Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0019 | 0.0064 | 0.0116 |
Plasmodium vivax | hypothetical protein, conserved | 0.0093 | 0.0831 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0093 | 0.0831 | 0.0772 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0019 | 0.0064 | 0.0116 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0019 | 0.0064 | 0.0064 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0378 | 0.3774 | 0.3734 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0831 | 0.0831 |
Plasmodium vivax | amine transporter, putative | 0.0093 | 0.0831 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0831 | 0.0831 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0378 | 0.3774 | 0.5 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0378 | 0.3774 | 0.3734 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0019 | 0.0064 | 0.0064 |
Echinococcus multilocularis | serotonin transporter | 0.0548 | 0.5533 | 0.5505 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Echinococcus multilocularis | serotonin receptor | 0.0981 | 1 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0093 | 0.0831 | 0.5 |
Loa Loa (eye worm) | TTK protein kinase | 0.0378 | 0.3774 | 0.3774 |
Brugia malayi | Melatonin receptor type 1A | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0019 | 0.0064 | 0.0064 |
Brugia malayi | larval opioid receptor | 0.0019 | 0.0064 | 0.0116 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0093 | 0.0831 | 0.0772 |
Loa Loa (eye worm) | hypothetical protein | 0.0548 | 0.5533 | 0.5533 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0981 | 1 | 1 |
Onchocerca volvulus | 0.0093 | 0.0831 | 0.1403 | |
Brugia malayi | AKH receptor | 0.0019 | 0.0064 | 0.0116 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0064 | 0.0116 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0064 | 0.0116 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0093 | 0.0831 | 0.1502 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0064 | 0.0116 |
Brugia malayi | G protein-coupled receptor | 0.0019 | 0.0064 | 0.0116 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0019 | 0.0064 | 0.0116 |
Brugia malayi | putative neuropeptide receptor | 0.0019 | 0.0064 | 0.0116 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0093 | 0.0831 | 0.1502 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0064 | 0.0116 |
Brugia malayi | Dopamine receptor | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0548 | 0.5533 | 0.5533 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0378 | 0.3774 | 0.6783 |
Brugia malayi | Serotonin receptor | 0.0019 | 0.0064 | 0.0116 |
Plasmodium falciparum | transporter, putative | 0.0093 | 0.0831 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0064 | 0.0116 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0093 | 0.0831 | 0.0772 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0093 | 0.0831 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Brugia malayi | Serotonin receptor | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Brugia malayi | G-protein coupled receptor | 0.0019 | 0.0064 | 0.0116 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0019 | 0.0064 | 0.0116 |
Echinococcus granulosus | serotonin transporter | 0.0548 | 0.5533 | 0.5505 |
Brugia malayi | neuropeptide F receptor | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0831 | 0.0831 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0093 | 0.0831 | 0.0772 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Onchocerca volvulus | 0.0093 | 0.0831 | 0.1403 | |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0548 | 0.5533 | 0.5533 |
Brugia malayi | sulfakinin receptor protein | 0.0019 | 0.0064 | 0.0116 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0093 | 0.0831 | 0.0772 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Brugia malayi | Protein kinase domain containing protein | 0.0378 | 0.3774 | 0.682 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0548 | 0.5533 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0019 | 0.0064 | 0.0116 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0548 | 0.5533 | 0.5533 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0093 | 0.0831 | 0.0831 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0548 | 0.5533 | 0.5505 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0093 | 0.0831 | 0.0772 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0019 | 0.0064 | 0.0064 |
Onchocerca volvulus | 0.0093 | 0.0831 | 0.1403 | |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0093 | 0.0831 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0093 | 0.0831 | 0.1502 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0093 | 0.0831 | 0.0772 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0831 | 0.0831 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0093 | 0.0831 | 0.0772 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0019 | 0.0064 | 0.0116 |
Toxoplasma gondii | hypothetical protein | 0.0093 | 0.0831 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0093 | 0.0831 | 0.0772 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0548 | 0.5533 | 0.5533 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0093 | 0.0831 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0093 | 0.0831 | 0.1502 |
Brugia malayi | GnHR receptor homolog | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0093 | 0.0831 | 0.0772 |
Echinococcus multilocularis | serotonin receptor | 0.0981 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0093 | 0.0831 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0013 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0019 | 0.0064 | 0.0116 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0064 | 0.0116 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0093 | 0.0831 | 0.0772 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0093 | 0.0831 | 0.0772 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0548 | 0.5533 | 0.5533 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Leishmania major | cytochrome p450-like protein | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Brugia malayi | follicle stimulating hormone receptor | 0.0019 | 0.0064 | 0.0116 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0378 | 0.3774 | 0.5 |
Plasmodium falciparum | amino acid transporter, putative | 0.0093 | 0.0831 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0093 | 0.0831 | 0.0772 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0019 | 0.0064 | 0.0064 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0093 | 0.0831 | 0.0772 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0548 | 0.5533 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0093 | 0.0831 | 0.0831 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0831 | 0.0831 |
Brugia malayi | RE15519p | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Brugia malayi | G-protein coupled receptor | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0093 | 0.0831 | 0.0772 |
Brugia malayi | hypothetical protein | 0.0093 | 0.0831 | 0.1502 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0378 | 0.3774 | 0.3734 |
Giardia lamblia | Kinase, TTK | 0.0378 | 0.3774 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0093 | 0.0831 | 0.0772 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0093 | 0.0831 | 0.0772 |
Loa Loa (eye worm) | hypothetical protein | 0.0981 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0548 | 0.5533 | 0.5505 |
Onchocerca volvulus | 0.0548 | 0.5533 | 1 | |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0019 | 0.0064 | 0.0064 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0093 | 0.0831 | 0.0772 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0019 | 0.0064 | 0.0064 |
Trypanosoma brucei | cytochrome P450, putative | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0093 | 0.0831 | 0.0772 |
Brugia malayi | Dopamine receptor protein 2 | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0981 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0093 | 0.0831 | 0.0772 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Brugia malayi | Dopamine receptor protein 1 | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0093 | 0.0831 | 0.0772 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0095 | 0.0856 | 0.0797 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0064 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0019 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0831 | 0.0831 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 7.5 uM | Antimicrobial activity against tolc-defecient Escherichia coli BW25113 after 17 hrs by two-fold serial dilution technique | ChEMBL. | 24044050 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.