Detailed information for compound 1770369

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 409.869 | Formula: C21H20ClN5O2
  • H donors: 3 H acceptors: 4 LogP: 4.29 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)Nc1cc(CNc2n(nc(c2C#N)C)c2ccccc2)cc(c1O)Cl
  • InChi: 1S/C21H20ClN5O2/c1-3-19(28)25-18-10-14(9-17(22)20(18)29)12-24-21-16(11-23)13(2)26-27(21)15-7-5-4-6-8-15/h4-10,24,29H,3,12H2,1-2H3,(H,25,28)
  • InChiKey: PULMEOOAOGBTBW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0604 0.3557 0.3557
Loa Loa (eye worm) hypothetical protein 0.028 0.1583 0.1583
Echinococcus granulosus hypothetical protein 0.0604 0.3557 0.353
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus granulosus tyrosine kinase 0.1008 0.6024 0.6007
Schistosoma mansoni protein kinase 0.0404 0.2339 0.2322
Giardia lamblia Protein 21.1 0.0404 0.2339 1
Echinococcus granulosus SH2 motif 0.0604 0.3557 0.353
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0604 0.3557 0.3525
Loa Loa (eye worm) TK/FER protein kinase 0.0404 0.2339 0.2339
Onchocerca volvulus 0.0404 0.2339 0.3861
Loa Loa (eye worm) RGC/RGC protein kinase 0.0404 0.2339 0.2339
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Loa Loa (eye worm) TK protein kinase 0.0404 0.2339 0.2339
Echinococcus multilocularis tyrosine protein kinase csk 0.0404 0.2339 0.2301
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0063 0.0255 0.0207
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Schistosoma mansoni ephrin receptor 0.0404 0.2339 0.2322
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0404 0.2339 0.2306
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.1008 0.6024 0.6007
Echinococcus granulosus tyrosine protein kinase csk 0.0404 0.2339 0.2306
Plasmodium falciparum protein kinase, putative 0.0404 0.2339 0.5
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Echinococcus granulosus tyrosine kinase 0.1008 0.6024 0.6007
Brugia malayi Variant SH3 domain containing protein 0.0604 0.3557 0.3557
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0404 0.2339 1
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Schistosoma mansoni serine/threonine protein kinase 0.0404 0.2339 0.2322
Plasmodium falciparum tyrosine kinase-like protein 0.0404 0.2339 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.1008 0.6024 0.6004
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Trichomonas vaginalis CAMK family protein kinase 0.0404 0.2339 1
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0404 0.2339 0.5
Onchocerca volvulus 0.0604 0.3557 0.589
Brugia malayi Carboxylesterase family protein 0.028 0.1583 0.1583
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.028 0.1583 0.1565
Schistosoma mansoni protein kinase 0.0404 0.2339 0.2322
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1008 0.6024 0.6004
Brugia malayi Protein kinase domain containing protein 0.1008 0.6024 0.6024
Loa Loa (eye worm) TK/ROR protein kinase 0.0404 0.2339 0.2339
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0404 0.2339 0.2339
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Schistosoma mansoni hypothetical protein 0.0047 0.0157 0.0137
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1008 0.6024 0.6004
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0404 0.2339 0.2301
Onchocerca volvulus 0.0404 0.2339 0.3861
Trichomonas vaginalis protein tyrosine kinase, putative 0.0404 0.2339 1
Echinococcus multilocularis protein kinase 0.0404 0.2339 0.2301
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0604 0.3557 0.3525
Leishmania major protein kinase, putative 0.0404 0.2339 0.5
Onchocerca volvulus 0.0029 0.0048 0.0046
Echinococcus granulosus activated cdc42 kinase 1 0.0404 0.2339 0.2306
Entamoeba histolytica protein kinase, putative 0.0404 0.2339 0.000000020096
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Trichomonas vaginalis AGC family protein kinase 0.0404 0.2339 1
Trypanosoma cruzi protein kinase, putative 0.0404 0.2339 0.5
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Loa Loa (eye worm) carboxylesterase 0.028 0.1583 0.1583
Loa Loa (eye worm) TK/DDR protein kinase 0.0404 0.2339 0.2339
Echinococcus multilocularis acetylcholinesterase 0.166 1 1
Loa Loa (eye worm) hypothetical protein 0.028 0.1583 0.1583
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus multilocularis neuropeptide receptor A26 0.0449 0.2611 0.2575
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0404 0.2339 0.2322
Echinococcus granulosus SHC transforming protein 3 0.0604 0.3557 0.353
Trypanosoma brucei protein kinase, putative 0.0404 0.2339 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.1008 0.6024 0.6024
Schistosoma mansoni signal transduction protein lnk-related 0.0604 0.3557 0.3543
Mycobacterium leprae PROBABLE HYDROLASE 0.0021 0 0.5
