Detailed information for compound 1702373

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 379.454 | Formula: C25H21N3O
  • H donors: 1 H acceptors: 3 LogP: 4.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)c1cccnc1)Cc1ccc(cc1)c1ccnc(c1)C
  • InChi: 1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29)
  • InChiKey: KHZOJCQBHJUJFY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens porcupine homolog (Drosophila) Starlite/ChEMBL References
Homo sapiens YES proto-oncogene 1, Src family tyrosine kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus zinc finger protein Get druggable targets OG5_133309 All targets in OG5_133309
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus protein cysteine N palmitoyltransferase Get druggable targets OG5_133309 All targets in OG5_133309
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi MBOAT family protein Get druggable targets OG5_133309 All targets in OG5_133309
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K00181 porcupine, putative Get druggable targets OG5_133309 All targets in OG5_133309
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) MBOAT family protein Get druggable targets OG5_133309 All targets in OG5_133309
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis zinc finger protein Get druggable targets OG5_133309 All targets in OG5_133309
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis protein cysteine N palmitoyltransferase Get druggable targets OG5_133309 All targets in OG5_133309
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni zinc finger protein Get druggable targets OG5_133309 All targets in OG5_133309
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0946 0.0946
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0523 0.0523
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0299 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.1352 0.1352
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0904 0.0904
Brugia malayi SRC-1 0.0045 0.1352 0.1352
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.1201 0.1201
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0026 0.068 0.068
Schistosoma mansoni tyrosine kinase 0.0045 0.1352 0.1352
Onchocerca volvulus 0.0034 0.0946 0.1065
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0768 0.5794
Loa Loa (eye worm) TK protein kinase 0.0041 0.1201 0.1201
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1352 0.1352
Echinococcus granulosus tyrosine kinase 0.0041 0.1201 0.1201
Schistosoma mansoni tyrosine kinase 0.001 0.0151 0.0151
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1555 0.1555
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0523 0.5
Brugia malayi diacylglycerol acyltransferase 0.0026 0.068 0.068
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0946 0.0946
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0946 0.0946
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0946 0.0946
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0946 0.0946
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.068 0.6506
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0026 0.068 0.3723
Echinococcus multilocularis zinc finger protein 0.0273 0.9121 0.9121
Schistosoma mansoni ap endonuclease 0.0021 0.0523 0.0523
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.068 0.068
Brugia malayi Sex muscle abnormal protein 5 0.0009 0.0108 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.068 0.0189
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.068 0.068
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.1352 0.1352
Brugia malayi hypothetical protein 0.0028 0.0768 0.0768
Leishmania major hypothetical protein, conserved 0.0028 0.0768 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.068 0.6426
Schistosoma mansoni ap endonuclease 0.0021 0.0523 0.0523
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0026 0.068 0.3723
Brugia malayi protein-tyrosine kinase 0.0041 0.1201 0.1201
Loa Loa (eye worm) hypothetical protein 0.0026 0.068 0.068
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0768 0.5794
Loa Loa (eye worm) hypothetical protein 0.0009 0.0108 0.0108
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.068 0.068
Brugia malayi Hhat protein 0.0026 0.068 0.068
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.1352 0.1352
Echinococcus granulosus NCK adaptor protein 0.0009 0.0108 0.0108
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.068 0.6506
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0523 0.5
Brugia malayi Pre-SET motif family protein 0.0034 0.0946 0.0946
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0151 0.0151
Echinococcus granulosus tyrosine protein kinase Lyn 0.0045 0.1352 0.1352
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.068 0.6506
Schistosoma mansoni zinc finger protein 0.0299 1 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.1352 0.1352
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1352 0.1352
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.068 0.068
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.1201 0.1201
Echinococcus granulosus zinc finger protein 0.0273 0.9121 0.9121
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1352 0.1352
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.1201 0.1201
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.068 0.6506
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0108 0.0108
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.068 0.068
Plasmodium vivax SET domain protein, putative 0.0034 0.0946 1
Leishmania major glycerol uptake protein, putative 0.0026 0.068 0.6426
Echinococcus granulosus sterol O acyltransferase 1 0.0026 0.068 0.068
Brugia malayi Pre-SET motif family protein 0.0234 0.7782 0.7782
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.068 0.068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1555 0.1555
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0151 0.0151
Onchocerca volvulus 0.0266 0.8885 1
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0299 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0946 1
Schistosoma mansoni tyrosine kinase 0.001 0.0151 0.0151
Loa Loa (eye worm) MBOAT family protein 0.0299 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0523 0.0523
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.068 0.6426
Leishmania major glycerol uptake protein, putative 0.0026 0.068 0.6426
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0151 0.0151
Leishmania major hypothetical protein, conserved 0.0026 0.068 0.6426
Schistosoma mansoni nck2/grb4 0.0009 0.0108 0.0108
Entamoeba histolytica protein kinase, putative 0.0036 0.1046 1
Schistosoma mansoni hypothetical protein 0.0013 0.0235 0.0235
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0235 0.0235
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.1352 0.1352
Echinococcus granulosus tyrosine protein kinase shark 0.0006 0.000000047947 0.000000047947
Loa Loa (eye worm) hypothetical protein 0.0026 0.068 0.068
