TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 357.465 | Formula: C21H28FN3O
H donors: 0 H acceptors: 2 LogP: 3.69 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: C[C@@H]1CN(CCN1C(=O)C12CC3CC(C2)CC(C1)C3)c1ncccc1F
InChi: 1S/C21H28FN3O/c1-14-13-24(19-18(22)3-2-4-23-19)5-6-25(14)20(26)21-10-15-7-16(11-21)9-17(8-15)12-21/h2-4,14-17H,5-13H2,1H3/t14-,15?,16?,17?,21?/m1/s1
InChiKey: RVRYMQWKKHZKBB-LFPRZYRFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, metabotropic 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Metabotropic glutamate receptor precursor.	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	ko:K04606 glutamate receptor, metabotropic 3, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	Metabotropic glutamate receptor precursor, putative	Get druggable targets OG5_127095	All targets in OG5_127095

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	1	1
Brugia malayi	cathepsin L-like precursor	0.0184	0.6115	0.6058
Echinococcus granulosus	cathepsin L	0.0051	0.0416	0.0416
Trypanosoma cruzi	cysteine proteinase, putative	0.0141	0.4301	0.4054
Leishmania major	cathepsin L-like protease	0.0275	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0275	1	1
Loa Loa (eye worm)	cathepsin B	0.0051	0.0416	0.0079
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0051	0.0416	0.0416
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0051	0.0416	0.0079
Brugia malayi	Cathepsin L-like precursor	0.0275	1	1
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0051	0.0416	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.4301	0.4054
Giardia lamblia	Cysteine protease	0.0051	0.0416	0.5
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0051	0.0416	0.0277
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0141	0.4301	0.4301
Leishmania major	cathepsin L-like protease	0.0275	1	1
Echinococcus granulosus	cathepsin L	0.0141	0.4301	0.4301
Echinococcus multilocularis	cathepsin L cysteine protease	0.0275	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0275	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0416	0.0079
Brugia malayi	Cathepsin L-like precursor	0.0275	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0051	0.0416	0.0416
Brugia malayi	cathepsin B-like cysteine proteinase	0.0051	0.0416	0.0277
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0141	0.4301	0.4054
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0051	0.0416	0.0277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.4301	0.4054
Leishmania major	cathepsin L-like protease	0.0275	1	1
Brugia malayi	Cathepsin L-like precursor	0.0184	0.6115	0.6058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0091	0.2133	0.1791
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.4301	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	1	1
Schistosoma mansoni	cathepsin s	0.0091	0.2133	0.2133
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	1	1
Giardia lamblia	Cysteine protease	0.0051	0.0416	0.5
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.006	0.0823	0.0823
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0049	0.034	0.02
Echinococcus multilocularis	cathepsin L cysteine protease	0.0275	1	1
Giardia lamblia	Hypothetical protein	0.0051	0.0416	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0051	0.0416	0.0416
Echinococcus granulosus	metabotropic glutamate receptor 5	0.006	0.0823	0.0823
Echinococcus granulosus	cathepsin l1	0.0184	0.6115	0.6115
Entamoeba histolytica	cysteine protease, putative	0.0141	0.4301	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0275	1	1
Loa Loa (eye worm)	hypothetical protein	0.0275	1	1
Brugia malayi	Cathepsin L-like precursor	0.0275	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0141	0.4301	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0141	0.4301	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	1	1
Giardia lamblia	Cathepsin L precursor	0.0051	0.0416	0.5
Onchocerca volvulus		0.0275	1	1
Brugia malayi	Cathepsin L-like precursor	0.0275	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0275	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0275	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0184	0.6115	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.4301	0.4054
Brugia malayi	fibroinase precursor	0.0051	0.0416	0.0277
Entamoeba histolytica	cysteine protease, putative	0.0141	0.4301	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0416	0.0079
Giardia lamblia	Encystation-specific protease	0.0051	0.0416	0.5
Loa Loa (eye worm)	cysteine protease	0.0275	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0275	1	1
Entamoeba histolytica	cysteine protease, putative	0.0141	0.4301	0.4054
Loa Loa (eye worm)	fibroinase	0.0275	1	1
Onchocerca volvulus		0.0275	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0141	0.4301	0.4301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0275	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0051	0.0416	0.0416
