Detailed information for compound 1773793

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 311.762 | Formula: C18H14ClNO2
  • H donors: 1 H acceptors: 1 LogP: 3.86 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1cc2c(o1)c1c(n2Cc2cccc(c2)Cl)cccc1
  • InChi: 1S/C18H14ClNO2/c19-13-5-3-4-12(8-13)10-20-16-7-2-1-6-15(16)18-17(20)9-14(11-21)22-18/h1-9,21H,10-11H2
  • InChiKey: CRKSCWBQGRHEER-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Entamoeba histolytica serine/threonine kinase, putative 0.0873 0.3928 0.3927
Echinococcus granulosus kinase suppressor of Ras 1 0.0873 0.3928 0.3927
Entamoeba histolytica serine/threonine kinase, putative 0.0873 0.3928 0.3927
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1309 0.5947 0.5954
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0069 0.0212 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0259 0.0641
Schistosoma mansoni shc transforming protein 0.1309 0.5947 0.5957
Loa Loa (eye worm) TK protein kinase 0.0873 0.3928 0.3923
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0259 0.0641
Loa Loa (eye worm) TK/Met protein kinase 0.0873 0.3928 0.3923
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0103 0.0091
Schistosoma mansoni growth factor receptor-bound protein 0.1309 0.5947 0.5957
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0873 0.3928 0.9996
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Brugia malayi Variant SH3 domain containing protein 0.1309 0.5947 0.5954
Brugia malayi RhoGAP domain containing protein 0.1309 0.5947 0.5954
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0873 0.3929 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0053 0.0136 0.0125
Echinococcus multilocularis SH2 motif 0.1309 0.5947 0.5952
Onchocerca volvulus 0.0873 0.3928 0.3722
Echinococcus multilocularis 0.1309 0.5947 0.5952
Echinococcus granulosus NCK adaptor protein 0.1309 0.5947 0.5951
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0328 0.032
Schistosoma mansoni protein kinase 0.0873 0.3928 0.3934
Brugia malayi cytokine inducible SH2-containing protein 5 0.1309 0.5947 0.5954
Entamoeba histolytica hypothetical protein 0.0036 0.0057 0.0046
Giardia lamblia Kinase, NEK 0.0873 0.3928 1
Echinococcus granulosus SH2 domain containing protein 7 0.1309 0.5947 0.5951
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.1309 0.5947 0.5951
Loa Loa (eye worm) TK/ACK protein kinase 0.0873 0.3928 0.3923
Entamoeba histolytica tyrosine kinase, putative 0.0877 0.3945 0.3944
Loa Loa (eye worm) serine/threonine protein kinase 0.0873 0.3928 0.3923
Echinococcus multilocularis tyrosine protein kinase Fgr 0.2182 0.9983 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1309 0.5947 0.5951
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0122 0.0114
Schistosoma mansoni kinase 0.0048 0.0113 0.0113
Echinococcus granulosus tyrosine protein kinase Srms 0.2182 0.9983 0.9999
Schistosoma mansoni tensin 0.1309 0.5947 0.5957
Echinococcus granulosus tyrosine protein kinase ABL1 0.2182 0.9983 0.9999
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Loa Loa (eye worm) TK protein kinase 0.0873 0.3928 0.3923
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.2182 0.9983 0.9999
Brugia malayi hypothetical protein 0.0036 0.0057 0.005
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0873 0.3928 0.3927
Echinococcus multilocularis tyrosine protein kinase csk 0.0873 0.3928 0.3927
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2182 0.9983 1
Brugia malayi Furin-like cysteine rich region family protein 0.0873 0.3928 0.393
Echinococcus multilocularis SH2 domain containing protein 7 0.1309 0.5947 0.5952
Onchocerca volvulus 0.0873 0.3928 0.3722
Leishmania major hypothetical protein, conserved 0.0873 0.3928 0.9996
Loa Loa (eye worm) hypothetical protein 0.0873 0.3928 0.3923
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0328 0.0816
Echinococcus multilocularis epidermal growth factor receptor 0.0873 0.3928 0.3927
Loa Loa (eye worm) hypothetical protein 0.0873 0.3928 0.3923
Trypanosoma brucei protein kinase, putative 0.0873 0.3929 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.1309 0.5947 0.5952
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1309 0.5947 0.5957
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.2182 0.9983 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.2182 0.9983 0.9999
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Echinococcus multilocularis SH2 motif 0.1309 0.5947 0.5952
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Schistosoma mansoni tensin-related 0.1309 0.5947 0.5957
Brugia malayi hypothetical protein 0.2182 0.9983 1
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Schistosoma mansoni tsg101-related 0.0058 0.0159 0.0159
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0103 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0328 0.0807
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0873 0.3928 0.393
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0873 0.3929 1
Echinococcus granulosus activin receptor type 0.0873 0.3929 0.3928
Echinococcus granulosus dna polymerase kappa 0.008 0.0259 0.0248
Brugia malayi Protein kinase domain containing protein 0.2182 0.9983 1
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Schistosoma mansoni tensin 0.1309 0.5947 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Entamoeba histolytica ankyrin repeat protein 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Schistosoma mansoni ephrin receptor 0.0873 0.3928 0.3934
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0122 0.0114
