Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.4977 | 0.4977 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0102 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 1 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0004 | 0.0004 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0102 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.4977 | 0.4977 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0102 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0004 | 0.0004 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0102 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0102 | 1 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0004 | 0.0004 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0102 | 1 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0102 | 1 | 0.5 | |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0102 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0.0004 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0102 | 1 | 0.5 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0102 | 1 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0102 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0102 | 1 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 1 | 1 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.0102 | 1 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.0004 | 0.0004 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.4977 | 0.4977 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0004 | 0.0004 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0102 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0102 | 1 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.0004 | 0.0004 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0102 | 1 | 0.5 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.0102 | 1 | 0.5 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0102 | 1 | 1 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0102 | 1 | 1 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0102 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0102 | 1 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0102 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.0004 | 0.0004 |
Plasmodium vivax | polyprenol reductase, putative | 0.0102 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0102 | 1 | 0.5 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0102 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.4977 | 0.4977 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0102 | 1 | 0.5 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0102 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.2674 | 0.2674 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0102 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.2674 | 0.2674 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0102 | 1 | 1 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0102 | 1 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0102 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.0004 | 0.0004 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0102 | 1 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2674 | 0.2674 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.1995 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.