TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 435.494 | Formula: C20H25N3O6S
H donors: 1 H acceptors: 6 LogP: 1.56 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCC(C(=O)c1nc2c(o1)cccc2)NC(=O)[C@@H]1C[C@H](CN1C(=O)C)S(=O)(=O)CC
InChi: 1S/C20H25N3O6S/c1-4-14(18(25)20-22-15-8-6-7-9-17(15)29-20)21-19(26)16-10-13(30(27,28)5-2)11-23(16)12(3)24/h6-9,13-14,16H,4-5,10-11H2,1-3H3,(H,21,26)/t13-,14?,16+/m1/s1
InChiKey: IMXDKOLRDYMZGE-XIFZVWCKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin S	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	histone deacetylase, putative	0.0391	0.1642	0.5904
Entamoeba histolytica	protein kinase , putative	0.0643	0.2781	1
Echinococcus multilocularis	cyclins	0.0237	0.0948	0.3186
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0057	0.0137	0.0459
Brugia malayi	serine/threonine protein kinase 6	0.0643	0.2781	0.2781
Echinococcus granulosus	histone deacetylase 7	0.014	0.0509	0.171
Loa Loa (eye worm)	histone deacetylase 3	0.0391	0.1642	0.1642
Brugia malayi	regulator of G-protein signaling egl-10	0.007	0.0194	0.0194
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0406	0.1712	0.1712
Echinococcus multilocularis	histone deacetylase 7	0.014	0.0509	0.171
Echinococcus granulosus	cyclins	0.0237	0.0948	0.3186
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.0057	0.0137	0.0491
Trichomonas vaginalis	cyclins, putative	0.0339	0.1408	0.5062
Loa Loa (eye worm)	hypothetical protein	0.0395	0.1662	0.1662
Schistosoma mansoni	histone deacetylase hda2	0.014	0.0509	0.171
Echinococcus multilocularis	cyclin k	0.0057	0.0137	0.0459
Trichomonas vaginalis	cyclin D, putative	0.0057	0.0137	0.0491
Trypanosoma cruzi	histone deacetylase, putative	0.014	0.0509	0.183
Trichomonas vaginalis	cyclins, putative	0.0339	0.1408	0.5062
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0137	0.0137
Trypanosoma brucei	cyclin 3	0.0057	0.0137	0.0491
Schistosoma mansoni	regulator of G protein signaling	0.007	0.0194	0.0653
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0406	0.1712	0.6156
Brugia malayi	Regulator of G protein signaling domain containing protein	0.007	0.0194	0.0194
Echinococcus multilocularis	regulator of G protein signaling 3	0.007	0.0194	0.0653
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0057	0.0137	0.0491
Echinococcus granulosus	cyclin dependent kinase	0.0406	0.1712	0.5752
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0339	0.1408	0.5062
Trichomonas vaginalis	AGC family protein kinase	0.0643	0.2781	1
Echinococcus multilocularis	cyclins	0.0237	0.0948	0.3186
Echinococcus granulosus	histone deacetylase 6	0.014	0.0509	0.171
Echinococcus multilocularis	cyclin B	0.0339	0.1408	0.473
Schistosoma mansoni	axis inhibition protein axin	0.007	0.0194	0.0653
Echinococcus multilocularis	cyclins	0.0237	0.0948	0.3186
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0057	0.0137	0.0491
Plasmodium vivax	histone deacetylase 1, putative	0.0391	0.1642	0.5904
Plasmodium falciparum	histone deacetylase 2	0.014	0.0509	0.183
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0406	0.1712	0.5752
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.007	0.0194	0.0653
Schistosoma mansoni	cyclin d	0.0057	0.0137	0.0459
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.007	0.0194	0.0194
Echinococcus granulosus	cyclin dependent kinase 1	0.0406	0.1712	0.5752
Trichomonas vaginalis	histone deacetylase, putative	0.0391	0.1642	0.5904
Echinococcus multilocularis	histone deacetylase 3	0.0391	0.1642	0.5516
Toxoplasma gondii	histone deacetylase HDAC1	0.014	0.0509	0.183
