Detailed information for compound 175592

Basic information

Technical information
  • TDR Targets ID: 175592
  • Name: 2-chloro-5-nitroaniline
  • MW: 172.569 | Formula: C6H5ClN2O2
  • H donors: 1 H acceptors: 2 LogP: 1.7 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(c(c1)N)Cl
  • InChi: 1S/C6H5ClN2O2/c7-5-2-1-4(9(10)11)3-6(5)8/h1-3H,8H2
  • InChiKey: KWIXNFOTNVKIGM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-chloro-5-nitro-aniline
  • (2-chloro-5-nitro-phenyl)amine
  • 6283-25-6
  • 2-Amino-1-chloro-4-nitrobenzene
  • 25375_FLUKA
  • 2-Chloro-5-nitrobenzenamine
  • 6-Chloro-3-nitroaniline
  • Aniline, 2-chloro-5-nitro-
  • Benzenamine, 2-chloro-5-nitro-
  • NSC7791
  • WLN: ZR BG ENW
  • Aniline, 6-chloro-3-nitro-
  • HSDB 6086
  • NSC 7791
  • BRN 2208878
  • ZINC01688375
  • 3-12-00-01661 (Beilstein Handbook Reference)
  • EINECS 228-498-7
  • C58150_ALDRICH
  • SBB003829

