Detailed information for compound 1781059

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 225.094 | Formula: C14H16BNO
  • H donors: 1 H acceptors: 0 LogP: 3.17 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CO[B-]([NH2+]1)(c1ccccc1)c1ccccc1
  • InChi: 1S/C14H16BNO/c1-3-7-13(8-4-1)15(16-11-12-17-15)14-9-5-2-6-10-14/h1-10H,11-12,16H2
  • InChiKey: QKVRQZFQCGZLDA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ORAI calcium release-activated calcium modulator 3 Starlite/ChEMBL References
Homo sapiens ORAI calcium release-activated calcium modulator 1 References
Homo sapiens ORAI calcium release-activated calcium modulator 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Protein orai-1 Get druggable targets OG5_130743 All targets in OG5_130743
Schistosoma japonicum IPR012446,Protein of unknown function DUF1650,domain-containing Get druggable targets OG5_130743 All targets in OG5_130743
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130743 All targets in OG5_130743
Brugia malayi hypothetical protein Get druggable targets OG5_130743 All targets in OG5_130743
Schistosoma mansoni Protein orai-1 Get druggable targets OG5_130743 All targets in OG5_130743
Echinococcus multilocularis calcium release activated calcium channel Get druggable targets OG5_130743 All targets in OG5_130743
Echinococcus granulosus calcium release activated calcium channel Get druggable targets OG5_130743 All targets in OG5_130743
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis muscleblind protein 1 0.0154 0.1134 0.1132
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0044 0.0042
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0034 0.0032
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0007 0.0004
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.039 0.0388
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0034 0.0032
Schistosoma mansoni flap endonuclease-1 0.0024 0.0149 0.0147
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.044 0.0438
Echinococcus multilocularis microtubule associated protein 2 0.0712 0.5364 0.5363
Loa Loa (eye worm) XPG I-region family protein 0.0005 0.0006 0.0004
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0054 0.2943
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0044 0.0042
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0004
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.1465 0.1463
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0034 0.1694
Schistosoma mansoni DNA helicase recq5 0.0009 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0042
Onchocerca volvulus 0.0049 0.0338 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0169 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0044 0.0042
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0132 0.013
Brugia malayi nuclear receptor NHR-88 0.001 0.0044 0.0042
Schistosoma mansoni ferritin 0.0009 0.0031 0.0029
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0005 0.0006 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0044 0.0042
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0096
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0112 0.011
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0042
Schistosoma mansoni thyroid hormone receptor 0.001 0.0044 0.0042
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0044 0.0042
Toxoplasma gondii exonuclease III APE 0.0019 0.0112 0.2546
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0044 0.1244
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0034 0.0032
Schistosoma mansoni hypothetical protein 0.0303 0.2263 0.2262
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0044 0.0042
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0338 0.0336
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0044 0.1244
Echinococcus granulosus flap endonuclease GEN 1 0.0005 0.0006 0.0004
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.044 1
Schistosoma mansoni ferritin light chain 0.0009 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.0154 0.1134 0.1132
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0044 0.0042
Schistosoma mansoni apoferritin-2 0.0009 0.0031 0.0029
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0112 0.6484
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0044 0.0042
Schistosoma mansoni coup transcription factor 0.001 0.0044 0.0042
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0044 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0042
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0132 0.013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0005 0.0006 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0044 0.0042
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0044 0.0042
Schistosoma mansoni exonuclease 0.0005 0.0006 0.0004
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0169 0.0166
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0044 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0044 0.0042
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0005 0.0006 0.0143
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0112 0.6513
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0034 0.0768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0044 0.0042
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0042
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0169 0.0166
Schistosoma mansoni microtubule-associated protein tau 0.0712 0.5364 0.5363
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0338 1
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0054 0.3206
Schistosoma mansoni Protein orai-1 0.1323 1 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0044 0.0042
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0005 0.0006 0.0004
Echinococcus granulosus calcium release activated calcium channel 0.1323 1 1
Brugia malayi Flap endonuclease-1 0.0027 0.0169 0.0166
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0044 0.0042
Schistosoma mansoni ap endonuclease 0.0019 0.0112 0.011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0044 0.0042
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0034 0.0032
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.044 0.0438
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.044 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.044 0.0438
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0338 0.0336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0044 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0009 0.0034 0.0032
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0112 0.1977
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0338 0.0336
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0112 0.011
Brugia malayi Muscleblind-like protein 0.0154 0.1134 0.1132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0044 0.0042
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0005 0.0006 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.044 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0112 0.011
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0338 0.0336
Schistosoma mansoni DNA helicase recq1 0.0009 0.0034 0.0032
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0007 0.0004
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0005 0.0006 0.0004
Brugia malayi hypothetical protein 0.0006 0.0007 0.0004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0076 0.1737
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0169 1
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0005 0.0006 0.0004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0044 0.0042
Entamoeba histolytica exonuclease, putative 0.0005 0.0006 0.0373
Echinococcus multilocularis expressed protein 0.0009 0.0031 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0044 0.0042
Echinococcus multilocularis flap endonuclease GEN 1 0.0005 0.0006 0.0004
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0169 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0042
Schistosoma mansoni thyroid hormone receptor 0.001 0.0044 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0044 0.0042