Echinococcus multilocularis	cyclin t1	0.0057	0.0137	0.0459
Echinococcus multilocularis	aurora kinase A	0.0643	0.2781	0.9343
Trichomonas vaginalis	AGC family protein kinase	0.0643	0.2781	1
Entamoeba histolytica	hypothetical protein	0.007	0.0194	0.0699
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0643	0.2781	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0237	0.0948	0.0948
Trypanosoma cruzi	cdc2-related kinase 1	0.0406	0.1712	0.6156
Echinococcus granulosus	cyclins	0.0237	0.0948	0.3186
Onchocerca volvulus	Histone deacetylase 10 homolog	0.014	0.0509	0.3615
Brugia malayi	hypothetical protein	0.007	0.0194	0.0194
Entamoeba histolytica	protein kinase domain containing protein	0.0643	0.2781	1
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.0057	0.0137	0.0491
Trichomonas vaginalis	cyclin B, putative	0.0339	0.1408	0.5062
Schistosoma mansoni	cyclin k	0.0057	0.0137	0.0459
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.007	0.0194	0.0653
Schistosoma mansoni	serine/threonine protein kinase	0.0643	0.2781	0.9343
Echinococcus granulosus	cyclins	0.0237	0.0948	0.3186
Echinococcus multilocularis	regulator of G protein signaling	0.007	0.0194	0.0653
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0406	0.1712	0.1712
Brugia malayi	A-kinase anchor protein 10, precursor	0.007	0.0194	0.0194
Echinococcus multilocularis	cyclin dependent kinase	0.0406	0.1712	0.5752
Schistosoma mansoni	cyclin l	0.0057	0.0137	0.0459
Trichomonas vaginalis	cyclins, putative	0.0057	0.0137	0.0491
Echinococcus multilocularis	histone deacetylase 6	0.014	0.0509	0.171
Schistosoma mansoni	hypothetical protein	0.0057	0.0137	0.0459
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.007	0.0194	0.0653
Echinococcus multilocularis	histone deacetylase 6	0.014	0.0509	0.171
Leishmania major	histone deacetylase, putative	0.014	0.0509	0.183
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0643	0.2781	1
Schistosoma mansoni	regulator of G protein signaling	0.007	0.0194	0.0653
Entamoeba histolytica	protein kinase, putative	0.0643	0.2781	1
Entamoeba histolytica	cyclin family protein	0.0237	0.0948	0.341
Entamoeba histolytica	histone deacetylase, putative	0.0391	0.1642	0.5904
Trypanosoma cruzi	cyclin 9, putative	0.0057	0.0137	0.0491
Entamoeba histolytica	cyclin C, putative	0.0057	0.0137	0.0491
Onchocerca volvulus	Cyclin L homolog	0.0057	0.0137	0.097
Echinococcus granulosus	Cyclin L1	0.0057	0.0137	0.0459
Loa Loa (eye worm)	cyclin domain-containing protein	0.0237	0.0948	0.0948
Echinococcus multilocularis	axis inhibition protein axin	0.007	0.0194	0.0653
Trypanosoma cruzi	cdc2-related kinase 1	0.0406	0.1712	0.6156
Loa Loa (eye worm)	hypothetical protein	0.0391	0.1642	0.1642
Trichomonas vaginalis	cyclin B, putative	0.0237	0.0948	0.341
Giardia lamblia	Kinase, CMGC CDK	0.0406	0.1712	0.5958
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0057	0.0137	0.0137
Trypanosoma brucei	cdc2-related kinase 1	0.0406	0.1712	0.6156
Echinococcus granulosus	cyclin b3	0.0237	0.0948	0.3186
Loa Loa (eye worm)	hypothetical protein	0.007	0.0194	0.0194
Brugia malayi	Regulator of G protein signaling domain containing protein	0.007	0.0194	0.0194
Schistosoma mansoni	hypothetical protein	0.0057	0.0137	0.0459
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0194	0.0699
Trypanosoma brucei	histone deacetylase 2	0.014	0.0509	0.183
Brugia malayi	serine/threonine kinase 12	0.0643	0.2781	0.2781
Trypanosoma brucei	histone deacetylase 3	0.014	0.0509	0.183
Loa Loa (eye worm)	cyclin domain-containing protein	0.0057	0.0137	0.0137
Trichomonas vaginalis	CMGC family protein kinase	0.0406	0.1712	0.6156
