TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 625.78 | Formula: C35H39N5O4S
H donors: 3 H acceptors: 5 LogP: 6.37 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)/C=C/c1ccc(cc1)NC(=O)C1(CCCC1)NC(=O)c1ccc2c(c1)n(C)c(c2C1CCCC1)c1csc(n1)N(C)C
InChi: 1S/C35H39N5O4S/c1-39(2)34-37-27(21-45-34)31-30(23-8-4-5-9-23)26-16-13-24(20-28(26)40(31)3)32(43)38-35(18-6-7-19-35)33(44)36-25-14-10-22(11-15-25)12-17-29(41)42/h10-17,20-21,23H,4-9,18-19H2,1-3H3,(H,36,44)(H,38,43)(H,41,42)/b17-12+
InChiKey: UJXIRYXCDFGNIK-SFQUDFHCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0473	0.8758	1
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0076	0.1212	0.169
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0076	0.1212	0.3316
Echinococcus multilocularis	GPCR, family 2	0.0095	0.1565	0.2183
Plasmodium vivax	ataxin-2 like protein, putative	0.0077	0.1225	1
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0021	0.0167	0.0456
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.094	0.2573
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0062	0.0087
Onchocerca volvulus		0.0027	0.0284	0.0076
Brugia malayi	hypothetical protein	0.0042	0.0553	0.0632
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0076	0.1212	0.1626
Echinococcus granulosus	tar DNA binding protein	0.0062	0.094	0.1311
Giardia lamblia	Fructose-bisphosphate aldolase	0.0327	0.5987	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.021	0.024
Schistosoma mansoni	survival motor neuron protein	0.0056	0.0822	0.2249
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0068	0.1055	0.147
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0284	0.0496
Echinococcus multilocularis	ornithine aminotransferase	0.0021	0.0167	0.0232
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0021	0.0167	0.0381
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.5987	0.5689
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0095	0.1565	0.1787
Echinococcus multilocularis	transcription factor Dp 1	0.0044	0.0602	0.084
Loa Loa (eye worm)	hypothetical protein	0.0023	0.021	0.024
Echinococcus granulosus	Niemann Pick C1 protein	0.0162	0.2849	0.3973
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0062	0.0071
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0021	0.0167	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.021	0.0293
Echinococcus multilocularis	tumor protein p63	0.039	0.7172	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0182	0.3228	0.3686
Entamoeba histolytica	hypothetical protein	0.0042	0.0553	0.0472
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.021	0.0575
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0284	0.0496
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0076	0.1212	0.9884
Echinococcus multilocularis	Niemann Pick C1 protein	0.0114	0.1923	0.2681
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1225	0.1399
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0182	0.3228	0.4501
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.5987	0.5689
Loa Loa (eye worm)	hypothetical protein	0.0023	0.021	0.024
Echinococcus multilocularis	survival motor neuron protein 1	0.0273	0.4949	0.69
Echinococcus granulosus	GPCR family 2	0.0095	0.1565	0.2183
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0115	0.1956	0.5353
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0284	0.0496
Toxoplasma gondii	LsmAD domain-containing protein	0.0077	0.1225	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.021	0.024
Loa Loa (eye worm)	hypothetical protein	0.0023	0.021	0.024
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0062	0.0087
Echinococcus granulosus	histone lysine methyltransferase setb	0.0068	0.1055	0.147
Loa Loa (eye worm)	hypothetical protein	0.0273	0.4949	0.5651
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.0153	0.0781
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.021	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0205	0.3655	0.4174
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.5987	0.5689
Brugia malayi	Calcitonin receptor-like protein seb-1	0.03	0.5456	0.623
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.021	0.0293
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0068	0.1055	0.2885
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0284	0.1911
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.094	0.2573
Brugia malayi	MH2 domain containing protein	0.0139	0.2408	0.2749
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.021	0.024
Schistosoma mansoni	hypothetical protein	0.0095	0.1565	0.4283
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0095	0.1565	0.2183
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.021	0.0293
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0149	0.2592	0.92
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0284	0.0325
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.5987	0.5689
Mycobacterium ulcerans	L-lysine aminotransferase	0.0021	0.0167	0.0051
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.021	0.024
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.021	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0691	0.0789
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.021	0.0293
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0182	0.3228	0.3686
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0149	0.2592	0.9195
Brugia malayi	ecdysteroid receptor	0.0023	0.021	0.024
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0062	0.0087
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0076	0.1212	0.9884
Plasmodium falciparum	ornithine aminotransferase	0.0021	0.0167	0.0898
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.0153	0.0781
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0021	0.0167	0.019
Brugia malayi	latrophilin 2 splice variant baaae	0.0205	0.3655	0.4174
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.094	0.1074
Schistosoma mansoni	coup transcription factor	0.0023	0.021	0.0575
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0095	0.1565	0.2183
Loa Loa (eye worm)	hypothetical protein	0.0023	0.021	0.024
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0284	0.0325
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0284	0.081
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0284	0.0325
Echinococcus granulosus	expressed conserved protein	0.0107	0.1792	0.2499
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.021	0.0293
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.021	0.024
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0182	0.3228	0.4501