Trichomonas vaginalis AGC family protein kinase 0.0873 0.3928 1
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Loa Loa (eye worm) hypothetical protein 0.0873 0.3928 0.3923
Schistosoma mansoni serine/threonine protein kinase 0.0873 0.3928 0.3934
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0873 0.3928 0.393
Loa Loa (eye worm) TK/FER protein kinase 0.0873 0.3928 0.3923
Echinococcus granulosus activated cdc42 kinase 1 0.0873 0.3928 0.3927
Schistosoma mansoni hypothetical protein 0.0034 0.0049 0.0049
Entamoeba histolytica hypothetical protein 0.0873 0.3928 0.3927
Loa Loa (eye worm) TK/ALK protein kinase 0.0873 0.3928 0.3923
Loa Loa (eye worm) TK/FER protein kinase 0.0873 0.3928 0.3923
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2182 0.9983 1
Schistosoma mansoni protein tyrosine kinase 0.0873 0.3928 0.3934
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.2182 0.9983 1
Echinococcus granulosus SHC transforming protein 3 0.1309 0.5947 0.5951
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0873 0.3928 0.3927
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0328 0.0816
Echinococcus multilocularis tyrosine protein kinase Srms 0.2182 0.9983 1
Echinococcus multilocularis signal transduction protein lnk realted 0.1309 0.5947 0.5952
Trichomonas vaginalis conserved hypothetical protein 0.0873 0.3928 1
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Echinococcus multilocularis tyrosine protein kinase csk 0.0873 0.3928 0.3927
Echinococcus granulosus tyrosine protein kinase Fyn 0.2182 0.9983 0.9999
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Schistosoma mansoni tensin 0.1309 0.5947 0.5957
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.2182 0.9983 1
Echinococcus multilocularis protein tyrosine kinase 0.0873 0.3928 0.3927
Echinococcus multilocularis transfer RNA-Thr 0.0873 0.3928 0.3927
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Schistosoma mansoni serine/threonine protein kinase 0.0873 0.3928 0.3934
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.009 0.021
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0873 0.3928 0.3934
Loa Loa (eye worm) TK/ABL protein kinase 0.2182 0.9983 0.9983
Brugia malayi hypothetical protein 0.0302 0.1287 0.1283
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0167 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0873 0.3928 0.3927
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0443 0.0435
Echinococcus granulosus tyrosine kinase 0.0873 0.3928 0.3927
Echinococcus multilocularis tyrosine protein kinase Src64B 0.2182 0.9983 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0873 0.3928 0.3934
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.2182 0.9983 1
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Schistosoma mansoni DNA polymerase eta 0.0078 0.0254 0.0254
Schistosoma mansoni vav2 0.1309 0.5947 0.5957
Schistosoma mansoni protein kinase 0.0873 0.3928 0.3934
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0873 0.3928 0.3927
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.1309 0.5947 0.5951
Echinococcus multilocularis tensin 0.1309 0.5947 0.5952
Echinococcus multilocularis FL cytokine receptor 0.0873 0.3928 0.3927
Entamoeba histolytica tyrosine kinase, putative 0.0877 0.3945 0.3944
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0873 0.3928 0.3927
Schistosoma mansoni protein kinase 0.0873 0.3929 0.3936
Entamoeba histolytica tyrosine kinase, putative 0.0877 0.3945 0.3944
Echinococcus granulosus hypothetical protein 0.1309 0.5947 0.5951
Entamoeba histolytica hypothetical protein 0.0873 0.3928 0.3927
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0873 0.3928 0.3722
Leishmania major DNA polymerase eta, putative 0.0078 0.0254 0.0628
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.009 0.021
Mycobacterium ulcerans DNA polymerase IV 0.008 0.0259 0.5
Echinococcus granulosus fibroblast growth factor receptor 4 0.0873 0.3928 0.3927
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0873 0.3928 0.3927
Loa Loa (eye worm) TK/FER protein kinase 0.2182 0.9983 0.9983
Entamoeba histolytica hypothetical protein 0.0036 0.0057 0.0046
Trypanosoma brucei unspecified product 0.0037 0.006 0.0134
Echinococcus granulosus tyrosine kinase 0.2182 0.9983 0.9999
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0047 0.011 0.0098
Echinococcus multilocularis insulin receptor 0.0873 0.3928 0.3927
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Brugia malayi Sex muscle abnormal protein 5 0.1309 0.5947 0.5954
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0873 0.3928 0.3927
Echinococcus multilocularis raf serine:threonine protein kinase 0.0873 0.3928 0.3927
Brugia malayi Immunoglobulin I-set domain containing protein 0.0873 0.3928 0.393
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.0254 0.0247
Echinococcus multilocularis tyrosine protein kinase Abl 0.2182 0.9983 1
Brugia malayi Protein kinase domain containing protein 0.2182 0.9983 1
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Echinococcus granulosus epidermal growth factor receptor 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Entamoeba histolytica tyrosine kinase, putative 0.0877 0.3945 0.3944
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0873 0.3928 0.9996
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0085 0.0197
Toxoplasma gondii protein kinase 0.0873 0.3928 0.9996
Schistosoma mansoni tyrosine kinase 0.2182 0.9983 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0259 0.0641
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0012 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0167 0.0406