Toxoplasma gondii	histone deacetylase HDAC3	0.0391	0.1642	0.5904
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0391	0.1642	0.5904
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0057	0.0137	0.0459
Leishmania major	cyclin 9, putative	0.0057	0.0137	0.0491
Schistosoma mansoni	serine/threonine protein kinase	0.0686	0.2977	1
Echinococcus multilocularis	cyclin G2	0.0057	0.0137	0.0459
Echinococcus multilocularis	cyclin b3	0.0237	0.0948	0.3186
Loa Loa (eye worm)	AUR protein kinase	0.0643	0.2781	0.2781
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0137	0.0491
Echinococcus multilocularis	histone deacetylase 1	0.0391	0.1642	0.5516
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.0057	0.0137	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0338	0.0338
Trypanosoma cruzi	histone deacetylase 1, putative	0.0391	0.1642	0.5904
Schistosoma mansoni	axis inhibition protein axin	0.007	0.0194	0.0653
Echinococcus multilocularis	regulator of G protein signaling 7	0.007	0.0194	0.0653
Brugia malayi	Histone deacetylase 1	0.0391	0.1642	0.1642
Trypanosoma cruzi	mitotic cyclin, putative	0.0057	0.0137	0.0491
Echinococcus multilocularis	axis inhibition protein axin	0.007	0.0194	0.0653
Schistosoma mansoni	g1/s-specific cyclin C	0.0057	0.0137	0.0459
Toxoplasma gondii	cyclin dependent kinase binding protein	0.0057	0.0137	0.0491
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0339	0.1408	0.1408
Trichomonas vaginalis	cyclin B, putative	0.0339	0.1408	0.5062
Loa Loa (eye worm)	AUR protein kinase	0.0643	0.2781	0.2781
Trypanosoma brucei	histone deacetylase, putative	0.014	0.0509	0.183
Onchocerca volvulus	Protein CNPPD1 homolog	0.0057	0.0137	0.097
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.007	0.0194	0.0653
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0081	0.0245	0.0245
Echinococcus granulosus	cyclin A3 4	0.0057	0.0137	0.0459
Schistosoma mansoni	z-protein (S1r protein)	0.007	0.0194	0.0653
Echinococcus multilocularis	cyclin y	0.0057	0.0137	0.0459
Echinococcus multilocularis	Regulator of G protein signaling 20	0.007	0.0194	0.0653
Plasmodium falciparum	protein kinase 5	0.0406	0.1712	0.6156
Schistosoma mansoni	cyclin G2	0.0057	0.0137	0.0459
Echinococcus multilocularis	nuclear receptor co repressor related (ncor)	0.06	0.2586	0.8688
Trypanosoma cruzi	histone deacetylase, putative	0.014	0.0509	0.183
Echinococcus granulosus	regulator of G protein signaling 3	0.007	0.0194	0.0653
Entamoeba histolytica	cell division protein kinase 2, putative	0.0406	0.1712	0.6156
Echinococcus granulosus	nuclear receptor co repressor related ncor	0.06	0.2586	0.8688
Echinococcus granulosus	histone deacetylase	0.014	0.0509	0.171
Trichomonas vaginalis	histone deacetylase, putative	0.0391	0.1642	0.5904
Echinococcus granulosus	histone deacetylase 3	0.0391	0.1642	0.5516
Loa Loa (eye worm)	histone deacetylase 1	0.0391	0.1642	0.1642
Brugia malayi	Histone deacetylase family protein	0.014	0.0509	0.0509
Echinococcus granulosus	axis inhibition protein axin	0.007	0.0194	0.0653
Brugia malayi	Protein kinase domain containing protein	0.0406	0.1712	0.1712
Echinococcus multilocularis	cyclin dependent kinase 5	0.0406	0.1712	0.5752
Brugia malayi	histone deacetylase 3 (HD3)	0.0391	0.1642	0.1642
Trypanosoma cruzi	cdc2-related kinase 3	0.0406	0.1712	0.6156
Brugia malayi	hypothetical protein	0.0057	0.0137	0.0137
Echinococcus multilocularis	cyclins	0.0237	0.0948	0.3186
Trichomonas vaginalis	cyclins, putative	0.0159	0.0596	0.2143
Trichomonas vaginalis	cyclin B3, putative	0.0057	0.0137	0.0491
Trypanosoma brucei	histone deacetylase 1	0.0391	0.1642	0.5904