Schistosoma mansoni protein kinase 0.0404 0.2339 0.2322
Echinococcus multilocularis tyrosine protein kinase csk 0.0404 0.2339 0.2301
Echinococcus multilocularis raf serine:threonine protein kinase 0.0404 0.2339 0.2301
Brugia malayi SH2 domain containing protein 0.0604 0.3557 0.3557
Brugia malayi Carboxylesterase family protein 0.166 1 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0404 0.2339 0.2306
Brugia malayi hypothetical protein 0.1008 0.6024 0.6024
Loa Loa (eye worm) TK/FER protein kinase 0.1008 0.6024 0.6024
Brugia malayi STAT protein, DNA binding domain containing protein 0.0604 0.3557 0.3557
Trypanosoma brucei Flagellum attachment zone protein 20 0.0404 0.2339 0.5
Loa Loa (eye worm) hypothetical protein 0.166 1 1
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Schistosoma mansoni tensin-related 0.0604 0.3557 0.3543
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0404 0.2339 0.2301
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Loa Loa (eye worm) TK/FER protein kinase 0.1008 0.6024 0.6024
Loa Loa (eye worm) hypothetical protein 0.0404 0.2339 0.2339
Echinococcus multilocularis carboxylesterase 5A 0.166 1 1
Loa Loa (eye worm) TK protein kinase 0.0404 0.2339 0.2339
Echinococcus granulosus tyrosine protein kinase pr2 0.0404 0.2339 0.2306
Brugia malayi SH2 domain containing protein 0.0604 0.3557 0.3557
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Loa Loa (eye worm) hypothetical protein 0.0063 0.0253 0.0253
Echinococcus multilocularis tyrosine kinase 0.0404 0.2339 0.2301
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0404 0.2339 0.2339
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Brugia malayi SH2 domain containing protein 0.0604 0.3557 0.3557
Schistosoma mansoni tyrosine protein kinase 0.0404 0.2339 0.2322
Schistosoma mansoni BC026374 protein (S09 family) 0.028 0.1583 0.1565
Entamoeba histolytica ankyrin repeat protein 0.0404 0.2339 0.000000020096
Loa Loa (eye worm) TK/ALK protein kinase 0.0404 0.2339 0.2339
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0404 0.2339 0.2301
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0157 0.0157
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0404 0.2339 0.2339
Schistosoma mansoni hypothetical protein 0.0604 0.3557 0.3543
Echinococcus multilocularis tyrosine protein kinase Fgr 0.1008 0.6024 0.6004
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0404 0.2339 0.2306
Echinococcus granulosus acetylcholinesterase 0.166 1 1
Loa Loa (eye worm) hypothetical protein 0.028 0.1583 0.1583
Toxoplasma gondii STE kinase 0.0404 0.2339 1
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Brugia malayi SRC-1 0.1008 0.6024 0.6024
Echinococcus granulosus calpain A 0.0066 0.0273 0.0232
Schistosoma mansoni protein kinase 0.0404 0.2339 0.2322
Brugia malayi hypothetical protein 0.0604 0.3557 0.3557
Loa Loa (eye worm) carboxylesterase 0.166 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0404 0.2339 1
Echinococcus multilocularis SH2 motif 0.0604 0.3557 0.3525
Echinococcus granulosus activin receptor type 0.0404 0.2339 0.2306
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Echinococcus multilocularis receptor type guanylyl cyclase 0.0404 0.2339 0.2301
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0404 0.2339 1
Trichomonas vaginalis conserved hypothetical protein 0.0404 0.2339 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0404 0.2339 0.2339
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1008 0.6024 0.6004
Echinococcus granulosus insulin receptor 0.0404 0.2339 0.2306
Schistosoma mansoni survival motor neuron protein 0.0047 0.0157 0.0137
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.028 0.1583 0.1565
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0404 0.2339 0.2339
Echinococcus granulosus neuropeptide receptor A26 0.0449 0.2611 0.2579
Onchocerca volvulus 0.0404 0.2339 0.3861
Echinococcus multilocularis natriuretic peptide receptor 1 0.0404 0.2339 0.2301
Schistosoma mansoni ephrin receptor 0.0404 0.2339 0.2322
Echinococcus granulosus neuroligin 0.028 0.1583 0.1548
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0404 0.2339 0.2301
Trichomonas vaginalis spcc417.12 protein, putative 0.028 0.1583 0.2898
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus multilocularis N chimaerin 0.0604 0.3557 0.3525
Schistosoma mansoni growth factor receptor-bound protein 0.0604 0.3557 0.3543
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0404 0.2339 0.2306
Echinococcus multilocularis protein KINase family member (kin 25) 0.0404 0.2339 0.2301
Echinococcus multilocularis tyrosine kinase 0.1008 0.6024 0.6004
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Echinococcus granulosus NCK adaptor protein 0.0604 0.3557 0.353
