Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Fibulin-1 precursor | 0.0041 | 0.0052 | 0.0055 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0072 | 0.0353 | 0.0723 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0353 | 0.0393 |
Brugia malayi | Trypsin family protein | 0.0036 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0041 | 0.0052 | 0.0106 |
Giardia lamblia | PHD finger protein 15 | 0.0259 | 0.2191 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0311 | 0.0347 |
Onchocerca volvulus | Arrow homolog | 0.0041 | 0.0052 | 0.0154 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0036 | 0.0006 | 0.0006 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0044 | 0.0085 | 0.0085 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0259 | 0.2191 | 1 |
Echinococcus granulosus | PWWP domain containing protein 2A | 0.0068 | 0.0311 | 0.0311 |
Schistosoma mansoni | bromodomain containing protein | 0.0044 | 0.0085 | 0.0094 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0311 | 0.0347 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0006 | 0.0012 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0353 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0174 | 0.136 | 0.136 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0072 | 0.0353 | 0.0353 |
Onchocerca volvulus | 0.0271 | 0.2315 | 0.6918 | |
Schistosoma mansoni | enhancer of polycomb | 0.0158 | 0.1201 | 0.1337 |
Echinococcus multilocularis | Mastin | 0.0036 | 0.0006 | 0.0006 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0308 | 0.2674 | 0.2977 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Schistosoma mansoni | enhancer of polycomb | 0.0158 | 0.1201 | 0.1337 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0085 | 0.0479 | 0.2184 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0072 | 0.0353 | 0.1612 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.1631 | 0.1747 |
Onchocerca volvulus | 0.0308 | 0.2674 | 0.7991 | |
Plasmodium vivax | SET domain containing protein | 0.0037 | 0.001 | 0.0048 |
Brugia malayi | Trypsin family protein | 0.0308 | 0.2674 | 0.2864 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0174 | 0.136 | 0.2783 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.0479 | 0.0533 |
Echinococcus multilocularis | peregrin | 0.1053 | 1 | 1 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0036 | 0.0006 | 0.0006 |
Echinococcus multilocularis | enteropeptidase | 0.0036 | 0.0006 | 0.0006 |
Echinococcus granulosus | Tolloid protein 1 | 0.0041 | 0.0052 | 0.0052 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0006 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0041 | 0.0052 | 0.0052 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0041 | 0.0052 | 0.0057 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0669 | 0.6226 | 0.6931 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.0085 | 0.0479 | 1 |
Brugia malayi | AF-10 protein | 0.0085 | 0.0479 | 0.0513 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0086 | 0.0489 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0052 | 0.0106 |
Schistosoma mansoni | SET domain protein | 0.0077 | 0.0407 | 0.0453 |
Echinococcus granulosus | hepatoma derived growth factor protein | 0.0068 | 0.0311 | 0.0311 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Entamoeba histolytica | ankyrin repeat protein, putative | 0.0036 | 0.00000001192 | 0.00000038277 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Echinococcus multilocularis | enhancer of polycomb | 0.0158 | 0.1201 | 0.1201 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0006 | 0.0012 |
Brugia malayi | PHD-finger family protein | 0.0259 | 0.2191 | 0.2347 |
Echinococcus granulosus | laminin | 0.0041 | 0.0052 | 0.0052 |
Echinococcus granulosus | zinc finger protein | 0.0044 | 0.0085 | 0.0085 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0036 | 0.0006 | 0.0006 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.00000001192 | 0.000000054403 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0052 | 0.0106 |
Echinococcus multilocularis | enhancer of polycomb | 0.0158 | 0.1201 | 0.1201 |
Leishmania major | hypothetical protein, conserved | 0.0072 | 0.0353 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0308 | 0.2674 | 0.2977 |
Echinococcus granulosus | PWWP domain containing protein 2A | 0.0068 | 0.0311 | 0.0311 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0036 | 0.0006 | 0.0006 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2674 | 0.5474 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0052 | 0.0106 |