Loa Loa (eye worm)	hypothetical protein	0.007	0.0194	0.0194
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0194	0.0699
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0194	0.0699
Schistosoma mansoni	Cyclin fold protein	0.0057	0.0137	0.0459
Trypanosoma cruzi	cyclin 6, putative	0.0339	0.1408	0.5062
Echinococcus multilocularis	cyclin dependent kinase 1	0.0406	0.1712	0.5752
Plasmodium vivax	histone deacetylase, putative	0.014	0.0509	0.183
Entamoeba histolytica	hypothetical protein	0.007	0.0194	0.0699
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0339	0.1408	0.1408
Entamoeba histolytica	cyclin, putative	0.0339	0.1408	0.5062
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0057	0.0137	0.0459
Loa Loa (eye worm)	hypothetical protein	0.007	0.0194	0.0194
Loa Loa (eye worm)	histone deacetylase 11	0.014	0.0509	0.0509
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0643	0.2781	1
Trichomonas vaginalis	AGC family protein kinase	0.0643	0.2781	1
Trichomonas vaginalis	CMGC family protein kinase	0.0406	0.1712	0.6156
Trypanosoma cruzi	histone deacetylase 1, putative	0.0391	0.1642	0.5904
Trypanosoma brucei	cdc2-related kinase 3	0.0406	0.1712	0.6156
Loa Loa (eye worm)	cyclin domain-containing protein	0.2242	1	1
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0391	0.1642	0.5904
Schistosoma mansoni	histone deacetylase	0.0391	0.1642	0.5516
Brugia malayi	hypothetical protein	0.007	0.0194	0.0194
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0686	0.2977	1
Trichomonas vaginalis	cyclins, putative	0.0057	0.0137	0.0491
Entamoeba histolytica	cyclin, domain containing protein	0.0057	0.0137	0.0491
Echinococcus multilocularis	regulator of G protein signaling 3	0.007	0.0194	0.0653
Plasmodium falciparum	histone deacetylase, putative	0.014	0.0509	0.183
Echinococcus multilocularis	histone deacetylase	0.014	0.0509	0.171
Entamoeba histolytica	cyclin, domain containing protein	0.0057	0.0137	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0339	0.1408	0.1408
Trichomonas vaginalis	cyclin B3, putative	0.0237	0.0948	0.341
Schistosoma mansoni	cyclin B3	0.0237	0.0948	0.3186
Schistosoma mansoni	cyclins	0.0237	0.0948	0.3186
Echinococcus multilocularis	regulator of G protein signaling 7	0.007	0.0194	0.0653
Echinococcus multilocularis	cyclin	0.0057	0.0137	0.0459
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0137	0.0491
Schistosoma mansoni	regulator of G protein signaling	0.007	0.0194	0.0653
Giardia lamblia	Cyclin A	0.0237	0.0948	0.307
Toxoplasma gondii	histone deacetylase HDAC5	0.014	0.0509	0.183
Echinococcus granulosus	cyclins	0.0237	0.0948	0.3186
Echinococcus granulosus	cyclins	0.0237	0.0948	0.3186
Toxoplasma gondii	aurora kinase	0.0643	0.2781	1
Giardia lamblia	G2/mitotic-specific cyclin B	0.0339	0.1408	0.4807
Entamoeba histolytica	hypothetical protein	0.0057	0.0137	0.0491
Trypanosoma brucei	aurora B kinase	0.0643	0.2781	1
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0137	0.0491
Echinococcus granulosus	histone deacetylase 6	0.014	0.0509	0.171
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0406	0.1712	0.1712
Giardia lamblia	Histone deacetylase	0.0391	0.1642	0.5692
Loa Loa (eye worm)	hypothetical protein	0.007	0.0194	0.0194
Loa Loa (eye worm)	hypothetical protein	0.014	0.0509	0.0509
Loa Loa (eye worm)	cyclin domain-containing protein	0.0057	0.0137	0.0137
Loa Loa (eye worm)	histone deacetylase 7A	0.014	0.0509	0.0509
Trypanosoma cruzi	histone deacetylase, putative	0.014	0.0509	0.183
Echinococcus granulosus	regulator of G protein signaling 7	0.007	0.0194	0.0653