Echinococcus granulosus tyrosine protein kinase Fps85D 0.1008 0.6024 0.6007
Echinococcus granulosus tyrosine protein kinase csk 0.0404 0.2339 0.2306
Loa Loa (eye worm) hypothetical protein 0.028 0.1583 0.1583
Echinococcus multilocularis para nitrobenzyl esterase 0.028 0.1583 0.1542
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0404 0.2339 0.2301
Echinococcus granulosus epidermal growth factor receptor 0.0404 0.2339 0.2306
Echinococcus multilocularis neuropeptide s receptor 0.0449 0.2611 0.2575
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Brugia malayi Guanylyl cyclase protein 23 0.0404 0.2339 0.2339
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.014 0.0092
Echinococcus multilocularis tyrosine protein kinase HCK 0.0404 0.2339 0.2301
Echinococcus multilocularis activin receptor type 0.0404 0.2339 0.2301
Schistosoma mansoni nck2/grb4 0.0604 0.3557 0.3543
Onchocerca volvulus 0.023 0.1275 0.2088
Onchocerca volvulus 0.0404 0.2339 0.3861
Echinococcus multilocularis tyrosine protein kinase shark 0.1008 0.6024 0.6004
Schistosoma mansoni growth factor receptor-bound protein 0.0604 0.3557 0.3543
Loa Loa (eye worm) hypothetical protein 0.028 0.1583 0.1583
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.0273 0.0225
Echinococcus granulosus signal transduction protein lnk realted 0.0604 0.3557 0.353
Brugia malayi Variant SH3 domain containing protein 0.0604 0.3557 0.3557
Echinococcus granulosus suppressor of cytokine signaling 6 0.0604 0.3557 0.353
Loa Loa (eye worm) STAT protein 0.0604 0.3557 0.3557
Echinococcus multilocularis tyrosine protein kinase csk 0.0404 0.2339 0.2301
Echinococcus multilocularis epidermal growth factor receptor 0.0404 0.2339 0.2301
Schistosoma mansoni tyrosine kinase 0.1008 0.6024 0.6015
Schistosoma mansoni tyrosine kinase 0.1008 0.6024 0.6015
Trichomonas vaginalis conserved hypothetical protein 0.0404 0.2339 1
Trichomonas vaginalis TK family protein kinase 0.0404 0.2339 1
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0404 0.2339 0.2306
Brugia malayi SH2 domain containing protein 0.1008 0.6024 0.6024
Loa Loa (eye worm) TK protein kinase 0.0404 0.2339 0.2339
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0604 0.3557 0.589
Echinococcus granulosus retinal guanylyl cyclase 2 0.0404 0.2339 0.2306
Loa Loa (eye worm) hypothetical protein 0.028 0.1583 0.1583
Brugia malayi Protein kinase domain containing protein 0.1008 0.6024 0.6024
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Loa Loa (eye worm) hypothetical protein 0.166 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0404 0.2339 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0404 0.2339 0.2301
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0404 0.2339 1
Brugia malayi hypothetical protein 0.0404 0.2339 0.2339
Brugia malayi bone morphogenetic protein type 1 receptor 0.0404 0.2339 0.2339
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0273 0.0252
Onchocerca volvulus 0.0604 0.3557 0.589
Loa Loa (eye worm) calpain family protein 1 0.0063 0.0253 0.0253
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Brugia malayi hypothetical protein 0.0404 0.2339 0.2339
Schistosoma mansoni tyrosine kinase 0.1008 0.6024 0.6015
Echinococcus granulosus tyrosine protein kinase Src42A 0.1008 0.6024 0.6007
Loa Loa (eye worm) TK/FER protein kinase 0.1008 0.6024 0.6024
Loa Loa (eye worm) RGC/RGC protein kinase 0.0404 0.2339 0.2339
Schistosoma mansoni tensin 0.0604 0.3557 0.3543
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0404 0.2339 0.2306
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0604 0.3557 0.353
Brugia malayi Raf kinase 0.0404 0.2339 0.2339
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Loa Loa (eye worm) calpain family protein 1 0.0044 0.014 0.014
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.166 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0604 0.3557 0.3525
Schistosoma mansoni protein tyrosine kinase 0.0404 0.2339 0.2322
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0048 0.0027
Loa Loa (eye worm) hypothetical protein 0.0404 0.2339 0.2339
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0404 0.2339 0.2306
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Brugia malayi tRNA modification GTPase TrmE family protein 0.0604 0.3557 0.3557
Loa Loa (eye worm) TK/CSK protein kinase 0.0404 0.2339 0.2339
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Echinococcus multilocularis neuroligin 0.028 0.1583 0.1542
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Schistosoma mansoni acetylcholinesterase 0.028 0.1583 0.1565
Loa Loa (eye worm) hypothetical protein 0.0404 0.2339 0.2339
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0604 0.3557 0.353
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.028 0.1583 1
