Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/FAK protein kinase | 2.3271 | 1 | 1 |
Brugia malayi | Ferm domain | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | Protein orai-1 | 0.7668 | 0.3248 | 0.3287 |
Onchocerca volvulus | 0.0273 | 0.0048 | 0.5 | |
Brugia malayi | neurofibromatosis homolog protein 1 | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Entamoeba histolytica | leucine-rich repeat containing protein | 0.0273 | 0.0048 | 0.5 |
Schistosoma mansoni | merlin/moesin/ezrin/radixin | 0.0273 | 0.0048 | 0.0048 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0273 | 0.0048 | 0.5 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.7668 | 0.3248 | 0.3254 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Trypanosoma cruzi | ribonuclease inhibitor, putative | 0.0273 | 0.0048 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Echinococcus multilocularis | protein tyrosine kinase | 2.2998 | 0.9882 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | talin | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | Moesin/ezrin/radixin homolog 1 | 0.0273 | 0.0048 | 0.0048 |
Plasmodium vivax | tyrosine kinase-like protein, putative | 0.0214 | 0.0022 | 0.5 |
Brugia malayi | Talin 1 | 0.0273 | 0.0048 | 0.0048 |
Trypanosoma cruzi | ribonuclease inhibitor, putative | 0.0273 | 0.0048 | 0.5 |
Brugia malayi | FERM domain | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Echinococcus granulosus | stromal interaction molecule 1 | 0.1489 | 0.0574 | 0.0535 |
Trypanosoma cruzi | ribonuclease inhibitor, putative | 0.0273 | 0.0048 | 0.5 |
Brugia malayi | protein-tyrosine-phosphatase | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Echinococcus multilocularis | stromal interaction molecule 1 | 0.1489 | 0.0574 | 0.0535 |
Brugia malayi | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Onchocerca volvulus | 0.0273 | 0.0048 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | Band 4.1-like protein | 0.0273 | 0.0048 | 0.0048 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0273 | 0.0048 | 0.5 |
Onchocerca volvulus | 4.1 G protein, putative homolog | 0.0273 | 0.0048 | 0.5 |
Onchocerca volvulus | 0.0273 | 0.0048 | 0.5 | |
Schistosoma mansoni | talin 2 | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | MyTH4 domain-containing protein | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | GH28553p | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.1489 | 0.0574 | 0.0574 |
Schistosoma mansoni | merlin/moesin/ezrin/radixin | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | hypothetical protein | 0.7668 | 0.3248 | 0.3248 |
Brugia malayi | Unc-112 related protein. | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | hypothetical protein | 0.1489 | 0.0574 | 0.0574 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Entamoeba histolytica | filopodin, putative | 0.0273 | 0.0048 | 0.5 |
Loa Loa (eye worm) | moesin | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Onchocerca volvulus | 0.0273 | 0.0048 | 0.5 | |
Brugia malayi | GRP1 binding protein | 0.0273 | 0.0048 | 0.0048 |
Brugia malayi | Ferm domain | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Echinococcus granulosus | protein tyrosine kinase | 2.2998 | 0.9882 | 1 |
Onchocerca volvulus | 0.0273 | 0.0048 | 0.5 | |
Plasmodium falciparum | tyrosine kinase-like protein | 0.0214 | 0.0022 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0273 | 0.0048 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2292 | 0.0922 | 0.0922 |
Schistosoma mansoni | merlin/moesin/ezrin/radixin | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.7668 | 0.3248 | 0.3248 |
Trypanosoma cruzi | hypothetical protein | 0.0273 | 0.0048 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Onchocerca volvulus | Putative 4.1 G protein | 0.0273 | 0.0048 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2292 | 0.0922 | 0.0922 |
Brugia malayi | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | Radixin | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Trichomonas vaginalis | protein MLP1, putative | 0.0273 | 0.0048 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0273 | 0.0048 | 0.5 |
Brugia malayi | Ferm domain (protein4.1-ezrin-radixin-moesin) family protein 4-like | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Entamoeba histolytica | filopodin, putative | 0.0273 | 0.0048 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0807 | 0.0279 | 0.0282 |
Loa Loa (eye worm) | neurofibromin 2 isoform 8 | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | Protein orai-1 | 0.7668 | 0.3248 | 0.3287 |
Echinococcus granulosus | calcium release activated calcium channel | 0.7668 | 0.3248 | 0.3254 |
Schistosoma mansoni | hypothetical protein | 0.0682 | 0.0225 | 0.0228 |
Plasmodium falciparum | protein kinase, putative | 0.0214 | 0.0022 | 0.5 |
Brugia malayi | MyTH4 domain containing protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Schistosoma mansoni | tyrosine kinase | 2.2998 | 0.9882 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0048 | 0.0048 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.7 uM | Antiproliferative activity against human HeLa cells after 48 hrs by MTS assay | ChEMBL. | 23855338 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23855338 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.