Loa Loa (eye worm) hypothetical protein 0.0873 0.3928 0.3923
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0873 0.3928 0.3927
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Loa Loa (eye worm) hypothetical protein 0.0873 0.3928 0.3923
Giardia lamblia DINP protein human, muc B family 0.006 0.0167 0.0397
Entamoeba histolytica hypothetical protein 0.0873 0.3928 0.3927
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Echinococcus granulosus SH2 domain containing adapter protein F 0.1309 0.5947 0.5951
Giardia lamblia Kinase 0.0873 0.3928 1
Schistosoma mansoni tyrosine kinase 0.2182 0.9983 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0103 0.0095
Schistosoma mansoni protein kinase 0.0873 0.3928 0.3934
Echinococcus granulosus tyrosine protein kinase Fyn 0.2182 0.9983 0.9999
Leishmania major protein kinase, putative 0.0873 0.3929 1
Brugia malayi hypothetical protein 0.0069 0.0212 0.0205
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0873 0.3928 0.3934
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.2182 0.9983 0.9999
Loa Loa (eye worm) STAT protein 0.1309 0.5947 0.5943
Echinococcus multilocularis protein kinase 0.0873 0.3928 0.3927
Onchocerca volvulus Tyrosine kinase homolog 0.0873 0.3928 0.3722
Echinococcus multilocularis suppressor of cytokine signaling 6 0.1309 0.5947 0.5952
Onchocerca volvulus 0.0873 0.3928 0.3722
Brugia malayi SH2 domain containing protein 0.2182 0.9983 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0873 0.3928 0.3923
Trypanosoma brucei polo-like protein kinase 0.0094 0.0328 0.0816
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Schistosoma mansoni hypothetical protein 0.0169 0.0674 0.0675
Loa Loa (eye worm) hypothetical protein 0.0302 0.1287 0.128
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0057 0.0046
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2182 0.9983 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.2183 0.9984 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0873 0.3928 0.3927
Echinococcus granulosus tyrosine kinase 0.2182 0.9983 0.9999
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0873 0.3928 0.3934
Echinococcus multilocularis kinase suppressor of Ras 1 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Giardia lamblia Protein 21.1 0.0873 0.3928 1
Onchocerca volvulus 0.2182 0.9983 0.9982
Echinococcus multilocularis protein KINase family member (kin 25) 0.0873 0.3928 0.3927
Entamoeba histolytica tyrosine kinase, putative 0.0873 0.3928 0.3927
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0873 0.3929 1
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0259 0.0641
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Entamoeba histolytica tyrosin kinase, putative 0.0873 0.3928 0.3927
Loa Loa (eye worm) RGC/RGC protein kinase 0.0873 0.3928 0.3923
Loa Loa (eye worm) SRC-1 0.2182 0.9983 0.9983
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2182 0.9983 1
Entamoeba histolytica hypothetical protein 0.0873 0.3928 0.3927
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0873 0.3928 0.3927
Schistosoma mansoni tyrosine protein kinase 0.0873 0.3928 0.3934
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Schistosoma mansoni GTPase activating protein 0.1309 0.5947 0.5957
Brugia malayi Flap endonuclease-1 0.0026 0.0012 0.0004
Loa Loa (eye worm) SH2 domain-containing protein 0.1309 0.5947 0.5943
Echinococcus granulosus signal transduction protein lnk realted 0.1309 0.5947 0.5951
Loa Loa (eye worm) SH2 domain-containing protein 0.1309 0.5947 0.5943
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0873 0.3928 0.3927
Loa Loa (eye worm) hypothetical protein 0.0078 0.0254 0.0247
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Schistosoma mansoni hypothetical protein 0.0169 0.0674 0.0675
Loa Loa (eye worm) TK protein kinase 0.0873 0.3928 0.3923
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0091 0.0212
Loa Loa (eye worm) TK protein kinase 0.0873 0.3928 0.3923
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0873 0.3928 0.3927
Brugia malayi ephrin receptor 1 precursor 0.0873 0.3928 0.393
Trichomonas vaginalis conserved hypothetical protein 0.0873 0.3928 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0873 0.3928 0.393
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Entamoeba histolytica serine/threonine kinase, putative 0.0873 0.3928 0.3927
Entamoeba histolytica hypothetical protein, conserved 0.0877 0.3945 0.3944
Echinococcus granulosus geminin 0.0169 0.0674 0.0664
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0873 0.3928 0.393
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0873 0.3928 0.393
Plasmodium falciparum tyrosine kinase-like protein 0.0873 0.3928 0.9996
Leishmania major protein kinase, putative 0.0873 0.3928 0.9996
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0136 0.0129
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0053 0.0136 0.0125
Echinococcus granulosus integrin linked protein kinase 0.0873 0.3928 0.3927
Echinococcus granulosus epidermal growth factor receptor 0.0873 0.3928 0.3927
Echinococcus multilocularis tyrosine protein kinase Src42A 0.2182 0.9983 1
Entamoeba histolytica receptor protein kinase, putative 0.0873 0.3928 0.3927
Echinococcus multilocularis tyrosine protein kinase csk 0.0873 0.3928 0.3927
Plasmodium falciparum protein kinase, putative 0.0873 0.3929 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.2182 0.9983 1
Entamoeba histolytica hypothetical protein 0.0036 0.0057 0.0046
Onchocerca volvulus 0.0873 0.3928 0.3722
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0069 0.0212 0.0201