Plasmodium falciparum flap endonuclease 1 0.0027 0.0169 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0044 0.0042
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0054 0.2943
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0338 0.0336
Entamoeba histolytica DNA-repair protein, putative 0.0005 0.0006 0.0373
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0042
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0112 0.6513
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.039 0.0388
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0097 0.0095
Entamoeba histolytica exonuclease, putative 0.0005 0.0006 0.0373
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.039 0.0388
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0005 0.0006 0.0143
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0044 0.0042
Echinococcus granulosus expressed protein 0.0009 0.0031 0.0029
Schistosoma mansoni Protein orai-1 0.1323 1 1
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0338 0.0336
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0004
Brugia malayi mbt repeat family protein 0.0049 0.0338 0.0336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0044 0.0042
Schistosoma mansoni ferritin 0.0009 0.0031 0.0029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0044 0.0042
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0054 0.1102
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0034 0.0768
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0338 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0044 0.0042
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0044 0.0042
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0169 0.3833
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.1323 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0044 0.0042
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.1465 0.1463
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.044 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0044 0.0042
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0044 0.0042
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0034 0.0032
Brugia malayi hypothetical protein 0.0006 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0056 0.039 0.0388
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0004
Brugia malayi nuclear hormone receptor 0.001 0.0044 0.0042
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0044 0.0042
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0112 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0044 0.0042
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0132 0.7733
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0112 0.6513
Schistosoma mansoni ferritin light chain 0.0009 0.0031 0.0029
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0112 0.2438
Schistosoma mansoni ferritin 0.0009 0.0031 0.0029
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0034 0.1694
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.044 0.0438
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.044 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0007 0.0004
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0169 1
Echinococcus multilocularis ferritin 0.0009 0.0031 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0007 0.0004
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0338 0.0336
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0169 0.3743
Onchocerca volvulus 0.001 0.0044 0.1244
Echinococcus multilocularis muscleblind protein 0.0154 0.1134 0.1132
Brugia malayi nuclear receptor RXR 0.0006 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0005 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0004
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0112 0.6513
Echinococcus granulosus bloom syndrome protein 0.0022 0.0132 0.013
Echinococcus granulosus ferritin 0.0009 0.0031 0.0029
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0112 0.1977
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.044 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0044 0.0042
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.039 0.0388
Schistosoma mansoni ap endonuclease 0.0019 0.0112 0.011
Echinococcus multilocularis exonuclease 1 0.0005 0.0006 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0044 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0044 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0044 0.0042
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0112 0.6643
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0078 0.4403
Brugia malayi steroid hormone receptor 0.001 0.0044 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0042
Brugia malayi ecdysteroid receptor 0.001 0.0044 0.0042
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.039 0.0388
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0034 0.0032
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0169 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0044 0.0042
Trichomonas vaginalis ferritin, putative 0.0009 0.0031 0.1535
Echinococcus granulosus microtubule associated protein 2 0.0712 0.5364 0.5363
Brugia malayi XPG I-region family protein 0.0005 0.0006 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0007 0.0004
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0031 0.5
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0112 0.6513
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0044 0.0042
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0005 0.0006 0.0143
Echinococcus multilocularis calcium release activated calcium channel 0.1323 1 1
Loa Loa (eye worm) RecQ helicase 0.0022 0.0132 0.013
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0044 0.0042
Echinococcus granulosus muscleblind protein 0.0154 0.1134 0.1132
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0044 0.0042
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0044 0.1244
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0338 0.0336
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0034 0.0032
Schistosoma mansoni ferritin 0.0009 0.0031 0.0029
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0007 0.0004
Loa Loa (eye worm) MBCTL1 0.0056 0.039 0.0388
Brugia malayi mbt repeat family protein 0.0049 0.0338 0.0336
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0112 0.011
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0044 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0044 0.0042
Echinococcus granulosus flap endonuclease 1 0.0027 0.0169 0.0166
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0112 0.6513
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.039 0.0388
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0112 0.6513
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0044 0.0042
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0054 0.2943
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0112 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.1134 0.1132
Echinococcus granulosus exonuclease 1 0.0005 0.0006 0.0004
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0169 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0132 0.7733
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0112 0.6513
Schistosoma mansoni apoferritin-2 0.0009 0.0031 0.0029

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 11.9 uM Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Cd2+ influx after 10 mins by FLIPR assay in presence of thapsigargin ChEMBL. 23602525
IC50 (binding) = 20.7 uM Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Ca2+ influx after 5 mins by FLIPR assay ChEMBL. 23602525
IC50 (binding) = 22 uM Inhibition of human TRPV6 transfected in HEK293 cells ChEMBL. 23602525
IC50 (binding) = 22.9 uM Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Ca2+ influx after 10 mins by FLIPR assay in presence of thapsigargin ChEMBL. 23602525
IC50 (binding) = 24.5 uM Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Cd2+ influx after 5 mins by FLIPR assay ChEMBL. 23602525

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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