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1326 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1056 0.794 0.7822
Trichomonas vaginalis conserved hypothetical protein 0.0279 0.2023 0.2023
Echinococcus granulosus tyrosine protein kinase Src42A 0.0016 0.0017 0.0017
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0086 0.0545 0.0545
Schistosoma mansoni tyrosine kinase 0.0019 0.0035 0.0035
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0165 0.1153 0.0642
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0086 0.0545 0.0545
Entamoeba histolytica hypothetical protein 0.0251 0.1805 0.1799
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.0035 0.0035
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0545 0.0545
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1326 1 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0086 0.0545 0.0539
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0086 0.0545 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0986 0.741 0.741
Entamoeba histolytica hypothetical protein 0.0086 0.0545 0.0539
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0251 0.1805 0.1805
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0086 0.0545 0.0545
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0445 0.3283 0.3283
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0086 0.0545 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0545 0.0545
Loa Loa (eye worm) acetylcholinesterase 1 0.0083 0.0526 0.0526
Brugia malayi Carboxylesterase family protein 0.0083 0.0526 0.0526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0986 0.741 0.741
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0086 0.0545 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0986 0.741 0.741
Trichomonas vaginalis PIKK family atypical protein kinase 0.0792 0.5932 0.5932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0715 0.5342 0.5342
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0019 0.0035 0.0035
Echinococcus granulosus tyrosine protein kinase Src42A 0.0019 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0986 0.741 0.741
Trichomonas vaginalis PIKK family atypical protein kinase 0.0889 0.6673 0.6673
Echinococcus multilocularis serine protein kinase ATM 0.0251 0.1805 0.1805
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.0021 0.0021
Echinococcus granulosus tyrosine protein kinase HCK 0.0015 0.0007 0.0007
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0194 0.1371 0.1371
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1056 0.794 0.7822
Echinococcus granulosus acetylcholinesterase 0.0083 0.0526 0.0526
Echinococcus granulosus tyrosine protein kinase Fyn 0.0019 0.0035 0.0035
Brugia malayi SRC-1 0.0019 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0986 0.741 0.741
Trichomonas vaginalis PIKK family atypical protein kinase 0.1326 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1326 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0086 0.0545 0.0545
Echinococcus multilocularis 0.0086 0.0545 0.0545
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0086 0.0545 0.5
Loa Loa (eye worm) TK protein kinase 0.0015 0.0007 0.0007
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0086 0.0545 0.0545
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0086 0.0545 0.0545
Entamoeba histolytica hypothetical protein 0.0086 0.0545 0.0539
Echinococcus multilocularis acetylcholinesterase 0.0083 0.0526 0.0526
Echinococcus granulosus serine protein kinase ATM 0.0251 0.1805 0.1805
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0279 0.2023 0.2153
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0017 0.0021 0.0021
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1326 1 1
Brugia malayi Carboxylesterase family protein 0.0083 0.0526 0.0526
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0194 0.1371 0.1371
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0545 0.0545
Echinococcus granulosus carboxylesterase 5A 0.0083 0.0526 0.0526
Echinococcus granulosus tyrosine kinase 0.0017 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0083 0.0526 0.0526
Trichomonas vaginalis PIKK family atypical protein kinase 0.1055 0.7932 0.7932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0716 0.535 0.535
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1326 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0086 0.0545 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0715 0.5342 0.5342
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0086 0.0545 0.0539
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0019 0.0035 0.0035
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0251 0.1805 0.1332
Echinococcus multilocularis acetylcholinesterase 0.0083 0.0526 0.0526
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.1805 0.1805
Leishmania major phosphatidylinositol 3-kinase, putative 0.0445 0.3283 0.2895
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0083 0.0526 0.0526
Loa Loa (eye worm) phosphatidylinositol 3 0.0445 0.3283 0.3283
Onchocerca volvulus 0.0086 0.0545 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0086 0.0545 0.0545
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0086 0.0545 0.0545
Echinococcus multilocularis tyrosine protein kinase Blk 0.0017 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0251 0.1805 0.1805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0986 0.741 0.741
Onchocerca volvulus 0.0086 0.0545 1
Loa Loa (eye worm) TK protein kinase 0.0017 0.0021 0.0021
Echinococcus granulosus tyrosine protein kinase Blk 0.0017 0.0021 0.0021
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0086 0.0545 0.0545
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0019 0.0035 0.0035
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0086 0.0545 0.0545
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0251 0.1805 0.1799
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0086 0.0545 0.0539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0445 0.3283 0.3283
Trichomonas vaginalis PIKK family atypical protein kinase 0.1326 1 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0086 0.0545 0.0539
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0086 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0165 0.1153 0.1153
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1326 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0545 0.0545
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0086 0.0545 0.0545
Schistosoma mansoni hypothetical protein 0.0086 0.0545 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0445 0.3283 0.3283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.1805 0.1805
Loa Loa (eye worm) hypothetical protein 0.0194 0.1371 0.1371
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0545 0.0545
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0086 0.0545 0.0545
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0551 0.4091 0.375
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0086 0.0545 0.0545
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1326 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0086 0.0545 0.0545
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1326 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.1805 0.1805
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0086 0.0545 0.0545
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0445 0.3283 0.3283
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.0035 0.0035
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0445 0.3283 0.2895
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0545 0.0545
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0019 0.0035 0.0035
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0086 0.0545 0.0539
