Detailed information for compound 1767373

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 388.368 | Formula: C20H20O8
  • H donors: 1 H acceptors: 2 LogP: 3.23 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)c1cc(=O)c2c(o1)c(OC)c(cc2O)OC
  • InChi: 1S/C20H20O8/c1-23-14-6-10(7-15(24-2)18(14)26-4)13-8-11(21)17-12(22)9-16(25-3)19(27-5)20(17)28-13/h6-9,22H,1-5H3
  • InChiKey: JKUQVSBSSAZZKM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus chromobox protein 1 0.0072 0.0719 0.1751
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0214 0.1663
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.1286 0.1077
Brugia malayi chromobox protein homolog 3 0.004 0.0258 0.079
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0249 0.0578
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0234 1
Schistosoma mansoni alpha-glucosidase 0.0144 0.1783 0.4403
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0249 0.1934
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0214 0.1663
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0234 0.1819
Onchocerca volvulus 0.0111 0.1286 0.4211
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0621 0.476
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.2125 0.6914
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.2125 0.5256
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0621 0.476
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0234 0.1819
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0077 0.0476
Echinococcus multilocularis aminopeptidase N 0.023 0.3031 0.7514
Toxoplasma gondii exonuclease III APE 0.0039 0.0234 0.171
Trypanosoma brucei Aminopeptidase M1, putative 0.0068 0.0659 0.5056
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.1286 0.1077
Brugia malayi Ets-domain containing protein 0.0075 0.0761 0.2439
Loa Loa (eye worm) hypothetical protein 0.0026 0.0056 0.0098
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.1286 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0249 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.0761 0.1854
Schistosoma mansoni hypothetical protein 0.0041 0.0272 0.0636
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0068 0.0659 0.16
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0214 0.3248
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0249 0.0578
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0214 0.1663
Brugia malayi Peptidase family M1 containing protein 0.0068 0.0659 0.2105
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0234 0.1819
Schistosoma mansoni importin beta-1 0.0028 0.0077 0.0151
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0621 0.1506
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1286 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.1084 0.3499
Plasmodium vivax importin-beta 2, putative 0.0028 0.0077 0.0476
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0151
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0068 0.0659 0.16
Entamoeba histolytica hypothetical protein 0.0041 0.0272 0.4132
Brugia malayi hypothetical protein 0.0068 0.0659 0.2105
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0659 0.16
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1084 0.266
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0659 0.16
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0086 0.0667
Onchocerca volvulus 0.0097 0.1089 0.3559
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0234 0.5
Mycobacterium ulcerans lipase LipD 0.0111 0.1286 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.1286 0.3164
Mycobacterium ulcerans beta-lactamase 0.0111 0.1286 1
Loa Loa (eye worm) hypothetical protein 0.0162 0.2041 0.5047
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0077 0.0476
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0214 0.0491
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.2125 0.5256
Brugia malayi intermediate filament protein 0.0026 0.0056 0.0129
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0272 0.0636
Echinococcus multilocularis snurportin 1 0.0298 0.4028 1
Brugia malayi hypothetical protein 0.0041 0.0272 0.0837
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0249 0.0578
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0621 0.1506
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0068 0.0659 0.5121
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0214 0.3248
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1286 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0311 0.0732
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0077 0.0476
Brugia malayi Heterochromatin protein 1 0.0072 0.0719 0.2304
Schistosoma mansoni chromobox protein 0.0072 0.0719 0.1751
Brugia malayi beta-lactamase 0.0111 0.1286 0.4163
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0234 0.0541
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0214 0.0491
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0302 0.2351
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0214 0.1663
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0214 0.1663
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.1084 0.266
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0362 0.1131
Trichomonas vaginalis esterase, putative 0.0111 0.1286 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0234 0.171
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0249 0.1934
Loa Loa (eye worm) hypothetical protein 0.004 0.0258 0.06
Entamoeba histolytica hypothetical protein 0.0041 0.0272 0.4132
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0214 0.1663
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.1084 0.266
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0081
