TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 487.506 | Formula: C25H18FN5O3S
H donors: 2 H acceptors: 4 LogP: 4.3 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1nc2c(s1)cc(cc2)C)CNC(=O)c1nn(c2ccc(cc2)F)c(=O)c2c1cccc2
InChi: 1S/C25H18FN5O3S/c1-14-6-11-19-20(12-14)35-25(28-19)29-21(32)13-27-23(33)22-17-4-2-3-5-18(17)24(34)31(30-22)16-9-7-15(26)8-10-16/h2-12H,13H2,1H3,(H,27,33)(H,28,29,32)
InChiKey: FDRCDUCLEJDSAR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	porcupine homolog (Drosophila)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	MBOAT family protein	Get druggable targets OG5_133309	All targets in OG5_133309
Echinococcus granulosus	zinc finger protein	Get druggable targets OG5_133309	All targets in OG5_133309
Echinococcus granulosus	protein cysteine N palmitoyltransferase	Get druggable targets OG5_133309	All targets in OG5_133309
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	Get druggable targets OG5_133309	All targets in OG5_133309
Schistosoma mansoni	zinc finger protein	Get druggable targets OG5_133309	All targets in OG5_133309
Loa Loa (eye worm)	MBOAT family protein	Get druggable targets OG5_133309	All targets in OG5_133309
Schistosoma japonicum	ko:K00181 porcupine, putative	Get druggable targets OG5_133309	All targets in OG5_133309
Echinococcus multilocularis	zinc finger protein	Get druggable targets OG5_133309	All targets in OG5_133309

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.016	0.0367
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.026	0.2716
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0025	0.0147	0.113
Entamoeba histolytica	vacuolar protein sorting 26	0.0026	0.016	0.4393
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0082	0.5087
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0775	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.0775	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0082	0.0725
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0025	0.0147	0.113
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0082	0.4547
Echinococcus granulosus	zinc finger protein	0.0273	0.3286	0.3286
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0775	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.016	0.0367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.4547
Toxoplasma gondii	cathepsin CPL	0.002	0.0082	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0034	0.026	0.0594
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.4547
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0082	0.0014
Leishmania major	cathepsin L-like protease	0.002	0.0082	0.0197
Plasmodium vivax	vivapain-2	0.002	0.0082	0.0725
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0775	1
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.016	0.1311
Onchocerca volvulus		0.002	0.0082	0.5087
Trypanosoma cruzi	GUP1, putative	0.0026	0.016	0.1311
Brugia malayi	Cathepsin L-like precursor	0.002	0.0082	0.0226
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.4547
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0082	0.4547
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.4547
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.4547
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0082	0.0187
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0026	0.016	0.016
Loa Loa (eye worm)	MBOAT family protein	0.0299	0.3611	0.8264
Echinococcus granulosus	snurportin 1	0.0359	0.4369	0.4369
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.016	0.016
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0082	0.4547
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0359	0.4369	1
Leishmania major	cathepsin L-like protease	0.002	0.0082	0.0197
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.0775	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0082	0.0725
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0018	0.0068	0.0068
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.016	0.1311
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0025	0.0147	0.008
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0299	0.3611	0.3611
Leishmania major	glycerol uptake protein, putative	0.0026	0.016	0.1311
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0082	0.0226
Brugia malayi	Hhat protein	0.0026	0.016	0.0444
Treponema pallidum	alginate O-acetylation protein (algI)	0.0026	0.016	0.5
Schistosoma mansoni	hypothetical protein	0.0042	0.0365	0.0365
Schistosoma mansoni	zinc finger protein	0.0299	0.3611	0.3611
Echinococcus granulosus	importin subunit beta 1	0.0034	0.026	0.026
Loa Loa (eye worm)	hhat protein	0.0026	0.016	0.0367
Schistosoma mansoni	hypothetical protein	0.0359	0.4369	0.4369
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0775	1
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.016	0.0367
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0365	0.0365
Plasmodium vivax	importin-beta 2, putative	0.0034	0.026	1
Onchocerca volvulus		0.002	0.0082	0.5087
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0026	0.016	0.016
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0082	0.0014
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0068	0.0693	0.8847
Loa Loa (eye worm)	hhat protein	0.0026	0.016	0.0367
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0775	1