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0167 0.0406
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1309 0.5947 0.5943
Schistosoma mansoni protein kinase 0.0873 0.3928 0.3934
Echinococcus granulosus expressed conserved protein 0.1309 0.5947 0.5951
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0328 0.0328
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0873 0.3928 1
Entamoeba histolytica tyrosin kinase, putative 0.0873 0.3928 0.3927
Schistosoma mansoni nck2/grb4 0.1309 0.5947 0.5957
Echinococcus multilocularis epidermal growth factor receptor 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0053 0.0136 0.0125
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Loa Loa (eye worm) TK/FER protein kinase 0.0873 0.3928 0.3923
Onchocerca volvulus 0.0873 0.3928 0.3722
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Entamoeba histolytica hypothetical protein 0.0873 0.3928 0.3927
Loa Loa (eye worm) hypothetical protein 0.2182 0.9983 0.9983
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2182 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0873 0.3928 0.3923
Brugia malayi hypothetical protein 0.0873 0.3928 0.393
Echinococcus granulosus tyrosine protein kinase csk 0.0873 0.3928 0.3927
Echinococcus multilocularis tyrosine protein kinase csk 0.0873 0.3928 0.3927
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0103 0.0091
Onchocerca volvulus 0.2186 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0873 0.3928 0.3927
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Entamoeba histolytica SH2-protein kinase domain containing protein 0.131 0.5948 0.5953
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0041
Echinococcus multilocularis geminin 0.0169 0.0674 0.0664
Loa Loa (eye worm) hypothetical protein 0.0873 0.3928 0.3923
Echinococcus multilocularis SH2 domain containing adapter protein F 0.1309 0.5947 0.5952
Schistosoma mansoni tyrosine kinase 0.2182 0.9983 1
Echinococcus granulosus SH2 motif 0.1309 0.5947 0.5951
Echinococcus multilocularis tyrosine protein kinase HCK 0.0873 0.3928 0.3927
Loa Loa (eye worm) SH2 domain-containing protein 0.1309 0.5947 0.5943
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0873 0.3928 0.3927
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1309 0.5947 0.5943
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0328 0.0317
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Loa Loa (eye worm) TK/FER protein kinase 0.2182 0.9983 0.9983
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0012 0.0004
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.1309 0.5947 0.5809
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1309 0.5947 0.5943
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0873 0.3928 0.3927
Echinococcus multilocularis tensin 0.1309 0.5947 0.5952
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0873 0.3928 0.3934
Echinococcus granulosus retinal guanylyl cyclase 2 0.0873 0.3928 0.3927
Schistosoma mansoni SH2A 0.1309 0.5947 0.5957
Schistosoma mansoni hypothetical protein 0.1309 0.5947 0.5957
Loa Loa (eye worm) TK/FER protein kinase 0.2182 0.9983 0.9983
Brugia malayi Protein kinase domain containing protein 0.2182 0.9983 1
Onchocerca volvulus 0.1309 0.5947 0.5809
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0873 0.3928 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0057 0.0046
Onchocerca volvulus 0.2182 0.9983 0.9982
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0259 0.0641
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0049 0.0041
Entamoeba histolytica hypothetical protein 0.0873 0.3928 0.3927
Schistosoma mansoni tyrosine kinase 0.2182 0.9983 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.2182 0.9983 0.9999
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Echinococcus multilocularis NCK adaptor protein 0.1309 0.5947 0.5952
Brugia malayi bone morphogenetic protein type 1 receptor 0.0873 0.3928 0.393
Brugia malayi Tensin 0.1309 0.5947 0.5954
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0873 0.3928 0.3923
Schistosoma mansoni protein kinase 0.0873 0.3928 0.3934
Brugia malayi SH2 domain containing protein 0.1309 0.5947 0.5954
Brugia malayi polk-prov protein 0.0043 0.009 0.0083
Entamoeba histolytica cysteine surface protein, putative 0.0877 0.3945 0.3944
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Schistosoma mansoni protein kinase 0.0873 0.3928 0.3934
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1309 0.5947 0.5952
Entamoeba histolytica ankyrin repeat protein 0.0873 0.3928 0.3927
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Toxoplasma gondii protein kinase domain-containing protein 0.0873 0.3928 0.9996
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Loa Loa (eye worm) hypothetical protein 0.0873 0.3928 0.3923
Loa Loa (eye worm) TK protein kinase 0.0873 0.3928 0.3923
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Entamoeba histolytica tyrosine kinase, putative 0.0873 0.3928 0.3927
Loa Loa (eye worm) TK/FER protein kinase 0.0873 0.3928 0.3923
Echinococcus multilocularis activin receptor type 0.0873 0.3929 0.3929
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0328 0.0807
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Brugia malayi hypothetical protein 0.0873 0.3928 0.393
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0103 0.0091
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0873 0.3928 0.3927
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0873 0.3928 0.3927
Schistosoma mansoni ephrin receptor 0.0873 0.3928 0.3934
Onchocerca volvulus 0.2182 0.9983 0.9982
