TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 493.601 | Formula: C24H23N5O3S2
H donors: 1 H acceptors: 5 LogP: 4.18 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cc(ccc1Oc1cccc(c1)Cc1cnn(c1)C(C)(C)C)S(=O)(=O)Nc1ncsc1
InChi: 1S/C24H23N5O3S2/c1-24(2,3)29-14-18(13-27-29)9-17-5-4-6-20(10-17)32-22-8-7-21(11-19(22)12-25)34(30,31)28-23-15-33-16-26-23/h4-8,10-11,13-16,28H,9H2,1-3H3
InChiKey: VMWIIVHPOCRPHW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sodium channel, voltage-gated, type IX, alpha subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania braziliensis	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania donovani	calcium channel protein, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus multilocularis	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania mexicana	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania major	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	hexose transporter	0.0106	0.0372	1
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.0351	0.1326	0.129
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0017	0.0015
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0017	0.0455
Echinococcus multilocularis	General substrate transporter	0.0091	0.0314	0.2082
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0029	0.0039
Echinococcus multilocularis	global transcription activator snf2l2	0.0068	0.0223	0.1476
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0087	0.023
Mycobacterium ulcerans	methionine aminopeptidase	0.0028	0.007	0.0053
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0045	0.0134	0.3609
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0045	0.0134	0.0132
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0087	0.023
Echinococcus granulosus	global transcription activator snf2l2	0.0068	0.0223	0.1476
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0041	0.0079
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0045	0.0134	0.0386
Brugia malayi	hypothetical protein	0.0016	0.0023	0.0021
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0045	0.0134	0.3609
Echinococcus multilocularis	BRK domain containing protein	0.0012	0.0005	0.0016
Toxoplasma gondii	hypothetical protein	0.0016	0.0023	0.062
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0041	0.0079
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0017	0.0015
Brugia malayi	Methionine aminopeptidase protein type I	0.0045	0.0134	0.0132
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0017	0.001
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0235	0.0233
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Toxoplasma gondii	SWI2/SNF2 Brahma-like putative	0.0012	0.0007	0.0188
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0106	0.0372	0.247
Echinococcus multilocularis	BRK domain containing protein	0.0012	0.0005	0.0016
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0794	0.3054	0.3049
Plasmodium vivax	calpain, putative	0.0021	0.0041	0.1104
Brugia malayi	hypothetical protein	0.0015	0.0017	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0017	0.001
Onchocerca volvulus		0.0015	0.0017	0.0015
Echinococcus granulosus	calpain A	0.0074	0.0249	0.165
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0017	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0368	0.0366
Leishmania major	glucose transporter, lmgt2	0.0033	0.0087	0.023
Onchocerca volvulus		0.0015	0.0017	0.0015
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0087	0.0297	0.4699
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.018	0.0659	0.439
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Schistosoma mansoni	hypothetical protein	0.0033	0.0088	0.1374
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0017	0.0099
Trypanosoma brucei	calpain-like protein, putative	0.0021	0.0041	0.0079
Schistosoma mansoni	hypothetical protein	0.0072	0.0239	0.3769
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0074	0.0249	0.165
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0087	0.023
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0087	0.008
Schistosoma mansoni	glucose transport protein	0.0106	0.0372	0.5882
Brugia malayi	Associated with TFs and helicases family protein	0.0012	0.0005	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0058	0.0135
Echinococcus granulosus	solute carrier family 22	0.0015	0.0017	0.0099
Brugia malayi	calpain family protein 1	0.0071	0.0235	0.0233
Leishmania major	glucose transporter, lmgt1	0.0033	0.0087	0.023
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0088	0.0086
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0087	0.023
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0074	0.0249	0.393
Leishmania major	hypothetical protein, conserved	0.0794	0.3054	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0155	0.2432
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0021	0.0041	0.0619
Schistosoma mansoni	calpain C (C02 family)	0.0021	0.0041	0.0619
Loa Loa (eye worm)	calpain family protein 1	0.005	0.0153	0.0151
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0017	0.001
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Onchocerca volvulus		0.0015	0.0017	0.0015
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Trypanosoma brucei	antigen, putative	0.0021	0.0041	0.0079
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0023	0.002
Echinococcus multilocularis	calpain 5	0.0021	0.0041	0.026
Echinococcus multilocularis	BRK domain containing protein	0.0012	0.0005	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0732	0.073
