Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.2167 | 0.2706 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.1319 | 0.1436 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0384 | 0.0336 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0105 | 0.8007 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0364 | 0.0455 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.2167 | 0.2706 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0021 | 0.1319 | 0.1379 |
Echinococcus granulosus | Smad4 | 0.0009 | 0.0364 | 0.0149 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.1026 | 0.1281 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0021 | 0.1319 | 0.1276 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0364 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3978 | 0.3948 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.2611 | 0.2575 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0009 | 0.0364 | 0.0149 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0105 | 0.8007 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0105 | 0.8007 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0009 | 0.0364 | 0.0316 |
Echinococcus granulosus | bloom syndrome protein | 0.0021 | 0.1319 | 0.1379 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.1026 | 0.1281 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0105 | 0.8007 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0021 | 0.1319 | 0.1276 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0105 | 0.8007 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.1319 | 0.1276 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0197 | 0.00000000087587 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.1026 | 0.0981 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0197 | 0.00000000087587 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0105 | 0.8007 | 0.5 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0009 | 0.0364 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.8007 | 0.7997 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0197 | 0.00000000087587 |
Entamoeba histolytica | recQ family helicase, putative | 0.0021 | 0.1319 | 0.1122 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0009 | 0.0364 | 0.0316 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0105 | 0.8007 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.3978 | 0.3948 |
Echinococcus granulosus | smad | 0.0009 | 0.0364 | 0.0149 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.1319 | 0.1084 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0105 | 0.8007 | 1 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0105 | 0.8007 | 0.7997 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0105 | 0.8007 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0009 | 0.0364 | 0.0149 |
Echinococcus multilocularis | smad | 0.0009 | 0.0364 | 0.0149 |
Schistosoma mansoni | DNA helicase recq5 | 0.0021 | 0.1319 | 0.1647 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0505 | 0.0458 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.2611 | 0.3262 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0364 | 0.0455 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0021 | 0.1319 | 0.1276 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.1026 | 0.0981 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0197 | 0.00000000087587 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1319 | 0.1276 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0105 | 0.8007 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0364 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.1026 | 0.1281 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.2032 | 0.1992 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0021 | 0.1319 | 0.1379 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0011 | 0.0505 | 0.0631 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0105 | 0.8007 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0057 | 0.4153 | 0.4885 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0105 | 0.8007 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0505 | 0.0043 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0394 | 0.0186 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0364 | 0.0316 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0197 | 0.00000000087587 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1026 | 0.0981 |
Schistosoma mansoni | smad | 0.0009 | 0.0364 | 0.0455 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0105 | 0.8007 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.1026 | 0.1002 |
Plasmodium vivax | RNA helicase-1, putative | 0.0105 | 0.8007 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0021 | 0.1319 | 0.1379 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0105 | 0.8007 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0021 | 0.1319 | 0.1379 |
Schistosoma mansoni | DNA helicase recq1 | 0.0021 | 0.1319 | 0.1647 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.2167 | 0.2472 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 1 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0364 | 0.0455 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.1026 | 0.1002 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.1319 | 0.1276 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0364 | 0.0316 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.2167 | 0.2472 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.2032 | 0.2537 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.469 | 0.5858 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0105 | 0.8007 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0011 | 0.0505 | 0.0043 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0105 | 0.8007 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0249 | 0.0311 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0473 | 0.0591 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0105 | 0.8007 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0105 | 0.8007 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.1026 | 0.0981 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.1026 | 0.1002 |
Echinococcus multilocularis | bloom syndrome protein | 0.0021 | 0.1319 | 0.1379 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0394 | 0.0186 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.2032 | 0.1992 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.1319 | 0.1122 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.3978 | 0.3948 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.1026 | 0.1002 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.1026 | 0.1002 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0197 | 0.00000000087587 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0105 | 0.8007 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0105 | 0.8007 | 1 |
Echinococcus multilocularis | Smad4 | 0.0009 | 0.0364 | 0.0149 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0009 | 0.0364 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0505 | 0.0458 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0364 | 0.0455 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0105 | 0.8007 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0009 | 0.0364 | 0.0149 |
Brugia malayi | Smad1 | 0.0009 | 0.0364 | 0.0316 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.1319 | 0.1436 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.2611 | 0.2575 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0197 | 0.00000000087587 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0394 | 0.0346 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0197 | 0.00000000087587 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.3978 | 0.3948 |
Entamoeba histolytica | recQ family DNA helicase | 0.0011 | 0.0505 | 0.0043 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.1026 | 0.1002 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0021 | 0.1319 | 0.1436 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0364 | 0.0455 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.1026 | 0.1281 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.1319 | 0.1122 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
permeability (ADMET) | = 7.1 ucm/s | Permeability across apical to basolateral side in human Caco2 cells at 10 uM | ChEMBL. | 23768906 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.