Plasmodium falciparum | phd finger protein, putative | 0.0259 | 0.2191 | 1 |
Onchocerca volvulus | 0.0376 | 0.3346 | 1 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Toxoplasma gondii | WD domain, G-beta repeat-containing protein | 0.0085 | 0.0479 | 0.2184 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0068 | 0.0311 | 0.8815 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0669 | 0.6226 | 0.6226 |
Echinococcus granulosus | enhancer of polycomb | 0.0158 | 0.1201 | 0.1201 |
Onchocerca volvulus | 0.023 | 0.1905 | 0.5694 | |
Echinococcus multilocularis | hepatoma derived growth factor protein | 0.0068 | 0.0311 | 0.0311 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0259 | 0.2191 | 1 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0259 | 0.2191 | 0.2191 |
Entamoeba histolytica | hypothetical protein | 0.0068 | 0.0311 | 1 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0949 | 0.8983 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0174 | 0.136 | 0.136 |
Onchocerca volvulus | 0.0036 | 0.0006 | 0.0018 | |
Plasmodium falciparum | conserved Plasmodium membrane protein, unknown function | 0.0085 | 0.0479 | 0.2184 |
Echinococcus multilocularis | PWWP domain containing protein 2A | 0.0068 | 0.0311 | 0.0311 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0259 | 0.2191 | 0.4486 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0036 | 0.0006 | 0.0006 |
Onchocerca volvulus | 0.0036 | 0.0006 | 0.0018 | |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0044 | 0.0085 | 0.0085 |
Brugia malayi | Bromodomain containing protein | 0.0985 | 0.9336 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0533 | 0.4885 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0669 | 0.6226 | 0.6226 |
Plasmodium vivax | hypothetical protein, conserved | 0.0085 | 0.0479 | 0.2184 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Echinococcus granulosus | E3 ubiquitin protein ligase TRIM33 | 0.0341 | 0.2997 | 0.2997 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0041 | 0.0052 | 0.0106 |
Schistosoma mansoni | bromodomain containing protein | 0.0044 | 0.0085 | 0.0094 |
Trypanosoma cruzi | transcription elongation factor-like protein, putative | 0.0068 | 0.0311 | 0.8815 |
Brugia malayi | Bromodomain containing protein | 0.0376 | 0.3346 | 0.3584 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.2191 | 0.4486 |
Trypanosoma brucei | transcription elongation factor s-II, putative | 0.0068 | 0.0311 | 0.6507 |
Schistosoma mansoni | transcription intermediary factor 1-related | 0.0341 | 0.2997 | 0.3336 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0041 | 0.0052 | 0.0235 |
Schistosoma mansoni | hepatoma derived growth factor | 0.0068 | 0.0311 | 0.0347 |
Schistosoma mansoni | hypothetical protein | 0.0259 | 0.2191 | 0.2439 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0085 | 0.0173 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.0085 | 0.0479 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0036 | 0.0006 | 0.0007 |
Echinococcus granulosus | histone lysine N methyltransferase H3 lysine 36 | 0.0069 | 0.0322 | 0.0322 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Echinococcus granulosus | expressed protein | 0.0362 | 0.3206 | 0.3206 |
Loa Loa (eye worm) | PWWP domain-containing protein | 0.0068 | 0.0311 | 0.0638 |
Echinococcus multilocularis | PWWP domain containing protein 2A | 0.0068 | 0.0311 | 0.0311 |
Loa Loa (eye worm) | trypsin family protein | 0.0036 | 0.0006 | 0.0012 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0036 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0085 | 0.0173 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Onchocerca volvulus | 0.0036 | 0.0006 | 0.0018 | |
Toxoplasma gondii | bromodomain-containing protein | 0.0036 | 0.00000001192 | 0.000000054403 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Brugia malayi | PHD-finger family protein | 0.0093 | 0.0563 | 0.0603 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0353 | 0.0723 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0068 | 0.0311 | 0.8815 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 0.3346 | 0.6851 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0052 | 0.0106 |
Brugia malayi | Trypsin family protein | 0.0036 | 0.0006 | 0.0006 |
Schistosoma mansoni | egf-like domain protein | 0.0041 | 0.0052 | 0.0057 |
Brugia malayi | PHD-finger family protein | 0.0044 | 0.0085 | 0.0091 |
Plasmodium falciparum | bromodomain protein 1 | 0.0036 | 0.00000001192 | 0.000000054403 |