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0017	0.0015
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Trypanosoma brucei	methionine aminopeptidase, putative	0.0045	0.0134	0.0386
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0017	0.0015
Trypanosoma cruzi	hypothetical protein, conserved	0.0794	0.3054	1
Echinococcus multilocularis	BRK domain containing protein	0.0012	0.0005	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0155	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0058	0.0056
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0041	0.0079
Echinococcus multilocularis	calpain 7 (C02 family)	0.0021	0.0041	0.026
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0045	0.0134	0.0882
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0045	0.0134	0.0882
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0395	0.1498	1
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0172	0.063	1
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0045	0.0135	0.0892
Schistosoma mansoni	hypothetical protein	0.0033	0.0088	0.1374
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.0372	0.247
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0105	0.0368	0.0366
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0088	0.0086
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0041	0.0079
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0087	0.023
Trypanosoma brucei	calpain-like protein, putative	0.0021	0.0041	0.0079
Brugia malayi	major facilitator superfamily protein	0.0015	0.0017	0.0015
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.01	0.0348	0.0308
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0017	0.0099
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0041	0.0079
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0041	0.0079
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0088	0.0577
Echinococcus multilocularis	hypothetical protein	0.0021	0.0041	0.026
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0017	0.0015
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0058	0.156
Brugia malayi	Sugar transporter family protein	0.0015	0.0017	0.0015
Loa Loa (eye worm)	calpain	0.0021	0.0041	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Onchocerca volvulus		0.0015	0.0017	0.0015
Echinococcus granulosus	calpain 5	0.0021	0.0041	0.026
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Echinococcus granulosus	sodium channel protein	0.0045	0.0135	0.0892
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0028	0.007	0.1882
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0058	0.156
Loa Loa (eye worm)	calpain family protein 1	0.0071	0.0235	0.0233
Schistosoma mansoni	hypothetical protein	0.0106	0.0372	0.5882
Onchocerca volvulus		0.0015	0.0017	0.0015
Trypanosoma brucei	kinesin, putative	0.0021	0.0041	0.0079
Echinococcus granulosus	calpain 7 C02 family	0.0021	0.0041	0.026
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0155	0.1021
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0088	0.0577
Entamoeba histolytica	hypothetical protein	0.01	0.0348	0.0308
Brugia malayi	major facilitator superfamily protein	0.0015	0.0017	0.0015
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0155	0.2432
Schistosoma mansoni	glucose transporter	0.0015	0.0017	0.0235
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0041	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Plasmodium vivax	sugar transporter, putative	0.0015	0.0017	0.0455
Trypanosoma cruzi	kinesin, putative	0.0021	0.0041	0.0079
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0087	0.008
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0088	0.0577
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0019	0.0032	0.0022
Echinococcus multilocularis	chromodomain helicase DNA binding protein 7	0.0012	0.0005	0.0016
Loa Loa (eye worm)	sugar transporter	0.0106	0.0372	0.0369
Trypanosoma cruzi	hexose transporter	0.0033	0.0087	0.023
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Schistosoma mansoni	hypothetical protein	0.0093	0.032	0.5067
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0395	0.1498	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0023	0.002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0045	0.0135	0.039
Schistosoma mansoni	sugar transporter	0.0015	0.0017	0.0235
Onchocerca volvulus		0.0015	0.0017	0.0015
Brugia malayi	Cache domain containing protein	0.0079	0.0269	0.0267
Schistosoma mansoni	calpain-7 (C02 family)	0.0021	0.0041	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0269	0.0267
Plasmodium falciparum	HP12 protein homolog, putative	0.0016	0.0023	0.062
Echinococcus granulosus	nmda type glutamate receptor	0.0026	0.0061	0.0392
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.1782	0.6905	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0153	0.0151
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0041	0.0079
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0041	0.0079
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0087	0.023
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0088	0.0577
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.0028	0.007	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0087	0.008
Onchocerca volvulus		0.0015	0.0017	0.0015
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0017	0.0455
Schistosoma mansoni	calpain (C02 family)	0.0021	0.0041	0.0619
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0087	0.023