Echinococcus granulosus dna polymerase eta 0.0078 0.0254 0.0243
Echinococcus multilocularis ephrin type A receptor 4 A 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Schistosoma mansoni hypothetical protein 0.1309 0.5947 0.5957
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Trichomonas vaginalis conserved hypothetical protein 0.0873 0.3928 1
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Echinococcus granulosus suppressor of cytokine signaling 6 0.1309 0.5947 0.5951
Schistosoma mansoni tyrosine kinase 0.2182 0.9983 1
Entamoeba histolytica hypothetical protein 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Echinococcus granulosus N chimaerin 0.1309 0.5947 0.5951
Entamoeba histolytica protein kinase, putative 0.131 0.5948 0.5953
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0328 0.0816
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0259 0.0641
Entamoeba histolytica serine/threonine kinase, putative 0.0873 0.3928 0.3927
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0085 0.0197
Echinococcus granulosus natriuretic peptide receptor 1 0.0873 0.3928 0.3927
Loa Loa (eye worm) RhoGAP domain-containing protein 0.1309 0.5947 0.5943
Echinococcus multilocularis tyrosine protein kinase pr2 0.0873 0.3928 0.3927
Echinococcus granulosus tyrosine protein kinase Fyn 0.2182 0.9983 0.9999
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2182 0.9983 1
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Echinococcus multilocularis N chimaerin 0.1309 0.5947 0.5952
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Plasmodium falciparum protein kinase, putative 0.0873 0.3928 0.9996
Schistosoma mansoni serine/threonine RGC 0.0873 0.3928 0.3934
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1309 0.5947 0.5952
Brugia malayi Protein kinase domain containing protein 0.2182 0.9983 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0259 0.0641
Schistosoma mansoni suppressor of cytokine signaling 0.1309 0.5947 0.5957
Entamoeba histolytica tyrosine kinase, putative 0.0877 0.3945 0.3944
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0873 0.3928 0.3927
Onchocerca volvulus 0.0302 0.1287 0.0992
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0259 0.0641
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.1309 0.5947 0.5943
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0873 0.3928 0.9996
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0122 0.0114
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0873 0.3928 0.3923
Trypanosoma brucei DNA polymerase eta, putative 0.0078 0.0254 0.0628
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Loa Loa (eye worm) TK/FER protein kinase 0.0873 0.3928 0.3923
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1309 0.5947 0.5951
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0012 0.001
Echinococcus multilocularis tyrosine protein kinase 0.0873 0.3928 0.3927
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Trichomonas vaginalis protein kinase atn1, putative 0.0873 0.3928 1
Loa Loa (eye worm) TK/RYK protein kinase 0.0873 0.3928 0.3923
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0053 0.0136 0.0137
Entamoeba histolytica serine/threonine kinase, putative 0.0873 0.3928 0.3927
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0873 0.3928 0.3923
Giardia lamblia Kinase, PLK 0.0094 0.0328 0.0807
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Trichomonas vaginalis protein tyrosine kinase, putative 0.0873 0.3928 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0873 0.3928 0.3927
Loa Loa (eye worm) TK protein kinase 0.0873 0.3928 0.3923
Echinococcus multilocularis integrin linked protein kinase 0.0873 0.3928 0.3927
Onchocerca volvulus 0.0877 0.3945 0.374
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Onchocerca volvulus 0.1309 0.5947 0.5809
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Entamoeba histolytica tyrosine kinase, putative 0.0873 0.3928 0.3927
Loa Loa (eye worm) RGC/RGC protein kinase 0.0873 0.3928 0.3923
Loa Loa (eye worm) RGC/RGC protein kinase 0.0873 0.3928 0.3923
Brugia malayi Variant SH3 domain containing protein 0.1309 0.5947 0.5954
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0873 0.3928 0.3927
Loa Loa (eye worm) TK/FAK protein kinase 0.0873 0.3928 0.3923
Echinococcus granulosus SH2 motif 0.1309 0.5947 0.5951
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Echinococcus multilocularis protein kinase 0.0873 0.3928 0.3927
Loa Loa (eye worm) TK/FER protein kinase 0.2182 0.9983 0.9983
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0873 0.3928 0.3927
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0259 0.0641
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0103 0.0103
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1309 0.5947 0.5952
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0069 0.0212 0.0201
Brugia malayi Variant SH3 domain containing protein 0.1309 0.5947 0.5954
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0873 0.3928 0.3923
Loa Loa (eye worm) TK/FER protein kinase 0.2182 0.9983 0.9983
Echinococcus multilocularis activated cdc42 kinase 1 0.0873 0.3928 0.3927
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Entamoeba histolytica tyrosin kinase, putative 0.0873 0.3928 0.3927
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0259 0.0641
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Schistosoma mansoni tsg101-related 0.0047 0.011 0.011
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.1309 0.5947 0.5952
Loa Loa (eye worm) protein kinase domain-containing protein 0.0873 0.3928 0.3923
