Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Sigma-1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.0198 | 0.2266 | 0.4176 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0126 | 0.0042 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0014 | 0.139 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 0.5406 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.3083 | 0.5692 |
Echinococcus granulosus | tumor protein p63 | 0.0395 | 0.477 | 0.3237 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0103 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0198 | 0.2266 | 0.4078 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.0103 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0103 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0126 | 0.0206 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0103 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0058 | 0.0486 | 0.0234 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0198 | 0.2266 | 0.2062 |
Onchocerca volvulus | 0.0056 | 0.0468 | 0.9524 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0103 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.2247 | 0.2042 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0262 | 0.3083 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0103 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase | 0.0262 | 0.3083 | 0.1079 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.1524 | 0.2801 |
Echinococcus multilocularis | serine:threonine protein kinase | 0.0262 | 0.3083 | 0.1079 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0126 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0806 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.2247 | 0.2042 |
Onchocerca volvulus | 0.0058 | 0.0486 | 1 | |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.0103 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 0.5406 | 1 |
Echinococcus granulosus | serine:threonine protein kinase | 0.0262 | 0.3083 | 0.1057 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0276 | 0.3263 | 0.1289 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0492 | 0.0885 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.0103 | 0.5 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0126 | 0.0042 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.0103 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.1524 | 0.268 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0126 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0103 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.5406 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0458 | 0.5579 | 0.5462 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0486 | 0.0874 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0103 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0257 | 0.0451 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0.0014 | 0.5 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0198 | 0.2266 | 0.0024 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0468 | 0.0687 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0468 | 0.0216 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0276 | 0.3263 | 0.1311 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0458 | 0.5579 | 0.4284 |
Brugia malayi | Protein kinase domain containing protein | 0.0262 | 0.3083 | 0.562 |
Brugia malayi | hypothetical protein | 0.0276 | 0.3263 | 0.5959 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0103 | 0.0165 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 0.5406 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.2641 | 0.4873 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0492 | 0.0732 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.0103 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/MARK protein kinase | 0.0262 | 0.3083 | 0.5692 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0028 | 0.0103 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.1524 | 0.2801 |
Echinococcus granulosus | serine:threonine protein kinase | 0.0262 | 0.3083 | 0.1057 |
Schistosoma mansoni | serine/threonine kinase | 0.0198 | 0.2266 | 0.2062 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0458 | 0.5579 | 0.4298 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0492 | 0.0885 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.0103 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0126 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.0103 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0198 | 0.2266 | 0.2062 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.0103 | 1 |
Brugia malayi | Kinase associated domain 1 family protein | 0.0196 | 0.2247 | 0.4043 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0458 | 0.5579 | 0.5462 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.2247 | 0.4141 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0492 | 0.0732 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.3263 | 0.6026 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0198 | 0.2266 | 0.2062 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0445 | 0.5406 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0395 | 0.477 | 0.3254 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0468 | 0.0216 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0103 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0806 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0458 | 0.5579 | 0.4298 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0257 | 0.029 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0126 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0458 | 0.5579 | 0.4284 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.