Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.2546 | 0.5658 | 0.5074 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.2404 | 0.5327 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0623 | 0.1185 | 0.2217 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.2483 | 0.551 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0115 | 0.0005 | 0.0009 |
Schistosoma mansoni | tyrosine kinase | 0.015 | 0.0085 | 0.0151 |
Echinococcus granulosus | peroxidasin | 0.0115 | 0.0005 | 0.0009 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0149 | 0.0083 | 0.0155 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.2404 | 0.5327 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0238 | 0.029 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0691 | 0.1343 | 0.0354 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0691 | 0.1343 | 0.2515 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.2404 | 0.5327 | 1 |
Onchocerca volvulus | 0.0691 | 0.1343 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.0262 | 0.0347 | 0.0643 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0623 | 0.1185 | 0.215 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.024 | 0.0294 | 0.0552 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0691 | 0.1343 | 0.018 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0262 | 0.0347 | 0.0651 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0691 | 0.1343 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0691 | 0.1343 | 0.2438 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0691 | 0.1343 | 0.018 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0262 | 0.0347 | 0.0651 |
Loa Loa (eye worm) | TK protein kinase | 0.2483 | 0.551 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0691 | 0.1343 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0691 | 0.1343 | 0.2438 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0262 | 0.0347 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0005 | 0.0009 |
Mycobacterium tuberculosis | Conserved protein | 0.0691 | 0.1343 | 0.018 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0262 | 0.0347 | 0.0651 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0115 | 0.0005 | 0.0009 |
Trypanosoma brucei | beta lactamase | 0.1222 | 0.2579 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0691 | 0.1343 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0691 | 0.1343 | 0.0354 |
Brugia malayi | beta-lactamase | 0.0691 | 0.1343 | 0.2432 |
Loa Loa (eye worm) | hypothetical protein | 0.0691 | 0.1343 | 0.2438 |
Loa Loa (eye worm) | TK protein kinase | 0.024 | 0.0294 | 0.0533 |
Echinococcus multilocularis | hemicentin 1 | 0.0115 | 0.0005 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0083 | 0.015 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0115 | 0.0005 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0005 | 0.0009 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.2404 | 0.5327 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0005 | 0.0009 |
Echinococcus granulosus | lachesin | 0.0115 | 0.0005 | 0.0009 |
Brugia malayi | dihydrofolate reductase family protein | 0.0623 | 0.1185 | 0.2144 |
Mycobacterium tuberculosis | Conserved protein | 0.0691 | 0.1343 | 0.018 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0623 | 0.1185 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0691 | 0.1343 | 0.2515 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0623 | 0.1185 | 0.2224 |
Echinococcus granulosus | dihydrofolate reductase | 0.0623 | 0.1185 | 0.2224 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0691 | 0.1343 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0691 | 0.1343 | 0.2438 |
Echinococcus granulosus | hemicentin 1 | 0.0115 | 0.0005 | 0.0009 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0691 | 0.1343 | 0.2522 |
Onchocerca volvulus | 0.0691 | 0.1343 | 1 | |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0691 | 0.1343 | 0.018 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.2546 | 0.5658 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0623 | 0.1185 | 0.2144 |
Leishmania major | hypothetical protein, conserved | 0.0691 | 0.1343 | 1 |
Echinococcus granulosus | neuroglian | 0.0115 | 0.0005 | 0.0009 |
Mycobacterium ulcerans | lipase LipD | 0.0691 | 0.1343 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0691 | 0.1343 | 0.2438 |
Mycobacterium leprae | conserved hypothetical protein | 0.0691 | 0.1343 | 0.1136 |
Schistosoma mansoni | nephrin | 0.0191 | 0.0181 | 0.033 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0691 | 0.1343 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0191 | 0.0181 | 0.0339 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0262 | 0.0347 | 0.0651 |
Brugia malayi | beta-lactamase family protein | 0.0691 | 0.1343 | 0.2432 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.024 | 0.0294 | 0.0552 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0262 | 0.0347 | 0.0651 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0262 | 0.0347 | 0.0651 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0604 | 0.114 | 0.2063 |
Echinococcus granulosus | tyrosine protein kinase otk | 0.0115 | 0.0005 | 0.0009 |
Echinococcus multilocularis | tyrosine protein kinase otk | 0.0115 | 0.0005 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0266 | 0.0482 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0115 | 0.0005 | 0.0009 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0691 | 0.1343 | 0.0354 |
Onchocerca volvulus | 0.0691 | 0.1343 | 1 | |
