Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Onchocerca volvulus | Putative 4.1 G protein | 0.0273 | 0.0048 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2292 | 0.0922 | 0.0922 |
Loa Loa (eye worm) | hypothetical protein | 0.7668 | 0.3248 | 0.3248 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Trypanosoma cruzi | hypothetical protein | 0.0273 | 0.0048 | 0.5 |
Plasmodium falciparum | tyrosine kinase-like protein | 0.0214 | 0.0022 | 0.5 |
Onchocerca volvulus | 0.0273 | 0.0048 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0273 | 0.0048 | 0.5 |
Schistosoma mansoni | merlin/moesin/ezrin/radixin | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.2292 | 0.0922 | 0.0922 |
Onchocerca volvulus | 0.0273 | 0.0048 | 0.5 | |
Brugia malayi | Ferm domain | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | GRP1 binding protein | 0.0273 | 0.0048 | 0.0048 |
Echinococcus granulosus | protein tyrosine kinase | 2.2998 | 0.9882 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | Protein orai-1 | 0.7668 | 0.3248 | 0.3287 |
Schistosoma mansoni | hypothetical protein | 0.0682 | 0.0225 | 0.0228 |
Echinococcus granulosus | calcium release activated calcium channel | 0.7668 | 0.3248 | 0.3254 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Plasmodium falciparum | protein kinase, putative | 0.0214 | 0.0022 | 0.5 |
Brugia malayi | MyTH4 domain containing protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | tyrosine kinase | 2.2998 | 0.9882 | 1 |
Loa Loa (eye worm) | neurofibromin 2 isoform 8 | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | Radixin | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | Ferm domain (protein4.1-ezrin-radixin-moesin) family protein 4-like | 0.0273 | 0.0048 | 0.0048 |
Trichomonas vaginalis | protein MLP1, putative | 0.0273 | 0.0048 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0273 | 0.0048 | 0.5 |
Entamoeba histolytica | filopodin, putative | 0.0273 | 0.0048 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0807 | 0.0279 | 0.0282 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Trypanosoma cruzi | ribonuclease inhibitor, putative | 0.0273 | 0.0048 | 0.5 |
Echinococcus granulosus | stromal interaction molecule 1 | 0.1489 | 0.0574 | 0.0535 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | FERM domain | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | Talin 1 | 0.0273 | 0.0048 | 0.0048 |
Plasmodium vivax | tyrosine kinase-like protein, putative | 0.0214 | 0.0022 | 0.5 |
Brugia malayi | Moesin/ezrin/radixin homolog 1 | 0.0273 | 0.0048 | 0.0048 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.7668 | 0.3248 | 0.3254 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Trypanosoma cruzi | ribonuclease inhibitor, putative | 0.0273 | 0.0048 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0273 | 0.0048 | 0.5 |
Echinococcus multilocularis | protein tyrosine kinase | 2.2998 | 0.9882 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | talin | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | Ferm domain | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | TK/FAK protein kinase | 2.3271 | 1 | 1 |
Entamoeba histolytica | leucine-rich repeat containing protein | 0.0273 | 0.0048 | 0.5 |
Brugia malayi | neurofibromatosis homolog protein 1 | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | Protein orai-1 | 0.7668 | 0.3248 | 0.3287 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Onchocerca volvulus | 0.0273 | 0.0048 | 0.5 | |
Schistosoma mansoni | merlin/moesin/ezrin/radixin | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | hypothetical protein | 0.1489 | 0.0574 | 0.0574 |
Brugia malayi | hypothetical protein | 0.7668 | 0.3248 | 0.3248 |
Brugia malayi | Unc-112 related protein. | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | moesin | 0.0273 | 0.0048 | 0.0048 |
Entamoeba histolytica | filopodin, putative | 0.0273 | 0.0048 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | GH28553p | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | MyTH4 domain-containing protein | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.1489 | 0.0574 | 0.0574 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | merlin/moesin/ezrin/radixin | 0.0273 | 0.0048 | 0.0048 |
Onchocerca volvulus | 0.0273 | 0.0048 | 0.5 | |
Schistosoma mansoni | Band 4.1-like protein | 0.0273 | 0.0048 | 0.0048 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0273 | 0.0048 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Onchocerca volvulus | 0.0273 | 0.0048 | 0.5 | |
Schistosoma mansoni | talin 2 | 0.0273 | 0.0048 | 0.0048 |
Onchocerca volvulus | 4.1 G protein, putative homolog | 0.0273 | 0.0048 | 0.5 |
Brugia malayi | protein-tyrosine-phosphatase | 0.0273 | 0.0048 | 0.0048 |
Trypanosoma cruzi | ribonuclease inhibitor, putative | 0.0273 | 0.0048 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Echinococcus multilocularis | stromal interaction molecule 1 | 0.1489 | 0.0574 | 0.0535 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 9.5 uM | Antiproliferative activity against human HeLa cells after 48 hrs by MTS assay | ChEMBL. | 23855338 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23855338 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.