Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0056 | 0.4144 | 0.5551 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0062 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0056 | 0.4144 | 0.5551 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6341 | 0.5 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0087 | 0.7465 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0054 | 0.3922 | 0.5254 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0058 | 0.4337 | 0.581 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0048 | 0.3283 | 0.4398 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.6341 | 0.7025 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0062 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.002 | 0.0188 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1557 | 0.0823 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.6341 | 0.3981 |
Mycobacterium ulcerans | polyketide synthase | 0.0058 | 0.4337 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0058 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0023 | 0.0571 | 0.0765 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0058 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0048 | 0.3185 | 0.4267 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0058 | 0.4337 | 0.581 |
Brugia malayi | RNA binding protein | 0.0076 | 0.6341 | 0.3981 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0047 | 0.3102 | 0.4155 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0058 | 0.4337 | 0.0684 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0038 | 0.2195 | 0.2941 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0105 | 0.9413 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0062 | 0.473 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0087 | 0.7465 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0062 | 0.473 | 0.6337 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6341 | 0.5 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0062 | 0.473 | 0.6337 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0062 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0042 | 0.2556 | 0.3424 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0087 | 0.7465 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0048 | 0.3283 | 0.4398 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0048 | 0.3283 | 0.4398 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0047 | 0.3102 | 0.4155 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.6341 | 0.3981 |
Onchocerca volvulus | 0.0101 | 0.9021 | 0.9285 | |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0038 | 0.2195 | 0.2941 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.6341 | 0.7025 |
Mycobacterium ulcerans | thioesterase | 0.0048 | 0.3283 | 0.4398 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0058 | 0.4337 | 0.581 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.6341 | 0.5 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0062 | 0.473 | 0.6337 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0062 | 0.473 | 0.6337 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.6341 | 0.7025 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0087 | 0.7465 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0058 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0058 | 0.4337 | 0.581 |
Loa Loa (eye worm) | fatty acid synthase | 0.0057 | 0.4253 | 0.4318 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6341 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0054 | 0.3922 | 0.3889 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0062 | 0.473 | 0.6337 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0038 | 0.2116 | 0.2574 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0047 | 0.3102 | 0.4155 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0033 | 0.1609 | 0.2155 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6341 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.6341 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.0062 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0058 | 0.4337 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.8637 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6341 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0058 | 0.4337 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0038 | 0.2195 | 0.2941 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0041 | 0.2515 | 0.3708 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.