Onchocerca volvulus	Cyclin L homolog	0.0057	0.0137	0.097
Echinococcus multilocularis	Cyclin L1	0.0057	0.0137	0.0459
Trypanosoma cruzi	histone deacetylase, putative	0.014	0.0509	0.183
Giardia lamblia	Hypothetical protein	0.0237	0.0948	0.307
Trichomonas vaginalis	conserved hypothetical protein	0.0237	0.0948	0.341
Trichomonas vaginalis	cyclin A, putative	0.0339	0.1408	0.5062
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0643	0.2781	0.9343
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0057	0.0137	0.0137
Echinococcus granulosus	cyclin B3 1	0.0237	0.0948	0.3186
Leishmania major	cyclin	0.0339	0.1408	0.5062
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0194	0.0699
Echinococcus granulosus	histone deacetylase 1	0.0391	0.1642	0.5516
Echinococcus granulosus	cyclin B	0.0339	0.1408	0.473
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0057	0.0137	0.0459
Echinococcus multilocularis	histone deacetylase 8	0.014	0.0509	0.171
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0057	0.0137	0.0137
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0057	0.0137	0.0137
Trichomonas vaginalis	cyclin A, putative	0.0057	0.0137	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0137	0.0137
Trypanosoma cruzi	aurora B kinase, putative	0.0643	0.2781	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0081	0.0245	0.0245
Echinococcus multilocularis	cyclins	0.0237	0.0948	0.3186
Plasmodium vivax	hypothetical protein, conserved	0.0057	0.0137	0.0491
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0194	0.0699
Leishmania major	protein kinase, putative	0.0643	0.2781	1
Echinococcus multilocularis	expressed protein	0.007	0.0194	0.0653
Trichomonas vaginalis	cyclin B, putative	0.0339	0.1408	0.5062
Echinococcus granulosus	expressed protein	0.007	0.0194	0.0653
Schistosoma mansoni	histone deacetylase	0.0391	0.1642	0.5516
Loa Loa (eye worm)	cyclin C	0.0057	0.0137	0.0137
Entamoeba histolytica	protein kinase, putative	0.0643	0.2781	1
Trichomonas vaginalis	cyclin B, putative	0.0339	0.1408	0.5062
Giardia lamblia	Kinase, CMGC CDK	0.0406	0.1712	0.5958
Schistosoma mansoni	serine/threonine protein kinase	0.0406	0.1712	0.5752
Trichomonas vaginalis	cyclin B3, putative	0.0057	0.0137	0.0491
Loa Loa (eye worm)	cyclin domain-containing protein	0.0057	0.0137	0.0137
Leishmania major	histone deacetylase, putative	0.0391	0.1642	0.5904
Plasmodium vivax	cyclin 4, putative	0.0057	0.0137	0.0491
Schistosoma mansoni	histone deacetylase 1 2 3	0.014	0.0509	0.171
Brugia malayi	cell division control protein 2 homolog	0.0406	0.1712	0.1712
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0237	0.0948	0.3186
Entamoeba histolytica	cyclin, putative	0.0237	0.0948	0.341
Plasmodium falciparum	cyclin 1	0.0057	0.0137	0.0491
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0643	0.2781	0.9343
Loa Loa (eye worm)	RGS-3 protein	0.007	0.0194	0.0194
Echinococcus granulosus	cyclin k	0.0057	0.0137	0.0459
Echinococcus multilocularis	cyclins	0.0237	0.0948	0.3186
Trichomonas vaginalis	histone deacetylase, putative	0.0391	0.1642	0.5904
Brugia malayi	cyclin fold protein 1 variant b	0.0057	0.0137	0.0137
Loa Loa (eye worm)	cyclin domain-containing protein	0.0057	0.0137	0.0137
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0686	0.2977	0.2977
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0137	0.0491
Trichomonas vaginalis	cyclin B, putative	0.0057	0.0137	0.0491
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0057	0.0137	0.0459
Toxoplasma gondii	cyclin 4, putative	0.0057	0.0137	0.0491
Plasmodium vivax	protein kinase Crk2	0.0406	0.1712	0.6156
