0026 0.0044
Loa Loa (eye worm) beta-lactamase 0.0068 0.0298 0.1516
Toxoplasma gondii proteasome subunit beta type, putative 0.0292 0.1824 1
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.0055 0.021 0.1023
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0055 0.0209 0.1059
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0292 0.1824 1
Mycobacterium ulcerans hypothetical protein 0.0068 0.0298 0.0298
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0055 0.0209 0.1059
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0292 0.1824 1
Echinococcus multilocularis proteasome subunit beta type 7 0.0028 0.0026 0.0044
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.0055 0.021 0.1023
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0041 0.0116 0.05
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0028 0.0026 0.0044
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0068 0.0298 0.0298
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.0055 0.021 0.1023
Echinococcus granulosus proteasome subunit beta type 6 0.0028 0.0026 0.0044
Loa Loa (eye worm) proteasome subunit beta type 1 0.0055 0.0209 0.1019
Mycobacterium tuberculosis Probable lipase LipD 0.0068 0.0298 0.0298
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0028 0.0026 0.0044
Brugia malayi proteasome subunit beta type 2 0.0041 0.0116 0.05
Trichomonas vaginalis D-aminoacylase, putative 0.0068 0.0298 0.1516
Echinococcus multilocularis nmda type glutamate receptor 0.0029 0.0037 0.0108
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0028 0.0026 0.0044
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0041 0.0116 0.0542
Echinococcus granulosus proteasome subunit beta t family 0.0028 0.0026 0.0044
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0055 0.021 0.1023
Echinococcus granulosus proteasome prosome macropain 0.0292 0.1824 1
Echinococcus multilocularis proteasome subunit alpha type 2 0.0028 0.0026 0.0044
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0041 0.0116 0.0542
Mycobacterium tuberculosis Conserved protein 0.0068 0.0298 0.0298
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0028 0.0026 0.0044
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0055 0.021 0.1023
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0028 0.0026 0.0044
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0041 0.0116 0.05
Mycobacterium leprae Probable lipase LipE 0.0068 0.0298 0.0581
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0292 0.1824 1
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0055 0.0209 0.1059
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0055 0.0209 0.1019
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0055 0.0209 0.1019
Echinococcus multilocularis 0.0055 0.021 0.1062
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0028 0.0026 0.0044
Mycobacterium tuberculosis Probable hydrolase 0.0068 0.0298 0.0298
Plasmodium vivax proteasome subunit beta type-5, putative 0.0292 0.1824 1
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.0055 0.021 0.1023
Leishmania major proteasome beta 2 subunit, putative 0.0041 0.0116 0.05
Onchocerca volvulus 0.0068 0.0298 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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