TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 552.645 | Formula: C34H24N4O2S
H donors: 2 H acceptors: 3 LogP: 8.07 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: S=C(NC(=O)c1nn(c(c1C(=O)c1ccccc1)c1ccccc1)c1ccccc1)Nc1cccc2c1cccc2
InChi: 1S/C34H24N4O2S/c39-32(25-16-6-2-7-17-25)29-30(33(40)36-34(41)35-28-22-12-18-23-13-10-11-21-27(23)28)37-38(26-19-8-3-9-20-26)31(29)24-14-4-1-5-15-24/h1-22H,(H2,35,36,40,41)
InChiKey: FEMFKRSHEHAMCO-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	alpha tubulin	0.0063	0.0554	0.2601
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.012	0.2129	0.2129
Echinococcus multilocularis	tubulin alpha chain	0.0063	0.0554	0.0554
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Schistosoma mansoni	tubulin subunit alpha	0.0063	0.0554	0.1027
Trypanosoma brucei	beta tubulin	0.0063	0.0554	0.2601
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0199	0.4269	0.4269
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0063	0.0554	0.0554
Echinococcus multilocularis	tubulin gamma 1 chain	0.0063	0.0554	0.0554
Trichomonas vaginalis	tubulin beta chain, putative	0.0063	0.0554	0.2601
Echinococcus granulosus	Tubulin beta 2C chain	0.0063	0.0554	0.0554
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0067	0.0669	0.0669
Trichomonas vaginalis	tubulin gamma chain, putative	0.0063	0.0554	0.2601
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.012	0.2129	0.3948
Leishmania major	alpha tubulin	0.0063	0.0554	0.2601
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Echinococcus granulosus	tubulin alpha chain	0.0063	0.0554	0.0554
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Trypanosoma brucei	Aminopeptidase M1, putative	0.012	0.2129	1
Leishmania major	alpha tubulin	0.0063	0.0554	0.2601
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0063	0.0554	0.0554
Trichomonas vaginalis	tubulin gamma chain, putative	0.0063	0.0554	0.2601
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0063	0.0554	0.0554
Echinococcus multilocularis	tubulin epsilon chain	0.0063	0.0554	0.0554
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0199	0.4269	0.4269
Trypanosoma cruzi	epsilon tubulin, putative	0.0063	0.0554	0.2601
Loa Loa (eye worm)	tubulin gamma chain	0.0063	0.0554	0.0626
Toxoplasma gondii	beta-tubulin, putative	0.0063	0.0554	0.8276
Echinococcus multilocularis	Tubulin beta 2C chain	0.0063	0.0554	0.0554
Schistosoma mansoni	alpha tubulin	0.0063	0.0554	0.1027
Leishmania major	alpha tubulin	0.0063	0.0554	0.2601
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Echinococcus granulosus	tubulin subunit beta	0.0063	0.0554	0.0554
Trypanosoma brucei	beta tubulin	0.0063	0.0554	0.2601
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0067	0.0669	0.3143
Trichomonas vaginalis	tubulin beta chain, putative	0.0063	0.0554	0.2601
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Plasmodium vivax	tubulin alpha chain, putative	0.0063	0.0554	1
Leishmania major	alpha tubulin	0.0063	0.0554	0.2601
Echinococcus multilocularis	Tubulin beta 2C chain	0.0063	0.0554	0.0554
Trypanosoma brucei	tubulin gamma chain	0.0063	0.0554	0.2601
Echinococcus granulosus	beta tubulin	0.0063	0.0554	0.0554
Giardia lamblia	Gamma tubulin	0.0063	0.0554	0.5
Trypanosoma brucei	epsilon tubulin	0.0063	0.0554	0.2601
Trichomonas vaginalis	tubulin gamma chain, putative	0.0063	0.0554	0.2601
Plasmodium falciparum	tubulin epsilon chain, putative	0.0063	0.0554	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0063	0.0554	0.0554
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0199	0.4269	0.7917
Echinococcus granulosus	tubulin alpha chain	0.0063	0.0554	0.0554
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.012	0.2129	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0063	0.0554	0.0554
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0199	0.4269	0.4269
Echinococcus multilocularis	hypothetical protein	0.0063	0.0554	0.0554
Loa Loa (eye worm)	tubulin beta-4 chain	0.0063	0.0554	0.0626
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.012	0.2129	0.2129