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Loa Loa (eye worm) TK/FER protein kinase 0.0873 0.3928 0.3923
Echinococcus granulosus retinal guanylyl cyclase 2 0.0873 0.3928 0.3927
Trypanosoma cruzi protein kinase, putative 0.0873 0.3928 0.9996
Entamoeba histolytica hypothetical protein 0.0873 0.3928 0.3927
Entamoeba histolytica tyrosine kinase, putative 0.0877 0.3945 0.3944
Echinococcus granulosus tyrosine protein kinase Src42A 0.1309 0.5947 0.5951
Entamoeba histolytica tyrosine kinase, putative 0.0877 0.3945 0.3944
Schistosoma mansoni hypothetical protein 0.0873 0.3928 0.3934
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0873 0.3928 0.3927
Schistosoma mansoni adapter molecule crk 0.1309 0.5947 0.5957
Entamoeba histolytica hypothetical protein 0.0873 0.3928 0.3927
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0328 0.0807
Loa Loa (eye worm) TK/FER protein kinase 0.2182 0.9983 0.9983
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Brugia malayi hypothetical protein 0.1309 0.5947 0.5954
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Echinococcus granulosus raf serine:threonine protein kinase 0.0873 0.3928 0.3927
Leishmania major DNA polymerase kappa, putative 0.006 0.0167 0.0406
Echinococcus granulosus tyrosine protein kinase csk 0.0873 0.3928 0.3927
Echinococcus granulosus activated cdc42 kinase 1 0.0873 0.3928 0.3927
Plasmodium falciparum flap endonuclease 1 0.0026 0.0012 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0259 0.0641
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0873 0.3928 0.3923
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0873 0.3929 1
Schistosoma mansoni protein kinase 0.0873 0.3929 0.3936
Loa Loa (eye worm) TK/EGFR protein kinase 0.0873 0.3928 0.3923
Brugia malayi Guanylyl cyclase protein 23 0.0873 0.3928 0.393
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Loa Loa (eye worm) TK/FER protein kinase 0.0873 0.3928 0.3923
Brugia malayi tRNA modification GTPase TrmE family protein 0.1309 0.5947 0.5954
Loa Loa (eye worm) RGC/RGC protein kinase 0.0873 0.3928 0.3923
Brugia malayi SH2 domain containing protein 0.2182 0.9983 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0078 0.0254 0.0628
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0873 0.3928 0.3927
Brugia malayi SH2 domain containing protein 0.1309 0.5947 0.5954
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Loa Loa (eye worm) TK protein kinase 0.0873 0.3928 0.3923
Echinococcus granulosus tyrosine protein kinase Blk 0.2182 0.9983 0.9999
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3929 0.3929
Entamoeba histolytica tyrosine kinase, putative 0.0873 0.3928 0.3927
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0259 0.0641
Schistosoma mansoni serine/threonine protein kinase 0.0873 0.3928 0.3934
Echinococcus granulosus protein kinase 0.0873 0.3928 0.3927
Loa Loa (eye worm) TK/DDR protein kinase 0.0873 0.3928 0.3923
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Echinococcus multilocularis heat shock protein 70 0.0873 0.3928 0.3927
Brugia malayi SRC-1 0.2182 0.9983 1
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Schistosoma mansoni tyrosine-protein kinase zap-70 0.1309 0.5947 0.5957
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.1309 0.5947 0.5952
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0012 0.001
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Onchocerca volvulus 0.2182 0.9983 0.9982
Echinococcus multilocularis tyrosine protein kinase shark 0.2182 0.9983 1
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Echinococcus granulosus growth factor receptor bound protein 2 0.1309 0.5947 0.5951
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0873 0.3928 0.3927
Plasmodium vivax protein kinase, putative 0.0873 0.3928 1
Echinococcus multilocularis dna polymerase eta 0.0078 0.0254 0.0243
Entamoeba histolytica tyrosin kinase, putative 0.0873 0.3928 0.3927
Onchocerca volvulus 0.0873 0.3928 0.3722
Echinococcus multilocularis c src tyrosine kinase 0.2182 0.9983 1
Leishmania major DNA polymerase eta, putative 0.0042 0.0085 0.0197
Loa Loa (eye worm) hypothetical protein 0.0043 0.009 0.0083
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Entamoeba histolytica hypothetical protein 0.0036 0.0057 0.0046
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0873 0.3928 0.393
Brugia malayi SH2 domain containing protein 0.1309 0.5947 0.5954
Echinococcus granulosus tyrosine protein kinase 0.0873 0.3928 0.3927
Echinococcus multilocularis dna polymerase kappa 0.008 0.0259 0.0248
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1309 0.5947 0.5957
Entamoeba histolytica hypothetical protein 0.0873 0.3928 0.3927
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0328 0.0807
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0328 0.0807
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0259 0.0641
Brugia malayi SH2 domain containing protein 0.1309 0.5947 0.5954
Onchocerca volvulus 0.2182 0.9983 0.9982
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Echinococcus granulosus tensin 0.1309 0.5947 0.5951
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0259 0.0641
Trypanosoma brucei unspecified product 0.0073 0.0229 0.0564
Schistosoma mansoni growth factor receptor-bound protein 0.1309 0.5947 0.5957
Loa Loa (eye worm) hypothetical protein 0.0873 0.3928 0.3923
Plasmodium falciparum protein kinase, putative 0.0873 0.3928 0.9996
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.1309 0.5947 0.5957
Echinococcus granulosus retinal guanylyl cyclase 2 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Trypanosoma brucei unspecified product 0.0037 0.006 0.0134