Onchocerca volvulus		0.0015	0.0017	0.0015
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0087	0.008
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0017	0.0099
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.0372	0.247
Schistosoma mansoni	hypothetical protein	0.0033	0.0088	0.1374
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0028	0.007	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0239	0.0237
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0071	0.0235	0.3706
Loa Loa (eye worm)	BRM protein	0.0043	0.0128	0.0125
Brugia malayi	hypothetical protein	0.0025	0.0058	0.0056
Schistosoma mansoni	sugar transporter	0.0015	0.0017	0.0235
Schistosoma mansoni	hypothetical protein	0.0011	0.0003	0.0019
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0028	0.007	0.0453
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0058	0.156
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0058	0.0135
Plasmodium vivax	hexose transporter	0.0106	0.0372	1
Schistosoma mansoni	sugar transporter	0.0015	0.0017	0.0235
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0045	0.0134	0.0386
Schistosoma mansoni	calpain-7 (C02 family)	0.0021	0.0041	0.0619
Echinococcus granulosus	GPCR family 2	0.0033	0.0088	0.0577
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.0028	0.007	0.5
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0041	0.0079
Echinococcus multilocularis	calpain family protein 1, d	0.005	0.0153	0.1007
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0017	0.001
Trypanosoma cruzi	hypothetical protein, conserved	0.0794	0.3054	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0087	0.023
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0017	0.0099
Onchocerca volvulus		0.0015	0.0017	0.0015
Echinococcus multilocularis	calpain	0.0021	0.0041	0.026
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.0372	0.247
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0058	0.156
Leishmania major	hypothetical protein, conserved	0.0025	0.0058	0.0135
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0087	0.008
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Brugia malayi	N-terminal motif family protein	0.0198	0.0732	0.073
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Brugia malayi	calpain 7	0.0021	0.0041	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Loa Loa (eye worm)	sugar transporter	0.0015	0.0017	0.0015
Brugia malayi	Sugar transporter family protein	0.0015	0.0017	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0017	0.001
Leishmania major	kinesin, putative	0.0021	0.0041	0.0079
Chlamydia trachomatis	methionine aminopeptidase	0.0028	0.007	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0041	0.0079
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0087	0.008
Echinococcus multilocularis	nmda type glutamate receptor	0.0026	0.0061	0.0392
Brugia malayi	hypothetical protein	0.0015	0.0017	0.0015
Onchocerca volvulus		0.0015	0.0017	0.0015
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0041	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0021	0.0041	0.0079
Onchocerca volvulus		0.0015	0.0017	0.0015
Schistosoma mansoni	hypothetical protein	0.0012	0.0005	0.0039
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0058	0.0135
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0155	0.1021
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0087	0.023
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0017	0.0099
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0087	0.023
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Echinococcus multilocularis	sodium channel protein	0.0045	0.0135	0.0892
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.0372	0.247
Schistosoma mansoni	hypothetical protein	0.0033	0.0088	0.1374
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.0368	0.0366
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0087	0.023
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0155	0.2432
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Brugia malayi	hypothetical protein	0.0015	0.0017	0.0015
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0087	0.023
Echinococcus multilocularis	BRK domain containing protein	0.0012	0.0005	0.0016
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0155	0.1021
Loa Loa (eye worm)	hypothetical protein	0.005	0.0153	0.0151
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0074	0.0249	0.393
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.0372	0.247
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0198	0.0732	0.073
Loa Loa (eye worm)	helicase DNA-binding protein	0.0012	0.0005	0.0002
Echinococcus granulosus	solute carrier family 22	0.0015	0.0017	0.0099
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0087	0.023
Onchocerca volvulus		0.0015	0.0017	0.0015
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0028	0.007	0.0077
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0045	0.0134	0.0386
Loa Loa (eye worm)	calpain 5	0.0021	0.0041	0.0039
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0087	0.023
Onchocerca volvulus		0.0015	0.0017	0.0015
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Echinococcus multilocularis	calpain A	0.0074	0.0249	0.165
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0087	0.023
Brugia malayi	calpain 5	0.0021	0.0041	0.0039
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0017	0.0455
Toxoplasma gondii	methionine aminopeptidase	0.0045	0.0134	0.3609
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0017	0.001
