Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor 4 | 0.0173 | 0.5106 | 0.5106 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0106 | 0.2015 | 0.2015 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0259 | 0.9101 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0106 | 0.2015 | 0.2015 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.4059 | 0.4059 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.5106 | 0.4997 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0086 | 0.1116 | 0.1116 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.021 | 0.6861 | 0.6861 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0278 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0259 | 0.9101 | 0.9101 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0106 | 0.2015 | 0.2015 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.4059 | 0.4059 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0106 | 0.2015 | 0.2015 |
Echinococcus multilocularis | glutamate receptor 2 | 0.024 | 0.8245 | 0.8245 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.5106 | 0.4997 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0259 | 0.9101 | 0.5 |
Echinococcus granulosus | glutamate receptor 1 | 0.0173 | 0.5106 | 0.5106 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0106 | 0.2015 | 0.3056 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.015 | 0.4059 | 0.4059 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.015 | 0.4059 | 1 |
Echinococcus granulosus | glutamate receptor 4 | 0.0173 | 0.5106 | 0.5106 |
Echinococcus granulosus | glutamate receptor 2 | 0.024 | 0.8245 | 0.8245 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0106 | 0.2015 | 0.2015 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0106 | 0.2015 | 0.2015 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.4059 | 0.3686 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0278 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.5106 | 0.4997 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0278 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.021 | 0.6861 | 0.6861 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.4059 | 0.3686 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0259 | 0.9101 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0086 | 0.1116 | 0.1116 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 17 nM | Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in Wistar rat cerebral hippocampus membrane after 10 mins | ChEMBL. | 23466604 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.