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0659 0.16
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0621 0.4828
Schistosoma mansoni intermediate filament proteins 0.0026 0.0056 0.0098
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0249 0.076
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1286 1
Leishmania major hypothetical protein, conserved 0.0111 0.1286 1
Trypanosoma cruzi aminopeptidase, putative 0.0068 0.0659 0.5121
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1286 0.3164
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0249 0.3776
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0234 0.0541
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0068 0.0659 0.5056
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.1286 0.3164
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0719 0.1751
Brugia malayi Fli-1 protein 0.0227 0.2983 0.973
Mycobacterium ulcerans hypothetical protein 0.0111 0.1286 1
Echinococcus multilocularis chromobox protein 1 0.0072 0.0719 0.1751
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0068 0.0659 0.5121
Loa Loa (eye worm) hypothetical protein 0.0111 0.1286 0.3164
Mycobacterium tuberculosis Conserved protein 0.0111 0.1286 0.1077
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0017 0.0131
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0258 0.0799
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0234 0.1819
Onchocerca volvulus 0.023 0.3031 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0659 0.16
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0234 0.5
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0249 0.1827
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0214 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0249 0.1934
Brugia malayi beta-lactamase family protein 0.0111 0.1286 0.4163
Schistosoma mansoni lamin 0.0026 0.0056 0.0098
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0621 0.476
Echinococcus granulosus aminopeptidase N 0.023 0.3031 0.7514
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0017 0.0131
Echinococcus granulosus intermediate filament protein 0.0026 0.0056 0.0098
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0272 0.0636
Entamoeba histolytica aminopeptidase, putative 0.0068 0.0659 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0249 0.0578
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0044 0.0311 0.2415
Loa Loa (eye worm) hypothetical protein 0.004 0.0249 0.0578
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0068 0.0659 0.16
Onchocerca volvulus 0.0068 0.0659 0.2129
Toxoplasma gondii ABC1 family protein 0.0111 0.1286 1
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0068 0.0659 0.5121
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0249 0.0578
Mycobacterium leprae Probable lipase LipE 0.0111 0.1286 0.5
Schistosoma mansoni ap endonuclease 0.0039 0.0234 0.0541
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0659 0.16
Schistosoma mansoni ets-related 0.0227 0.2983 0.7395
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0249 0.1934
Schistosoma mansoni lamin 0.0026 0.0056 0.0098
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0017 0.0131
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0234 0.1819
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0234 0.0541
Brugia malayi Importin beta-1 subunit 0.0028 0.0077 0.0198
Mycobacterium ulcerans aminopeptidase N PepN 0.0068 0.0659 0.5056
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0249 0.0578
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0659 0.16
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0214 0.1553
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0017 0.0131
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.1084 0.266
Entamoeba histolytica hypothetical protein 0.0041 0.0272 0.4132
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.0761 0.1854
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0249 0.1934
Echinococcus granulosus lamin dm0 0.0026 0.0056 0.0098
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0017 0.0131
Loa Loa (eye worm) hypothetical protein 0.0111 0.1286 0.3164
Plasmodium falciparum importin beta, putative 0.0028 0.0077 0.2782
Plasmodium vivax hypothetical protein, conserved 0.0111 0.1286 1
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.3066 0.7601
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.1286 0.3164
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.0761 0.1854
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.4028 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.1286 0.4163
Schistosoma mansoni alpha-glucosidase 0.0144 0.1783 0.4403
Loa Loa (eye worm) hypothetical protein 0.0111 0.1286 0.3164
Entamoeba histolytica hypothetical protein 0.0041 0.0272 0.4132
Brugia malayi beta-lactamase family protein 0.0111 0.1286 0.4163
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0214 0.1663
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.3066 0.7601
Echinococcus multilocularis lamin 0.0026 0.0056 0.0098
Schistosoma mansoni hypothetical protein 0.0298 0.4028 1
Echinococcus granulosus snurportin 1 0.0298 0.4028 1
Mycobacterium tuberculosis Conserved protein 0.0111 0.1286 0.1077
Loa Loa (eye worm) hypothetical protein 0.0206 0.2683 0.6647
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0249 0.0578
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0621 0.1506
Echinococcus multilocularis lamin dm0 0.0026 0.0056 0.0098
Brugia malayi Peptidase family M1 containing protein 0.023 0.3031 0.9886
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0659 0.16
Echinococcus multilocularis musashi 0.0026 0.0056 0.0098