Brugia malayi	Papain family cysteine protease containing protein	0.0141	0.4301	0.4219
Giardia lamblia	Hypothetical protein	0.0051	0.0416	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.0823	0.0501
Entamoeba histolytica	cysteine protease, putative	0.0141	0.4301	0.4054
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0184	0.6115	0.6058
Giardia lamblia	Cathepsin L precursor	0.0051	0.0416	0.5
Onchocerca volvulus	Cathepsin F homolog	0.0275	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0051	0.0416	0.5
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0275	1	1
Giardia lamblia	Cathepsin L precursor	0.0051	0.0416	0.5
Onchocerca volvulus		0.0275	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0275	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0051	0.0416	0.0277
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0051	0.0416	0.0079
Echinococcus multilocularis	cathepsin b	0.0051	0.0416	0.0416
Brugia malayi	Papain family cysteine protease containing protein	0.0051	0.0416	0.0277
Brugia malayi	Papain family cysteine protease containing protein	0.0275	1	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6115	0.5978
Leishmania major	cathepsin L-like protease	0.0275	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	1	1
Echinococcus multilocularis	cathepsin b	0.0051	0.0416	0.0416
Onchocerca volvulus		0.0275	1	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6115	0.5978
Giardia lamblia	Cathepsin B precursor	0.0051	0.0416	0.5
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2133	0.1856
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0416	0.0079
Trypanosoma cruzi	cysteine protease, putative	0.0141	0.4301	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0275	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0051	0.0416	0.0277
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0051	0.0416	0.0416
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	1	1
Plasmodium vivax	vivapain-2	0.0275	1	1
Loa Loa (eye worm)	ctsf protein	0.0275	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0275	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0275	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0051	0.0416	0.0277
Brugia malayi	cathepsin L precursor	0.0051	0.0416	0.0277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0184	0.6115	0.5946
Trypanosoma cruzi	cysteine peptidase, putative	0.0275	1	1
Giardia lamblia	Cathepsin B precursor	0.0051	0.0416	0.5
Entamoeba histolytica	cysteine protease, putative	0.0141	0.4301	0.4054
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0056	0.0626	0.0626
Giardia lamblia	Cathepsin B precursor	0.0051	0.0416	0.5
Echinococcus granulosus	cysteine protease	0.0141	0.4301	0.4301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	1	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0051	0.0416	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2133	0.1856
Giardia lamblia	Cathepsin L precursor	0.0051	0.0416	0.5
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0091	0.2133	0.1856
Onchocerca volvulus	Cathepsin L homolog	0.0275	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0275	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0051	0.0416	0.0416
Plasmodium vivax	vivapain-3	0.0141	0.4301	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2133	0.1856
Giardia lamblia	Cathepsin B precursor	0.0051	0.0416	0.5
Entamoeba histolytica	cysteine protease, putative	0.0275	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0141	0.4301	0.4054
Echinococcus granulosus	cathepsin b	0.0051	0.0416	0.0416
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	1	1
Plasmodium vivax	unspecified product	0.0141	0.4301	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0416	0.0079
Giardia lamblia	Cysteine protease	0.0051	0.0416	0.5
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0051	0.0416	0.5
Giardia lamblia	Cathepsin B precursor	0.0051	0.0416	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0275	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0275	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0275	1	1
Entamoeba histolytica	cysteine protease, putative	0.0141	0.4301	0.4054
Leishmania major	cathepsin L-like protease	0.0275	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0184	0.6115	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0141	0.4301	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0141	0.4301	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0275	1	1
Onchocerca volvulus		0.0275	1	1
Brugia malayi	Cathepsin L-like precursor	0.0184	0.6115	0.6058
Leishmania major	cathepsin L-like protease	0.0275	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0051	0.0416	0.0416
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0275	1	1
Giardia lamblia	Cathepsin L-like protease	0.0051	0.0416	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0184	0.6115	0.5946
