Detailed information for compound 1723824

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 468.997 | Formula: C21H29ClN4O4S
  • H donors: 1 H acceptors: 3 LogP: 2.73 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1ccc(cc1c1nc(C(C)C)c(c(=O)[nH]1)Cl)S(=O)(=O)N1CCN(CC1)C
  • InChi: 1S/C21H29ClN4O4S/c1-5-12-30-17-7-6-15(31(28,29)26-10-8-25(4)9-11-26)13-16(17)20-23-19(14(2)3)18(22)21(27)24-20/h6-7,13-14H,5,8-12H2,1-4H3,(H,23,24,27)
  • InChiKey: YCVPIQVPVZOBCC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 5A, cGMP-specific Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum expressed protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0055 0.0045 0.0071
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.1028 0.1197 0.2098
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0004 0.0007
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.1028 0.1197 0.6373
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0066 0.011
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0051 0.0082
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0074 0.0066 0.0333
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0033 0.0018 0.0018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0045 0.0045
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0024 0.0024
Schistosoma mansoni choline o-acyltransferase 0.1028 0.1197 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0051 0.025
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0074 0.0066 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0074 0.0066 0.0554
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0007
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0033 0.0018 0.0031
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Leishmania major carnitine/choline acetyltransferase, putative 0.1028 0.1197 0.2098
Trypanosoma cruzi cruzipain precursor, putative 0.0061 0.0051 0.0082
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.1602 0.1875 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.004 0.0333
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0056 0.8278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0051 0.025
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0023 0.0007 0.0453
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0018
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0066 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0051 0.025
Schistosoma mansoni hypothetical protein 0.0038 0.0024 0.0203
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0074 0.0066 1
Leishmania major carnitine palmitoyltransferase-like protein 0.1602 0.1875 0.3292
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0074 0.0066 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0051 0.025
Trypanosoma brucei hypothetical protein, conserved 0.1028 0.1197 0.6373
Loa Loa (eye worm) dihydrofolate reductase 0.0074 0.0066 0.0066
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.1028 0.1197 0.2098
Trypanosoma cruzi hypothetical protein, conserved 0.1028 0.1197 0.2098
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0045
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0074 0.0066 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0066 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0051 0.025
Trypanosoma cruzi hypothetical protein, conserved 0.1028 0.1197 0.2098
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.004 0.007
Leishmania major cathepsin L-like protease 0.0061 0.0051 0.0082
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0004 0.5
Onchocerca volvulus 0.1028 0.1197 0.5
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0033 0.0018 0.0018
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.0066 1
Schistosoma mansoni ap endonuclease 0.0021 0.0004 0.0034
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.0066 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.004 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.004 0.007
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.005 0.0039 0.5537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0051 0.025
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0074 0.0066 0.0109
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0007 0.0453
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0004 0.0007
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.1028 0.1197 0.2098
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Toxoplasma gondii hypothetical protein 0.0065 0.0056 0.8281
Toxoplasma gondii hypothetical protein 0.0023 0.0007 0.0453
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0074 0.0066 0.0333
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0018 0.2175
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Loa Loa (eye worm) choline O-acetyltransferase 0.1028 0.1197 0.1197
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0035 0.0055
Schistosoma mansoni choline o-acyltransferase 0.1028 0.1197 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0018 0.2175
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0066 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.005 0.0039 0.5537
Leishmania major cathepsin L-like protease 0.0061 0.0051 0.0082
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0066 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0066 1
Echinococcus multilocularis geminin 0.019 0.0204 0.0359
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.1028 0.1197 0.1197
Echinococcus multilocularis dihydrofolate reductase 0.0074 0.0066 0.0116
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0074 0.0066 1
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.1602 0.1875 0.1875
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0033 0.0018 0.0147
Leishmania major cathepsin L-like protease 0.0061 0.0051 0.0082
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Chlamydia trachomatis dihydrofolate reductase 0.0074 0.0066 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.004 0.004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0045 0.0045
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.1602 0.1875 0.1875
Toxoplasma gondii GAF domain-containing protein 0.0023 0.0007 0.0453
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.005 0.0039 0.0061
Echinococcus granulosus dihydrofolate reductase 0.0074 0.0066 0.0116
Toxoplasma gondii hypothetical protein 0.0023 0.0007 0.0453
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.4823 0.5689 1
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.1028 0.1197 0.1197
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0066 1
Echinococcus multilocularis choline O acetyltransferase 0.1028 0.1197 0.2103
Schistosoma mansoni microtubule-associated protein tau 0.0656 0.0755 0.6311
Loa Loa (eye worm) hypothetical protein 0.0038 0.0024 0.0024
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.1028 0.1197 0.2098
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0066 1
Trypanosoma cruzi hypothetical protein, conserved 0.1028 0.1197 0.2098
Schistosoma mansoni hypothetical protein 0.019 0.0204 0.1705
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Echinococcus granulosus geminin 0.019 0.0204 0.0359
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0004 0.5
Onchocerca volvulus 0.1028 0.1197 0.5
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0033 0.0018 0.0031
Echinococcus multilocularis microtubule associated protein 2 0.0656 0.0755 0.1328
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0066 0.011
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0051 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0051 0.025
Onchocerca volvulus 0.1028 0.1197 0.5
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0004 0.0004
Schistosoma mansoni dihydrofolate reductase 0.0074 0.0066 0.0554
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0056 0.8278
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0051 0.0082
Echinococcus granulosus choline O acetyltransferase 0.1028 0.1197 0.2103
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0066 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0051 0.025
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0007 0.0453
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.004 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0051 0.025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.004 0.0333
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.1602 0.1875 0.3297
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0056 0.8278
Brugia malayi Choline O-acetyltransferase 0.1028 0.1197 0.1197
Plasmodium falciparum GAF domain-related protein, putative 0.0023 0.0007 0.0453
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.1602 0.1875 0.3292
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.4823 0.5689 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0074 0.0066 0.0117
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.4823 0.5689 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0004 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0051 0.025
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0018 0.2175
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0007 0.0453
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0074 0.0066 0.0333
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.1028 0.1197 0.6373
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0004 0.5
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0074 0.0066 1
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.4823 0.5689 1
Brugia malayi Dihydrofolate reductase 0.0074 0.0066 0.0066
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.1028 0.1197 0.6373
Trypanosoma cruzi hypothetical protein, conserved 0.1028 0.1197 0.2098
Echinococcus granulosus microtubule associated protein 2 0.0656 0.0755 0.1328
Schistosoma mansoni hypothetical protein 0.019 0.0204 0.1705
Loa Loa (eye worm) hypothetical protein 0.1028 0.1197 0.1197
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.4823 0.5689 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0074 0.0066 0.0117
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0074 0.0066 0.0109
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0074 0.0066 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.004 0.007
Brugia malayi Choline O-acetyltransferase 0.1028 0.1197 0.1197
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.1602 0.1875 0.3297
Onchocerca volvulus 0.1028 0.1197 0.5
Schistosoma mansoni ap endonuclease 0.0021 0.0004 0.0034
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0023 0.0007 0.0453
Brugia malayi dihydrofolate reductase family protein 0.0074 0.0066 0.0066
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.1028 0.1197 0.2098
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.0066 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.004 0.0333
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0051 0.025
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0045 0.0045
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0066 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0023 0.0007 0.0453
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0007 0.0453
Trypanosoma cruzi hypothetical protein, conserved 0.1028 0.1197 0.2098
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0066 0.011

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.6 nM Inhibition of human recombinant PDE5A by [3H]cGMP based tritium scintillation proximity assay ChEMBL. 23137303

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.