Mycobacterium ulcerans carboxylesterase, LipT 0.028 0.1583 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0404 0.2339 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0404 0.2339 0.2306
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0404 0.2339 0.2306
Brugia malayi Tyrosine-protein kinase PR2 0.0404 0.2339 0.2339
Loa Loa (eye worm) TK/FER protein kinase 0.0404 0.2339 0.2339
Schistosoma mansoni vav2 0.0604 0.3557 0.3543
Schistosoma mansoni adapter molecule crk 0.0604 0.3557 0.3543
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0404 0.2339 0.2339
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Onchocerca volvulus 0.1008 0.6024 1
Trichomonas vaginalis conserved hypothetical protein 0.0404 0.2339 1
Trichomonas vaginalis protein kinase atn1, putative 0.0404 0.2339 1
Echinococcus multilocularis NCK adaptor protein 0.0604 0.3557 0.3525
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0404 0.2339 1
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Onchocerca volvulus 0.1008 0.6024 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1008 0.6024 0.6007
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0404 0.2339 0.2339
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0604 0.3557 0.3306
Onchocerca volvulus 0.028 0.1583 0.2602
Echinococcus multilocularis tyrosine protein kinase pr2 0.0404 0.2339 0.2301
Echinococcus granulosus tyrosine protein kinase Fyn 0.1008 0.6024 0.6007
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Echinococcus granulosus SH2 motif 0.0604 0.3557 0.353
Onchocerca volvulus 0.0047 0.0157 0.0227
Brugia malayi RhoGAP domain containing protein 0.0604 0.3557 0.3557
Brugia malayi Protein kinase domain containing protein 0.1008 0.6024 0.6024
Echinococcus multilocularis insulin receptor 0.0404 0.2339 0.2301
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0404 0.2339 0.2322
Schistosoma mansoni protein kinase 0.0404 0.2339 0.2322
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0604 0.3557 0.3543
Schistosoma mansoni protein kinase 0.0404 0.2339 0.2322
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0404 0.2339 0.3861
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0787 0.4674 0.4649
Brugia malayi cytokine inducible SH2-containing protein 5 0.0604 0.3557 0.3557
Echinococcus multilocularis integrin linked protein kinase 0.0404 0.2339 0.2301
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0404 0.2339 0.2339
Loa Loa (eye worm) hypothetical protein 0.0404 0.2339 0.2339
Plasmodium falciparum protein kinase, putative 0.0404 0.2339 0.5
Brugia malayi Protein kinase domain containing protein 0.1008 0.6024 0.6024
Brugia malayi Immunoglobulin I-set domain containing protein 0.0404 0.2339 0.2339
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Loa Loa (eye worm) TK protein kinase 0.1008 0.6024 0.6024
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.1008 0.6024 0.6007
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0404 0.2339 1
Brugia malayi Furin-like cysteine rich region family protein 0.0404 0.2339 0.2339
Brugia malayi SH2 domain containing protein 0.0604 0.3557 0.3557
Giardia lamblia Kinase, NEK 0.0404 0.2339 1
Trichomonas vaginalis STE family protein kinase 0.0404 0.2339 1
Echinococcus granulosus tyrosine protein kinase csk 0.0404 0.2339 0.2306
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Trichomonas vaginalis conserved hypothetical protein 0.0404 0.2339 1
Brugia malayi Carboxylesterase family protein 0.028 0.1583 0.1583
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Brugia malayi Variant SH3 domain containing protein 0.0604 0.3557 0.3557
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0404 0.2339 0.2301
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.1008 0.6024 0.6007
Echinococcus multilocularis 0.0604 0.3557 0.3525
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Brugia malayi Carboxylesterase family protein 0.028 0.1583 0.1583
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0604 0.3557 0.3525
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0404 0.2339 0.2306
Brugia malayi integrin-linked kinase 0.0404 0.2339 0.2339
Schistosoma mansoni serine/threonine RGC 0.0404 0.2339 0.2322
Echinococcus multilocularis tyrosine protein kinase Blk 0.1008 0.6024 0.6004
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0604 0.3557 0.3543
Schistosoma mansoni protein kinase 0.0404 0.2339 0.2322
Brugia malayi ephrin receptor 1 precursor 0.0404 0.2339 0.2339
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0404 0.2339 0.2322
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1008 0.6024 0.6004
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.0253 0.0233
Brugia malayi hypothetical protein 0.023 0.1272 0.1272
Echinococcus granulosus epidermal growth factor receptor 0.0404 0.2339 0.2306