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0545 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0861 0.6454 0.6454
Loa Loa (eye worm) hypothetical protein 0.027 0.1953 0.1953
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0086 0.0545 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0165 0.1153 0.1153
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0016 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.2605 0.2605
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0545 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0784 0.5872 0.5872
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0019 0.0035 0.0035
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0086 0.0545 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0716 0.535 0.535
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0545 0.0545
Schistosoma mansoni hypothetical protein 0.0194 0.1371 0.1371
Trichomonas vaginalis PIKK family atypical protein kinase 0.1055 0.7932 0.7932
Echinococcus granulosus tyrosine protein kinase Fyn 0.0019 0.0035 0.0035
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0445 0.3283 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.1805 0.1805
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0019 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0716 0.535 0.535
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0086 0.0545 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0986 0.741 0.741
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0086 0.0545 0.0545
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0086 0.0545 0.0545
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1326 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0086 0.0545 0.0539
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0086 0.0545 0.0545
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.1805 0.1805
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0086 0.0545 0.0539
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0251 0.1805 0.1805
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0545 0.0545
Entamoeba histolytica hypothetical protein 0.0086 0.0545 0.0539
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0086 0.0545 0.0545
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0086 0.0545 0.0545
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0627 0.4673 0.4366
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0086 0.0545 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1055 0.7932 0.7932
Trichomonas vaginalis PIKK family atypical protein kinase 0.1132 0.8522 0.8522
Loa Loa (eye worm) carboxylesterase 0.0083 0.0526 0.0526
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0086 0.0545 0.5
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0086 0.0545 0.5
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0086 0.0545 0.0545
Loa Loa (eye worm) phosphatidylinositol 3 0.1326 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0445 0.3283 0.3283
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0086 0.0545 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0086 0.0545 1
Trypanosoma cruzi target of rapamycin kinase 3 0.1056 0.794 0.7822
Plasmodium vivax hypothetical protein 0.0086 0.0545 0.5
Brugia malayi FAT domain containing protein 0.0194 0.1371 0.1371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0792 0.5932 0.5932
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1153 0.1153
Plasmodium vivax hypothetical protein, conserved 0.0086 0.0545 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0715 0.5342 0.5342
Schistosoma mansoni tyrosine kinase 0.0019 0.0035 0.0035
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0086 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0086 0.0545 0.0545
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0086 0.0545 0.5
Brugia malayi protein-tyrosine kinase 0.0017 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0784 0.5872 0.5872
Mycobacterium ulcerans carboxylesterase, LipT 0.0014 0 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0019 0.0035 0.0035
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0086 0.0545 0.0539
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0086 0.0545 0.0545
Toxoplasma gondii target of rapamycin (TOR), putative 0.0986 0.741 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0019 0.0035 0.0035
Echinococcus multilocularis tyrosine protein kinase HCK 0.0015 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0545 0.0545
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1326 1 1
Toxoplasma gondii FATC domain-containing protein 0.0251 0.1805 0.1835
Loa Loa (eye worm) phosphatidylinositol kinase 0.0086 0.0545 0.0545
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0716 0.535 0.535
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0086 0.0545 0.0545
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0251 0.1805 0.1805
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0545 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.1055 0.7932 0.7932
Echinococcus granulosus tyrosine protein kinase Src64B 0.0019 0.0035 0.0035
Echinococcus multilocularis carboxylesterase 5A 0.0083 0.0526 0.0526
Schistosoma mansoni fkbp-rapamycin associated protein 0.0251 0.1805 0.1805
Loa Loa (eye worm) hypothetical protein 0.0083 0.0526 0.0526
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0086 0.0545 0.0545
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.1371 0.1371
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0445 0.3283 0.2895
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0086 0.0545 0.0545
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0445 0.3283 0.3283
Echinococcus multilocularis Zinc finger, PHD finger 0.0086 0.0545 0.0545
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0086 0.0545 0.0545
Echinococcus granulosus acetylcholinesterase 0.0083 0.0526 0.0526
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0445 0.3283 0.2895
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0251 0.1805 0.1332
Giardia lamblia GTOR 0.1326 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0445 0.3283 0.3283
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0086 0.0545 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.1055 0.7932 0.7932
Entamoeba histolytica protein kinase rad3, putative 0.0251 0.1805 0.1799
Mycobacterium leprae conserved hypothetical protein 0.0086 0.0545 0.5
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0251 0.1805 0.1332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0545 0.0545
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1326 1 1
Loa Loa (eye worm) SRC-1 0.0019 0.0035 0.0035
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0445 0.3283 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0792 0.5932 0.5932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0445 0.3283 0.3283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0445 0.3283 0.3283
Loa Loa (eye worm) hypothetical protein 0.0279 0.2023 0.2023
Trichomonas vaginalis PIKK family atypical protein kinase 0.1326 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0019 0.0035 0.0035
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0086 0.0545 0.0545
Echinococcus multilocularis tyrosine protein kinase Srms 0.0017 0.0021 0.0021
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0086 0.0545 0.0545
Entamoeba histolytica hypothetical protein 0.0086 0.0545 0.0539

Activities

Activity type Activity value Assay description Source Reference
Log A (functional) = 2.31 Activity expressed by taste potency (taste intensity relative to sucrose on a mole/mole basis) ChEMBL. 7365747
Log A (functional) = 2.31 Activity expressed by taste potency (taste intensity relative to sucrose on a mole/mole basis) ChEMBL. 7365747

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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