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0328 0.0807
Echinococcus granulosus tyrosine protein kinase Fps85D 0.2182 0.9983 0.9999
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.2182 0.9983 0.9999
Onchocerca volvulus 0.1309 0.5947 0.5809
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0259 0.0641
Entamoeba histolytica tyrosine kinase, putative 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.1309 0.5947 0.5809
Entamoeba histolytica tyrosine kinase, putative 0.0873 0.3928 0.3927
Echinococcus granulosus receptor type guanylyl cyclase 0.0873 0.3928 0.3927
Trichomonas vaginalis DNA polymerase eta, putative 0.008 0.0259 0.0632
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Trichomonas vaginalis STE family protein kinase 0.0873 0.3928 1
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Entamoeba histolytica SH2 domain containing protein 0.1309 0.5947 0.5952
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0057 0.0058
Loa Loa (eye worm) TK protein kinase 0.2182 0.9983 0.9983
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0328 0.0321
Loa Loa (eye worm) TK protein kinase 0.0873 0.3928 0.3923
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Loa Loa (eye worm) TK/CSK protein kinase 0.0873 0.3928 0.3923
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0328 0.0317
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0328 0.0317
Brugia malayi SH2 domain containing protein 0.1309 0.5947 0.5954
Entamoeba histolytica tyrosine kinase, putative 0.0877 0.3945 0.3944
Echinococcus granulosus tyrosine protein kinase Src42A 0.2182 0.9983 0.9999
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0012 0.001
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Echinococcus multilocularis receptor type guanylyl cyclase 0.0873 0.3928 0.3927
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Schistosoma mansoni protein kinase 0.0873 0.3929 0.3936
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0873 0.3928 0.3923
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Entamoeba histolytica protein kinase, putative 0.0877 0.3945 0.3944
Mycobacterium ulcerans DNA polymerase IV 0.008 0.0259 0.5
Echinococcus granulosus insulin receptor 0.0873 0.3928 0.3927
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0873 0.3928 0.3722
Brugia malayi Tyrosine-protein kinase abl-1 0.2182 0.9983 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0873 0.3928 0.3927
Loa Loa (eye worm) hypothetical protein 0.0873 0.3928 0.3923
Brugia malayi Protein kinase domain containing protein 0.2182 0.9983 1
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Plasmodium falciparum tyrosine kinase-like protein 0.0873 0.3928 0.9996
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0103 0.0095
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Brugia malayi SH2 domain containing protein 0.1309 0.5947 0.5954
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0114
Echinococcus multilocularis tyrosine protein kinase Blk 0.2182 0.9983 1
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0107 0.0244
Echinococcus multilocularis tyrosine kinase 0.2182 0.9983 1
Entamoeba histolytica tyrosine kinase, putative 0.0877 0.3945 0.3944
Loa Loa (eye worm) TK/FER protein kinase 0.2182 0.9983 0.9983
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Trichomonas vaginalis conserved hypothetical protein 0.0873 0.3928 1
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Loa Loa (eye worm) TK/FER protein kinase 0.2182 0.9983 0.9983
Entamoeba histolytica SH2-protein kinase domain containing protein 0.2182 0.9983 1
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0873 0.3928 0.3927
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0873 0.3928 0.3927
Trichomonas vaginalis hypothetical protein 0.0034 0.0048 0.0092
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0873 0.3928 0.3923
Schistosoma mansoni serine/threonine protein kinase 0.0873 0.3928 0.3934
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0873 0.3928 0.3927
Brugia malayi integrin-linked kinase 0.0873 0.3928 0.393
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0873 0.3928 0.3927
Schistosoma mansoni protein kinase 0.0873 0.3928 0.3934
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Toxoplasma gondii STE kinase 0.0873 0.3928 0.9996
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Brugia malayi Raf kinase 0.0873 0.3928 0.393
Schistosoma mansoni terminal deoxycytidyl transferase 0.0053 0.0136 0.0137
Schistosoma mansoni tyrosine kinase 0.2182 0.9983 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0873 0.3928 0.3927
Schistosoma mansoni suppressor of cytokine signaling 0.1309 0.5947 0.5957
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Loa Loa (eye worm) TK/ROR protein kinase 0.0873 0.3928 0.3923
Plasmodium vivax tyrosine kinase-like protein, putative 0.0873 0.3928 1
Entamoeba histolytica receptor protein kinase, putative 0.0873 0.3928 0.3927
Brugia malayi MH2 domain containing protein 0.0119 0.0443 0.0436
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0873 0.3928 0.3927
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Onchocerca volvulus 0.1309 0.5947 0.5809
Echinococcus granulosus tensin C1 domain containing phosphatase 0.1309 0.5947 0.5951
Trichomonas vaginalis conserved hypothetical protein 0.0873 0.3928 1
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Trypanosoma brucei Pseudokinase, putative 0.0873 0.3928 0.9996
Schistosoma mansoni protein kinase 0.0873 0.3928 0.3934
Loa Loa (eye worm) hypothetical protein 0.0873 0.3928 0.3923