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0604 0.3557 0.3543
Echinococcus multilocularis BC026374 protein (S09 family) 0.028 0.1583 0.1542
Schistosoma mansoni hypothetical protein 0.0404 0.2339 0.2322
Loa Loa (eye worm) hypothetical protein 0.0404 0.2339 0.2339
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0404 0.2339 0.2301
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Brugia malayi Hemopexin family protein 0.0024 0.0021 0.0021
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0404 0.2339 0.2306
Entamoeba histolytica SH2-protein kinase domain containing protein 0.1008 0.6024 1
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Brugia malayi Sex muscle abnormal protein 5 0.0604 0.3557 0.3557
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0604 0.3557 0.353
Loa Loa (eye worm) TK/FER protein kinase 0.1008 0.6024 0.6024
Entamoeba histolytica SH2 domain containing protein 0.0604 0.3557 0.3306
Echinococcus multilocularis growth factor receptor bound protein 2 0.0604 0.3557 0.3525
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0404 0.2339 0.5
Brugia malayi SH2 domain containing protein 0.0604 0.3557 0.3557
Schistosoma mansoni gliotactin 0.028 0.1583 0.1565
Echinococcus granulosus ephrin type A receptor 4 A 0.0404 0.2339 0.2306
Loa Loa (eye worm) hypothetical protein 0.0044 0.014 0.014
Echinococcus granulosus retinal guanylyl cyclase 2 0.0404 0.2339 0.2306
Echinococcus multilocularis tensin 0.0604 0.3557 0.3525
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Schistosoma mansoni protein kinase 0.0404 0.2339 0.2322
Loa Loa (eye worm) hypothetical protein 0.0044 0.014 0.014
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Onchocerca volvulus 0.0404 0.2339 0.3861
Loa Loa (eye worm) TK protein kinase 0.0404 0.2339 0.2339
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Schistosoma mansoni tensin 0.0604 0.3557 0.3543
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0404 0.2339 0.2339
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Leishmania major hypothetical protein, conserved 0.0404 0.2339 0.5
Onchocerca volvulus 0.1008 0.6024 1
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Echinococcus granulosus acetylcholinesterase 0.166 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0604 0.3557 0.3557
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0604 0.3557 0.589
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0048 0.0007
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Trichomonas vaginalis conserved hypothetical protein 0.0404 0.2339 1
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Loa Loa (eye worm) SRC-1 0.1008 0.6024 0.6024
Schistosoma mansoni serine/threonine protein kinase 0.0404 0.2339 0.2322
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0404 0.2339 0.2306
Echinococcus granulosus c src tyrosine kinase 0.1008 0.6024 0.6007
Brugia malayi Variant SH3 domain containing protein 0.0604 0.3557 0.3557
Echinococcus multilocularis calpain A 0.0066 0.0273 0.0225
Schistosoma mansoni SH2A 0.0604 0.3557 0.3543
Loa Loa (eye worm) TK/ABL protein kinase 0.1008 0.6024 0.6024
Loa Loa (eye worm) TK/FER protein kinase 0.1008 0.6024 0.6024
Onchocerca volvulus 0.0604 0.3557 0.589
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0404 0.2339 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.1008 0.6024 0.6015
Loa Loa (eye worm) matrixin family protein 0.0042 0.0126 0.0126
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.1008 0.6024 0.6004
Echinococcus multilocularis tyrosine protein kinase Abl 0.1008 0.6024 0.6004
Echinococcus multilocularis SH2 motif 0.0604 0.3557 0.3525
Schistosoma mansoni protein kinase 0.0404 0.2339 0.2322
Schistosoma mansoni suppressor of cytokine signaling 0.0604 0.3557 0.3543
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Brugia malayi C-terminal src kinase protein 1 0.0404 0.2339 0.2339
Onchocerca volvulus 0.1008 0.6024 1
Echinococcus multilocularis SHC transforming protein 3 0.0604 0.3557 0.3525
Echinococcus granulosus natriuretic peptide receptor 1 0.0404 0.2339 0.2306
Loa Loa (eye worm) TK protein kinase 0.0404 0.2339 0.2339
Loa Loa (eye worm) TK/RYK protein kinase 0.0404 0.2339 0.2339
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0404 0.2339 0.2339
Echinococcus multilocularis heat shock protein 70 0.0404 0.2339 0.2301
Echinococcus granulosus tyrosine protein kinase HCK 0.0404 0.2339 0.2306
Echinococcus granulosus tyrosine protein kinase 0.0404 0.2339 0.2306
Loa Loa (eye worm) TK/FER protein kinase 0.0404 0.2339 0.2339
Brugia malayi Matrixin family protein 0.0042 0.0126 0.0126
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Loa Loa (eye worm) acetylcholinesterase 1 0.166 1 1
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus multilocularis protein tyrosine kinase 0.0404 0.2339 0.2301