Schistosoma mansoni | phd finger protein | 0.0103 | 0.0664 | 0.074 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0311 | 0.0347 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0036 | 0.0006 | 0.0006 |
Onchocerca volvulus | 0.0072 | 0.0353 | 0.1056 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Plasmodium vivax | hypothetical protein, conserved | 0.0259 | 0.2191 | 1 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0036 | 0.0006 | 0.0006 |
Onchocerca volvulus | 0.0036 | 0.0006 | 0.0018 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.1854 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0044 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0052 | 0.0106 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.0085 | 0.0091 |
Toxoplasma gondii | hypothetical protein | 0.0068 | 0.0311 | 0.1421 |
Echinococcus granulosus | enteropeptidase | 0.0036 | 0.0006 | 0.0006 |
Brugia malayi | jmjC domain containing protein | 0.0174 | 0.136 | 0.1456 |
Trypanosoma cruzi | MIZ/SP-RING zinc finger, putative | 0.0068 | 0.0311 | 0.8815 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0006 | 0.0007 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0041 | 0.0052 | 0.0235 |
Echinococcus multilocularis | expressed protein | 0.0362 | 0.3206 | 0.3206 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0006 | 0.0012 |
Echinococcus granulosus | enhancer of polycomb | 0.0158 | 0.1201 | 0.1201 |
Trypanosoma cruzi | transcription elongation factor s-II, putative | 0.0068 | 0.0311 | 0.8815 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2674 | 0.5474 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.4885 | 1 |
Brugia malayi | PWWP domain containing protein | 0.0068 | 0.0311 | 0.0334 |
Schistosoma mansoni | enhancer of polycomb | 0.0158 | 0.1201 | 0.1337 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0094 | 0.0574 | 0.0615 |
Toxoplasma gondii | kringle domain-containing protein | 0.0072 | 0.0353 | 0.1612 |
Onchocerca volvulus | 0.0068 | 0.0311 | 0.0931 | |
Brugia malayi | Trypsin-like protease protein 5 | 0.0036 | 0.0006 | 0.0006 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0259 | 0.2191 | 0.2191 |
Leishmania major | hypothetical protein, conserved | 0.0068 | 0.0311 | 0.8815 |
Echinococcus multilocularis | laminin | 0.0041 | 0.0052 | 0.0052 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0037 | 0.001 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0006 | 0.0012 |
Brugia malayi | Kringle domain containing protein | 0.0072 | 0.0353 | 0.0378 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.1631 | 0.3339 |
Schistosoma mansoni | hepatoma derived growth factor | 0.0068 | 0.0311 | 0.0347 |
Echinococcus multilocularis | histone lysine N methyltransferase, H3 lysine 36 | 0.0069 | 0.0322 | 0.0322 |
Onchocerca volvulus | 0.0036 | 0.0006 | 0.0018 | |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0311 | 0.0638 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0036 | 0.0006 | 0.0006 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.1905 | 0.3901 |
Onchocerca volvulus | 0.0068 | 0.0311 | 0.0931 | |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0041 | 0.0052 | 0.0106 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0036 | 0.0006 | 0.0007 |
Brugia malayi | hypothetical protein | 0.0068 | 0.0311 | 0.0334 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0072 | 0.0353 | 0.1612 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0072 | 0.0353 | 0.0353 |
Echinococcus multilocularis | fibrillin 1 | 0.0041 | 0.0052 | 0.0052 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0041 | 0.0052 | 0.0055 |
Echinococcus granulosus | Mastin | 0.0036 | 0.0006 | 0.0006 |
Brugia malayi | Protein kinase domain containing protein | 0.0072 | 0.0353 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0563 | 0.1153 |
Brugia malayi | Trypsin family protein | 0.0036 | 0.0006 | 0.0006 |
Brugia malayi | hypothetical protein | 0.0068 | 0.0311 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0006 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0006 | 0.0007 |
Onchocerca volvulus | Alhambra homolog | 0.0259 | 0.2191 | 0.6548 |
Echinococcus multilocularis | E3 ubiquitin protein ligase TRIM33 | 0.0341 | 0.2997 | 0.2997 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0041 | 0.0052 | 0.0055 |
Schistosoma mansoni | enhancer of polycomb | 0.0158 | 0.1201 | 0.1337 |
Schistosoma mansoni | zinc finger protein | 0.0044 | 0.0085 | 0.0094 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.