Toxoplasma gondii	hypothetical protein	0.0057	0.0137	0.0491
Loa Loa (eye worm)	hypothetical protein	0.007	0.0194	0.0194
Echinococcus granulosus	histone deacetylase 6	0.014	0.0509	0.171
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0057	0.0137	0.0137
Onchocerca volvulus		0.0057	0.0137	0.097
Trichomonas vaginalis	cyclins, putative	0.0339	0.1408	0.5062
Onchocerca volvulus		0.0339	0.1408	1
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0406	0.1712	0.6156
Echinococcus granulosus	histone deacetylase 8	0.014	0.0509	0.171
Entamoeba histolytica	cyclin family protein	0.0237	0.0948	0.341
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0406	0.1712	0.6156
Leishmania major	mitotic cyclin, putative	0.0057	0.0137	0.0491
Plasmodium vivax	histone deacetylase, putative	0.014	0.0509	0.183
Echinococcus granulosus	cyclin t1	0.0057	0.0137	0.0459
Schistosoma mansoni	regulator of G protein signaling	0.007	0.0194	0.0653
Schistosoma mansoni	regulator of G protein signaling	0.007	0.0194	0.0653
Plasmodium vivax	histone deacetylase 2, putative	0.014	0.0509	0.183
Echinococcus granulosus	cyclin G2	0.0057	0.0137	0.0459
Echinococcus granulosus	Regulator of G protein signaling 20	0.007	0.0194	0.0653
Brugia malayi	PXA domain containing protein	0.007	0.0194	0.0194
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0057	0.0137	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.0643	0.2781	1
Brugia malayi	regulator of G-protein signaling rgs-7	0.007	0.0194	0.0194
Echinococcus granulosus	G1:S specific cyclin D1	0.0057	0.0137	0.0459
Plasmodium vivax	cyclin homologue, putative	0.0057	0.0137	0.0491
Trypanosoma brucei	cyclin 9	0.0057	0.0137	0.0491
Brugia malayi	Histone deacetylase family protein	0.014	0.0509	0.0509
Brugia malayi	hypothetical protein	0.0057	0.0137	0.0137
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0643	0.2781	1
Trypanosoma cruzi	cyclin, putative	0.0339	0.1408	0.5062
Brugia malayi	Cyclin C	0.0057	0.0137	0.0137
Echinococcus granulosus	cyclin	0.0057	0.0137	0.0459
Trypanosoma brucei	mitotic cyclin 6	0.0339	0.1408	0.5062
Schistosoma mansoni	histone deacetylase 4 5	0.014	0.0509	0.171
Brugia malayi	histone deacetylase 1 (HD1)	0.0391	0.1642	0.1642
Loa Loa (eye worm)	cyclin domain-containing protein	0.0057	0.0137	0.0137
Plasmodium falciparum	cyclin	0.0237	0.0948	0.341
Trichomonas vaginalis	cyclin D, putative	0.0237	0.0948	0.341
Loa Loa (eye worm)	PXA domain-containing protein	0.007	0.0194	0.0194
Schistosoma mansoni	cyclin G	0.0057	0.0137	0.0459
Echinococcus multilocularis	histone deacetylase 6	0.014	0.0509	0.171
Toxoplasma gondii	histone deacetylase HDAC4	0.014	0.0509	0.183
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0057	0.0137	0.0491
Brugia malayi	serine/threonine-protein kinase 6	0.0643	0.2781	0.2781
Schistosoma mansoni	histone deacetylase hda2	0.014	0.0509	0.171
Trichomonas vaginalis	CMGC family protein kinase	0.0406	0.1712	0.6156
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.007	0.0194	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0339	0.1408	0.1408
Echinococcus granulosus	cyclin y	0.0057	0.0137	0.0459
Entamoeba histolytica	cell division protein kinase 2, putative	0.0406	0.1712	0.6156
Trypanosoma cruzi	histone deacetylase, putative	0.014	0.0509	0.183
Echinococcus multilocularis	cyclin G2	0.0057	0.0137	0.0459
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.007	0.0194	0.0699
Echinococcus granulosus	cyclin y	0.0057	0.0137	0.0459
Echinococcus granulosus	regulator of G protein signaling 3	0.007	0.0194	0.0653
Leishmania major	histone deacetylase, putative	0.0391	0.1642	0.5904