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.021	0.024
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.021	0.0575
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.021	0.024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.021	0.024
Loa Loa (eye worm)	hypothetical protein	0.0023	0.021	0.024
Echinococcus granulosus	survival motor neuron protein 1	0.0273	0.4949	0.69
Plasmodium falciparum	ataxin-2 like protein, putative	0.0077	0.1225	1
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0062	0.0071
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0284	0.0496
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0056	0.0822	0.0939
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0153	0.0331
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.03	0.5456	0.623
Schistosoma mansoni	hypothetical protein	0.0095	0.1565	0.4283
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.016	0.2804	1
Schistosoma mansoni	cellular tumor antigen P53	0.0057	0.0849	0.2323
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.094	0.1074
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.021	0.0293
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.5987	0.5689
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0132	0.0254
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0327	0.5987	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1923	0.2196
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.5987	0.5689
Plasmodium falciparum	ataxin-2 like protein, putative	0.0077	0.1225	1
Schistosoma mansoni	hypothetical protein	0.0047	0.0658	0.1799
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0076	0.1212	0.1384
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0062	0.0071
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.021	0.024
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.021	0.0293
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.094	0.1074
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.5987	0.5689
Brugia malayi	nuclear receptor NHR-88	0.0023	0.021	0.024
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0284	0.0496
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.021	0.0293
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.094	0.2573
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0553	0.0772
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0062	0.0087
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.094	0.1311
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0076	0.1212	0.9884
Brugia malayi	RNA binding protein	0.0062	0.094	0.1074
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.021	0.0575
Brugia malayi	TAR-binding protein	0.0062	0.094	0.1074
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.021	0.0293
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.021	0.024
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.1055	0.2885
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.021	0.024
Schistosoma mansoni	hypothetical protein	0.0047	0.0658	0.1799
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.021	0.024
Loa Loa (eye worm)	hypothetical protein	0.03	0.5456	0.623
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0021	0.0167	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0049	0.0691	0.0963
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.021	0.0575
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0095	0.1565	0.2183
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.094	0.2573
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.021	0.0575
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.021	0.024
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0327	0.5987	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0182	0.3228	0.8832
Loa Loa (eye worm)	hypothetical protein	0.002	0.0153	0.0175
Brugia malayi	hypothetical protein	0.0273	0.4949	0.5651
Onchocerca volvulus		0.0068	0.1055	0.0863
Schistosoma mansoni	hypothetical protein	0.0095	0.1565	0.4283
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0095	0.1565	0.2183
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.021	0.0575
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.021	0.024
Echinococcus multilocularis	sterol regulatory element binding protein	0.0049	0.0691	0.0963
Mycobacterium ulcerans	hypothetical protein	0.0149	0.2592	0.92
Echinococcus multilocularis	Niemann Pick C1 protein	0.0162	0.2849	0.3973
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0284	0.0496
Entamoeba histolytica	hypothetical protein	0.0042	0.0553	0.0472
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.021	0.0293
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.021	0.024
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0068	0.1055	0.8532
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0553	0.0772
Brugia malayi	Latrophilin receptor protein 2	0.0095	0.1565	0.1787
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.021	0.0575
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0021	0.0167	0.0898
Echinococcus granulosus	tumor protein p63	0.039	0.7172	1
Brugia malayi	Pre-SET motif family protein	0.0473	0.8758	1
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0284	0.0325
Brugia malayi	Niemann-Pick C1 protein precursor	0.0114	0.1923	0.2196
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.021	0.0293
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0065	0.1007	0.1404
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0284	0.0496
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0149	0.2592	0.2042
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0021	0.0167	0.0051
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0068	0.1055	0.147
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0021	0.0167	0.0051
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0182	0.3228	0.4501
Plasmodium vivax	ornithine aminotransferase, putative	0.0021	0.0167	0.0898
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0062	0.0087
Schistosoma mansoni	hypothetical protein	0.0047	0.0658	0.1799
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0284	0.0496
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0284	0.1911
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.021	0.024
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.021	0.024
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.021	0.024
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.5987	0.5689
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0132	0.0254
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0132	0.0254
Loa Loa (eye worm)	RNA binding protein	0.0062	0.094	0.1074