Echinococcus multilocularis | neurotracting:lsamp:neurotrimin:obcam | 0.0115 | 0.0005 | 0.0009 |
Onchocerca volvulus | 0.042 | 0.0714 | 0.5299 | |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0115 | 0.0005 | 0.0009 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0691 | 0.1343 | 0.2522 |
Plasmodium vivax | hypothetical protein, conserved | 0.0691 | 0.1343 | 1 |
Echinococcus multilocularis | neuroglian | 0.0191 | 0.0181 | 0.0339 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0216 | 0.0239 | 0.0449 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0691 | 0.1343 | 0.5 |
Brugia malayi | SRC-1 | 0.0262 | 0.0347 | 0.0622 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0691 | 0.1343 | 0.2432 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0604 | 0.114 | 0.207 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0115 | 0.0005 | 0.0009 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0115 | 0.0005 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0005 | 0.0009 |
Echinococcus multilocularis | roundabout 2 | 0.0227 | 0.0266 | 0.0499 |
Loa Loa (eye worm) | SRC-1 | 0.0262 | 0.0347 | 0.063 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0262 | 0.0347 | 0.0651 |
Toxoplasma gondii | ABC1 family protein | 0.0691 | 0.1343 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0005 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0266 | 0.0482 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0262 | 0.0347 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0005 | 0.0009 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0262 | 0.0347 | 0.0651 |
Echinococcus granulosus | tyrosine kinase | 0.024 | 0.0294 | 0.0552 |
Mycobacterium ulcerans | beta-lactamase | 0.0691 | 0.1343 | 0.0354 |
Schistosoma mansoni | tyrosine kinase | 0.2404 | 0.5327 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.024 | 0.0294 | 0.0552 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0115 | 0.0005 | 0.0009 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0691 | 0.1343 | 0.018 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0262 | 0.0347 | 0.0651 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0691 | 0.1343 | 0.2438 |
Echinococcus multilocularis | roundabout 2 | 0.0115 | 0.0005 | 0.0009 |
Entamoeba histolytica | protein kinase, putative | 0.0216 | 0.0239 | 0.5 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0115 | 0.0005 | 0.0009 |
Brugia malayi | beta-lactamase family protein | 0.0691 | 0.1343 | 0.2432 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0691 | 0.1343 | 0.018 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0533 | 0.0977 | 0.7265 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0205 | 0.0214 | 0.0401 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0262 | 0.0347 | 0.0651 |
Echinococcus multilocularis | roundabout 2 | 0.0115 | 0.0005 | 0.0009 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.1222 | 0.2579 | 0.3117 |
Mycobacterium leprae | Probable lipase LipE | 0.0691 | 0.1343 | 0.1136 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.024 | 0.0294 | 0.0552 |
Echinococcus granulosus | twitchin | 0.0191 | 0.0181 | 0.0339 |
Echinococcus granulosus | roundabout 2 | 0.0227 | 0.0266 | 0.0499 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.1222 | 0.2579 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0005 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0005 | 0.0009 |
Schistosoma mansoni | cell adhesion molecule | 0.0149 | 0.0083 | 0.0147 |
Echinococcus granulosus | contactin | 0.0115 | 0.0005 | 0.0009 |
Echinococcus granulosus | roundabout 2 | 0.0115 | 0.0005 | 0.0009 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0691 | 0.1343 | 0.46 |
Loa Loa (eye worm) | TK protein kinase | 0.0216 | 0.0239 | 0.0434 |
Echinococcus multilocularis | hemicentin 1 | 0.0115 | 0.0005 | 0.0009 |
Mycobacterium tuberculosis | Conserved protein | 0.0691 | 0.1343 | 0.018 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0262 | 0.0347 | 0.0651 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0115 | 0.0005 | 0.0009 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0262 | 0.0347 | 0.0651 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0691 | 0.1343 | 0.5 |
Echinococcus multilocularis | lachesin | 0.0115 | 0.0005 | 0.0009 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0216 | 0.0239 | 0.0449 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0262 | 0.0347 | 0.0651 |
Echinococcus multilocularis | neuroglian | 0.0115 | 0.0005 | 0.0009 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0691 | 0.1343 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0691 | 0.1343 | 0.2438 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0205 | 0.0214 | 0.0401 |
Loa Loa (eye worm) | beta-lactamase | 0.0691 | 0.1343 | 0.2438 |
Trichomonas vaginalis | esterase, putative | 0.0691 | 0.1343 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.024 | 0.0294 | 0.0525 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.024 | 0.0294 | 0.0552 |
Echinococcus multilocularis | peroxidasin | 0.0115 | 0.0005 | 0.0009 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0262 | 0.0347 | 0.0651 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.1222 | 0.2579 | 0.1582 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0262 | 0.0347 | 0.0651 |
Schistosoma mansoni | tyrosine kinase | 0.0262 | 0.0347 | 0.0643 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0691 | 0.1343 | 0.018 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.