Loa Loa (eye worm)	fibroinase	0.002	0.0082	0.0187
Leishmania major	hypothetical protein, conserved	0.0026	0.016	0.1311
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.016	0.894
Leishmania major	glycerol uptake protein, putative	0.0026	0.016	0.1311
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0018	0.0068	0.0068
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0026	0.016	0.0367
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0026	0.016	0.0093
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0082	0.2235
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.4547
Schistosoma mansoni	importin beta-1	0.0034	0.026	0.026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0082	0.4547
Leishmania major	GTP-binding protein, putative	0.0025	0.0147	0.113
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.016	0.0093
Brugia malayi	isocitrate dehydrogenase	0.0018	0.0068	0.0187
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.016	0.4393
Schistosoma mansoni	sterol O-acyltransferase 1	0.0026	0.016	0.016
Onchocerca volvulus		0.002	0.0082	0.5087
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0365	0.0299
Toxoplasma gondii	hypothetical protein	0.0026	0.016	0.4826
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.016	0.1311
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0082	0.4547
Brugia malayi	Cathepsin L-like precursor	0.002	0.0082	0.0226
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0025	0.0147	0.416
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0025	0.0147	0.0408
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.016	0.016
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0299	0.3611	0.3567
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.016	0.016
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.016	0.0093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.4547
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0179	0.158
Trypanosoma brucei	glycerol uptake protein, putative	0.0026	0.016	0.1311
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0026	0.016	0.016
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.026	0.2716
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0775	1
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.016	0.016
Echinococcus multilocularis	cysteine protease	0.002	0.0082	0.0014
Toxoplasma gondii	HEAT repeat-containing protein	0.0034	0.026	1
Leishmania major	cathepsin L-like protease	0.0074	0.0775	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0082	0.0014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.4547
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0026	0.016	0.0093
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0018	0.0068	0.0155
Brugia malayi	hypothetical protein	0.0042	0.0365	0.101
Onchocerca volvulus		0.0026	0.016	1
Brugia malayi	Importin beta-1 subunit	0.0034	0.026	0.0719
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0775	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.4547
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0025	0.0147	0.0147
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0775	1
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0026	0.016	0.016
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0082	0.0187
Echinococcus multilocularis	snurportin 1	0.0359	0.4369	0.4331
Schistosoma mansoni	ran	0.0025	0.0147	0.0147
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0026	0.016	0.016
Plasmodium vivax	vivapain-2	0.002	0.0082	0.0725
Entamoeba histolytica	hypothetical protein	0.0042	0.0365	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.016	0.0367
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0026	0.016	0.4826
Echinococcus multilocularis	cysteine protease	0.002	0.0082	0.0014
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.016	0.4393
Loa Loa (eye worm)	hypothetical protein	0.002	0.0082	0.0187
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0179	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0082	0.0226
Onchocerca volvulus		0.002	0.0082	0.5087
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0018	0.0068	0.5
Trypanosoma cruzi	cruzipain precursor, putative	0.0074	0.0775	1
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0026	0.016	0.0367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.4547
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.4547
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.016	0.016
Brugia malayi	MBOAT family protein	0.0299	0.3611	1
Entamoeba histolytica	hypothetical protein	0.0027	0.0179	0.4915
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0026	0.016	0.016
Echinococcus multilocularis	importin subunit beta 1	0.0034	0.026	0.0193
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0082	0.0082
Brugia malayi	Cathepsin L-like precursor	0.002	0.0082	0.0226
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0082	0.5087
Entamoeba histolytica	hypothetical protein	0.0042	0.0365	1
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.0068	0.0187
Trichomonas vaginalis	porcupine, putative	0.0026	0.016	0.894
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0082	0.4547
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0025	0.0147	0.416
Leishmania major	glycerol uptake protein, putative	0.0026	0.016	0.1311
