Detailed information for compound 1734011

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 491.489 | Formula: C26H23F2N5O3
  • H donors: 2 H acceptors: 3 LogP: 3.78 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: FCc1c(oc2c1cccc2)C(=O)Nc1ccc(nc1)N1CCN(CC1)C(=O)Nc1ccccc1F
  • InChi: 1S/C26H23F2N5O3/c27-15-19-18-5-1-4-8-22(18)36-24(19)25(34)30-17-9-10-23(29-16-17)32-11-13-33(14-12-32)26(35)31-21-7-3-2-6-20(21)28/h1-10,16H,11-15H2,(H,30,34)(H,31,35)
  • InChiKey: FEPAPMZQKUCVRC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens diacylglycerol O-acyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128200 All targets in OG5_128200
Schistosoma japonicum Diacylglycerol O-acyltransferase 1, putative Get druggable targets OG5_128200 All targets in OG5_128200
Loa Loa (eye worm) diacylglycerol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium falciparum diacylglycerol O-acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium vivax diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Theileria parva diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Cryptosporidium hominis acyl-CoA:diacylglycerol acyltransferase 1-related enzyme Get druggable targets OG5_128200 All targets in OG5_128200
Schistosoma japonicum Diacylglycerol O-acyltransferase 1, putative Get druggable targets OG5_128200 All targets in OG5_128200
Neospora caninum sterol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Neospora caninum diacylglycerol acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Brugia malayi diacylglycerol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Cryptosporidium parvum diacylglycerol acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme Get druggable targets OG5_128200 All targets in OG5_128200
Candida albicans Acyl-CoA cholesterol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Babesia bovis diacylglycerol acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Candida albicans Acyl-CoA cholesterol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium knowlesi diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Echinococcus multilocularis diacylglycerol O acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Echinococcus granulosus diacylglycerol O acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Schistosoma mansoni diacylglycerol O-acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Schistosoma japonicum ko:K00635 diacylglycerol O-acyltransferase [EC2.3.1.20], putative Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium yoelii acyl transferase-related Get druggable targets OG5_128200 All targets in OG5_128200
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium berghei diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Loa Loa (eye worm) hypothetical protein 0.0026 0.0246 0.0246
Echinococcus multilocularis mitogen activated protein kinase 3 0.0314 0.916 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0638 0.0638
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0271 0.7831 0.855
Loa Loa (eye worm) hypothetical protein 0.0038 0.0638 0.0638
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0246 0.0246
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0038 0.061 0.0666
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Treponema pallidum alginate O-acetylation protein (algI) 0.0026 0.0246 0.5
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.1454
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0153 0.4197 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0038 0.061 0.0666
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0038 0.061 0.0666
Brugia malayi MBOAT family protein 0.0026 0.0246 0.0246
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0038 0.061 0.0666
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0246 0.0269
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0246 0.0246
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0246 0.0269
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0038 0.061 0.0666
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0328 0.0783
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0314 0.916 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.1189 0.1189
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Brugia malayi hypothetical protein 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0246 0.0246
Plasmodium vivax phosphodiesterase gamma, putative 0.0038 0.061 0.1454
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0408
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Onchocerca volvulus 0.0341 1 1
Schistosoma mansoni hypothetical protein 0.0191 0.5365 0.5857
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.061 0.0666
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Schistosoma mansoni sterol O-acyltransferase 1 0.0026 0.0246 0.0269
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0271 0.7831 0.855
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0038 0.061 0.0666
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0328 0.0359
Brugia malayi MBOAT family protein 0.0026 0.0246 0.0246
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0246 0.0269
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0308 0.8993 0.9818
Loa Loa (eye worm) hypothetical protein 0.0038 0.061 0.061
Giardia lamblia Kinase, CMGC MAPK 0.0314 0.916 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0246 0.0269
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0328 0.0783
Leishmania major glycerol uptake protein, putative 0.0026 0.0246 0.0269
Schistosoma mansoni hypothetical protein 0.0026 0.0246 0.0269
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0038 0.061 0.0666
Leishmania major glycerol uptake protein, putative 0.0026 0.0246 0.0269
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0038 0.061 0.0666
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0246 0.0269
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0308 0.8993 0.9818
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0038 0.061 0.0666
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Trichomonas vaginalis CMGC family protein kinase 0.0314 0.916 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0038 0.061 0.0666
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0314 0.916 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0038 0.061 0.0666
Trichomonas vaginalis CMGC family protein kinase 0.0314 0.916 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0308 0.8993 0.9818
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0038 0.061 0.0666
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0314 0.916 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.061 0.0408
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.3617 0.3617
Brugia malayi MAP kinase sur-1 0.0314 0.916 0.916
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0153 0.4197 0.4582
Brugia malayi diacylglycerol acyltransferase 0.0153 0.4197 0.4197
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.3617 0.3617
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0038 0.061 0.0666
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Leishmania major hypothetical protein, conserved 0.0038 0.061 0.0666
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0314 0.916 0.916
Leishmania major hypothetical protein, conserved 0.0028 0.0328 0.0359
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0328 0.0359
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0246 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0408
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0038 0.061 0.0666
Brugia malayi MBOAT family protein 0.0026 0.0246 0.0246
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0246 0.0269
Loa Loa (eye worm) hypothetical protein 0.0128 0.3399 0.3399
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0246 0.5
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0038 0.061 0.0666
Echinococcus granulosus sterol O acyltransferase 1 0.0026 0.0246 0.0269
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0246 0.0269
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0038 0.061 0.0666
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.061 0.0666
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0038 0.061 0.0666
Trypanosoma cruzi GUP1, putative 0.0026 0.0246 0.0269
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0038 0.061 0.0666
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0153 0.4197 0.4582
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0038 0.061 0.0666
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0038 0.061 0.0666
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0308 0.8993 0.9818
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0038 0.061 0.0666
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0038 0.061 0.0666
Trypanosoma brucei protein kinase, putative 0.0314 0.916 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0038 0.061 0.061
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Loa Loa (eye worm) hhat protein 0.0026 0.0246 0.0246
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0246 0.5
