Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Macaca fascicularis | Renin | Starlite/ChEMBL | References |
Homo sapiens | renin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium vivax | aspartyl protease, putative | Renin | 406 aa | 348 aa | 27.0 % |
Candida albicans | secretory aspartyl proteinase SAP4p | Renin | 406 aa | 344 aa | 25.6 % |
Candida albicans | secretory aspartyl proteinase SAP4p | Renin | 406 aa | 344 aa | 25.6 % |
Neospora caninum | hypothetical protein | Renin | 406 aa | 359 aa | 31.8 % |
Dictyostelium discoideum | hypothetical protein | Renin | 406 aa | 396 aa | 21.7 % |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | Renin | 406 aa | 406 aa | 27.3 % |
Candida albicans | secretory aspartyl proteinase SAP10p, related to SAP9p | Renin | 406 aa | 352 aa | 20.7 % |
Plasmodium yoelii | Eukaryotic aspartyl protease, putative | Renin | 406 aa | 355 aa | 25.9 % |
Candida albicans | secretory aspartyl proteinase SAP10p, related to SAP9p | Renin | 406 aa | 352 aa | 20.7 % |
Candida albicans | secretory aspartyl proteinase SAP7p | Renin | 406 aa | 373 aa | 24.4 % |
Cryptosporidium parvum | secreted pepsinogen like aspartyl protease having a signal peptide | Renin | 406 aa | 382 aa | 22.0 % |
Babesia bovis | aspartyl protease, putative | Renin | 406 aa | 338 aa | 25.4 % |
Babesia bovis | aspartyl protease, putative | Renin | 406 aa | 327 aa | 26.6 % |
Candida albicans | secretory aspartyl proteinase SAP5p | Renin | 406 aa | 347 aa | 24.5 % |
Plasmodium berghei | plasmepsin VII | Renin | 406 aa | 367 aa | 26.2 % |
Plasmodium knowlesi | aspartyl protease, putative | Renin | 406 aa | 371 aa | 26.1 % |
Plasmodium berghei | plasmepsin X | Renin | 406 aa | 355 aa | 25.6 % |
Toxoplasma gondii | aspartyl protease ASP3 | Renin | 406 aa | 354 aa | 32.2 % |
Plasmodium falciparum | plasmepsin VII | Renin | 406 aa | 374 aa | 25.7 % |
Candida albicans | secretory aspartyl proteinase SAP6p | Renin | 406 aa | 355 aa | 26.2 % |
Plasmodium vivax | aspartyl protease, putative | Renin | 406 aa | 370 aa | 25.1 % |
Drosophila melanogaster | CG31926 gene product from transcript CG31926-RB | Renin | 406 aa | 338 aa | 32.8 % |
Candida albicans | secretory aspartyl proteinase SAP6p | Renin | 406 aa | 355 aa | 26.2 % |
Cryptosporidium parvum | AT hook motif protein, putative | Renin | 406 aa | 399 aa | 21.3 % |
Candida albicans | secretory aspartyl proteinase SAP7p | Renin | 406 aa | 373 aa | 24.4 % |
Plasmodium falciparum | plasmepsin X | renin | 406 aa | 352 aa | 26.4 % |
Schistosoma japonicum | Lysosomal aspartic protease precursor, putative | Renin | 406 aa | 326 aa | 33.1 % |
Neospora caninum | Cathepsin D enzyme (EC 3.4.23.5), related | Renin | 406 aa | 415 aa | 29.4 % |
Plasmodium falciparum | plasmepsin III | Renin | 406 aa | 346 aa | 29.8 % |
Onchocerca volvulus | Sphingomyelin phosphodiesterase 1 homolog | Renin | 406 aa | 398 aa | 36.2 % |
Candida albicans | secretory aspartyl proteinase SAP5p | Renin | 406 aa | 347 aa | 24.5 % |
Toxoplasma gondii | aspartyl protease | Renin | 406 aa | 423 aa | 29.1 % |
Plasmodium knowlesi | eukaryotic aspartyl protease, putative | Renin | 406 aa | 353 aa | 27.5 % |
Onchocerca volvulus | Renin | 406 aa | 391 aa | 27.1 % | |
Plasmodium falciparum | plasmepsin X | Renin | 406 aa | 352 aa | 26.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | casein kinase II, putative | 0.0792 | 0.3847 | 0.5 |
Plasmodium vivax | unspecified product | 0.0792 | 0.3847 | 0.5 |
Trypanosoma cruzi | casein kinase II, putative | 0.0792 | 0.3847 | 0.5 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0792 | 0.3847 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1858 | 1 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.1858 | 1 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0348 | 0.1284 | 0.1284 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0792 | 0.3847 | 0.5 |
Brugia malayi | Casein kinase II, alpha chain | 0.0792 | 0.3847 | 0.3847 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0792 | 0.3847 | 0.3847 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.1858 | 1 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.0792 | 0.3847 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0792 | 0.3847 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0792 | 0.3847 | 1 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0792 | 0.3847 | 0.3847 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0792 | 0.3847 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1858 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1858 | 1 | 1 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.1858 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.1265 | 0.6574 | 0.6574 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0792 | 0.3847 | 1 |
Mycobacterium leprae | Possible transporter protein | 0.0125 | 0 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0792 | 0.3847 | 0.3847 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0792 | 0.3847 | 1 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.1858 | 1 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0792 | 0.3847 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0348 | 0.1284 | 0.1284 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0792 | 0.3847 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0792 | 0.3847 | 0.5 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0792 | 0.3847 | 0.3847 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0792 | 0.3847 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0792 | 0.3847 | 0.5 |
Trypanosoma brucei | Casein kinase II | 0.0792 | 0.3847 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.8 nM | Inhibition of trypsin-activated human recombinant renin using (Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg) as substrate incubated for 10 mins prior to substrate addition measured after 90 mins by fluorescence assay | ChEMBL. | 23886807 |
IC50 (binding) | = 14 nM | Inhibition of cynomolgus monkey plasma renin assessed as angiotensin 1 level after 60 mins by competitive radioimmunoassay | ChEMBL. | 23886807 |
Ratio IC50 (binding) | = 2.8 | Ratio of compound IC50 to Aliskiren hemifumarate IC50 for cynomolgus monkey plasma renin | ChEMBL. | 23886807 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.