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0056 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0214 0.1663
Loa Loa (eye worm) beta-lactamase 0.0111 0.1286 0.3164
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0017 0.0131
Trypanosoma brucei Aminopeptidase M1, putative 0.0068 0.0659 0.5056
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1286 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0249 0.1934
Onchocerca volvulus 0.0032 0.013 0.0377
Echinococcus multilocularis chromobox protein 1 0.0072 0.0719 0.1751
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0234 0.171
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.1286 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0258 0.2003
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0272 0.0636
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0214 0.0491
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.2125 0.5256
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.1286 0.1077
Loa Loa (eye worm) hypothetical protein 0.0111 0.1286 0.3164
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1286 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0214 0.1663
Mycobacterium leprae conserved hypothetical protein 0.0111 0.1286 0.5
Schistosoma mansoni survival motor neuron protein 0.0047 0.0362 0.086
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.2125 0.5256
Onchocerca volvulus 0.0111 0.1286 0.4211
Echinococcus granulosus lamin 0.0026 0.0056 0.0098
Loa Loa (eye worm) hypothetical protein 0.0064 0.0602 0.1459
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0086 0.0667
Loa Loa (eye worm) hypothetical protein 0.0232 0.3066 0.7601
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.1286 0.1077
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.1286 0.1077
Onchocerca volvulus 0.0111 0.1286 0.4211
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0659 0.16
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0283
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.1286 0.1077
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0258 0.2003
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0214 0.1663
Loa Loa (eye worm) peptidase family M1 containing protein 0.0186 0.2389 0.5914
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0234 0.3552
Trypanosoma brucei glucosidase, putative 0.0037 0.0214 0.1553
Brugia malayi hypothetical protein 0.0232 0.3066 1
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1286 1
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.1286 0.1077
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0077 0.0151
Onchocerca volvulus 0.0026 0.0056 0.0131
Loa Loa (eye worm) hypothetical protein 0.0111 0.1286 0.3164
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0621 0.0396
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0659 0.16
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0017 0.0131
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.1286 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.1084 0.266
Trypanosoma cruzi Aminopeptidase M1, putative 0.0068 0.0659 0.5121
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0719 0.5592
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0302 0.2351
Loa Loa (eye worm) hypothetical protein 0.0111 0.1286 0.3164
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0719 0.5592
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0056 0.0098
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0234 0.171
Schistosoma mansoni hypothetical protein 0.0047 0.0362 0.086
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1286 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0621 0.476
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0044 0.0311 0.0732
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0234 0.0712
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0621 0.1506
Loa Loa (eye worm) fli-1 protein 0.0227 0.2983 0.7395
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0068 0.0659 0.5121
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0214 0.1663
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1084 0.266
Brugia malayi Ets-domain containing protein 0.0075 0.0761 0.2439
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0056 0.0129
Schistosoma mansoni chromobox protein 0.0072 0.0719 0.1751
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0017 0.0131
Onchocerca volvulus 0.0026 0.0056 0.0131
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0249 0.0578
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0044 0.0311 0.0732
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0214 0.1663
Loa Loa (eye worm) hypothetical protein 0.0044 0.0311 0.0732
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1084 0.266
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0068 0.0659 0.5121
Loa Loa (eye worm) aminopeptidase N 0.0068 0.0659 0.16
Schistosoma mansoni ap endonuclease 0.0039 0.0234 0.0541
Schistosoma mansoni gabp alpha 0.0075 0.0761 0.1854
Schistosoma mansoni alpha glucosidase 0.0037 0.0214 0.0491
Mycobacterium tuberculosis Conserved protein 0.0111 0.1286 0.1077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1286 0.3164
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.1084 0.266
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0302 0.0947
Onchocerca volvulus 0.0047 0.0362 0.1144
Brugia malayi RNA, U transporter 1 0.0079 0.083 0.2667
Echinococcus granulosus chromobox protein 1 0.0072 0.0719 0.1751
Echinococcus granulosus importin subunit beta 1 0.0028 0.0077 0.0151

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 25 uM Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay ChEMBL. 23800391

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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