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0038 0.061 0.0666
Leishmania major glycerol uptake protein, putative 0.0026 0.0246 0.0269
Leishmania major hypothetical protein, conserved 0.0026 0.0246 0.0269
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0038 0.061 0.0666
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.1454
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0038 0.061 0.0666
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0038 0.061 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.061 0.0408
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0328 0.0783
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0246 0.0269
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0408
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0408
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0246 0.0269
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0308 0.8993 0.9818
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0038 0.061 0.1454
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0038 0.061 0.0666
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.061 0.0666
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0408
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0666
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Plasmodium falciparum phosphodiesterase delta, putative 0.0038 0.061 0.1454
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0153 0.4197 0.4582
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0246 0.0269
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0314 0.916 1
Schistosoma mansoni zinc finger protein 0.0026 0.0246 0.0269
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0246 0.0269
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.1454
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0038 0.061 0.061
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0308 0.8993 0.9805
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.1454
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0153 0.4197 0.4582
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0038 0.061 0.0666
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0038 0.061 0.061
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0328 0.0359
Schistosoma mansoni hypothetical protein 0.0191 0.5365 0.5857
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0408
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0038 0.061 0.0666
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.1189 0.1189
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0246 0.0269
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0246 0.0269
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0038 0.061 0.0666
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0038 0.061 0.1454
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0246 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0038 0.061 0.0408
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0246 0.0269
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0153 0.4197 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0246 0.0269
Leishmania major hypothetical protein, conserved 0.0038 0.061 0.0666
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0666
Brugia malayi MBOAT family protein 0.0026 0.0246 0.0246
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0246 0.0269
Loa Loa (eye worm) hypothetical protein 0.0308 0.8993 0.8993
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0314 0.916 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0246 0.0269
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0038 0.061 0.0408
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.061 0.0408
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0246 0.5
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0038 0.061 0.0666
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0408
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0246 0.0246
Leishmania major cAMP-specific phosphodiesterase, putative 0.0038 0.061 0.0666
Brugia malayi Hhat protein 0.0026 0.0246 0.0246
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.1454
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0038 0.061 0.0666
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0408
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0408
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0038 0.061 0.061
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.061 0.0666
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0308 0.8993 0.9818
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Loa Loa (eye worm) hypothetical protein 0.0028 0.0328 0.0328
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0408
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0408
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0038 0.061 0.061
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0246 0.0269
Entamoeba histolytica hypothetical protein 0.0026 0.0246 0.5
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0246 0.0269
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0038 0.061 0.0666
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0246 0.0269
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.061 0.0666
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0314 0.916 1
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0328 0.0359
Echinococcus granulosus mitogen activated protein kinase 0.0314 0.916 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0038 0.061 0.0408
Echinococcus granulosus mitogen activated protein kinase 3 0.0314 0.916 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0246 0.0269
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Loa Loa (eye worm) hypothetical protein 0.0038 0.061 0.061
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0 0.5
Loa Loa (eye worm) PDE1B protein 0.0038 0.061 0.061
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Loa Loa (eye worm) hhat protein 0.0026 0.0246 0.0246
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Brugia malayi MBOAT family protein 0.0026 0.0246 0.0246
Trypanosoma cruzi GUP1, putative 0.0026 0.0246 0.0269
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0271 0.7831 0.7831
Loa Loa (eye worm) hypothetical protein 0.0341 1 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0038 0.061 0.1454
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0038 0.061 0.0666
Loa Loa (eye worm) hypothetical protein 0.0056 0.1189 0.1189
Trichomonas vaginalis CMGC family protein kinase 0.0314 0.916 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0038 0.061 0.061
Echinococcus multilocularis geminin 0.0191 0.5365 0.5857
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0314 0.916 1
Brugia malayi MH2 domain containing protein 0.0135 0.3617 0.3617
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0038 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0038 0.061 0.061
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0038 0.061 0.0666
Trichomonas vaginalis CMGC family protein kinase 0.0314 0.916 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.1189 0.1189
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0408
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0246 0.0246
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0246 0.0269
Loa Loa (eye worm) hypothetical protein 0.0026 0.0246 0.0246
Echinococcus granulosus geminin 0.0191 0.5365 0.5857
Echinococcus multilocularis sterol O acyltransferase 1 0.0026 0.0246 0.0269
Leishmania major glycerol uptake protein, putative 0.0026 0.0246 0.0269
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.061 0.0666
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0246 0.0269
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0314 0.916 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0271 0.7831 0.7831
Brugia malayi hypothetical protein 0.0028 0.0328 0.0328
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.061 0.0408
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.061 0.0666
Loa Loa (eye worm) hypothetical protein 0.0026 0.0246 0.0246
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0153 0.4197 0.4197
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0153 0.4197 0.4582
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0246 0.0269
Leishmania major glycerol uptake protein, putative 0.0026 0.0246 0.0269
Toxoplasma gondii hypothetical protein 0.0026 0.0246 0.0269
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.061 0.0666
Schistosoma mansoni hypothetical protein 0.0038 0.0638 0.0697
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.061 0.0408
Echinococcus multilocularis mitogen activated protein kinase 0.0314 0.916 1
Schistosoma mansoni serine/threonine protein kinase 0.0314 0.916 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 60 nM Inhibition of human DGAT1 expressed in Sf9 cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-Co A substrates incubated for 2 hrs by scintillation counting method ChEMBL. 23317570

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.