Echinococcus multilocularis	Tubulin beta 2C chain	0.0063	0.0554	0.0554
Echinococcus granulosus	tubulin beta 1 chain	0.0063	0.0554	0.0554
Echinococcus multilocularis	tubulin alpha chain	0.0063	0.0554	0.0554
Echinococcus granulosus	beta tubulin	0.0063	0.0554	0.0554
Echinococcus granulosus	tubulin beta 4A class IVa	0.0063	0.0554	0.0554
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.012	0.2129	1
Trypanosoma brucei	alpha tubulin	0.0063	0.0554	0.2601
Loa Loa (eye worm)	tubulin beta-1 chain	0.0063	0.0554	0.0626
Brugia malayi	prolyl oligopeptidase family protein	0.0199	0.4269	0.4269
Echinococcus multilocularis	Tubulin beta 2C chain	0.0063	0.0554	0.0554
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0067	0.0669	1
Trypanosoma brucei	alpha tubulin	0.0063	0.0554	0.2601
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0063	0.0554	0.2601
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0067	0.0669	0.1241
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Schistosoma mansoni	tubulin subunit beta	0.0063	0.0554	0.1027
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Echinococcus multilocularis	tubulin alpha	0.0063	0.0554	0.0554
Echinococcus granulosus	Tubulin alpha 1 chain	0.0063	0.0554	0.0554
Trichomonas vaginalis	tubulin alpha chain, putative	0.0063	0.0554	0.2601
Echinococcus multilocularis	tubulin alpha 1C chain	0.0063	0.0554	0.0554
Trichomonas vaginalis	tubulin beta chain, putative	0.0063	0.0554	0.2601
Plasmodium falciparum	alpha tubulin 1	0.0063	0.0554	1
Leishmania major	alpha tubulin	0.0063	0.0554	0.2601
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.012	0.2129	0.2129
Loa Loa (eye worm)	tubulin beta-2A chain	0.0063	0.0554	0.0626
Echinococcus multilocularis	tubulin beta 1 chain	0.0063	0.0554	0.0554
Echinococcus granulosus	peroxisome assembly protein 26	0.0063	0.0554	0.0554
Leishmania major	alpha tubulin	0.0063	0.0554	0.2601
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Echinococcus multilocularis	beta tubulin	0.0063	0.0554	0.0554
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Echinococcus granulosus	tubulin alpha 1C chain	0.0063	0.0554	0.0554
Echinococcus granulosus	tubulin epsilon chain	0.0063	0.0554	0.0554
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.012	0.2129	0.2129
Schistosoma mansoni	tubulin subunit alpha	0.0063	0.0554	0.1027
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0078	0.0975	0.1807
Trichomonas vaginalis	tubulin beta chain, putative	0.0063	0.0554	0.2601
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0067	0.0669	0.3143
Echinococcus granulosus	tubulin alpha chain	0.0063	0.0554	0.0554
Plasmodium vivax	tubulin beta chain, putative	0.0063	0.0554	1
Echinococcus granulosus	alpha tubulin	0.0063	0.0554	0.0554
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0063	0.0554	0.2601
Toxoplasma gondii	beta-1 tubulin, putative	0.0063	0.0554	0.8276
Leishmania major	alpha tubulin	0.0063	0.0554	0.2601
Plasmodium vivax	tubulin gamma chain, putative	0.0063	0.0554	1
Trypanosoma brucei	Aminopeptidase M1, putative	0.012	0.2129	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0063	0.0554	0.0554
Leishmania major	alpha tubulin	0.0063	0.0554	0.2601
Brugia malayi	alpha-tubulin	0.0063	0.0554	0.0554
Brugia malayi	Tubulin alpha-2 chain	0.0063	0.0554	0.0554
Leishmania major	alpha tubulin	0.0063	0.0554	0.2601
Brugia malayi	prolyl oligopeptidase family protein	0.0067	0.0669	0.0669
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Echinococcus multilocularis	tubulin alpha chain	0.0063	0.0554	0.0554
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0063	0.0554	0.8276
Schistosoma mansoni	alpha tubulin	0.0063	0.0554	0.1027
Trypanosoma cruzi	Aminopeptidase M1, putative	0.012	0.2129	1
Schistosoma mansoni	neuropeptide receptor	0.024	0.5393	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0063	0.0554	0.0554
Echinococcus granulosus	tubulin alpha 1C chain	0.0063	0.0554	0.0554
Echinococcus granulosus	tubulin alpha 3 chain	0.0063	0.0554	0.0554
Giardia lamblia	Beta tubulin	0.0063	0.0554	0.5