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.068 0.6426
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.1352 0.1352
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0234 0.7782 0.7782
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0151 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1555 0.1555
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.068 0.0189
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0523 0.0523
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.1352 0.1352
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.1157 0.1157
Echinococcus multilocularis sterol O acyltransferase 1 0.0026 0.068 0.068
Leishmania major glycerol uptake protein, putative 0.0026 0.068 0.6426
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0523 0.5
Brugia malayi MBOAT family protein 0.0026 0.068 0.068
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.1352 0.1352
Leishmania major glycerol uptake protein, putative 0.0026 0.068 0.6426
Loa Loa (eye worm) MBOAT family protein 0.0026 0.068 0.068
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.1046 0.1046
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.068 0.6506
Schistosoma mansoni tyrosine kinase 0.0045 0.1352 0.1352
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0151 0.0151
Schistosoma mansoni hypothetical protein 0.0026 0.068 0.068
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0026 0.068 0.068
Schistosoma mansoni sterol O-acyltransferase 1 0.0026 0.068 0.068
Echinococcus multilocularis NCK adaptor protein 0.0009 0.0108 0.0108
Brugia malayi MBOAT family protein 0.0026 0.068 0.068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1555 0.1555
Trichomonas vaginalis porcupine, putative 0.0026 0.068 0.0189
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0523 0.5
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.068 0.6426
Echinococcus multilocularis tyrosine protein kinase shark 0.0006 0.000000047947 0.000000047947
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0026 0.068 0.3723
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1555 0.1555
Schistosoma mansoni adapter molecule crk 0.0009 0.0108 0.0108
Echinococcus granulosus c src tyrosine kinase 0.001 0.0151 0.0151
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.1201 0.1201
Loa Loa (eye worm) hypothetical protein 0.0026 0.068 0.068
Trypanosoma cruzi GUP1, putative 0.0026 0.068 0.6426
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.068 0.068
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0009 0.0108 0.0108
Onchocerca volvulus 0.0026 0.068 0.0766
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.068 0.068
Loa Loa (eye worm) hhat protein 0.0026 0.068 0.068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1555 0.1555
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0946 0.0946
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.068 0.068
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1352 0.1352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1555 0.1555
Loa Loa (eye worm) hypothetical protein 0.0026 0.068 0.068
Loa Loa (eye worm) SRC-1 0.0045 0.1352 0.1352
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0026 0.068 0.068
Brugia malayi MBOAT family protein 0.0026 0.068 0.068
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0768 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0009 0.0108 0.0108
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0108 0.0108
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.068 0.068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0946 0.0946
Brugia malayi MBOAT family protein 0.0026 0.068 0.068
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0026 0.068 0.068
Schistosoma mansoni tyrosine kinase 0.0006 0.000000047947 0.000000047947
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0108 0.0108
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0768 1
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0026 0.068 0.6426
Toxoplasma gondii hypothetical protein 0.0026 0.068 0.3723
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0768 1
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0108 0.0108
Loa Loa (eye worm) MBOAT family protein 0.0026 0.068 0.068
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.068 0.068
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.068 0.068
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0009 0.0108 0.0108
Brugia malayi hypothetical protein 0.0018 0.0425 0.0425
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.1352 0.1352
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.1157 0.1157
Trypanosoma cruzi GUP1, putative 0.0026 0.068 0.6426
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.068 0.068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1555 0.1555
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.068 0.0189
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1352 0.1352
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0034 0.0946 0.0946
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.068 0.068
Echinococcus granulosus growth factor receptor bound protein 2 0.0009 0.0108 0.0108
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0768 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.1352 0.1352
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0523 0.0523
Treponema pallidum alginate O-acetylation protein (algI) 0.0026 0.068 1
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.068 0.068
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.068 0.0189
Loa Loa (eye worm) hypothetical protein 0.0028 0.0768 0.0768
Loa Loa (eye worm) TK protein kinase 0.0036 0.1046 0.1046
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.1201 0.1201
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1555 0.1555
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.068 0.068
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.068 0.6426
Trichomonas vaginalis set domain proteins, putative 0.0266 0.8885 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0009 0.0108 0.0108
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.1046 0.1046
Leishmania major glycerol uptake protein, putative 0.0026 0.068 0.6426
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.068 0.068
Entamoeba histolytica hypothetical protein 0.0026 0.068 0.6506
Loa Loa (eye worm) hhat protein 0.0026 0.068 0.068
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0235 0.0235
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0523 0.4998
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0768 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1352 0.1352
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.068 0.068

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 74 pM Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity by STF luciferase assay ChEMBL. 26522946
Potency (functional) 9.7232 uM PubChem BioAssay. qHTS for small molecule inhibitors of Yes1 kinase: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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