Echinococcus multilocularis protein kinase 0.0404 0.2339 0.2301
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Onchocerca volvulus 0.0404 0.2339 0.3861
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0048 0.0027
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0404 0.2339 0.2301
Echinococcus granulosus tyrosine protein kinase Srms 0.1008 0.6024 0.6007
Echinococcus granulosus growth factor receptor bound protein 2 0.0604 0.3557 0.353
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.1008 0.6024 0.6004
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.1008 0.6024 0.6007
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0404 0.2339 0.3861
Echinococcus granulosus SH2 domain containing adapter protein F 0.0604 0.3557 0.353
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0404 0.2339 1
Plasmodium falciparum protein kinase, putative 0.0404 0.2339 0.5
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0404 0.2339 0.2306
Brugia malayi Tensin 0.0604 0.3557 0.3557
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0404 0.2339 0.2301
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1272 0.123
Onchocerca volvulus 0.028 0.1583 0.2602
Onchocerca volvulus 0.1008 0.6024 1
Echinococcus granulosus tensin 0.0604 0.3557 0.353
Brugia malayi calpain family protein 1 0.0063 0.0253 0.0253
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0404 0.2339 0.2339
Loa Loa (eye worm) TK/ACK protein kinase 0.0404 0.2339 0.2339
Loa Loa (eye worm) hypothetical protein 0.0029 0.0048 0.0048
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0604 0.3557 0.3525
Plasmodium vivax protein kinase, putative 0.0404 0.2339 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0604 0.3557 0.3557
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.028 0.1583 0.1565
Onchocerca volvulus 0.0404 0.2339 0.3861
Onchocerca volvulus 0.0044 0.014 0.0198
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0604 0.3557 0.3543
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.1008 0.6024 0.6004
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Loa Loa (eye worm) hypothetical protein 0.0404 0.2339 0.2339
Brugia malayi SH2 domain containing protein 0.0604 0.3557 0.3557
Echinococcus multilocularis SH2 motif 0.0604 0.3557 0.3525
Echinococcus granulosus SH2 domain containing protein 7 0.0604 0.3557 0.353
Schistosoma mansoni tensin 0.0604 0.3557 0.3543
Loa Loa (eye worm) protein kinase domain-containing protein 0.0404 0.2339 0.2339
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0404 0.2339 0.2339
Loa Loa (eye worm) RGC/RGC protein kinase 0.0404 0.2339 0.2339
Schistosoma mansoni suppressor of cytokine signaling 0.0604 0.3557 0.3543
Brugia malayi Receptor family ligand binding region containing protein 0.0404 0.2339 0.2339
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1272 0.1235
Schistosoma mansoni GTPase activating protein 0.0604 0.3557 0.3543
Onchocerca volvulus 0.0604 0.3557 0.589
Echinococcus multilocularis kinase suppressor of Ras 1 0.0404 0.2339 0.2301
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Entamoeba histolytica protein kinase, putative 0.0404 0.2339 0.000000020096
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Echinococcus multilocularis epidermal growth factor receptor 0.0404 0.2339 0.2301
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Onchocerca volvulus 0.028 0.1583 0.2602
Loa Loa (eye worm) hypothetical protein 0.0404 0.2339 0.2339
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Echinococcus granulosus neuropeptide s receptor 0.0449 0.2611 0.2579
Schistosoma mansoni tyrosine kinase 0.1008 0.6024 0.6015
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0604 0.3557 0.3525
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0604 0.3557 0.3525
Echinococcus multilocularis SH2 domain containing protein 7 0.0604 0.3557 0.3525
Echinococcus multilocularis transfer RNA-Thr 0.0404 0.2339 0.2301
Echinococcus granulosus tyrosine protein kinase Blk 0.1008 0.6024 0.6007
Echinococcus multilocularis c src tyrosine kinase 0.1008 0.6024 0.6004
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1008 0.6024 0.6004
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0404 0.2339 0.2339
Echinococcus multilocularis activated cdc42 kinase 1 0.0404 0.2339 0.2301
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0404 0.2339 0.2322
Loa Loa (eye worm) hypothetical protein 0.0063 0.0253 0.0253
Onchocerca volvulus Tyrosine kinase homolog 0.0404 0.2339 0.3861
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0038 0.0105 0.014
Loa Loa (eye worm) TK/FER protein kinase 0.0404 0.2339 0.2339
Echinococcus multilocularis FL cytokine receptor 0.0404 0.2339 0.2301
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Onchocerca volvulus 0.0404 0.2339 0.3861