Echinococcus granulosus	tubulin gamma 1 chain	0.0063	0.0554	0.0554
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0067	0.0669	0.3143
Trichomonas vaginalis	tubulin beta chain, putative	0.0063	0.0554	0.2601
Echinococcus granulosus	tubulin alpha	0.0063	0.0554	0.0554
Brugia malayi	hypothetical protein	0.0051	0.0239	0.0239
Trypanosoma cruzi	tubulin gamma chain	0.0063	0.0554	0.2601
Leishmania major	gamma-tubulin	0.0063	0.0554	0.2601
Leishmania major	epsilon tubulin, putative	0.0063	0.0554	0.2601
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0554	0.0626
Loa Loa (eye worm)	beta-tubulin	0.0063	0.0554	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0289	0.6717	0.7593
Schistosoma mansoni	tubulin subunit alpha	0.0063	0.0554	0.1027
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0063	0.0554	0.2601
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.012	0.2129	0.2129
Brugia malayi	Tubulin alpha chain	0.0063	0.0554	0.0554
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Echinococcus granulosus	Tubulin alpha 1 chain	0.0063	0.0554	0.0554
Brugia malayi	Peptidase family M1 containing protein	0.012	0.2129	0.2129
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.012	0.2129	0.2129
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.012	0.2129	0.2129
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0067	0.0669	0.0669
Onchocerca volvulus		0.0409	1	1
Trypanosoma cruzi	beta tubulin, putative	0.0063	0.0554	0.2601
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0078	0.0975	0.4578
Trichomonas vaginalis	tubulin beta chain, putative	0.0063	0.0554	0.2601
Brugia malayi	hypothetical protein	0.012	0.2129	0.2129
Brugia malayi	tubulin alpha-2 chain	0.0063	0.0554	0.0554
Toxoplasma gondii	beta tubulin	0.0063	0.0554	0.8276
Loa Loa (eye worm)	aminopeptidase N	0.012	0.2129	0.2407
Trypanosoma brucei	alpha tubulin	0.0063	0.0554	0.2601
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0975	0.1102
Brugia malayi	tubulin alpha chain - mouse	0.0063	0.0554	0.0554
Echinococcus granulosus	Tubulin beta 2C chain	0.0063	0.0554	0.0554
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Leishmania major	alpha tubulin	0.0063	0.0554	0.2601
Echinococcus granulosus	tubulin subunit TubB	0.0063	0.0554	0.0554
Giardia lamblia	Beta tubulin	0.0063	0.0554	0.5
Onchocerca volvulus		0.012	0.2129	0.2129
Plasmodium falciparum	alpha tubulin 2	0.0063	0.0554	1
Echinococcus multilocularis	tubulin subunit TubB	0.0063	0.0554	0.0554
Entamoeba histolytica	aminopeptidase, putative	0.012	0.2129	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0063	0.0554	0.2601
Brugia malayi	Tubulin alpha-2 chain	0.0063	0.0554	0.0554
Loa Loa (eye worm)	BEN-1 protein	0.0063	0.0554	0.0626
Brugia malayi	Tubulin beta-1 chain	0.0063	0.0554	0.0554
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.012	0.2129	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0063	0.0554	0.0554
Loa Loa (eye worm)	tubulin alpha chain	0.0063	0.0554	0.0626
Echinococcus multilocularis	beta tubulin	0.0063	0.0554	0.0554
Brugia malayi	beta-tubulin, identical	0.0063	0.0554	0.0554
Schistosoma mansoni	tubulin subunit beta	0.0063	0.0554	0.1027
Plasmodium vivax	tubulin epsilon chain, putative	0.0063	0.0554	1
Schistosoma mansoni	tubulin subunit epsilon	0.0063	0.0554	0.1027
Brugia malayi	Tubulin gamma chain	0.0063	0.0554	0.0554
Echinococcus granulosus	tubulin alpha chain	0.0063	0.0554	0.0554
Echinococcus granulosus	Tubulin beta 2C chain	0.0063	0.0554	0.0554
Trypanosoma cruzi	epsilon tubulin, putative	0.0063	0.0554	0.2601
Trypanosoma brucei	beta tubulin	0.0063	0.0554	0.2601
Toxoplasma gondii	alpha-tubulin I, putative	0.0063	0.0554	0.8276
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Loa Loa (eye worm)	prolyl oligopeptidase	0.0199	0.4269	0.4826
Loa Loa (eye worm)	alpha-tubulin	0.0063	0.0554	0.0626
Loa Loa (eye worm)	BEN-1 protein	0.0063	0.0554	0.0626
Echinococcus multilocularis	neuropeptide receptor	0.024	0.5393	0.5393