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0284	0.0447
Loa Loa (eye worm)	hypothetical protein	0.006	0.0899	0.1027
Echinococcus granulosus	Protein patched homolog 1	0.0049	0.0691	0.0963
Entamoeba histolytica	hypothetical protein	0.0042	0.0553	0.0472
Schistosoma mansoni	hypothetical protein	0.0056	0.0822	0.2249
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.021	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0284	0.0325
Echinococcus granulosus	ornithine aminotransferase	0.0021	0.0167	0.0232
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.021	0.024
Loa Loa (eye worm)	hypothetical protein	0.002	0.0153	0.0175
Leishmania major	hypothetical protein, conserved	0.0077	0.1225	1
Trichomonas vaginalis	set domain proteins, putative	0.0539	1	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0095	0.1565	0.1787
Echinococcus multilocularis	ornithine aminotransferase	0.0021	0.0167	0.0232
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0182	0.3228	0.8832
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.021	0.024
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0062	0.0087
Mycobacterium tuberculosis	Probable aminotransferase	0.0149	0.2592	0.9226
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.021	0.0293
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.021	0.024
Brugia malayi	Pre-SET motif family protein	0.0068	0.1055	0.1204
Schistosoma mansoni	hypothetical protein	0.0034	0.042	0.1149
Brugia malayi	hypothetical protein	0.0077	0.1225	0.1399
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0021	0.0167	0.0051
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.094	0.2573
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0114	0.1923	0.2873
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0553	0.1514
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0021	0.0167	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1565	0.1787
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.021	0.0293
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0062	0.017
Schistosoma mansoni	hypothetical protein	0.0205	0.3655	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.021	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0849	0.0969
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.03	0.5456	0.623
Brugia malayi	hypothetical protein	0.005	0.0708	0.0808
Schistosoma mansoni	hypothetical protein	0.0095	0.1565	0.4283
Echinococcus multilocularis	protein dispatched 1	0.0056	0.0822	0.1146
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0284	0.0447
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0149	0.2592	0.9226
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0284	0.081
Schistosoma mansoni	patched 1	0.0049	0.0691	0.189
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.021	0.0293
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.016	0.2804	1
Echinococcus granulosus	Aminotransferase class III	0.0021	0.0167	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0023	0.021	0.024
Loa Loa (eye worm)	hypothetical protein	0.0023	0.021	0.024
Trypanosoma cruzi	PAB1-binding protein , putative	0.0077	0.1225	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0034	0.042	0.0585
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0284	0.1911
Loa Loa (eye worm)	hypothetical protein	0.002	0.0153	0.0175
Loa Loa (eye worm)	hypothetical protein	0.002	0.0153	0.0175
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0021	0.0167	0.0051
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0049	0.0691	0.0789
Entamoeba histolytica	hypothetical protein	0.0042	0.0553	0.0472
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.021	0.0575
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.021	0.024
Plasmodium vivax	SET domain protein, putative	0.0068	0.1055	0.8532
Brugia malayi	nuclear hormone receptor	0.0023	0.021	0.024
Brugia malayi	steroid hormone receptor	0.0023	0.021	0.024
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.021	0.024
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1055	0.1204
Brugia malayi	CHE-14 protein	0.0049	0.0691	0.0789
Schistosoma mansoni	hypothetical protein	0.0042	0.0553	0.1514
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0021	0.0167	0.0381
Loa Loa (eye worm)	hypothetical protein	0.002	0.0153	0.0175
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.021	0.0293
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.1055	0.2885
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.021	0.024
Schistosoma mansoni	hypothetical protein	0.0047	0.0658	0.1799
Loa Loa (eye worm)	transcription factor SMAD2	0.0139	0.2408	0.2749
Onchocerca volvulus		0.0057	0.0849	0.0653
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0182	0.3228	0.4501
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0076	0.1212	0.1384
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0034	0.042	0.0585
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.021	0.0575
Echinococcus multilocularis	expressed conserved protein	0.0107	0.1792	0.2499
Echinococcus multilocularis	protein patched	0.0049	0.0691	0.0963
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0132	0.0254
Echinococcus multilocularis	Aminotransferase class III	0.0021	0.0167	0.0232
Echinococcus granulosus	Niemann Pick C1 protein	0.0114	0.1923	0.2681
Loa Loa (eye worm)	MH2 domain-containing protein	0.0139	0.2408	0.2749
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.021	0.0575
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.021	0.024
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.016	0.2804	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0077	0.1225	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0327	0.5987	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0182	0.3228	0.8832
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0021	0.0167	0.0051
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0021	0.0167	0.0381
Trypanosoma cruzi	PAB1-binding protein , putative	0.0077	0.1225	1
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0284	0.0325
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.021	0.0293
Echinococcus granulosus	transcription factor Dp 1	0.0044	0.0602	0.084
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.1055	0.2885
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0076	0.1212	0.169
Onchocerca volvulus		0.0056	0.0822	0.0625
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0076	0.1212	0.9884

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2181615

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1716316