Loa Loa (eye worm) TK/FER protein kinase 0.1008 0.6024 0.6024
Loa Loa (eye worm) SH2 domain-containing protein 0.0604 0.3557 0.3557
Loa Loa (eye worm) SH2 domain-containing protein 0.0604 0.3557 0.3557
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Loa Loa (eye worm) TK protein kinase 0.0404 0.2339 0.2339
Loa Loa (eye worm) hypothetical protein 0.023 0.1272 0.1272
Brugia malayi protein-tyrosine kinase 0.1008 0.6024 0.6024
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0273 0.0252
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Loa Loa (eye worm) hypothetical protein 0.0404 0.2339 0.2339
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.1008 0.6024 0.6007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1104 0.1104
Echinococcus multilocularis tyrosine protein kinase 0.0404 0.2339 0.2301
Leishmania major protein kinase, putative 0.0404 0.2339 0.5
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0404 0.2339 0.2301
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Schistosoma mansoni serine/threonine protein kinase 0.0404 0.2339 0.2322
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus granulosus tyrosine kinase 0.0404 0.2339 0.2306
Echinococcus granulosus suppressor of cytokine signaling 7 0.0604 0.3557 0.353
Plasmodium falciparum tyrosine kinase-like protein 0.0404 0.2339 0.5
Echinococcus granulosus family S9 non peptidase ue S09 family 0.028 0.1583 0.1548
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0063 0.0255 0.0214
Echinococcus multilocularis acetylcholinesterase 0.166 1 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0604 0.3557 0.3525
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0404 0.2339 0.2322
Brugia malayi Tyrosine-protein kinase abl-1 0.1008 0.6024 0.6024
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0604 0.3557 0.3543
Onchocerca volvulus 0.0404 0.2339 0.3861
Echinococcus multilocularis tensin 0.0604 0.3557 0.3525
Brugia malayi Carboxylesterase family protein 0.028 0.1583 0.1583
Schistosoma mansoni protein kinase 0.0404 0.2339 0.2322
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1008 0.6024 0.6004
Echinococcus multilocularis tyrosine protein kinase Src64B 0.1008 0.6024 0.6004
Echinococcus granulosus expressed conserved protein 0.0604 0.3557 0.353
Loa Loa (eye worm) TK protein kinase 0.0404 0.2339 0.2339
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0404 0.2339 0.2306
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0404 0.2339 0.2339
Entamoeba histolytica protein kinase, putative 0.0604 0.3557 0.3306
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.0273 0.0232
Toxoplasma gondii protein kinase 0.0404 0.2339 1
Schistosoma mansoni serine/threonine protein kinase 0.0404 0.2339 0.2322
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0404 0.2339 0.5
Mycobacterium tuberculosis Carboxylesterase LipT 0.028 0.1583 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0604 0.3557 0.353
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0604 0.3557 0.3557
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0404 0.2339 0.2301
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0604 0.3557 0.3557
Schistosoma mansoni protein kinase 0.0404 0.2339 0.2322
Echinococcus granulosus tyrosine protein kinase ABL1 0.1008 0.6024 0.6007
Loa Loa (eye worm) hypothetical protein 0.0404 0.2339 0.2339
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Echinococcus granulosus activated cdc42 kinase 1 0.0404 0.2339 0.2306
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0604 0.3557 0.3525
Brugia malayi SH2 domain containing protein 0.1008 0.6024 0.6024
Loa Loa (eye worm) hypothetical protein 0.0404 0.2339 0.2339
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0404 0.2339 0.2322
Loa Loa (eye worm) TK protein kinase 0.0404 0.2339 0.2339
Plasmodium vivax tyrosine kinase-like protein, putative 0.0404 0.2339 1
Schistosoma mansoni tyrosine kinase 0.1008 0.6024 0.6015
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0048 0.0027
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0604 0.3557 0.3557
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Echinococcus granulosus integrin linked protein kinase 0.0404 0.2339 0.2306
Trypanosoma brucei Pseudokinase, putative 0.0404 0.2339 0.5
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0604 0.3557 0.353
Loa Loa (eye worm) TK/FER protein kinase 0.1008 0.6024 0.6024
Echinococcus multilocularis tyrosine protein kinase Srms 0.1008 0.6024 0.6004
Trypanosoma cruzi protein kinase, putative 0.0404 0.2339 0.5
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0404 0.2339 0.2301
Onchocerca volvulus 0.028 0.1583 0.2602
Loa Loa (eye worm) TK/FER protein kinase 0.1008 0.6024 0.6024