Leishmania major	cathepsin L-like protease	0.0275	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0051	0.0416	0.0416
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0141	0.4301	0.4054
Onchocerca volvulus		0.0275	1	1
Entamoeba histolytica	cysteine protease, putative	0.0141	0.4301	0.4054
Giardia lamblia	Cathepsin B precursor	0.0051	0.0416	0.5
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0416	0.0079
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0275	1	1
Entamoeba histolytica	cysteine proteinase 2	0.0141	0.4301	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0184	0.6115	0.6115
Entamoeba histolytica	cysteine protease, putative	0.0141	0.4301	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	1	1
Onchocerca volvulus		0.0184	0.6115	0.5946
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	1	1
Echinococcus granulosus	cathepsin b	0.0051	0.0416	0.0416
Giardia lamblia	Cathepsin L precursor	0.0051	0.0416	0.5
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0091	0.2133	0.2019
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0416	0.0079
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	1	1
Brugia malayi	Cathepsin L-like precursor	0.0091	0.2133	0.2019
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0141	0.4301	0.4219
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0051	0.0416	0.5
Entamoeba histolytica	cysteine protease, putative	0.0141	0.4301	0.4054
Giardia lamblia	Cathepsin B precursor	0.0051	0.0416	0.5
Echinococcus multilocularis	cathepsin L	0.0051	0.0416	0.0416
Leishmania major	cathepsin L-like protease	0.0275	1	1
Giardia lamblia	Cysteine protease	0.0051	0.0416	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0051	0.0416	0.0416
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	1	1
Echinococcus granulosus	cathepsin l1	0.0275	1	1
Echinococcus multilocularis	cysteine protease	0.0275	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0275	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0141	0.4301	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	1	1
Onchocerca volvulus		0.0275	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0141	0.4301	0.4301
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0141	0.4301	0.4301
Giardia lamblia	Cathepsin L precursor	0.0051	0.0416	0.5
Giardia lamblia	Cathepsin B precursor	0.0051	0.0416	0.5
Schistosoma mansoni	cathepsin B (C01 family)	0.0051	0.0416	0.0416
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0051	0.0416	0.0277
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0051	0.0416	0.0416
Plasmodium vivax	unspecified product	0.0091	0.2133	0.1791
Brugia malayi	cathepsin L-like cysteine proteinase	0.0051	0.0416	0.0277
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0051	0.0416	0.0416
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0051	0.0416	0.0079
Trypanosoma cruzi	cruzipain precursor, putative	0.0091	0.2133	0.1791
Echinococcus multilocularis	cathepsin L	0.0141	0.4301	0.4301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.4301	0.4054
Schistosoma mansoni	cathepsin S (C01 family)	0.0051	0.0416	0.0416
Plasmodium vivax	vivapain-1	0.0141	0.4301	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0416	0.0079
Giardia lamblia	Cathepsin L-like protease	0.0051	0.0416	0.5
Brugia malayi	Cathepsin L-like precursor	0.0275	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0141	0.4301	0.4054
Brugia malayi	cathepsin F-like cysteine proteinase	0.0091	0.2133	0.2019
Entamoeba histolytica	cysteine proteinase, putative	0.0141	0.4301	0.4054
Echinococcus multilocularis	cysteine protease	0.0275	1	1
Entamoeba histolytica	cysteine protease, putative	0.0141	0.4301	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6115	0.5978
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0051	0.0416	0.0416
Entamoeba histolytica	cysteine proteinase, putative	0.0275	1	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0051	0.0416	0.0416
Entamoeba histolytica	cysteine proteinase, putative	0.0141	0.4301	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	1	1
Toxoplasma gondii	cathepsin CPL	0.0275	1	1
Plasmodium vivax	vivapain-2	0.0275	1	1
Schistosoma mansoni	cathepsin C	0.0051	0.0416	0.0416
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.15	Negative allosteric modulation of human mGluR1 expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization	ChEMBL.	23727046
IC50 (binding)	= 712 nM	Negative allosteric modulation of human mGluR1 expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization	ChEMBL.	23727046
Inhibition (binding)	= 2.4 %	Negative allosteric modulation of human mGluR1 expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization at 30 uM relative to glutamate	ChEMBL.	23727046

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2397343

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1762898