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Giardia lamblia Kinase, NEK 0.0873 0.3928 1
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0229 0.0564
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Entamoeba histolytica protein kinase domain containing protein 0.0873 0.3928 0.3927
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Entamoeba histolytica hypothetical protein 0.0873 0.3928 0.3927
Entamoeba histolytica tyrosine kinase, putative 0.0877 0.3945 0.3944
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0091 0.0212
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.1309 0.5947 0.5957
Trichomonas vaginalis conserved hypothetical protein 0.0873 0.3928 1
Schistosoma mansoni tensin-related 0.1309 0.5947 0.5957
Trypanosoma brucei Flagellum attachment zone protein 20 0.0873 0.3928 0.9996
Echinococcus granulosus protein tyrosine kinase 0.0873 0.3928 0.3927
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0053 0.0136 0.0129
Loa Loa (eye worm) TK protein kinase 0.0873 0.3928 0.3923
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0873 0.3928 0.3927
Entamoeba histolytica tyrosine kinase, putative 0.0873 0.3928 0.3927
Echinococcus granulosus c src tyrosine kinase 0.2182 0.9983 0.9999
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0873 0.3928 0.3927
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1309 0.5947 0.5952
Onchocerca volvulus 0.0873 0.3928 0.3722
Brugia malayi Protein kinase domain containing protein 0.0873 0.3928 0.393
Loa Loa (eye worm) sex muscle abnormal protein 5 0.1309 0.5947 0.5943
Trichomonas vaginalis CAMK family protein kinase 0.0873 0.3928 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.1309 0.5947 0.5951
Brugia malayi SH2 domain containing protein 0.1309 0.5947 0.5954
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Brugia malayi protein-tyrosine kinase 0.2182 0.9983 1
Brugia malayi C-terminal src kinase protein 1 0.0873 0.3928 0.393
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Echinococcus multilocularis tyrosine kinase 0.0873 0.3928 0.3927
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0873 0.3928 0.3927
Brugia malayi STAT protein, DNA binding domain containing protein 0.1309 0.5947 0.5954
Brugia malayi Variant SH3 domain containing protein 0.1309 0.5947 0.5954
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0873 0.3928 0.3927
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0873 0.3929 0.3929
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0443 0.0435
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.008 0.0259 0.0632
Trichomonas vaginalis conserved hypothetical protein 0.0873 0.3928 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0873 0.3928 0.3927
Onchocerca volvulus 0.1309 0.5947 0.5809
Echinococcus multilocularis SH2 motif 0.1309 0.5947 0.5952
Plasmodium vivax tyrosine kinase-like protein, putative 0.0873 0.3928 1
Brugia malayi Protein kinase domain containing protein 0.0877 0.3945 0.3947
Brugia malayi Immunoglobulin I-set domain containing protein 0.0873 0.3928 0.393
Brugia malayi Receptor family ligand binding region containing protein 0.0873 0.3928 0.393
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0012 0.001
Schistosoma mansoni hypothetical protein 0.0036 0.0057 0.0058
Echinococcus granulosus tyrosine protein kinase csk 0.0873 0.3928 0.3927
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0873 0.3928 1
Entamoeba histolytica protein kinase, putative 0.0873 0.3928 0.3927
Trichomonas vaginalis TK family protein kinase 0.0873 0.3928 1
Trichomonas vaginalis TKL family protein kinase 0.0873 0.3928 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0873 0.3928 0.3923
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0328 0.0807
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0107 0.0244
Loa Loa (eye worm) hypothetical protein 0.1309 0.5947 0.5943
Loa Loa (eye worm) TK/FER protein kinase 0.2182 0.9983 0.9983
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Loa Loa (eye worm) TK/EPH protein kinase 0.0873 0.3928 0.3923
Echinococcus multilocularis SHC transforming protein 3 0.1309 0.5947 0.5952
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1309 0.5947 0.5952
Echinococcus granulosus tyrosine protein kinase shark 0.2182 0.9983 0.9999
Schistosoma mansoni signal transduction protein lnk-related 0.1309 0.5947 0.5957
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0873 0.3929 0.3928
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0873 0.3928 1
Schistosoma mansoni tsg101-related 0.0058 0.0159 0.0159
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0873 0.3928 0.3927
Loa Loa (eye worm) hypothetical protein 0.0873 0.3928 0.3923
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0091 0.0212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0103 0.0091
Echinococcus granulosus ephrin type A receptor 4 A 0.0873 0.3928 0.3927
Onchocerca volvulus 0.0873 0.3928 0.3722
Schistosoma mansoni tyrosine kinase 0.0873 0.3928 0.3934
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0873 0.3928 0.3934
Trypanosoma cruzi protein kinase, putative 0.0873 0.3928 0.9996
Brugia malayi Tyrosine-protein kinase PR2 0.0873 0.3928 0.393
Onchocerca volvulus 0.1309 0.5947 0.5809

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.1 uM Cytotoxicity against human A498 cells after 48 hrs by MTT assay ChEMBL. 23831809
IC50 (ADMET) > 50 uM Cytotoxicity against human Detroit 551 cells after 48 hrs by MTT assay ChEMBL. 23831809

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23831809

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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