Loa Loa (eye worm)	ctsf protein	0.002	0.0082	0.0187
Echinococcus multilocularis	sterol O acyltransferase 1	0.0026	0.016	0.0093
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0179	1
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0082	0.5087
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0082	0.0082
Brugia malayi	MBOAT family protein	0.0026	0.016	0.0444
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0082	0.0014
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0082	0.4547
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0775	1
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0026	0.016	0.4826
Plasmodium falciparum	importin beta, putative	0.0034	0.026	1
Leishmania major	cathepsin L-like protease	0.0074	0.0775	1
Trichomonas vaginalis	ran, putative	0.0025	0.0147	0.8226
Leishmania major	cathepsin L-like protease	0.002	0.0082	0.0197
Leishmania major	cathepsin L-like protease	0.002	0.0082	0.0197
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0365	0.0365
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.016	0.0093
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0082	0.0197
Schistosoma mansoni	hypothetical protein	0.0026	0.016	0.016
Schistosoma mansoni	ran	0.0025	0.0147	0.0147
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0082	0.4547
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0026	0.016	0.4826
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0026	0.016	0.0093
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0025	0.0147	0.5
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0025	0.0147	0.0338
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.4547
Brugia malayi	MBOAT family protein	0.0026	0.016	0.0444
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0025	0.0147	0.416
Echinococcus granulosus	cathepsin l1	0.002	0.0082	0.0082
Brugia malayi	Cathepsin L-like precursor	0.002	0.0082	0.0226
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.4547
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0082	0.4547
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0082	0.2235
Leishmania major	cathepsin L-like protease	0.002	0.0082	0.0197
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0179	0.158
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0026	0.016	0.0093
Entamoeba histolytica	hypothetical protein, conserved	0.0026	0.016	0.4393
Leishmania major	cathepsin L-like protease	0.0074	0.0775	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0775	1
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.016	0.894
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.016	0.016
Trypanosoma cruzi	major cysteine proteinase, putative	0.0059	0.0573	0.7155
Brugia malayi	MBOAT family protein	0.0026	0.016	0.0444
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0082	0.4547
Echinococcus granulosus	sterol O acyltransferase 1	0.0026	0.016	0.016
Onchocerca volvulus		0.002	0.0082	0.5087
Entamoeba histolytica	cysteine protease, putative	0.002	0.0082	0.2235
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0026	0.016	0.894
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.016	0.894
Loa Loa (eye worm)	hypothetical protein	0.0026	0.016	0.0367
Brugia malayi	RNA, U transporter 1	0.0096	0.1043	0.2888
Brugia malayi	diacylglycerol acyltransferase	0.0026	0.016	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0026	0.016	0.0367
Leishmania major	cysteine peptidase A (CPA)	0.002	0.0082	0.0197
Entamoeba histolytica	hypothetical protein	0.0026	0.016	0.4393
Entamoeba histolytica	hypothetical protein	0.0042	0.0365	1
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0082	0.0082
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.0775	1
Trypanosoma cruzi	GUP1, putative	0.0026	0.016	0.1311
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0082	0.0082
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0025	0.0147	0.113
Echinococcus multilocularis	zinc finger protein	0.0273	0.3286	0.324
Leishmania major	glycerol uptake protein, putative	0.0026	0.016	0.1311
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0026	0.016	0.016
Loa Loa (eye worm)	cysteine protease	0.002	0.0082	0.0187
Brugia malayi	MBOAT family protein	0.0026	0.016	0.0444
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0082	0.4547
Brugia malayi	Cathepsin L-like precursor	0.002	0.0082	0.0226
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0179	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0082	0.4547
Trypanosoma brucei	glycerol uptake protein, putative	0.0026	0.016	0.1311
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0775	1
Onchocerca volvulus		0.002	0.0082	0.5087
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.016	0.4393
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0082	0.0725
Onchocerca volvulus		0.002	0.0082	0.5087
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0026	0.016	0.4826
Entamoeba histolytica	hypothetical protein	0.0042	0.0365	1
Entamoeba histolytica	Ran family GTPase	0.0025	0.0147	0.4043
Leishmania major	glycerol uptake protein, putative	0.0026	0.016	0.1311

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 100 nM	Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay	ChEMBL.	23477365

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2322621

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1724903