Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | References |
Homo sapiens | carnitine palmitoyltransferase 1B (muscle) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | carnitine palmitoyltransferase 1B (muscle) | 738 aa | 617 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0076 | 0.0094 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0109 | 0.1103 | 0.135 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.0143 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0007 | 0.0009 |
Echinococcus granulosus | choline O acetyltransferase | 0.0039 | 0.0143 | 0.0135 |
Echinococcus multilocularis | GPCR, family 2 | 0.0035 | 0.0076 | 0.0069 |
Onchocerca volvulus | 0.0039 | 0.0143 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0076 | 0.0069 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0039 | 0.0143 | 0.0166 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0109 | 0.1103 | 0.1342 |
Schistosoma mansoni | choline o-acyltransferase | 0.0039 | 0.0143 | 0.0135 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.0076 | 0.0094 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0039 | 0.0143 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0007 | 0.0009 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0215 | 0.2554 | 0.2549 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0039 | 0.0143 | 0.0175 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.0076 | 0.0085 |
Onchocerca volvulus | 0.0039 | 0.0143 | 1 | |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0039 | 0.0143 | 0.0166 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.0076 | 0.0069 |
Onchocerca volvulus | 0.0039 | 0.0143 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0628 | 0.0621 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0215 | 0.2554 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0075 | 0.0628 | 0.076 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.0076 | 0.0085 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0109 | 0.1103 | 0.1342 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0076 | 0.0069 |
Brugia malayi | Choline O-acetyltransferase | 0.0039 | 0.0143 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0628 | 0.0769 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0215 | 0.2554 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0624 | 0.8173 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0757 | 1 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0215 | 0.2554 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0007 | 0.0009 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0757 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0039 | 0.0143 | 0.0135 |
Brugia malayi | Choline O-acetyltransferase | 0.0039 | 0.0143 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0143 | 0.0175 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0076 | 0.0069 |
Onchocerca volvulus | 0.0039 | 0.0143 | 1 | |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.0076 | 0.0069 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0039 | 0.0143 | 0.0175 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0039 | 0.0143 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0076 | 0.0069 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0039 | 0.0143 | 0.0135 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0624 | 0.8173 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0039 | 0.0143 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0076 | 0.0069 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0039 | 0.0143 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0215 | 0.2554 | 0.2549 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0039 | 0.0143 | 0.5 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0039 | 0.0143 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0076 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1103 | 0.135 |
Echinococcus granulosus | GPCR family 2 | 0.0035 | 0.0076 | 0.0069 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0039 | 0.0143 | 0.0175 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.