Schistosoma mansoni	serine-rich repeat protein	0.0093	0.032	0.5067
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0045	0.0134	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Echinococcus granulosus	solute carrier family 22	0.0015	0.0017	0.0099
Echinococcus granulosus	solute carrier family 22	0.0015	0.0017	0.0099
Echinococcus granulosus	General substrate transporter	0.0091	0.0314	0.2082
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0017	0.0099
Toxoplasma gondii	methionine aminopeptidase	0.0028	0.007	0.1882
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.0372	0.247
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.0028	0.007	0.1882
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0017	0.0455
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0074	0.0249	0.165
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.0239	0.0237
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0028	0.007	0.0053
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0045	0.0134	0.0386
Echinococcus granulosus	calpain A	0.0021	0.0041	0.026
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0026	0.0061	0.0392
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0019	0.0032	0.0015
Trypanosoma cruzi	kinesin, putative	0.0021	0.0041	0.0079
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0155	0.1021
Onchocerca volvulus		0.0015	0.0017	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0017	0.001
Treponema pallidum	methionine aminopeptidase (map)	0.0028	0.007	1
Plasmodium vivax	hypothetical protein, conserved	0.0016	0.0023	0.062
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0021	0.0041	0.0079
Onchocerca volvulus		0.0015	0.0017	0.0015
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0028	0.007	0.1079
Echinococcus granulosus	voltage dependent calcium channel subunit	0.018	0.0659	0.439
Onchocerca volvulus		0.005	0.0153	0.0151
Schistosoma mansoni	helicase	0.0068	0.0223	0.3515
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0028	0.007	0.0077
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0087	0.023
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0155	0.0153
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0017	0.0099
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Schistosoma mansoni	glucose transport protein	0.0106	0.0372	0.5882
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Toxoplasma gondii	facilitative glucose transporter GT1	0.0106	0.0372	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Brugia malayi	BRM protein	0.0068	0.0223	0.0221
Leishmania major	glucose transporter, lmgt3	0.0033	0.0087	0.023
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0372	0.0365
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0087	0.008
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0017	0.0235
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0041	0.0079
Echinococcus granulosus	calpain	0.0021	0.0041	0.026
Trypanosoma brucei	calpain-like protein, putative	0.0021	0.0041	0.0079
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0088	0.0577
Schistosoma mansoni	glucose transport protein	0.0106	0.0372	0.5882
Onchocerca volvulus		0.0015	0.0017	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0235	0.0233
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0003	0.0008
Schistosoma mansoni	sugar transporter	0.0015	0.0017	0.0235
Brugia malayi	Sugar transporter family protein	0.0106	0.0372	0.0369
Loa Loa (eye worm)	BRM protein	0.0035	0.0095	0.0093
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.0368	0.0366
Echinococcus multilocularis	Chromo domain	0.0012	0.0005	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0015
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0017	0.001
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.0028	0.007	0.1882
Trypanosoma brucei	calpain-like protein, putative	0.0021	0.0041	0.0079
Onchocerca volvulus	Putative transporter	0.0015	0.0017	0.0015
Echinococcus multilocularis	BRK domain containing protein	0.0012	0.0005	0.0016
Echinococcus granulosus	BRK domain containing protein	0.0012	0.0005	0.0016
Echinococcus granulosus	Chromo domain	0.0012	0.0005	0.0016
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Schistosoma mansoni	hypothetical protein	0.0012	0.0005	0.0039
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0794	0.3054	1
Leishmania major	hypothetical protein, conserved	0.0016	0.0023	0.002
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0794	0.3054	0.3049
Trypanosoma brucei	hypothetical protein, conserved	0.0016	0.0023	0.002
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0088	0.0086
Giardia lamblia	DNA repair protein RAD52	0.0351	0.1326	0.1311
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0017	0.0455
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0087	0.023
Echinococcus multilocularis	BRK domain	0.0012	0.0005	0.0016
Brugia malayi	calpain family protein 1	0.0071	0.0235	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0088	0.0086
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0003	0.0008
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0017	0.001
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0028	0.007	0.1079
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.0372	0.247

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.6778	Inhibition of NaV1.7 ion channel (unknown origin)	ChEMBL.	23177785

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2326427

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1728280