Echinococcus multilocularis	tubulin alpha chain	0.0063	0.0554	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0239	0.027
Echinococcus granulosus	Tubulin alpha 1 chain	0.0063	0.0554	0.0554
Loa Loa (eye worm)	tubulin beta chain	0.0063	0.0554	0.0626
Trypanosoma cruzi	alpha tubulin, putative	0.0063	0.0554	0.2601
Echinococcus granulosus	aminopeptidase N	0.0409	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.024	0.5393	0.5393
Loa Loa (eye worm)	hypothetical protein	0.0367	0.8846	1
Giardia lamblia	Beta tubulin	0.0063	0.0554	0.5
Echinococcus granulosus	Tubulin beta 2C chain	0.0063	0.0554	0.0554
Trypanosoma brucei	beta tubulin	0.0063	0.0554	0.2601
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.012	0.2129	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.012	0.2129	0.2129
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0063	0.0554	0.2601
Echinococcus multilocularis	aminopeptidase N	0.0409	1	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.012	0.2129	0.2129
Leishmania major	alpha tubulin	0.0063	0.0554	0.2601
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0067	0.0669	0.3143
Trichomonas vaginalis	tubulin, putative	0.0063	0.0554	0.2601
Trypanosoma brucei	epsilon tubulin	0.0063	0.0554	0.2601
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.012	0.2129	0.3948
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Giardia lamblia	Alpha-tubulin	0.0063	0.0554	0.5
Toxoplasma gondii	alpha tubulin TUBA1	0.0063	0.0554	0.8276
Echinococcus multilocularis	tubulin alpha chain	0.0063	0.0554	0.0554
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0078	0.0975	0.0975
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0331	0.7871	0.8898
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.012	0.2129	0.2129
Giardia lamblia	Alpha-tubulin	0.0063	0.0554	0.5
Trypanosoma brucei	beta tubulin	0.0063	0.0554	0.2601
Plasmodium vivax	tubulin alpha chain, putative	0.0063	0.0554	1
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.012	0.2129	1
Schistosoma mansoni	tubulin subunit beta	0.0063	0.0554	0.1027
Loa Loa (eye worm)	tubulin alpha chain	0.0063	0.0554	0.0626
Schistosoma mansoni	alpha tubulin	0.0063	0.0554	0.1027
Mycobacterium ulcerans	aminopeptidase N PepN	0.012	0.2129	1
Echinococcus granulosus	neuropeptide receptor	0.024	0.5393	0.5393
Echinococcus multilocularis	tubulin subunit beta	0.0063	0.0554	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0975	0.1102
Trichomonas vaginalis	tubulin alpha chain, putative	0.0063	0.0554	0.2601
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.012	0.2129	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0063	0.0554	0.2601
Plasmodium falciparum	tubulin gamma chain	0.0063	0.0554	1
Loa Loa (eye worm)	alpha-tubulin	0.0063	0.0554	0.0626
Trypanosoma brucei	epsilon tubulin	0.0063	0.0554	0.2601
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0063	0.0554	0.0626
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Schistosoma mansoni	tubulin subunit beta	0.0063	0.0554	0.1027
Echinococcus granulosus	tubulin alpha 3 chain	0.0063	0.0554	0.0554
Schistosoma mansoni	tubulin subunit beta	0.0063	0.0554	0.1027
Echinococcus multilocularis	peroxisome assembly protein 26	0.0063	0.0554	0.0554
Schistosoma mansoni	tubulin subunit beta	0.0063	0.0554	0.1027
Echinococcus granulosus	tubulin alpha chain	0.0063	0.0554	0.0554
Schistosoma mansoni	tubulin subunit gamma	0.0063	0.0554	0.1027
Leishmania major	beta tubulin	0.0063	0.0554	0.2601
Leishmania major	alpha tubulin	0.0063	0.0554	0.2601
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0067	0.0669	0.3143
Echinococcus granulosus	Tubulin beta 2C chain	0.0063	0.0554	0.0554
Plasmodium falciparum	tubulin beta chain	0.0063	0.0554	1
Trypanosoma cruzi	aminopeptidase, putative	0.012	0.2129	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 51.24 %	Anticancer activity against human HepG2 cells assessed as viable cells at 10'-5 M after 48 hrs by XTT assay relative to control	ChEMBL.	23664495

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2392442

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1775888