Echinococcus granulosus	cyclins	0.0057	0.0137	0.0459
Trypanosoma cruzi	cdc2-related kinase 3	0.0406	0.1712	0.6156
Loa Loa (eye worm)	AUR protein kinase	0.0643	0.2781	0.2781
Leishmania major	histone deacetylase, putative	0.014	0.0509	0.183
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0237	0.0948	0.3186
Leishmania major	mitotic cyclin, putative	0.0057	0.0137	0.0491
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0194	0.0699
Schistosoma mansoni	histone deacetylase 4 5	0.014	0.0509	0.171
Schistosoma mansoni	protein kinase	0.0643	0.2781	0.9343
Echinococcus granulosus	aurora kinase A	0.0643	0.2781	0.9343
Schistosoma mansoni	cyclin B	0.0339	0.1408	0.473
Schistosoma mansoni	serine/threonine protein kinase	0.0081	0.0245	0.0823
Trichomonas vaginalis	cyclin B, putative	0.0057	0.0137	0.0491
Trypanosoma cruzi	hypothetical protein, conserved	0.0057	0.0137	0.0491
Brugia malayi	histone deacetylase 11	0.014	0.0509	0.0509
Trichomonas vaginalis	cyclins, putative	0.0339	0.1408	0.5062
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0616	0.2661	0.8938
Schistosoma mansoni	serine/threonine protein kinase	0.0406	0.1712	0.5752
Echinococcus granulosus	axis inhibition protein axin	0.007	0.0194	0.0653
Giardia lamblia	Aurora kinase	0.0643	0.2781	1
Plasmodium falciparum	histone deacetylase 1	0.0391	0.1642	0.5904
Trypanosoma cruzi	mitotic cyclin, putative	0.0057	0.0137	0.0491
Toxoplasma gondii	histone deacetylase HDAC2	0.0391	0.1642	0.5904
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0643	0.2781	1
Trichomonas vaginalis	cyclins, putative	0.0237	0.0948	0.341
Brugia malayi	PXA domain containing protein	0.007	0.0194	0.0194
Schistosoma mansoni	serine/threonine protein kinase	0.0686	0.2977	1
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0686	0.2977	1
Echinococcus multilocularis	cyclin y	0.0057	0.0137	0.0459
Echinococcus multilocularis	cyclins	0.0237	0.0948	0.3186
Trichomonas vaginalis	histone deacetylase, putative	0.0391	0.1642	0.5904
Echinococcus granulosus	cyclin G2	0.0057	0.0137	0.0459
Trypanosoma cruzi	cyclin, putative	0.0339	0.1408	0.5062
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0057	0.0137	0.0137
Echinococcus multilocularis	cyclin dependent kinase 1	0.0406	0.1712	0.5752
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0391	0.1642	0.5904
Echinococcus granulosus	regulator of G protein signaling 7	0.007	0.0194	0.0653
Loa Loa (eye worm)	CYL-1 protein	0.0057	0.0137	0.0137
Trypanosoma brucei	histone deacetylase 4	0.014	0.0509	0.183
Echinococcus granulosus	cyclin dependent kinase 5	0.0406	0.1712	0.5752
Loa Loa (eye worm)	histone deacetylase	0.014	0.0509	0.0509
Toxoplasma gondii	hypothetical protein	0.018	0.069	0.2481
Echinococcus multilocularis	cyclin B3 1	0.0237	0.0948	0.3186
Echinococcus multilocularis	G1:S specific cyclin D1	0.0057	0.0137	0.0459
Trichomonas vaginalis	cyclin D, putative	0.0237	0.0948	0.341
Entamoeba histolytica	hypothetical protein	0.007	0.0194	0.0699
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0616	0.2661	0.8938
Trypanosoma brucei	mitotic cyclin	0.0057	0.0137	0.0491
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0339	0.1408	0.5062
Trichomonas vaginalis	histone deacetylase, putative	0.0391	0.1642	0.5904
Loa Loa (eye worm)	hypothetical protein	0.007	0.0194	0.0194
Echinococcus multilocularis	cyclin A3 4	0.0057	0.0137	0.0459

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 100 nM	Inhibition of human cathepsin-S	ChEMBL.	23639544

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2380730

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1764060