Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0552 | 0.1952 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0552 | 0.1952 | 0.5 |
Schistosoma mansoni | fusion | 0.0552 | 0.1952 | 0.2271 |
Leishmania major | hypothetical protein, conserved | 0.0552 | 0.1952 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0552 | 0.1952 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.1551 | 0.8592 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0552 | 0.1952 | 0.2271 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.1551 | 0.8592 | 0.5 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0552 | 0.1952 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1551 | 0.8592 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1551 | 0.8592 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0552 | 0.1952 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0552 | 0.1952 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0552 | 0.1952 | 0.2271 |
Schistosoma mansoni | hypothetical protein | 0.1551 | 0.8592 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1551 | 0.8592 | 0.825 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.1551 | 0.8592 | 0.825 |
Schistosoma mansoni | zinc finger protein | 0.0552 | 0.1952 | 0.2271 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0552 | 0.1952 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0552 | 0.1952 | 0.2271 |
Loa Loa (eye worm) | hypothetical protein | 0.0552 | 0.1952 | 0.2271 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.1551 | 0.8592 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0552 | 0.1952 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0552 | 0.1952 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0552 | 0.1952 | 0.2271 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0552 | 0.1952 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0552 | 0.1952 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0552 | 0.1952 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.1551 | 0.8592 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.1551 | 0.8592 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0552 | 0.1952 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.1551 | 0.8592 | 1 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0552 | 0.1952 | 0.2271 |
Onchocerca volvulus | 0.0552 | 0.1952 | 0.2271 | |
Leishmania major | hypothetical protein, conserved | 0.0552 | 0.1952 | 0.5 |
Onchocerca volvulus | 0.0552 | 0.1952 | 0.2271 | |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.1551 | 0.8592 | 0.825 |
Schistosoma mansoni | hypothetical protein | 0.0552 | 0.1952 | 0.2271 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0552 | 0.1952 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0552 | 0.1952 | 0.5 |
Schistosoma mansoni | RNA binding protein | 0.0552 | 0.1952 | 0.2271 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1551 | 0.8592 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1551 | 0.8592 | 1 |
Onchocerca volvulus | 0.0552 | 0.1952 | 0.2271 | |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0552 | 0.1952 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1551 | 0.8592 | 0.825 |
Plasmodium vivax | hypothetical protein, conserved | 0.1551 | 0.8592 | 0.5 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0552 | 0.1952 | 0.2271 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.1551 | 0.8592 | 0.825 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.1551 | 0.8592 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0552 | 0.1952 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.1551 | 0.8592 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1551 | 0.8592 | 0.5 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.1551 | 0.8592 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.1551 | 0.8592 | 1 |
Onchocerca volvulus | 0.0552 | 0.1952 | 0.2271 | |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1551 | 0.8592 | 0.825 |
Chlamydia trachomatis | DNA topoisomerase I | 0.1551 | 0.8592 | 0.5 |
Onchocerca volvulus | 0.1551 | 0.8592 | 1 | |
Echinococcus multilocularis | tumor protein p63 | 0.1763 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.477 | Inhibition against Acetylcholinesterase (AChE) | ChEMBL. | 8558505 |
IC50 (binding) | = 3000 nM | In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate. | ChEMBL. | 1469686 |
IC50 (binding) | = 3000 nM | Inhibition concentration against rat acetylcholinesterase | ChEMBL. | 7932538 |
IC50 (binding) | = 3000 nM | In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate. | ChEMBL. | 1469686 |
IC50 (binding) | = 3000 nM | Inhibition concentration against rat acetylcholinesterase | ChEMBL. | 7932538 |
IC50 (binding) | = 3000 nM | Inhibition of AChE | ChEMBL. | 20053484 |
Log IC50 (binding) | = 3.477 | Inhibition against Acetylcholinesterase (AChE) | ChEMBL. | 8558505 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.