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Loa Loa (eye worm) hypothetical protein 0.028 0.1583 0.1583
Schistosoma mansoni hypothetical protein 0.0604 0.3557 0.3543
Loa Loa (eye worm) matrixin family protein 0.0038 0.0105 0.0105
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.028 0.1583 0.2898
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus granulosus para nitrobenzyl esterase 0.028 0.1583 0.1548
Echinococcus granulosus protein kinase 0.0404 0.2339 0.2306
Echinococcus granulosus tyrosine protein kinase shark 0.1008 0.6024 0.6007
Brugia malayi SH2 domain containing protein 0.0604 0.3557 0.3557
Loa Loa (eye worm) carboxylesterase 0.028 0.1583 0.1583
Echinococcus granulosus tyrosine protein kinase Src64B 0.1008 0.6024 0.6007
Echinococcus multilocularis tyrosine protein kinase csk 0.0404 0.2339 0.2301
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0404 0.2339 0.2339
Echinococcus granulosus kinase suppressor of Ras 1 0.0404 0.2339 0.2306
Echinococcus granulosus N chimaerin 0.0604 0.3557 0.353
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0404 0.2339 0.2339
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Onchocerca volvulus 0.0604 0.3557 0.589
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1008 0.6024 0.6004
Schistosoma mansoni tensin-related 0.0604 0.3557 0.3543
Loa Loa (eye worm) TK/FER protein kinase 0.0404 0.2339 0.2339
Loa Loa (eye worm) TK/FER protein kinase 0.1008 0.6024 0.6024
Brugia malayi Protein kinase domain containing protein 0.1008 0.6024 0.6024
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0404 0.2339 0.2306
Loa Loa (eye worm) TK/FAK protein kinase 0.0404 0.2339 0.2339
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0604 0.3557 0.3557
Trichomonas vaginalis conserved hypothetical protein 0.0404 0.2339 1
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Brugia malayi Pre-SET motif family protein 0.0029 0.0048 0.0048
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0404 0.2339 0.2301
Schistosoma mansoni tyrosine kinase 0.1008 0.6024 0.6015
Brugia malayi hypothetical protein 0.028 0.1583 0.1583
Loa Loa (eye worm) RGC/RGC protein kinase 0.0404 0.2339 0.2339
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Loa Loa (eye worm) hypothetical protein 0.0404 0.2339 0.2339
Loa Loa (eye worm) hypothetical protein 0.0404 0.2339 0.2339
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Brugia malayi Protein kinase domain containing protein 0.0404 0.2339 0.2339
Loa Loa (eye worm) TK/EGFR protein kinase 0.0404 0.2339 0.2339
Loa Loa (eye worm) TK protein kinase 0.0404 0.2339 0.2339
Echinococcus granulosus protein tyrosine kinase 0.0404 0.2339 0.2306
Echinococcus granulosus receptor type guanylyl cyclase 0.0404 0.2339 0.2306
Onchocerca volvulus 0.1008 0.6024 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0404 0.2339 0.2339
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Echinococcus granulosus carboxylesterase 5A 0.166 1 1
Loa Loa (eye worm) hypothetical protein 0.1008 0.6024 0.6024
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.028 0.1583 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0604 0.3557 0.3557
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.028 0.1583 0.1542
Onchocerca volvulus Matrilysin homolog 0.0038 0.0105 0.014
Echinococcus granulosus BC026374 protein S09 family 0.028 0.1583 0.1548
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0604 0.3557 0.353
Loa Loa (eye worm) hypothetical protein 0.0604 0.3557 0.3557
Brugia malayi calpain family protein 1 0.0063 0.0253 0.0253
Loa Loa (eye worm) TK/Met protein kinase 0.0404 0.2339 0.2339
Echinococcus granulosus tyrosine protein kinase Fyn 0.1008 0.6024 0.6007
Echinococcus granulosus fibroblast growth factor receptor 4 0.0404 0.2339 0.2306
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Onchocerca volvulus 0.028 0.1583 0.2602
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0604 0.3557 0.3525
Trichomonas vaginalis TKL family protein kinase 0.0404 0.2339 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0048 0.0027
Toxoplasma gondii protein kinase domain-containing protein 0.0404 0.2339 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0404 0.2339 0.2339
Onchocerca volvulus 0.0604 0.3557 0.589
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0404 0.2339 0.2301
Loa Loa (eye worm) TK/FER protein kinase 0.0404 0.2339 0.2339
Loa Loa (eye worm) TK/FER protein kinase 0.0404 0.2339 0.2339
Schistosoma mansoni shc transforming protein 0.0604 0.3557 0.3543
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.028 0.1583 0.1565
Schistosoma mansoni tyrosine kinase 0.0404 0.2339 0.2322
Brugia malayi Pre-SET motif family protein 0.0202 0.1104 0.1104

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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